{"id":"https://openalex.org/W2013325511","doi":"https://doi.org/10.1152/ajpgi.00482.2003","title":"Distribution and function of the cannabinoid-1 receptor in the modulation of ion transport in the guinea pig ileum: relationship to capsaicin-sensitive nerves","display_name":"Distribution and function of the cannabinoid-1 receptor in the modulation of ion transport in the guinea pig ileum: relationship to capsaicin-sensitive nerves","publication_year":2004,"publication_date":"2004-04-06","ids":{"openalex":"https://openalex.org/W2013325511","doi":"https://doi.org/10.1152/ajpgi.00482.2003","mag":"2013325511","pmid":"https://pubmed.ncbi.nlm.nih.gov/14701723"},"language":"en","primary_location":{"id":"doi:10.1152/ajpgi.00482.2003","doi":"https://doi.org/10.1152/ajpgi.00482.2003","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.00482.2003","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009478562","display_name":"Wallace Keith MacNaughton","orcid":"https://orcid.org/0000-0002-7050-666X","observed_orcids":["https://orcid.org/0000-0002-7050-666X"]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Wallace K. MacNaughton","raw_affiliation_strings":["Dept. of Physiology and Biophysics, Univ. of Calgary, 3330 Hospital Dr. NW, Calgary, AB, T2N 4N1, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Physiology and Biophysics, Univ. of Calgary, 3330 Hospital Dr. NW, Calgary, AB, T2N 4N1, Canada","institution_ids":["https://openalex.org/I168635309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023515936","display_name":"Marja D. Sepers","orcid":"https://orcid.org/0000-0002-6510-2804","observed_orcids":["https://orcid.org/0000-0002-6510-2804"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marja D. Van Sickle","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050933461","display_name":"Catherine M. Keenan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Catherine M. Keenan","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075032970","display_name":"Kelly C. Cushing","orcid":"https://orcid.org/0000-0003-3914-9673","observed_orcids":["https://orcid.org/0000-0003-3914-9673"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kelly Cushing","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025755881","display_name":"Ken Mackie","orcid":"https://orcid.org/0000-0001-8501-6199","observed_orcids":["https://orcid.org/0000-0001-8501-6199"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ken Mackie","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085949365","display_name":"Keith A. Sharkey","orcid":"https://orcid.org/0000-0001-9560-1711","observed_orcids":["https://orcid.org/0000-0001-9560-1711"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keith A. Sharkey","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.143,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.93628961,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"286","issue":"5","first_page":"G863","last_page":"G871"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.04610000178217888,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.021700000390410423,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cb1-receptor","display_name":"CB1 receptor","score":0.9010000228881836},{"id":"https://openalex.org/keywords/ileum","display_name":"ileum","score":0.7730000019073486},{"id":"https://openalex.org/keywords/ion-transport","display_name":"ion transport","score":0.7450000047683716},{"id":"https://openalex.org/keywords/short-circuit-current","display_name":"short-circuit current","score":0.7950000166893005},{"id":"https://openalex.org/keywords/submucosal-plexus","display_name":"submucosal plexus","score":0.8320000171661377},{"id":"https://openalex.org/keywords/secretomotor-neurons","display_name":"secretomotor neurons","score":0.8539999723434448},{"id":"https://openalex.org/keywords/capsaicin-sensitive-nerves","display_name":"capsaicin-sensitive sensory nerves","score":0.746999979019165},{"id":"https://openalex.org/keywords/trpv1","display_name":"TRPV1","score":0.7870000004768372},{"id":"https://openalex.org/keywords/vip","display_name":"VIP","score":0.5659999847412109},{"id":"https://openalex.org/keywords/neuropeptide-y","display_name":"neuropeptide Y","score":0.9980000257492065},{"id":"https://openalex.org/keywords/win-55-212-2","display_name":"WIN 