{"id":"https://openalex.org/W2013340582","doi":"https://doi.org/10.1253/jcj.65.1064","title":"Improving Glucose Metabolism and/or Sarcoplasmic Reti-culum Ca2+-ATPase Function is Warranted for Immature Pressure Overload Hypertrophied Myocardium","display_name":"Improving Glucose Metabolism and/or Sarcoplasmic Reti-culum Ca2+-ATPase Function is Warranted for Immature Pressure Overload Hypertrophied Myocardium","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2013340582","doi":"https://doi.org/10.1253/jcj.65.1064","mag":"2013340582","pmid":"https://pubmed.ncbi.nlm.nih.gov/11767999"},"language":"en","primary_location":{"id":"doi:10.1253/jcj.65.1064","doi":"https://doi.org/10.1253/jcj.65.1064","is_oa":true,"landing_page_url":"https://doi.org/10.1253/jcj.65.1064","pdf_url":"https://www.jstage.jst.go.jp/article/jcj/65/12/65_12_1064/_pdf","source":{"id":"https://openalex.org/S150042853","display_name":"Japanese Circulation Journal-english Edition","issn_l":"0047-1828","issn":["0047-1828","1347-4839"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313287","host_organization_name":"Japanese Circulation Society","host_organization_lineage":["https://openalex.org/P4310313287"],"host_organization_lineage_names":["Japanese Circulation Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Circulation Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/jcj/65/12/65_12_1064/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021174309","display_name":"Koh Takeuchi","orcid":"https://orcid.org/0000-0002-6227-4627","observed_orcids":["https://orcid.org/0000-0002-6227-4627"]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koh Takeuchi","raw_affiliation_strings":["First Department of Surgery, Hirosaki University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, Hirosaki University School of Medicine","institution_ids":["https://openalex.org/I146516829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080653511","display_name":"Mitsugi Nagashima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitsugi Nagashima","raw_affiliation_strings":["Cardiac Surgery, Children's Hospital of Boston and Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiac Surgery, Children's Hospital of Boston and Harvard Medical School","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kazuo Itoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuo Itoh","raw_affiliation_strings":["First Department of Surgery, Hirosaki University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, Hirosaki University School of Medicine","institution_ids":["https://openalex.org/I146516829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053475713","display_name":"Masahito Minagawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahito Minagawa","raw_affiliation_strings":["First Department of Surgery, Hirosaki University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, Hirosaki University School of Medicine","institution_ids":["https://openalex.org/I146516829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011802629","display_name":"Mamoru Munakata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mamoru Munakata","raw_affiliation_strings":["First Department of Surgery, Hirosaki University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, Hirosaki University School of Medicine","institution_ids":["https://openalex.org/I146516829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036433445","display_name":"Ikko Ichinoseki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ikko Ichinoseki","raw_affiliation_strings":["First Department of Surgery, Hirosaki University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, Hirosaki University School of Medicine","institution_ids":["https://openalex.org/I146516829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108267065","display_name":"Kozo Fukui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kozo Fukui","raw_affiliation_strings":["First Department of Surgery, Hirosaki University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, Hirosaki University School of Medicine","institution_ids":["https://openalex.org/I146516829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044364350","display_name":"Francis X. Jr McGowan","orcid":"https://orcid.org/0000-0002-1892-8806","observed_orcids":["https://orcid.org/0000-0002-1892-8806"]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Francis X McGowan Jr","raw_affiliation_strings":["Departments of Anesthesia, Hirosaki University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesia, Hirosaki University School of Medicine","institution_ids":["https://openalex.org/I146516829"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001927963","display_name":"Pedro J. del Nido","orcid":"https://orcid.org/0000-0003-4252-8789","observed_orcids":["https://orcid.org/0000-0003-4252-8789"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pedro J del Nido","raw_affiliation_strings":["Cardiac Surgery, Children's Hospital