{"id":"https://openalex.org/W2013336671","doi":"https://doi.org/10.1097/nen.0b013e3181a2b8f4-9","title":"Dephosphorylation of \u03b2-Arrestin 1 in Glioblastomas","display_name":"Dephosphorylation of \u03b2-Arrestin 1 in Glioblastomas","publication_year":2009,"publication_date":"2009-05-01","ids":{"openalex":"https://openalex.org/W2013336671","doi":"https://doi.org/10.1097/nen.0b013e3181a2b8f4-9","mag":"2013336671","pmid":"https://pubmed.ncbi.nlm.nih.gov/19404096"},"language":"en","primary_location":{"id":"doi:10.1097/nen.0b013e3181a2b8f4-9","doi":"https://doi.org/10.1097/nen.0b013e3181a2b8f4-9","is_oa":false,"landing_page_url":"https://doi.org/10.1097/nen.0b013e3181a2b8f4-9","pdf_url":null,"source":{"id":"https://openalex.org/S38023437","display_name":"Journal of Neuropathology & Experimental Neurology","issn_l":"0022-3069","issn":["0022-3069","1554-6578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuropathology & Experimental Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083211399","display_name":"James William Mandell","orcid":"https://orcid.org/0000-0002-5000-8276","observed_orcids":["https://orcid.org/0000-0002-5000-8276"]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James W. Mandell","raw_affiliation_strings":["Department of Pathology, University of Virginia Health System, Charlottesville, VA 22903, USA. jwm2m@virginia.edu","Department of Pathology, University of Virginia Health System, Charlottesville, Virginia (JWM, SA, TDB)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Virginia Health System, Charlottesville, VA 22903, USA. jwm2m@virginia.edu","institution_ids":["https://openalex.org/I2799765794"]},{"raw_affiliation_string":"Department of Pathology, University of Virginia Health System, Charlottesville, Virginia (JWM, SA, TDB)","institution_ids":["https://openalex.org/I2799765794"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063726836","display_name":"George F. Glass","orcid":"https://orcid.org/0000-0001-6651-6884","observed_orcids":["https://orcid.org/0000-0001-6651-6884"]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Glass","raw_affiliation_strings":["Department of Pathology, University of Virginia Health System, Charlottesville, Virginia (JWM, SA, TDB)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Virginia Health System, Charlottesville, Virginia (JWM, SA, TDB)","institution_ids":["https://openalex.org/I2799765794"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057658579","display_name":"Erwin P. Gianchandani","orcid":"https://orcid.org/0000-0003-4989-0246","observed_orcids":["https://orcid.org/0000-0003-4989-0246"]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erwin P. Gianchandani","raw_affiliation_strings":["Department of Pathology, University of Virginia Health System, Charlottesville, Virginia (JWM, SA, TDB)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Virginia Health System, Charlottesville, Virginia (JWM, SA, TDB)","institution_ids":["https://openalex.org/I2799765794"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028371968","display_name":"Corinne N. Locke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Corinne N. Locke","raw_affiliation_strings":["Department of Pathology, University of Virginia Health System, Charlottesville, Virginia (JWM, SA, TDB)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Virginia Health System, Charlottesville, Virginia (JWM, SA, TDB)","institution_ids":["https://openalex.org/I2799765794"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000906257","display_name":"Samson Amos","orcid":"https://orcid.org/0000-0003-2780-2276","observed_orcids":["https://orcid.org/0000-0003-2780-2276"]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samson Amos","raw_affiliation_strings":["Department of Pathology, University of Virginia Health System, Charlottesville, Virginia (JWM, SA, TDB)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Virginia Health System, Charlottesville, Virginia (JWM, SA, TDB)","institution_ids":["https://openalex.org/I2799765794"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072332019","display_name":"T. David Bourne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas David Bourne","raw_affiliation_strings":["Department of Pathology, University of Virginia Health System, Charlottesville, Virginia (JWM, SA, TDB)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Virginia Health System, Charlottesville, Virginia (JWM, SA, TDB)","institution_ids":["https://openalex.org/I2799765794"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023905352","display_name":"David