{"id":"https://openalex.org/W2013398170","doi":"https://doi.org/10.1111/j.1755-3768.2014.3446.x","title":"Changes in vitreous haze over time with intravitreal sirolimus in noninfectious posterior\u2010segment uveitis (NI\u2010PSU): results of SAKURA Study 1","display_name":"Changes in vitreous haze over time with intravitreal sirolimus in noninfectious posterior\u2010segment uveitis (NI\u2010PSU): results of SAKURA Study 1","publication_year":2014,"publication_date":"2014-08-20","ids":{"openalex":"https://openalex.org/W2013398170","doi":"https://doi.org/10.1111/j.1755-3768.2014.3446.x","mag":"2013398170"},"language":"en","primary_location":{"id":"doi:10.1111/j.1755-3768.2014.3446.x","doi":"https://doi.org/10.1111/j.1755-3768.2014.3446.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1755-3768.2014.3446.x","pdf_url":null,"source":{"id":"https://openalex.org/S21165490","display_name":"Acta Ophthalmologica","issn_l":"0001-639X","issn":["0001-639X","1755-375X","1755-3768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Ophthalmologica","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086216178","display_name":"Bahram Bodaghi","orcid":"https://orcid.org/0000-0002-0962-5301","observed_orcids":["https://orcid.org/0000-0002-0962-5301"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B BODAGHI","raw_affiliation_strings":["Ophthalmology, Paris"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Paris","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101410551","display_name":"Yusuf Ahmed Ali","orcid":"https://orcid.org/0000-0003-2282-445X","observed_orcids":["https://orcid.org/0000-0003-2282-445X"]},"institutions":[{"id":"https://openalex.org/I4210099140","display_name":"Santen (United States)","ror":"https://ror.org/0108v8438","country_code":"US","type":"company","lineage":["https://openalex.org/I149737975","https://openalex.org/I4210099140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y ALI","raw_affiliation_strings":["Santen, Emeryville"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Santen, Emeryville","institution_ids":["https://openalex.org/I4210099140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002580961","display_name":"Y F Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099140","display_name":"Santen (United States)","ror":"https://ror.org/0108v8438","country_code":"US","type":"company","lineage":["https://openalex.org/I149737975","https://openalex.org/I4210099140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y YANG","raw_affiliation_strings":["Santen, Emeryville"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Santen, Emeryville","institution_ids":["https://openalex.org/I4210099140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088813606","display_name":"Michelle Chernock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099140","display_name":"Santen (United States)","ror":"https://ror.org/0108v8438","country_code":"US","type":"company","lineage":["https://openalex.org/I149737975","https://openalex.org/I4210099140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M CHERNOCK","raw_affiliation_strings":["Santen, Emeryville"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Santen, Emeryville","institution_ids":["https://openalex.org/I4210099140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113548501","display_name":"STEPHAN R. THURAU","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S THURAU","raw_affiliation_strings":["Ophthalmology, Munich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Munich","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012009183","display_name":"Carlos Eduardo Pavesio","orcid":"https://orcid.org/0000-0002-1625-2777","observed_orcids":["https://orcid.org/0000-0002-1625-2777"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C PAVESIO","raw_affiliation_strings":["Ophthalmology, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, London","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"92","issue":"s253","first_page":"0","last_page":"0"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitreous-haze","display_name":"vitreous haze","score":0.9610000252723694},{"id":"https://openalex.org/keywords/mtor-inhibition","display_name":"mTOR