of Boston and Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiac Surgery, Children's Hospital of Boston and Harvard Medical School","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4874,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.709087,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"65","issue":"12","first_page":"1064","last_page":"1070"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.5625,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.5625,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.3257000148296356,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.06109999865293503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pressure-overload-hypertrophy","display_name":"pressure overload hypertrophy","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.7139999866485596},{"id":"https://openalex.org/keywords/serca2","display_name":"SERCA2","score":0.7260000109672546},{"id":"https://openalex.org/keywords/sarcoplasmic-reticulum-ca2-atpase","display_name":"sarcoplasmic reticulum Ca2+-ATPase","score":0.9470000267028809},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.6700000166893005},{"id":"https://openalex.org/keywords/glycolysis-inhibition","display_name":"glycolysis inhibition","score":0.6589999794960022},{"id":"https://openalex.org/keywords/2-deoxy-d-glucose","display_name":"2-deoxyglucose","score":0.9599999785423279},{"id":"https://openalex.org/keywords/pyruvate","display_name":"pyruvate","score":0.9950000047683716},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.8230000138282776},{"id":"https://openalex.org/keywords/excitation-contraction-coupling","display_name":"excitation-contraction coupling","score":0.9129999876022339},{"id":"https://openalex.org/keywords/calcium-handling","display_name":"calcium handling","score":0.6880000233650208},{"id":"https://openalex.org/keywords/dobutamine-response","display_name":"dobutamine response","score":0.8040000200271606},{"id":"https://openalex.org/keywords/contractile-failure","display_name":"contractile failure","score":0.9259999990463257},{"id":"https://openalex.org/keywords/rabbit-heart","display_name":"rabbit heart","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7882727384567261},{"id":"https://openalex.org/C2778271984","wikidata":"https://www.wikidata.org/wiki/Q17126794","display_name":"Pressure overload","level":4,"score":0.7170871496200562},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7130643129348755},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.6221304535865784},{"id":"https://openalex.org/C2781185063","wikidata":"https://www.wikidata.org/wiki/Q422782","display_name":"Dobutamine","level":3,"score":0.6019400358200073},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.5647835731506348},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5186640024185181},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.49944090843200684},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.49828457832336426},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.49352729320526123},{"id":"https://openalex.org/C155710745","wikidata":"https://www.wikidata.org/wiki/Q575278","display_name":"Inotrope","level":2,"score":0.48965245485305786},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.45103275775909424},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.4445191025733948},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.36127299070358276},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2588893473148346},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23782026767730713},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.21305608749389648},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.20270276069641113},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11390769481658936},{"id":"https://openalex.org/C3018791406","wikidata":"https://www.wikidata.org/wiki/Q945225","display_name":"Cardiac hypertrophy","level":3,"score":0.08789849281311035}],"mesh":[{"descriptor_ui":"D000252","descriptor_name":"Calcium-Transporting ATPases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000252","descriptor_name":"Calcium-Transporting ATPases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004452","descriptor_name":"Echocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019284","descriptor_name":"Thapsigargin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D053498","descriptor_name":"Sarcoplasmic Reticulum Calcium-Transporting ATPases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1253/jcj.65.1064","doi":"https://doi.org/10.1253/jcj.65.1064","is_oa":true,"landing_page_url":"https://doi.org/10.1253/jcj.65.1064","pdf_url":"https://www.jstage.jst.go.jp/article/jcj/65/12/65_12_1064/_pdf","source":{"id":"https://openalex.org/S150042853","display_name":"Japanese Circulation Journal-english Edition","issn_l":"0047-1828","issn":["0047-1828","1347-4839"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313287","host_organization_name":"Japanese