{"id":"https://openalex.org/W2013403124","doi":"https://doi.org/10.1016/0014-5793(90)80386-w","title":"Evidence for communication between nerve growth factor and protein tyrosine phosphorylation","display_name":"Evidence for communication between nerve growth factor and protein tyrosine phosphorylation","publication_year":1990,"publication_date":"1990-10-01","ids":{"openalex":"https://openalex.org/W2013403124","doi":"https://doi.org/10.1016/0014-5793(90)80386-w","mag":"2013403124","pmid":"https://pubmed.ncbi.nlm.nih.gov/2171996"},"language":"en","primary_location":{"id":"doi:10.1016/0014-5793(90)80386-w","doi":"https://doi.org/10.1016/0014-5793(90)80386-w","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-5793(90)80386-w","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://discovery.dundee.ac.uk/en/publications/858695a7-be57-47b9-b9cc-bd857985d408","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007482490","display_name":"N\u00e9stor G\u00f3mez","orcid":"https://orcid.org/0000-0002-1348-2737","observed_orcids":["https://orcid.org/0000-0002-1348-2737"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"N\u00e9stor G\u00f3mez","raw_affiliation_strings":["Department of Biochemistry, University of Dundee, UK","Department of Biochemistry, University of Dundee Dundee UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Dundee, UK","institution_ids":["https://openalex.org/I177639307"]},{"raw_affiliation_string":"Department of Biochemistry, University of Dundee Dundee UK","institution_ids":["https://openalex.org/I177639307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005973308","display_name":"Nicholas K. Tonks","orcid":"https://orcid.org/0000-0002-2394-1538","observed_orcids":["https://orcid.org/0000-0002-2394-1538"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas K. Tonks","raw_affiliation_strings":["Department of Biochemistry, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031585426","display_name":"Christine F. Morrison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christine Morrison","raw_affiliation_strings":["MRC Brain Metabolism Unit, University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Brain Metabolism Unit, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035463634","display_name":"Tony Harmar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tony Harmar","raw_affiliation_strings":["MRC Brain Metabolism Unit, University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Brain Metabolism Unit, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010890113","display_name":"Philip Cohen","orcid":"https://orcid.org/0000-0001-7632-9492","observed_orcids":["https://orcid.org/0000-0001-7632-9492"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Philip Cohen","raw_affiliation_strings":["Department of Biochemistry, University of Dundee, Dundee, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Dundee, Dundee, UK","institution_ids":["https://openalex.org/I177639307"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":7.5276,"has_fulltext":false,"cited_by_count":103,"citation_normalized_percentile":{"value":0.98490596,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"271","issue":"1-2","first_page":"119","last_page":"122"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.8682000041007996,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.8682000041007996,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.052000001072883606,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.04569999873638153,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.875},{"id":"https://openalex.org/keywords/myelin-basic-protein-kinase","display_name":"myelin basic protein kinase","score":0.9440000057220459},{"id":"https://openalex.org/keywords/pc12-cells","display_name":"PC12 cells","score":0.9179999828338623},{"id":"https://openalex.org/keywords/cd45","display_name":"CD45","score":0.9110000133514404},{"id":"https://openalex.org/keywords/protein-phosphatase-2a","display_name":"protein phosphatase 2A","score":0.9929999709129333},{"id":"https://openalex.org/keywords/threonine-phosphorylation","display_name":"threonine phosphorylation","score":0.800000011920929},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.6700000166893005},{"id":"https://openalex.org/keywords/kinase-activation","display_name":"kinase activation","score":0.4259999990463257},{"id":"https://openalex.org/keywords/vanadate","display_name":"vanadate","score":0.7129999995231628},{"id":"https://openalex.org/keywords/okadaic-acid","display_name":"okadaic acid","score":1.0}],"concepts":[{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.8573704957962036},{"id":"https://openalex.org/C2776953658","wikidata":"https://www.wikidata.org/wiki/Q414042","display_name":"Okadaic acid","level":4,"score":0.7275114059448242},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6716732978820801},{"id":"https://openalex.org/C389152","wikidata":"https://www.wikidata.org/wiki/Q6593007","display_name":"Protein phosphatase 2","level":4,"score":0.6514020562171936},{"id":"https://openalex.org/C87325107","wikidata":"https://www.wikidata.org/wiki/Q7251493","display_name":"Protein phosphorylation","level":4,"score":0.6101862788200378},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.5740543603897095},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.546137809753418},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.49892592430114746},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4792875647544861},{"id":"https://openalex.org/C2775880066","wikidata":"https://www.wikidata.org/wiki/Q186521","display_name":"Threonine","level":4,"score":0.45333394408226013},{"id":"https://openalex.org/C2780876595","wikidata":"https://www.wikidata.org/wiki/Q410974","display_name":"Myelin