{"id":"https://openalex.org/W2013355161","doi":"https://doi.org/10.1271/bbb.66.464","title":"Kinetic Resolutions of Indan Derivatives Using Bacteria","display_name":"Kinetic Resolutions of Indan Derivatives Using Bacteria","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2013355161","doi":"https://doi.org/10.1271/bbb.66.464","mag":"2013355161","pmid":"https://pubmed.ncbi.nlm.nih.gov/11999429"},"language":"en","primary_location":{"id":"doi:10.1271/bbb.66.464","doi":"https://doi.org/10.1271/bbb.66.464","is_oa":false,"landing_page_url":"https://doi.org/10.1271/bbb.66.464","pdf_url":null,"source":{"id":"https://openalex.org/S94095188","display_name":"Bioscience Biotechnology and Biochemistry","issn_l":"0916-8451","issn":["0916-8451","1347-6947"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, Biotechnology, and Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071047935","display_name":"Naoki Tarui","orcid":"https://orcid.org/0009-0001-6359-9773","observed_orcids":["https://orcid.org/0009-0001-6359-9773"]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoki TARUI","raw_affiliation_strings":["Pharmaceutical Research Division, Takeda Chemical Industries, Ltd., Osaka, Japan. Tarui_Naoki@takeda.co.jp","Pharmaceutical Research Division, Takeda Chemical Industries, Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Research Division, Takeda Chemical Industries, Ltd., Osaka, Japan. Tarui_Naoki@takeda.co.jp","institution_ids":["https://openalex.org/I44892455"]},{"raw_affiliation_string":"Pharmaceutical Research Division, Takeda Chemical Industries, Ltd","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074659092","display_name":"Hayao WATANABE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hayao WATANABE","raw_affiliation_strings":["Pharmaceutical Research Division, Takeda Chemical Industries, Ltd. 2-17-85, Jusohonmachi, Yodogawa-ku, Osaka 532-8686, Japan","Pharmaceutical Research Division, Takeda Chemical Industries, Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Research Division, Takeda Chemical Industries, Ltd. 2-17-85, Jusohonmachi, Yodogawa-ku, Osaka 532-8686, Japan","institution_ids":["https://openalex.org/I44892455"]},{"raw_affiliation_string":"Pharmaceutical Research Division, Takeda Chemical Industries, Ltd","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110069847","display_name":"Kohji FUKATSU","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kohji FUKATSU","raw_affiliation_strings":["Pharmaceutical Research Division, Takeda Chemical Industries, Ltd. 2-17-85, Jusohonmachi, Yodogawa-ku, Osaka 532-8686, Japan","Pharmaceutical Research Division, Takeda Chemical Industries, Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Research Division, Takeda Chemical Industries, Ltd. 2-17-85, Jusohonmachi, Yodogawa-ku, Osaka 532-8686, Japan","institution_ids":["https://openalex.org/I44892455"]},{"raw_affiliation_string":"Pharmaceutical Research Division, Takeda Chemical Industries, Ltd","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110619871","display_name":"Shigenori Ohkawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigenori OHKAWA","raw_affiliation_strings":["Pharmaceutical Research Division, Takeda Chemical Industries, Ltd. 2-17-85, Jusohonmachi, Yodogawa-ku, Osaka 532-8686, Japan","Pharmaceutical Research Division, Takeda Chemical Industries, Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Research Division, Takeda Chemical Industries, Ltd. 2-17-85, Jusohonmachi, Yodogawa-ku, Osaka 532-8686, Japan","institution_ids":["https://openalex.org/I44892455"]},{"raw_affiliation_string":"Pharmaceutical Research Division, Takeda Chemical Industries, Ltd","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045137047","display_name":"Kazuo Nakahama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuo NAKAHAMA","raw_affiliation_strings":["Pharmaceutical Research Division, Takeda Chemical Industries, Ltd. 2-17-85, Jusohonmachi, Yodogawa-ku, Osaka 532-8686, Japan","Pharmaceutical Research Division, Takeda Chemical Industries, Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Research Division, Takeda Chemical Industries, Ltd. 2-17-85, Jusohonmachi, Yodogawa-ku, Osaka 532-8686, Japan","institution_ids":["https://openalex.org/I44892455"]},{"raw_affiliation_string":"Pharmaceutical Research Division, Takeda Chemical Industries, Ltd","institution_ids":["https://openalex.org/I44892455"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I44892455"],"apc_list":{"value":3272,"currency":"USD","value_usd":3272},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"66","issue":"2","first_page":"464","last_page":"466"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kinetic-resolution","display_name":"kinetic resolution","score":0.9919999837875366},{"id":"https://openalex.org/keywords/indane-derivatives","display_name":"indan derivatives","score":0.9409999847412109},{"id":"https://openalex.org/keywords/corynebacterium-ammoniagenes","display_name":"Corynebacterium