Circulation Society","host_organization_lineage":["https://openalex.org/P4310313287"],"host_organization_lineage_names":["Japanese Circulation Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Circulation Journal","raw_type":"journal-article"},{"id":"pmid:11767999","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11767999","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese circulation journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1253/jcj.65.1064","doi":"https://doi.org/10.1253/jcj.65.1064","is_oa":true,"landing_page_url":"https://doi.org/10.1253/jcj.65.1064","pdf_url":"https://www.jstage.jst.go.jp/article/jcj/65/12/65_12_1064/_pdf","source":{"id":"https://openalex.org/S150042853","display_name":"Japanese Circulation Journal-english Edition","issn_l":"0047-1828","issn":["0047-1828","1347-4839"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313287","host_organization_name":"Japanese Circulation Society","host_organization_lineage":["https://openalex.org/P4310313287"],"host_organization_lineage_names":["Japanese Circulation Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Circulation Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2013340582.pdf","grobid_xml":"https://content.openalex.org/works/W2013340582.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1829875776","https://openalex.org/W1864185943","https://openalex.org/W1948436988","https://openalex.org/W1978156375","https://openalex.org/W1981563200","https://openalex.org/W1986409524","https://openalex.org/W1998826582","https://openalex.org/W2020024927","https://openalex.org/W2022128387","https://openalex.org/W2036637373","https://openalex.org/W2040984407","https://openalex.org/W2072287097","https://openalex.org/W2087985294","https://openalex.org/W2094909991","https://openalex.org/W2111523164","https://openalex.org/W2118089140","https://openalex.org/W2124328401","https://openalex.org/W2138783312","https://openalex.org/W2253241974","https://openalex.org/W2277574742","https://openalex.org/W2344156160","https://openalex.org/W2411034585","https://openalex.org/W2500434365"],"related_works":["https://openalex.org/W2032709887","https://openalex.org/W2016615402","https://openalex.org/W7100506113","https://openalex.org/W2557043611","https://openalex.org/W2330884421","https://openalex.org/W2003364331","https://openalex.org/W2082295516","https://openalex.org/W2123584886","https://openalex.org/W2275368222","https://openalex.org/W2106040905"],"abstract_inverted_index":{"The":[0,23,69,101,113],"cellular":[1],"mechanisms":[2],"of":[3,30,71,129,136,169,189,202],"abnormal":[4],"calcium":[5,92],"regulation":[6],"and":[7,47,54,65,83,90,108,156,176,186],"excitation-contraction":[8],"coupling":[9],"in":[10,15,37,45,97,119,143,166,198],"relation":[11],"to":[12,39,87,104,193],"glucose":[13,209],"metabolism":[14],"the":[16,27,98,190,203],"hypertrophied":[17,34,99],"heart":[18],"are":[19,179],"not":[20],"well":[21,146],"understood.":[22],"present":[24],"study":[25],"evaluated":[26],"myocardial":[28,102,154],"mechanics":[29],"6-7-week-old":[31],"pressure":[32,171],"overload":[33,172],"rabbit":[35],"hearts":[36],"response":[38,103],"dobutamine":[40,105,109],"by":[41,62,74,126,207],"(1)":[42],"serial":[43],"echocardiograms":[44],"vivo":[46],"(2)":[48],"isolated":[49],"Langendorff":[50],"perfusion.":[51],"Cytosolic":[52],"Ca2+([Ca2+]i)":[53],"sarcoplasmic":[55],"reticulum":[56],"Ca2+-ATPase":[57],"(SERCA2)":[58],"expression":[59],"were":[60],"measured":[61],"fluorescence":[63],"spectroscopy":[64],"Western":[66],"immunoblotting,":[67],"respectively.":[68],"effect":[70],"glycolytic":[72,160],"inhibition":[73],"2-deoxy-D-glucose":[75],"+/-":[76],"pyruvate":[77],"was":[78,106,117,123,163],"also":[79],"evaluated.":[80],"Both":[81],"systolic":[82],"diastolic":[84,91],"[Ca2+]i":[85,144,157],"tended":[86],"be":[88],"higher":[89,118],"removal":[93],"(tauCa)":[94],"significantly":[95,124],"slower":[96,149,184],"heart.":[100],"blunted":[107],"insignificantly":[110],"improved":[111],"tauCa.":[112,150],"SERCA2":[114,139],"protein":[115],"level":[116],"early":[120],"hypertrophy,":[121,173],"but":[122],"reduced":[125,187],"6":[127],"weeks":[128],"age,":[130],"with":[131,181,200],"progressive":[132],"contractile":[133,174,191],"failure.":[134],"Inhibition":[135],"glycolysis":[137],"or":[138],"caused":[140,206],"an":[141],"increase":[142],"as":[145,147],"a":[148],"Pyruvate":[151],"completely":[152],"preserved":[153],"function":[155],"handling":[158],"during":[159],"inhibition.":[161],"It":[162],"concluded":[164],"that":[165],"this":[167],"model":[168],"advanced":[170],"failure":[175],"inotrope":[177],"insensitivity":[178],"associated":[180],"increased":[182],"[Ca2+]i,":[183],"tauCa":[185],"sensitivity":[188],"proteins":[192],"Ca2+.":[194],"These":[195],"changes":[196],"occur":[197],"association":[199],"downregulation":[201],"SERCA2,":[204],"probably":[205],"impaired":[208],"metabolism.":[210]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}