basic protein","level":4,"score":0.4459967613220215},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.43554627895355225},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42768359184265137},{"id":"https://openalex.org/C2781116636","wikidata":"https://www.wikidata.org/wiki/Q426228","display_name":"Vanadate","level":2,"score":0.4103166460990906},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.39962491393089294},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37105607986450195},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35864806175231934},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.3192670941352844},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.2018274962902069},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1527450978755951},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009414","descriptor_name":"Nerve Growth Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054648","descriptor_name":"Protein Phosphatase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/0014-5793(90)80386-w","doi":"https://doi.org/10.1016/0014-5793(90)80386-w","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-5793(90)80386-w","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:2171996","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2171996","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"},{"id":"pmh:oai:discovery.dundee.ac.uk:openaire/858695a7-be57-47b9-b9cc-bd857985d408","doi":null,"is_oa":true,"landing_page_url":"https://discovery.dundee.ac.uk/en/publications/858695a7-be57-47b9-b9cc-bd857985d408","pdf_url":null,"source":{"id":"https://openalex.org/S4306400523","display_name":"Discovery Research Portal (University of Dundee)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177639307","host_organization_name":"University of Dundee","host_organization_lineage":["https://openalex.org/I177639307"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"G\u00f3mez, N, Tonks, N K, Morrison, C, Harmar, T & Cohen, P 1990, 'Evidence for communication between nerve growth factor and protein tyrosine phosphorylation', FEBS Letters, vol. 271, no. 1-2, pp. 119-122. https://doi.org/10.1016/0014-5793(90)80386-W","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:discovery.dundee.ac.uk:openaire/858695a7-be57-47b9-b9cc-bd857985d408","doi":null,"is_oa":true,"landing_page_url":"https://discovery.dundee.ac.uk/en/publications/858695a7-be57-47b9-b9cc-bd857985d408","pdf_url":null,"source":{"id":"https://openalex.org/S4306400523","display_name":"Discovery Research Portal (University of Dundee)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177639307","host_organization_name":"University of Dundee","host_organization_lineage":["https://openalex.org/I177639307"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"G\u00f3mez, N, Tonks, N K, Morrison, C, Harmar, T & Cohen, P 1990, 'Evidence for communication between nerve growth factor and protein tyrosine phosphorylation', FEBS Letters, vol. 271, no. 1-2, pp. 119-122. https://doi.org/10.1016/0014-5793(90)80386-W","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.46810001134872437,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1511031451","https://openalex.org/W1581101118","https://openalex.org/W1593099788","https://openalex.org/W1597741258","https://openalex.org/W1673236791","https://openalex.org/W1912665547","https://openalex.org/W1967433712","https://openalex.org/W1970587959","https://openalex.org/W1987428363","https://openalex.org/W2002623358","https://openalex.org/W2010573070","https://openalex.org/W2019687443","https://openalex.org/W2033727409","https://openalex.org/W2051699208","https://openalex.org/W2053286013","https://openalex.org/W2080669192","https://openalex.org/W2119361029","https://openalex.org/W2128635872","https://openalex.org/W2178456244"],"related_works":["https://openalex.org/W2090657443","https://openalex.org/W1970019106","https://openalex.org/W1597741258","https://openalex.org/W2019687443","https://openalex.org/W2036152447","https://openalex.org/W2089063720","https://openalex.org/W2087592022","https://openalex.org/W1982747157","https://openalex.org/W1997218197","https://openalex.org/W1581618262"],"abstract_inverted_index":{"Nerve":[0],"growth":[1],"factor":[2],"(NGF)":[3],"stimulation":[4],"of":[5,58,71],"PC12":[6],"cells":[7],"activated":[8],"two":[9],"myelin":[10],"basic":[11],"protein":[12,45,49,83],"(MBP)":[13],"kinase":[14],"activities":[15],"greater":[16],"than":[17],"10-fold":[18],"within":[19],"5":[20],"min,":[21],"which":[22],"were":[23,62],"resolved":[24],"by":[25,39,64],"chromatography":[26],"on":[27,34],"Mono":[28],"Q.":[29],"Each":[30],"enzyme":[31],"phosphorylated":[32],"MBP":[33],"threonine":[35],"and":[36,60,66,81],"was":[37],"inactivated":[38],"incubation":[40],"with":[41],"either":[42],"CD45,":[43],"a":[44,53,75],"tyrosine":[46,84],"phosphatase,":[47],"or":[48],"phosphatase":[50],"2A":[51],"(PP2A),":[52],"serine/threonine":[54],"phosphatase.":[55],"The":[56],"effects":[57],"CD45":[59],"PP2A":[61],"prevented":[63],"vanadate":[65],"okadaic":[67],"acid,":[68],"respectively.":[69],"Activation":[70],"the":[72],"MBP-kinases":[73],"provides":[74],"mechanism":[76],"for":[77],"communication":[78],"between":[79],"NGF":[80],"intracellular":[82],"phosphorylation.":[85]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}