{"id":"https://openalex.org/W2013369241","doi":"https://doi.org/10.1021/ol0262791","title":"Nagahamide A, an Antibacterial Depsipeptide from the Marine Sponge Theonella swinhoei1","display_name":"Nagahamide A, an Antibacterial Depsipeptide from the Marine Sponge Theonella swinhoei1","publication_year":2002,"publication_date":"2002-08-09","ids":{"openalex":"https://openalex.org/W2013369241","doi":"https://doi.org/10.1021/ol0262791","mag":"2013369241","pmid":"https://pubmed.ncbi.nlm.nih.gov/12201711"},"language":"en","primary_location":{"id":"doi:10.1021/ol0262791","doi":"https://doi.org/10.1021/ol0262791","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ol0262791","pdf_url":null,"source":{"id":"https://openalex.org/S201989124","display_name":"Organic Letters","issn_l":"1523-7052","issn":["1523-7052","1523-7060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111653077","display_name":"Yumika Okada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["JP","NL"],"is_corresponding":false,"raw_author_name":"Yumika Okada","raw_affiliation_strings":["Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan, and Institute for Systematics and Ecology, The University of Amsterdam, P.O. Box 94766, 1090 GT Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan, and Institute for Systematics and Ecology, The University of Amsterdam, P.O. Box 94766, 1090 GT Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I74801974","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074774949","display_name":"Shigeki Matsunaga","orcid":"https://orcid.org/0000-0002-8360-2386","observed_orcids":["https://orcid.org/0000-0002-8360-2386","https://orcid.org/0000-0003-4136-3548"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["JP","NL"],"is_corresponding":false,"raw_author_name":"Shigeki Matsunaga","raw_affiliation_strings":["Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan, and Institute for Systematics and Ecology, The University of Amsterdam, P.O. Box 94766, 1090 GT Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan, and Institute for Systematics and Ecology, The University of Amsterdam, P.O. Box 94766, 1090 GT Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I74801974","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082158083","display_name":"Rob W. M. van Soest","orcid":"https://orcid.org/0000-0002-4623-0093","observed_orcids":["https://orcid.org/0000-0002-4623-0093"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["JP","NL"],"is_corresponding":false,"raw_author_name":"Rob W. M. van Soest","raw_affiliation_strings":["Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan, and Institute for Systematics and Ecology, The University of Amsterdam, P.O. Box 94766, 1090 GT Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan, and Institute for Systematics and Ecology, The University of Amsterdam, P.O. Box 94766, 1090 GT Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I74801974","https://openalex.org/I887064364"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018358366","display_name":"Nobuhiro Fusetani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["JP","NL"],"is_corresponding":false,"raw_author_name":"Nobuhiro Fusetani","raw_affiliation_strings":["Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan, and Institute for Systematics and Ecology, The University of Amsterdam, P.O. Box 94766, 1090 GT Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan, and Institute for Systematics and Ecology, The University of Amsterdam, P.O. Box 94766, 1090 GT Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I74801974","https://openalex.org/I887064364"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.9119,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.68768328,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"4","issue":"18","first_page":"3039","last_page":"3042"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11340","display_name":"Marine Sponges and Natural Products","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11340","display_name":"Marine Sponges and Natural Products","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13971","display_name":"Isoquinoline Alkaloid Synthesis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/depsipeptides","display_name":"depsipeptides","score":0.8420000076293945},{"id":"https://openalex.org/keywords/marine-sponges","display_name":"marine sponges","score":0.7409999966621399},{"id":"https://openalex.org/keywords/theonella-swinhoei","display_name":"Theonella swinhoei","score":1.0},{"id":"https://openalex.org/keywords/antibacterial-natural-products","display_name":"antibacterial natural products","score":0.8820000290870667},{"id":"https://openalex.org/keywords/structure-elucidation","display_name":"structure elucidation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/absolute-configuration","display_name":"absolute configuration","score":0.9739999771118164},{"id":"https://openalex.org/keywords/marfey-s-analysis","display_name":"Marfey's