inhibition","score":0.5789999961853027},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8538976907730103},{"id":"https://openalex.org/C2777921159","wikidata":"https://www.wikidata.org/wiki/Q32089","display_name":"Sirolimus","level":2,"score":0.7194567918777466},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.6504004597663879},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5162339210510254},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4732556641101837},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.4201834201812744},{"id":"https://openalex.org/C2778257484","wikidata":"https://www.wikidata.org/wiki/Q555066","display_name":"Visual acuity","level":2,"score":0.4183729290962219},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.34323036670684814},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33773767948150635},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1111/j.1755-3768.2014.3446.x","doi":"https://doi.org/10.1111/j.1755-3768.2014.3446.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1755-3768.2014.3446.x","pdf_url":null,"source":{"id":"https://openalex.org/S21165490","display_name":"Acta Ophthalmologica","issn_l":"0001-639X","issn":["0001-639X","1755-375X","1755-3768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Ophthalmologica","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2524541339","https://openalex.org/W3035843449","https://openalex.org/W2274938071","https://openalex.org/W2753875929","https://openalex.org/W2751166036","https://openalex.org/W2283495358","https://openalex.org/W896585617","https://openalex.org/W2938219965","https://openalex.org/W2534106669","https://openalex.org/W2005391764"],"abstract_inverted_index":{"Abstract":[0],"Purpose":[1],"To":[2],"evaluate":[3],"changes":[4],"in":[5,12,13,131,188,221],"vitreous":[6],"haze":[7],"(VH)":[8],"scores":[9,54,70],"over":[10],"time":[11],"SAKURA":[14],"Study":[15],"1,":[16],"a":[17,100,133,225],"randomized,":[18],"double\u2010masked,":[19],"multicenter,":[20],"international":[21],"phase":[22],"III":[23],"study":[24],"of":[25,103,136],"subjects":[26,32],"with":[27,33,93,111,150,154,159,174,212,224],"active":[28,34],"NI\u2010PSU.":[29],"Methods":[30],"347":[31],"NI\u2010PSU":[35,191],"(VH":[36],"score":[37,102,135],"\u22651.5+)":[38],"were":[39,55,71],"randomized":[40],"to":[41,218],"intravitreal":[42,213],"sirolimus":[43,182,214],"(44,":[44],"440,":[45],"or":[46],"880":[47],"\u00b5g),":[48],"given":[49],"every":[50,165],"2":[51,59,149,200],"months.":[52],"VH":[53,69,101,134,193],"assessed":[56],"at":[57,105,164,176],"Week":[58,148],"and":[60,79,156,172,206],"Months":[61,177],"1\u20135.":[62],"Results":[63],"At":[64],"baseline,":[65],"the":[66,75,83,203],"mean":[67],"(SD)":[68],"1.9":[72,80],"(0.44)":[73],"for":[74,82],"440":[76,94,112,121,151,183,215],"\u00b5g":[77,85,113,116,122,130,152,216],"group":[78],"(0.50)":[81],"44":[84,115,129],"group.":[86],"The":[87],"risk:benefit":[88],"profile":[89],"was":[90,123,143,162,195],"most":[91],"favorable":[92],"\u00b5g:":[95],"Significantly":[96],"more":[97,126],"patients":[98],"achieved":[99],"0":[104],"Month":[106,209],"5":[107],"(the":[108],"primary":[109],"endpoint)":[110],"vs":[114,118,139],"(22.8%":[117,153],"10.3%;":[119],"p=.025).":[120],"also":[124],"significantly":[125,185],"effective":[127,220],"than":[128],"achieving":[132],"0/0.5+":[137],"(51.8%":[138],"35%;":[140],"p=.012).":[141],"Improvement":[142],"seen":[144,163,196],"as":[145,147,197,199],"early":[146,198],"VH=0/0.5+)":[155],"continued":[157,207],"improvement":[158,194],"this":[160,189],"dose":[161],"analysis":[166],"visit":[167],"(36.0%,":[168],"40.4%,":[169],"49.1%,":[170],"42.1%,":[171],"51.8%":[173],"VH=0/0.5+":[175],"1\u20135,":[178],"respectively).":[179],"Conclusion":[180],"Intravitreal":[181],"\u03bcg":[184],"improved":[186],"inflammation":[187],"diverse":[190],"population.":[192],"weeks":[201],"after":[202],"first":[204],"injection":[205],"through":[208],"5.":[210],"Treatment":[211],"appears":[217],"be":[219],"treating":[222],"NI\u2010PSU,":[223],"balanced":[226],"safety":[227],"profile.":[228],"Commercial":[229],"interest":[230]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}