{"id":"https://openalex.org/W2013308408","doi":"https://doi.org/10.1097/01.tp.0000085046.39523.d5","title":"C2 monitoring in maintenance renal transplant recipients: is it worthwhile?","display_name":"C2 monitoring in maintenance renal transplant recipients: is it worthwhile?","publication_year":2003,"publication_date":"2003-10-27","ids":{"openalex":"https://openalex.org/W2013308408","doi":"https://doi.org/10.1097/01.tp.0000085046.39523.d5","mag":"2013308408","pmid":"https://pubmed.ncbi.nlm.nih.gov/14578761"},"language":"en","primary_location":{"id":"doi:10.1097/01.tp.0000085046.39523.d5","doi":"https://doi.org/10.1097/01.tp.0000085046.39523.d5","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.tp.0000085046.39523.d5","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040396132","display_name":"Karsten Midtvedt","orcid":"https://orcid.org/0000-0002-3302-1110","observed_orcids":["https://orcid.org/0000-0002-3302-1110"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"Karsten Midtvedt","raw_affiliation_strings":["National Hospital of Norway, Oslo, Norway. karsten.midtvedt@rikshospitalet.no","Karsten Midtvedt, M.D., Ph.D., Medical Department, National Hospital, 0027 Oslo, Norway. E-mail","National Hospital of Norway, Oslo, Norway","Ullevaal University Hospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Hospital of Norway, Oslo, Norway. karsten.midtvedt@rikshospitalet.no","institution_ids":[]},{"raw_affiliation_string":"Karsten Midtvedt, M.D., Ph.D., Medical Department, National Hospital, 0027 Oslo, Norway. E-mail","institution_ids":["https://openalex.org/I1281400175"]},{"raw_affiliation_string":"National Hospital of Norway, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]},{"raw_affiliation_string":"Ullevaal University Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012961394","display_name":"Per Fauchald","orcid":"https://orcid.org/0000-0003-3046-0967","observed_orcids":["https://orcid.org/0000-0003-3046-0967"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Per Fauchald","raw_affiliation_strings":["National Hospital of Norway, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Hospital of Norway, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000287095","display_name":"Stein Bergan","orcid":"https://orcid.org/0000-0002-3199-2722","observed_orcids":["https://orcid.org/0000-0002-3199-2722"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Stein Bergan","raw_affiliation_strings":["National Hospital of Norway, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Hospital of Norway, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042378713","display_name":"Aud H\u00f8ieggen","orcid":"https://orcid.org/0000-0001-7520-7645","observed_orcids":["https://orcid.org/0000-0001-7520-7645"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Aud H\u00f8ieggen","raw_affiliation_strings":["Ullevaal University Hospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ullevaal University Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008867854","display_name":"Stein Ivar Hallan","orcid":"https://orcid.org/0000-0002-9045-3569","observed_orcids":["https://orcid.org/0000-0002-9045-3569"]},"institutions":[{"id":"https://openalex.org/I4210104358","display_name":"St Olav's University Hospital","ror":"https://ror.org/01a4hbq44","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I4210104358"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Stein Hallan","raw_affiliation_strings":["St. Olavs Hospital, Trondheim, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Olavs Hospital, Trondheim, Norway","institution_ids":["https://openalex.org/I4210104358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030715474","display_name":"Einar Svarstad","orcid":"https://orcid.org/0000-0002-9160-4293","observed_orcids":["https://orcid.org/0000-0002-9160-4293"]},"institutions":[{"id":"https://openalex.org/I2800132241","display_name":"Stavanger University Hospital","ror":"https://ror.org/04zn72g03","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2800132241"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Einar Svarstad","raw_affiliation_strings":["Stavanger Hospital, Stavanger, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stavanger Hospital, Stavanger, Norway","institution_ids":["https://openalex.org/I2800132241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113886199","display_name":"Harald Bergrem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800740805","display_name":"Haukeland