55,212-2","score":0.9739999771118164},{"id":"https://openalex.org/keywords/sr141716a","display_name":"SR141716A","score":0.9919999837875366},{"id":"https://openalex.org/keywords/denervation","display_name":"denervation","score":0.5040000081062317},{"id":"https://openalex.org/keywords/guinea-pig","display_name":"guinea pig","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7070581316947937},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7000411748886108},{"id":"https://openalex.org/C2778988552","wikidata":"https://www.wikidata.org/wiki/Q419401","display_name":"Carbachol","level":3,"score":0.5172775387763977},{"id":"https://openalex.org/C8330315","wikidata":"https://www.wikidata.org/wiki/Q414964","display_name":"Vasoactive intestinal peptide","level":4,"score":0.5103011131286621},{"id":"https://openalex.org/C2775893369","wikidata":"https://www.wikidata.org/wiki/Q410557","display_name":"Hexamethonium","level":3,"score":0.49686649441719055},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4849722385406494},{"id":"https://openalex.org/C2780071552","wikidata":"https://www.wikidata.org/wiki/Q5036336","display_name":"Capsazepine","level":5,"score":0.45911046862602234},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.4509146809577942},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4369139075279236},{"id":"https://openalex.org/C46721173","wikidata":"https://www.wikidata.org/wiki/Q368952","display_name":"Endocannabinoid system","level":3,"score":0.4211084246635437},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4167788028717041},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.412704199552536},{"id":"https://openalex.org/C2775859210","wikidata":"https://www.wikidata.org/wiki/Q26272","display_name":"Atropine","level":2,"score":0.3274902105331421},{"id":"https://openalex.org/C160145004","wikidata":"https://www.wikidata.org/wiki/Q413209","display_name":"TRPV1","level":4,"score":0.3058556318283081},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.2805039882659912},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.24491989612579346},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.19342827796936035},{"id":"https://openalex.org/C155164980","wikidata":"https://www.wikidata.org/wiki/Q304043","display_name":"Transient receptor potential channel","level":3,"score":0.14752578735351562},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12859275937080383}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002211","descriptor_name":"Capsaicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004573","descriptor_name":"Electrolytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007082","descriptor_name":"Ileum","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D007082","descriptor_name":"Ileum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013368","descriptor_name":"Submucous Plexus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017136","descriptor_name":"Ion Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043884","descriptor_name":"Receptor, Cannabinoid, CB1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043884","descriptor_name":"Receptor, Cannabinoid, CB1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpgi.00482.2003","doi":"https://doi.org/10.1152/ajpgi.00482.2003","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.00482.2003","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},{"id":"pmid:14701723","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14701723","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Gastrointestinal and liver physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3990679123","display_name":"Neuronal cannabinoids","funder_award_id":"R01DA011322","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G4633347076","display_name":"Cannabinoid Modulation of Neuronal Function","funder_award_id":"K02DA000286","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320321767","display_name":"Alberta Heritage Foundation for Medical