Schiff","orcid":"https://orcid.org/0000-0002-1896-2502","observed_orcids":["https://orcid.org/0000-0002-1896-2502","https://orcid.org/0000-0003-1561-9220"]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Schiff","raw_affiliation_strings":["Department of Pathology, University of Virginia Health System, Charlottesville, Virginia (JWM, SA, TDB)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Virginia Health System, Charlottesville, Virginia (JWM, SA, TDB)","institution_ids":["https://openalex.org/I2799765794"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000119406","display_name":"Jason A. Papin","orcid":"https://orcid.org/0000-0002-2769-5805","observed_orcids":["https://orcid.org/0000-0002-2769-5805"]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason A. Papin","raw_affiliation_strings":["Department of Pathology, University of Virginia Health System, Charlottesville, Virginia (JWM, SA, TDB)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Virginia Health System, Charlottesville, Virginia (JWM, SA, TDB)","institution_ids":["https://openalex.org/I2799765794"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5083211399"],"corresponding_institution_ids":["https://openalex.org/I2799765794"],"apc_list":{"value":5036,"currency":"USD","value_usd":5036},"apc_paid":null,"fwci":0.453,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.67976477,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"68","issue":"5","first_page":"535","last_page":"541"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.7157999873161316,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.7157999873161316,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.21860000491142273,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.02329999953508377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-arrestin-1","display_name":"\u03b2-arrestin1","score":0.984000027179718},{"id":"https://openalex.org/keywords/dephosphorylation","display_name":"dephosphorylation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.8799999952316284},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.8560000061988831},{"id":"https://openalex.org/keywords/u251-cells","display_name":"U251 cells","score":0.7540000081062317},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor-signaling","display_name":"G protein-coupled receptor signaling","score":0.7739999890327454},{"id":"https://openalex.org/keywords/src-signaling","display_name":"Src signaling","score":0.6330000162124634},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7749999761581421},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinase-transactivation","display_name":"receptor tyrosine kinase transactivation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/gliomagenesis","display_name":"gliomagenesis","score":0.7689999938011169}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7742434740066528},{"id":"https://openalex.org/C181912034","wikidata":"https://www.wikidata.org/wiki/Q1101143","display_name":"Dephosphorylation","level":4,"score":0.7606722116470337},{"id":"https://openalex.org/C2777503648","wikidata":"https://www.wikidata.org/wiki/Q905671","display_name":"Arrestin","level":4,"score":0.572058916091919},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5336179733276367},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5231543779373169},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.447672039270401},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4424266517162323},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40993550419807434},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3833022117614746},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35235780477523804},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.08577081561088562},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.08316850662231445}],"mesh":[{"descriptor_ui":"D000071557","descriptor_name":"beta-Arrestins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071559","descriptor_name":"beta-Arrestin 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019390","descriptor_name":"Arrestins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/nen.0b013e3181a2b8f4-9","doi":"https://doi.org/10.1097/nen.0b013e3181a2b8f4-9","is_oa":false,"landing_page_url":"https://doi.org/10.1097/nen.0b013e3181a2b8f4-9","pdf_url":null,"source":{"id":"https://openalex.org/S38023437","display_name":"Journal of Neuropathology & Experimental