{"id":"https://openalex.org/W2013370165","doi":"https://doi.org/10.1158/1538-7445.am2013-3098","title":"Abstract 3098: MiRNA-145 is a master regulator of the hallmarks of thyroid cancer.","display_name":"Abstract 3098: MiRNA-145 is a master regulator of the hallmarks of thyroid cancer.","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W2013370165","doi":"https://doi.org/10.1158/1538-7445.am2013-3098","mag":"2013370165"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2013-3098","doi":"https://doi.org/10.1158/1538-7445.am2013-3098","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-3098","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046576171","display_name":"Myriem Boufraqech","orcid":"https://orcid.org/0000-0001-7700-9992","observed_orcids":["https://orcid.org/0000-0001-7700-9992"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Myriem Boufraqech","raw_affiliation_strings":["NCI/NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NCI/NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060590657","display_name":"Lisa Zhang","orcid":"https://orcid.org/0000-0002-4255-9609","observed_orcids":["https://orcid.org/0000-0002-4255-9609"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa Zhang","raw_affiliation_strings":["NCI/NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NCI/NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109111790","display_name":"Meenu Jain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meenu Jain","raw_affiliation_strings":["NCI/NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NCI/NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Neelam Gulati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neelam Gulati","raw_affiliation_strings":["NCI/NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NCI/NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006574108","display_name":"Naris Nilubol","orcid":"https://orcid.org/0000-0002-7348-7804","observed_orcids":["https://orcid.org/0000-0002-7348-7804"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naris Nilubol","raw_affiliation_strings":["NCI/NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NCI/NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058322869","display_name":"Mio Kitano","orcid":"https://orcid.org/0000-0003-0496-9022","observed_orcids":["https://orcid.org/0000-0003-0496-9022"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mio Kitano","raw_affiliation_strings":["NCI/NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NCI/NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083064982","display_name":"Yin Xiong","orcid":"https://orcid.org/0000-0001-6540-8267","observed_orcids":["https://orcid.org/0000-0001-6540-8267"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yin Xiong","raw_affiliation_strings":["NCI/NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NCI/NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076916905","display_name":"Electron Kebebew","orcid":"https://orcid.org/0000-0001-5254-1456","observed_orcids":["https://orcid.org/0000-0001-5254-1456"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Electron Kebebew","raw_affiliation_strings":["NCI/NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NCI/NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"8_Supplement","first_page":"3098","last_page":"3098"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.8130000233650208,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.8130000233650208,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.18299999833106995,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-145","display_name":"miR-145","score":0.9559999704360962},{"id":"https://openalex.org/keywords/thyroid-cancer","display_name":"thyroid cancer","score":0.9599999785423279},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.5450000166893005},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.843999981880188},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9990000128746033},{"id":"https://openalex.org/keywords/thyroid-differentiation","display_name":"thyroid differentiation","score":0.6909999847412109},{"id":"https://openalex.org/keywords/nis","display_name":"Ni","score":0.7599999904632568},{"id":"https://openalex.org/keywords/pax8","display_name":"PAX8","score":0.996999979019165},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8090000152587891},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.996999979019165},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.8700000047683716},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.7419999837875366},{"id":"https://openalex.org/keywords/undifferentiated-thyroid-cancer","display_name":"undifferentiated thyroid