University Hospital","ror":"https://ror.org/03np4e098","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2800740805"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Harald Bergrem","raw_affiliation_strings":["Haukeland University Hospital, Bergen, Norway","June 2003"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haukeland University Hospital, Bergen, Norway","institution_ids":["https://openalex.org/I2800740805"]},{"raw_affiliation_string":"June 2003","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052079960","display_name":"Bjoern O. Eriksen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298853749","display_name":"University Hospital of North Norway","ror":"https://ror.org/030v5kp38","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1298853749","https://openalex.org/I63903255"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Bjoern O. Eriksen","raw_affiliation_strings":["University Hospital of North Norway, Troms\u00f8, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital of North Norway, Troms\u00f8, Norway","institution_ids":["https://openalex.org/I1298853749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104069059","display_name":"Per F. Pfeffer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Per F. Pfeffer","raw_affiliation_strings":["National Hospital of Norway, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Hospital of Norway, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017584679","display_name":"Ingvild Dalen","orcid":"https://orcid.org/0000-0002-8160-3211","observed_orcids":["https://orcid.org/0000-0002-8160-3211"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Ingvild Dalen","raw_affiliation_strings":["National Hospital of Norway, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Hospital of Norway, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008920107","display_name":"Torbjoern Leivestad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Torbjoern Leivestad","raw_affiliation_strings":["National Hospital of Norway, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Hospital of Norway, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5040396132"],"corresponding_institution_ids":["https://openalex.org/I1281400175"],"apc_list":null,"apc_paid":null,"fwci":3.6472,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.93032196,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"76","issue":"8","first_page":"1236","last_page":"1238"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9800000190734863},{"id":"https://openalex.org/keywords/c2-monitoring","display_name":"C2 monitoring","score":0.6980000138282776},{"id":"https://openalex.org/keywords/kidney-transplant-recipients","display_name":"kidney transplant recipients","score":0.6859999895095825},{"id":"https://openalex.org/keywords/maintenance-immunosuppression","display_name":"maintenance immunosuppression","score":0.8410000205039978},{"id":"https://openalex.org/keywords/trough-concentration","display_name":"trough concentration","score":0.8539999723434448},{"id":"https://openalex.org/keywords/serum-creatinine","display_name":"serum creatinine","score":0.8289999961853027},{"id":"https://openalex.org/keywords/graft-function","display_name":"graft function","score":0.9890000224113464},{"id":"https://openalex.org/keywords/therapeutic-drug-monitoring","display_name":"therapeutic drug monitoring","score":0.6480000019073486},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.5220000147819519},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.8881350755691528},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.7336259484291077},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7324199080467224},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6809554696083069},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.6738759279251099},{"id":"https://openalex.org/C2992666275","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Renal