analysis","score":0.8339999914169312},{"id":"https://openalex.org/keywords/relative-configuration","display_name":"relative configuration","score":0.8090000152587891},{"id":"https://openalex.org/keywords/polyketides","display_name":"polyketides","score":0.9729999899864197}],"concepts":[{"id":"https://openalex.org/C168831097","wikidata":"https://www.wikidata.org/wiki/Q413248","display_name":"Depsipeptide","level":2,"score":0.9362115859985352},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.8550447225570679},{"id":"https://openalex.org/C2778849931","wikidata":"https://www.wikidata.org/wiki/Q18960","display_name":"Sponge","level":2,"score":0.8548542261123657},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8111368417739868},{"id":"https://openalex.org/C25170562","wikidata":"https://www.wikidata.org/wiki/Q2052053","display_name":"Absolute configuration","level":2,"score":0.7185812592506409},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.7139908075332642},{"id":"https://openalex.org/C2778635478","wikidata":"https://www.wikidata.org/wiki/Q516751","display_name":"Polyketide","level":4,"score":0.5086129903793335},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.4693504273891449},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1865655481815338},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.15410178899765015},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.10616648197174072},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.08813858032226562},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0543045699596405},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011161","descriptor_name":"Porifera","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047630","descriptor_name":"Depsipeptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/ol0262791","doi":"https://doi.org/10.1021/ol0262791","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ol0262791","pdf_url":null,"source":{"id":"https://openalex.org/S201989124","display_name":"Organic Letters","issn_l":"1523-7052","issn":["1523-7052","1523-7060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Letters","raw_type":"journal-article"},{"id":"pmid:12201711","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12201711","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic letters","raw_type":"Journal Article"},{"id":"pmh:oai:dare.uva.nl:openaire_cris_publications/2893ec12-ca7d-496f-a34a-1b6d7854bfad","doi":null,"is_oa":false,"landing_page_url":"https://handle.uba.uva.nl/personal/pure/en/publications/nagahamide-a-an-antibacterial-depsipeptide-from-the-marine-sponge-theonella-swinhoei(2893ec12-ca7d-496f-a34a-1b6d7854bfad).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400088","display_name":"UvA-DARE (University of Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887064364","host_organization_name":"University of Amsterdam","host_organization_lineage":["https://openalex.org/I887064364"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Okada, Y, Matsunaga, S, van Soest, R W M & Fusetani, N 2002, 'Nagahamide A, an antibacterial depsipeptide from the marine sponge Theonella swinhoei.', Organic Letters, vol. 4, no. 18, pp. 3039-3042. https://doi.org/10.1021/ol0262791","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:uvapub:oai:dare.uva.nl:publications/2893ec12-ca7d-496f-a34a-1b6d7854bfad","doi":null,"is_oa":false,"landing_page_url":"https://dare.uva.nl/personal/pure/en/publications/nagahamide-a-an-antibacterial-depsipeptide-from-the-marine-sponge-theonella-swinhoei(2893ec12-ca7d-496f-a34a-1b6d7854bfad).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Organic Letters, 4(18), 3039 - 3042. American Chemical Society","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1988007647","https://openalex.org/W1990782501","https://openalex.org/W2069805785","https://openalex.org/W2085598367","https://openalex.org/W2951866067","https://openalex.org/W2952198446"],"related_works":["https://openalex.org/W2140327041","https://openalex.org/W2159485970","https://openalex.org/W2951793791","https://openalex.org/W782655687","https://openalex.org/W1532459302","https://openalex.org/W2610621865","https://openalex.org/W2092926254","https://openalex.org/W3011576312","https://openalex.org/W2095186498","https://openalex.org/W2951650124"],"abstract_inverted_index":{"[structure:":[0],"see":[1],"text]":[2],"An":[3],"antibacterial":[4],"depsipeptide,":[5],"nagahamide":[6],"A":[7],"(1),":[8],"has":[9],"been":[10],"isolated":[11],"from":[12],"the":[13,23,45],"marine":[14],"sponge":[15],"Theonella":[16],"swinhoei.":[17],"Its":[18],"structure":[19],"was":[20,36,48],"determined":[21,37],"on":[22],"basis":[24],"of":[25,32,44,52,57],"spectral":[26],"and":[27,41],"chemical":[28],"methods.":[29],"Absolute":[30],"configuration":[31],"amino":[33],"acid":[34],"residues":[35],"by":[38,50],"Marfey's":[39],"analysis,":[40],"relative":[42],"stereochemistry":[43],"polyketide":[46],"moiety":[47],"assigned":[49],"comparison":[51],"NMR":[53],"data":[54],"with":[55],"those":[56],"a":[58],"model":[59],"compound.":[60]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}