cancer","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.744864284992218},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6650452613830566},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6338032484054565},{"id":"https://openalex.org/C147447768","wikidata":"https://www.wikidata.org/wiki/Q411624","display_name":"Vimentin","level":3,"score":0.6152738928794861},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5892296433448792},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.5044687986373901},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49158820509910583},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.4553036093711853},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.43369126319885254},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.43292221426963806},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.43022939562797546},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.41330671310424805},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34361809492111206},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32880890369415283},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3032248318195343},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.27680185437202454},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23701152205467224},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.1671622395515442},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.15047132968902588},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0667262077331543},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.06212016940116882},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2013-3098","doi":"https://doi.org/10.1158/1538-7445.am2013-3098","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-3098","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2332925999","https://openalex.org/W2332954476","https://openalex.org/W3045982208","https://openalex.org/W3031649235","https://openalex.org/W3029462153","https://openalex.org/W2115544910","https://openalex.org/W2164323068","https://openalex.org/W4210717120","https://openalex.org/W2015539179","https://openalex.org/W2087476005"],"abstract_inverted_index":{"Abstract":[0],"microRNA-145":[1],"(miR-145)":[2],"in":[3,15,25,29,41,67,77,108,122,139,158,168,176,200],"an":[4],"important":[5,185],"member":[6],"of":[7,10,18,53,65,102,120,129,137,152,174,191,227,230,236,241],"the":[8,98,103,127,169,189,228,237,242],"family":[9],"microRNAs":[11],"which":[12,112],"are":[13],"downregulated":[14],"several":[16],"types":[17],"tumors.":[19],"However,":[20],"miR-145":[21,66,85,121,138,175],"expression":[22,128,157],"and":[23,28,44,69,82,96,111,133,147,172,180,195],"function":[24],"thyroid":[26,46,71,78,109,142,153,192,201,231],"cancer":[27,79,110,193,202],"cellular":[30],"differentiation":[31],"is":[32,113,223],"unknown.":[33],"In":[34],"our":[35],"study,":[36],"we":[37],"performed":[38,74],"miRNA":[39],"profiling":[40],"normal,":[42],"benign":[43],"malignant":[45],"cancers":[47],"including":[48],"undifferentiated":[49,70],"tumors":[50],"with":[51,115,164],"validation":[52],"differentially":[54],"expressed":[55],"miRNAs":[56],"by":[57],"quantitative":[58],"RT":[59],"PCR.":[60],"We":[61,73],"found":[62,83],"significant":[63],"downregulation":[64],"differentiated":[68],"cancer.":[72,232],"functional":[75],"studies":[76],"cell":[80,87,90,94,123,154],"lines":[81,124],"that":[84],"decreases":[86,93],"proliferation,":[88],"induces":[89],"cycle":[91],"arrest,":[92],"invasion":[95],"targets":[97],"PI3K/Akt":[99],"pathway,":[100],"one":[101],"most":[104],"commonly":[105],"activated":[106],"pathways":[107],"associated":[114],"epithelial-mesenchymal":[116],"transition":[117],"(EMT).":[118],"Overexpression":[119],"also":[125],"decreased":[126,145,178],"EMT":[130],"markers":[131],"vimentin":[132],"N-cadherin.":[134],"Furthermore,":[135],"inhibition":[136],"normal":[140],"primary":[141],"cultured":[143],"cells":[144,194],"NIS":[146],"PAX8":[148],"expression,":[149],"key":[150],"regulators":[151],"differentiation.":[155],"miRNA-145":[156],"tumor":[159],"tissue":[160],"was":[161],"inversely":[162],"correlated":[163],"VEGF":[165,181],"serum":[166],"levels":[167],"same":[170],"patients":[171],"overexpression":[173],"vitro":[177],"angiogenesis":[179],"secretion.":[182],"MiRNA-145":[183,222],"has":[184],"regulatory":[186],"effects":[187],"on":[188],"hallmarks":[190,229],"thus":[196],"may":[197],"be":[198],"involved":[199],"progression.":[203],"Citation":[204],"Format:":[205],"Myriem":[206],"Boufraqech,":[207],"Lisa":[208],"Zhang,":[209],"Meenu":[210],"Jain,":[211],"Neelam":[212],"Gulati,":[213],"Naris":[214],"Nilubol,":[215],"Mio":[216],"Kitano,":[217],"Yin":[218],"Xiong,":[219],"Electron":[220],"Kebebew.":[221],"a":[224],"master":[225],"regulator":[226],"[abstract].":[233],"In:":[234],"Proceedings":[235],"104th":[238],"Annual":[239],"Meeting":[240],"American":[243],"Association":[244],"for":[245],"Cancer":[246,256],"Research;":[247],"2013":[248],"Apr":[249],"6-10;":[250],"Washington,":[251],"DC.":[252],"Philadelphia":[253],"(PA):":[254],"AACR;":[255],"Res":[257],"2013;73(8":[258],"Suppl):Abstract":[259],"nr":[260],"3098.":[261],"doi:10.1158/1538-7445.AM2013-3098":[262]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2016-06-24T00:00:00"}