ammoniagenes","score":0.8809999823570251},{"id":"https://openalex.org/keywords/enzymatic-hydrolysis","display_name":"enzymatic hydrolysis","score":0.722000002861023},{"id":"https://openalex.org/keywords/amide-hydrolysis","display_name":"amide hydrolysis","score":0.902999997138977},{"id":"https://openalex.org/keywords/racemic-resolution","display_name":"racemic resolution","score":0.4740000069141388},{"id":"https://openalex.org/keywords/enantiomeric-excess","display_name":"enantiomeric excess","score":0.7279999852180481},{"id":"https://openalex.org/keywords/biocatalysis","display_name":"biocatalysis","score":0.6840000152587891},{"id":"https://openalex.org/keywords/chiral-amines","display_name":"chiral amines","score":0.6399999856948853},{"id":"https://openalex.org/keywords/chiral-amides","display_name":"chiral amides","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C28173026","wikidata":"https://www.wikidata.org/wiki/Q337361","display_name":"Kinetic resolution","level":4,"score":0.8092725276947021},{"id":"https://openalex.org/C2778678469","wikidata":"https://www.wikidata.org/wiki/Q411119","display_name":"Ethylamine","level":2,"score":0.7927689552307129},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7652310132980347},{"id":"https://openalex.org/C131779359","wikidata":"https://www.wikidata.org/wiki/Q471875","display_name":"Amine gas treating","level":2,"score":0.6813169121742249},{"id":"https://openalex.org/C2776730177","wikidata":"https://www.wikidata.org/wiki/Q421721","display_name":"Acetamide","level":2,"score":0.659430205821991},{"id":"https://openalex.org/C2778439535","wikidata":"https://www.wikidata.org/wiki/Q188777","display_name":"Amide","level":2,"score":0.6524229049682617},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.6047345399856567},{"id":"https://openalex.org/C3141732","wikidata":"https://www.wikidata.org/wiki/Q568761","display_name":"Enantiomeric excess","level":4,"score":0.5302989482879639},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.44602125883102417},{"id":"https://openalex.org/C31684184","wikidata":"https://www.wikidata.org/wiki/Q33293","display_name":"Peptide bond","level":3,"score":0.43447864055633545},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.42473888397216797},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16732841730117798},{"id":"https://openalex.org/C146686406","wikidata":"https://www.wikidata.org/wiki/Q898628","display_name":"Enantioselective synthesis","level":3,"score":0.07618948817253113},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.07049292325973511}],"mesh":[{"descriptor_ui":"D003352","descriptor_name":"Corynebacterium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007189","descriptor_name":"Indans","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D007189","descriptor_name":"Indans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007189","descriptor_name":"Indans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1271/bbb.66.464","doi":"https://doi.org/10.1271/bbb.66.464","is_oa":false,"landing_page_url":"https://doi.org/10.1271/bbb.66.464","pdf_url":null,"source":{"id":"https://openalex.org/S94095188","display_name":"Bioscience Biotechnology and Biochemistry","issn_l":"0916-8451","issn":["0916-8451","1347-6947"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, Biotechnology, and Biochemistry","raw_type":"journal-article"},{"id":"pmid:11999429","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11999429","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, biotechnology, and biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W2067062613","https://openalex.org/W2072472251","https://openalex.org/W2081186248","https://openalex.org/W2107378378","https://openalex.org/W2147537758"],"related_works":["https://openalex.org/W2082373628","https://openalex.org/W1506837247","https://openalex.org/W2054421758","https://openalex.org/W2071809379","https://openalex.org/W2057170215","https://openalex.org/W2051888937","https://openalex.org/W2075444769","https://openalex.org/W2681784660","https://openalex.org/W2950546407","https://openalex.org/W2037273491"],"abstract_inverted_index":{"Racemic":[0],"indan":[1],"derivatives":[2],"have":[3],"been":[4],"resolved":[5],"by":[6],"the":[7,22,33],"hydrolysis":[8],"of":[9,25],"amide":[10],"bonds":[11],"using":[12],"Corynebacterium":[13],"ammoniagenes":[14],"IFO12612":[15],"to":[16,31,35],"produce":[17],"(S)-amine":[18,43],"and":[19,51],"(R)-amides.":[20],"In":[21],"kinetic":[23],"resolution":[24],"1":[26],"(N-12-(6-methoxy-indan-1-yl)ethyl]acetamide),":[27],"it":[28],"was":[29],"possible":[30],"run":[32],"reaction":[34],"44%":[36],"conversion":[37],"on":[38],"a":[39],"10-g":[40],"scale,":[41],"obtaining":[42],"4":[44],"((S)-2-(6-methoxy-indan-1-yl)ethylamine)":[45],"at":[46,53],">99%":[47],"enantiomeric":[48],"excess":[49],"(ee)":[50],"(R)-1":[52],"98%":[54],"ee.":[55]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}