transplant","level":3,"score":0.510391891002655},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.5088360905647278},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41830259561538696},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.35496461391448975},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.16087007522583008}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011182","descriptor_name":"Postoperative Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016030","descriptor_name":"Kidney Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/01.tp.0000085046.39523.d5","doi":"https://doi.org/10.1097/01.tp.0000085046.39523.d5","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.tp.0000085046.39523.d5","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},{"id":"pmid:14578761","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14578761","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1983297225","https://openalex.org/W1986707370","https://openalex.org/W1989553664","https://openalex.org/W2007364301","https://openalex.org/W2018857408","https://openalex.org/W2056810545","https://openalex.org/W2079402257","https://openalex.org/W2148715165","https://openalex.org/W4205197699"],"related_works":["https://openalex.org/W2119151276","https://openalex.org/W2015035555","https://openalex.org/W2035063173","https://openalex.org/W1999930096","https://openalex.org/W2130104807","https://openalex.org/W2324328134","https://openalex.org/W2013386646","https://openalex.org/W2014748697","https://openalex.org/W2347342398","https://openalex.org/W3029962454"],"abstract_inverted_index":{"Presently,":[0],"there":[1],"is":[2,267],"little":[3],"knowledge":[4],"regarding":[5],"cyclosporine":[6],"(CsA)":[7],"concentration":[8,78],"at":[9,298],"2":[10],"hr":[11],"post-dose":[12],"(C2)":[13],"monitoring":[14],"in":[15,25,61,83,116,214,218,230,264,286,292,294],"maintenance":[16,265],"patients.":[17],"This":[18],"study":[19],"evaluates":[20],"the":[21,71,117,219,231,287],"actual":[22],"C2":[23,74,151,170,187,203,223,246,263,300],"range":[24,233,289],"stable":[26],"renal":[27,58,85],"transplant":[28,59,86],"recipients":[29,60,87],"(who":[30],"underwent":[31],"transplantation":[32],">12":[33],"months":[34],"ago).":[35],"In":[36],"addition,":[37],"we":[38,283],"investigated":[39],"whether":[40],"underexposure":[41],"or":[42],"overexposure":[43,273],"to":[44,67,97,271,274],"CsA":[45,64,76,100,124,127,133,136,293],"(assessed":[46],"by":[47,54,90],"C2)":[48],"affects":[49],"graft":[50],"function":[51],"(as":[52],"measured":[53,103],"serum":[55],"[S]-creatinine).":[56],"All":[57],"Norway":[62],"receiving":[63],"were":[65,81,102,114],"asked":[66],"participate;":[68],"1447":[69],"fulfilled":[70],"criteria.":[72],"Valid":[73],"and":[75,111,139,155,221,245,256,290,304],"trough":[77],"(C0)":[79],"measurements":[80],"performed":[82,115],"1032":[84],"(71%)":[88],"monitored":[89],"C0.":[91],"Target":[92],"C0":[93,228,257,285],"level":[94],"was":[95,182,210,258],"75":[96],"125":[98],"mumol/L.":[99],"levels":[101,152,165,171,188,204,229],"using":[104],"a":[105,240,268,299],"Cloned":[106],"Enzyme":[107],"Donor":[108],"Immunoassay":[109],"method,":[110],"all":[112],"analyses":[113],"same":[118,181],"laboratory":[119],"(overall":[120],"mean":[121],"[+/-standard":[122],"deviation]":[123],"C0=112+/-31":[125],"mug/L,":[126],"C2=697+/-211":[128],"mug/L":[129,157,175,192],"[range":[130],"81-1580":[131],"mug/L],":[132],"dose":[134,137],"[mg/day]=208+/-61,":[135],"[mg/kg/day]=2.8+/-1.1,":[138],"S-creatinine=141+/-58":[140],"mumol/L).":[141,235],"A":[142,236],"univariate":[143],"analysis":[144],"of":[145,262],"variance":[146],"showed":[147,239],"that":[148],"patients":[149,168,185,201,217,226,249,266],"with":[150,167,169,186,200,202],"between":[153,216,243,254,302],"700":[154,303],"800":[156,305],"(n=203,":[158],"S-creatinine=136+/-49":[159],"mumol/L)":[160,178,196],"had":[161,227],"significantly":[162],"lower":[163],"S-creatinine":[164,194,215,244,255],"compared":[166,199],"greater":[172,205],"than":[173,190,206],"950":[174,207],"(n=94,":[176],"S-creatinine=152+/-56":[177],"(P<0.02).":[179],"The":[180,251],"true":[183],"for":[184,247],"less":[189],"450":[191],"(n=95,":[193],"141+/-72":[195],"(P<0.05)":[197],"when":[198],"mug/L.":[208,306],"There":[209],"no":[211],"significant":[212,241],"difference":[213],"low":[220],"intermediate":[222],"group;":[224],"666":[225],"therapeutic":[232,288],"(75-125":[234],"linear":[237],"regression":[238],"relation":[242,253],"these":[248],"(P=0.03).":[250],"corresponding":[252],"nonsignificant":[259],"(P=0.3).":[260],"Monitoring":[261],"valuable":[269],"tool":[270],"detect":[272],"CsA.":[275],"Until":[276],"results":[277],"from":[278],"prospective":[279],"studies":[280],"are":[281],"available,":[282],"recommend":[284],"reduction":[291],"overexposed":[295],"patients,":[296],"aiming":[297],"value":[301]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}