Research","ror":"https://ror.org/0160cpw27"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1498175036","https://openalex.org/W1583251247","https://openalex.org/W1851651927","https://openalex.org/W1877665463","https://openalex.org/W1965121027","https://openalex.org/W1966373924","https://openalex.org/W1971117369","https://openalex.org/W1972841948","https://openalex.org/W1973418737","https://openalex.org/W1978702462","https://openalex.org/W1982006018","https://openalex.org/W1997887063","https://openalex.org/W2002297978","https://openalex.org/W2009130932","https://openalex.org/W2018280327","https://openalex.org/W2024083629","https://openalex.org/W2025369248","https://openalex.org/W2028633707","https://openalex.org/W2031064270","https://openalex.org/W2039458094","https://openalex.org/W2043636245","https://openalex.org/W2045998472","https://openalex.org/W2047701166","https://openalex.org/W2051114875","https://openalex.org/W2055343868","https://openalex.org/W2056225586","https://openalex.org/W2062890784","https://openalex.org/W2065948307","https://openalex.org/W2082391857","https://openalex.org/W2087852949","https://openalex.org/W2088855137","https://openalex.org/W2089478925","https://openalex.org/W2108129929","https://openalex.org/W2109058900","https://openalex.org/W2131809780","https://openalex.org/W2136914582","https://openalex.org/W2143719410","https://openalex.org/W2169352888","https://openalex.org/W2170372540","https://openalex.org/W2171988137","https://openalex.org/W2296943649","https://openalex.org/W2306383888","https://openalex.org/W2414278917","https://openalex.org/W4406066347"],"related_works":["https://openalex.org/W1877665463","https://openalex.org/W3123758640","https://openalex.org/W2025369248","https://openalex.org/W2002908129","https://openalex.org/W2089822540","https://openalex.org/W1979041887","https://openalex.org/W2166633700","https://openalex.org/W6980469976","https://openalex.org/W1575101240","https://openalex.org/W2140601684"],"abstract_inverted_index":{"We":[0],"investigated":[1],"the":[2,11,15,37,59,63,72,75,115,138,178,190,206,248],"distribution":[3],"and":[4,33,39,56,92,127,164,172],"function":[5],"of":[6,14,26,74,106,217,230,250],"cannabinoid":[7],"(CB)(1)":[8],"receptors":[9,20,45,52,241],"in":[10,58,84,111,226],"submucosal":[12,27,60,64,85],"plexus":[13],"guinea":[16],"pig":[17],"ileum.":[18,231],"CB(1)":[19,44,81,179,191,240],"were":[21,68,133,146,166,208],"found":[22],"on":[23,53,205,220,242,254],"both":[24],"types":[25],"secretomotor":[28,41,256],"neurons,":[29,42],"colocalizing":[30],"with":[31,47,137],"VIP":[32,149],"neuropeptide":[34],"Y":[35],"(NPY),":[36],"noncholinergic":[38],"cholinergic":[40,255],"respectively.":[43],"colocalized":[46],"transient":[48],"receptor":[49,82,150,158,180,192],"potential":[50],"vanilloid-1":[51],"paravascular":[54,91],"nerves":[55,67],"fibers":[57],"plexus.":[61],"In":[62,77,114],"ganglia,":[65],"these":[66,234],"preferentially":[69],"localized":[70],"at":[71,239],"periphery":[73],"ganglia.":[76],"denervated":[78,228],"ileal":[79],"segments,":[80],"immunoreactivity":[83],"neurons":[86],"was":[87,96,101,187,223],"not":[88,209,224],"modified,":[89],"but":[90,145],"intraganglionic":[93],"fiber":[94],"staining":[95],"absent.":[97],"Short-circuit":[98],"current":[99],"(I(sc))":[100],"measured":[102],"as":[103],"an":[104],"indicator":[105],"net":[107],"electrogenic":[108],"ion":[109],"transport":[110],"Ussing":[112],"chambers.":[113],"ion-transport":[116],"studies,":[117],"I(sc)":[118,196],"responses":[119,161,197],"to":[120,128,162,198],"capsaicin,":[121],"which":[122,202],"activates":[123],"extrinsic":[124,243],"primary":[125,244],"afferents,":[126],"electrical":[129],"field":[130],"stimulation":[131],"(EFS)":[132],"reduced":[134,167],"by":[135,143,148,168,177,189,211],"pretreatment":[136],"muscarinic":[139],"antagonist":[140],"atropine,":[141],"abolished":[142],"tetrodotoxin,":[144],"unaffected":[147],"desensitization,":[151],"hexamethonium,":[152],"alpha-amino-3-hydroxy-5-methlisoxazole-4-proprionic":[153],"acid,":[154],"or":[155,200],"N-methyl-d-aspartate":[156],"glutamate":[157],"antagonists.":[159],"The":[160,214],"capsaicin":[163],"EFS":[165],"47":[169],"+/-":[170,174],"12":[171],"30":[173],"14%,":[175],"respectively,":[176],"agonist":[181],"WIN":[182,212,218],"55,212-2.":[183,213],"This":[184],"inhibitory":[185,215],"effect":[186,216],"blocked":[188],"antagonist,":[193],"SR":[194],"141716A.":[195],"forskolin":[199],"carbachol,":[201],"act":[203,238,253],"directly":[204],"epithelium,":[207],"affected":[210],"55,212-2":[219],"EFS-evoked":[221],"secretion":[222],"observed":[225],"extrinsically":[227],"segments":[229],"Taken":[232],"together,":[233],"data":[235],"show":[236],"cannabinoids":[237],"afferent":[245],"nerves,":[246],"inhibiting":[247],"release":[249],"transmitters":[251],"that":[252],"pathways.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