Neurology","issn_l":"0022-3069","issn":["0022-3069","1554-6578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuropathology & Experimental Neurology","raw_type":"journal-article"},{"id":"pmid:19404096","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19404096","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuropathology and experimental neurology","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.cedarville.edu:pharmaceutical_sciences_publications-1102","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.cedarville.edu/pharmaceutical_sciences_publications/103","pdf_url":null,"source":{"id":"https://openalex.org/S4377196552","display_name":"DigitalCommons-Cedarville (Cedarville University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169138485","host_organization_name":"Cedarville University","host_organization_lineage":["https://openalex.org/I169138485"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutical Sciences Faculty Publications","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G86665353","display_name":"Medical Scientist Training Program","funder_award_id":"T32GM007267","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W38036891","https://openalex.org/W1503899947","https://openalex.org/W1971584376","https://openalex.org/W1972775688","https://openalex.org/W1986312095","https://openalex.org/W1991170716","https://openalex.org/W1993937267","https://openalex.org/W2008369989","https://openalex.org/W2014716705","https://openalex.org/W2029625635","https://openalex.org/W2040827479","https://openalex.org/W2048260140","https://openalex.org/W2121889629","https://openalex.org/W2137960802","https://openalex.org/W2138341116","https://openalex.org/W2151312020","https://openalex.org/W2151335185","https://openalex.org/W2154391976","https://openalex.org/W2162478991"],"related_works":["https://openalex.org/W2287874729","https://openalex.org/W2607116172","https://openalex.org/W2598710356","https://openalex.org/W7222797866","https://openalex.org/W2019222394","https://openalex.org/W2010897402","https://openalex.org/W2120045213","https://openalex.org/W2122528173","https://openalex.org/W2124304752","https://openalex.org/W7128756712"],"abstract_inverted_index":{"Beta-Arrestins":[0],"act":[1],"as":[2,14],"signal":[3],"terminators":[4],"for":[5,17,46],"G":[6],"protein-coupled":[7],"receptors;":[8],"they":[9],"have":[10],"also":[11],"been":[12],"implicated":[13],"scaffolding":[15],"proteins":[16],"Src":[18,47],"and":[19,25,37,48,60,73,86,90,97,115,120,144],"mitogen-activated":[20,49],"protein":[21,50],"kinase":[22,51],"signaling":[23],"pathways":[24],"transactivators":[26],"of":[27,41,131,152,185,189],"receptor":[28,158],"tyrosine":[29],"kinases,":[30],"suggesting":[31],"their":[32],"possible":[33],"role":[34,66],"in":[35,67,108,113,160],"development":[36],"oncogenic":[38],"signaling.":[39],"Dephosphorylation":[40],"serine":[42],"412":[43],"is":[44,181],"necessary":[45],"transactivation.":[52],"We":[53,101],"hypothesized":[54],"that":[55,177],"altered":[56],"beta-arrestin":[57,75,105,125,139,165,171,178],"1":[58,76,106,126,140,166,172,179],"phosphorylation":[59,107,147,167],"activation":[61],"status":[62],"could":[63],"play":[64],"a":[65],"gliomagenesis.":[68],"Using":[69],"monoclonal":[70],"anti-phospho-(serine":[71],"412)-":[72],"total":[74,170],"antibodies,":[77],"we":[78],"performed":[79],"immunohistochemistry":[80,143],"on":[81,94],"126":[82],"human":[83],"glioma":[84],"samples":[85,134],"7":[87],"nonneoplastic":[88,99,109],"controls":[89],"Western":[91,149],"blot":[92],"analysis":[93],"5":[95,98],"glioblastomas":[96],"controls.":[100],"found":[102],"high":[103,124],"constitutive":[104],"brain":[110],"tissue,":[111],"particularly":[112],"neurons":[114],"neuropil.":[116],"Most":[117],"Grade":[118],"II":[119],"III":[121],"gliomas":[122],"retained":[123],"phosphorylation.":[127],"By":[128],"contrast,":[129],"most":[130],"the":[132,186],"glioblastoma":[133],"(58/81)":[135],"showed":[136],"nearly":[137],"complete":[138],"dephosphorylation":[141],"by":[142,148],"decreased":[145,164],"relative":[146],"blot.":[150],"Expression":[151],"constitutively":[153],"activated":[154],"epidermal":[155],"growth":[156],"factor":[157],"vIII":[159],"U251":[161],"cells":[162],"caused":[163],"without":[168],"altering":[169],"levels.":[173],"These":[174],"results":[175],"suggest":[176],"dephosphorylation/inactivation":[180],"associated":[182],"with":[183],"aspects":[184],"malignant":[187],"behavior":[188],"glioblastomas.":[190]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}