{"id":"https://openalex.org/W2013305709","doi":"https://doi.org/10.3109/10715768809066905","title":"Semi-Quinone Formation from the Catechol and Ortho-Quinone Metabolites of the Antitumor Agent VP-16\u2013213","display_name":"Semi-Quinone Formation from the Catechol and Ortho-Quinone Metabolites of the Antitumor Agent VP-16\u2013213","publication_year":1988,"publication_date":"1988-01-01","ids":{"openalex":"https://openalex.org/W2013305709","doi":"https://doi.org/10.3109/10715768809066905","mag":"2013305709","pmid":"https://pubmed.ncbi.nlm.nih.gov/2854106"},"language":"en","primary_location":{"id":"doi:10.3109/10715768809066905","doi":"https://doi.org/10.3109/10715768809066905","is_oa":false,"landing_page_url":"https://doi.org/10.3109/10715768809066905","pdf_url":null,"source":{"id":"https://openalex.org/S4210177992","display_name":"Free Radical Research Communications","issn_l":"8755-0199","issn":["8755-0199"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pure.amsterdamumc.nl/en/publications/1b191df3-21bc-4eb9-8880-83a2939ea74f","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108665048","display_name":"Jan M. S. van Maanen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. M.S. Van Maanen","raw_affiliation_strings":["Department of Oncology, Free University Hospital, Amsterdam, The Netherlands","Department of Oncology, Free University Hospital, De Boelelaan 1117, 1081, HV, Amsterdam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Free University Hospital, Amsterdam, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Department of Oncology, Free University Hospital, De Boelelaan 1117, 1081, HV, Amsterdam","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084218830","display_name":"Udo H. Verkerk","orcid":"https://orcid.org/0000-0002-4920-1861","observed_orcids":["https://orcid.org/0000-0002-4920-1861"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"U. H. Verkerk","raw_affiliation_strings":["Department of Pharmacochemistry, Molecular Toxicology, Free University, De Boelelaan 1083, 1081, HV, Amsterdam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacochemistry, Molecular Toxicology, Free University, De Boelelaan 1083, 1081, HV, Amsterdam","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027314925","display_name":"J. Broersen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J. Broersen","raw_affiliation_strings":["Department of Pharmacochemistry, Molecular Toxicology, Free University, De Boelelaan 1083, 1081, HV, Amsterdam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacochemistry, Molecular Toxicology, Free University, De Boelelaan 1083, 1081, HV, Amsterdam","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110072576","display_name":"M.V.M. Lafleur","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. V. M. Lafleur","raw_affiliation_strings":["Department of Oncology, Free University Hospital, De Boelelaan 1117, 1081, HV, Amsterdam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Free University Hospital, De Boelelaan 1117, 1081, HV, Amsterdam","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111625774","display_name":"John de Vries","orcid":"https://orcid.org/0000-0002-4984-3936","observed_orcids":["https://orcid.org/0000-0002-4984-3936"]},"institutions":[{"id":"https://openalex.org/I7876267","display_name":"Open University of the Netherlands","ror":"https://ror.org/018dfmf50","country_code":"NL","type":"education","lineage":["https://openalex.org/I7876267"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J. De Vries","raw_affiliation_strings":["Department of Science, Open University, P.O. Box 2960 6401 DL Heerlen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Science, Open University, P.O. Box 2960 6401 DL Heerlen, The Netherlands","institution_ids":["https://openalex.org/I7876267"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055105229","display_name":"J. Ret\u00e8l","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Retel","raw_affiliation_strings":["Department of Oncology, Free University Hospital, De Boelelaan 1117, 1081, HV, Amsterdam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Free University Hospital, De Boelelaan 1117, 1081, HV, Amsterdam","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105878379","display_name":"Herbert M. Pinedo","orcid":"https://orcid.org/0000-0002-8980-371X","observed_orcids":["https://orcid.org/0000-0002-8980-371X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. M. Pinedo","raw_affiliation_strings":["Department of Oncology, Free University Hospital, De Boelelaan 1117, 1081, HV, Amsterdam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Free University Hospital, De Boelelaan 1117, 1081, HV, Amsterdam","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.8667,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.94447015,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"4","issue":"6","first_page":"371","last_page":"384"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":0.9399999976158142},{"id":"https://openalex.org/keywords/catechol-metabolites","display_name":"catechol metabolites","score":0.8579999804496765},{"id":"https://openalex.org/keywords/ortho-quinones","display_name":"ortho-quinones","score":0.9340000152587891},{"id":"https://openalex.org/keywords/autoxidation","display_name":"autoxidation","score":0.9509999752044678},{"id":"https://openalex.org/keywords/hyperfine-structure","display_name":"hyperfine structure","score":0.7649999856948853},{"id":"https://openalex.org/keywords/horseradish-peroxidase","display_name":"horseradish peroxidase","score":0.8859999775886536},{"id":"https://openalex.org/keywords/nadph-cytochrome-p450-reductase","display_name":"NADPH-cytochrome P450 reductase","score":0.9580000042915344},{"id":"https://openalex.org/keywords/spin-trapping","display_name":"spin trapping","score":0.6269999742507935},{"id":"https://openalex.org/keywords/pobn","display_name":"POBN","score":0.7239999771118164},{"id":"https://openalex.org/keywords/dna-inactivation","display_name":"DNA inactivation","score":0.8069999814033508},{"id":"https://openalex.org/keywords/phi-x174-dna","display_name":"phi X174 DNA","score":0.8539999723434448}],"concepts":[{"id":"https://openalex.org/C2780643102","wikidata":"https://www.wikidata.org/wiki/Q412382","display_name":"Quinone","level":2,"score":0.9571362733840942},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8882894515991211},{"id":"https://openalex.org/C2777713698","wikidata":"https://www.wikidata.org/wiki/Q282440","display_name":"Catechol","level":2,"score":0.7669467926025391},{"id":"https://openalex.org/C2777676563","wikidata":"https://www.wikidata.org/wiki/Q413665","display_name":"Horseradish peroxidase","level":3,"score":0.7154960036277771},{"id":"https://openalex.org/C2778815226","wikidata":"https://www.wikidata.org/wiki/Q4431226","display_name":"Spin trapping","level":3,"score":0.6736681461334229},{"id":"https://openalex.org/C2776778087","wikidata":"https://www.wikidata.org/wiki/Q427071","display_name":"Hydroxyl radical","level":3,"score":0.5385260581970215},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.5112276077270508},{"id":"https://openalex.org/C2781109383","wikidata":"https://www.wikidata.org/wiki/Q898497","display_name":"Hydroxylation","level":3,"score":0.4916394352912903},{"id":"https://openalex.org/C2776370595","wikidata":"https://www.wikidata.org/wiki/Q3955012","display_name":"Semiquinone","level":3,"score":0.49140846729278564},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.4829632341861725},{"id":"https://openalex.org/C139066938","wikidata":"https://www.wikidata.org/wiki/Q185056","display_name":"Radical","level":2,"score":0.34703320264816284},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.34229665994644165},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.25971323251724243},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1946418285369873}],"mesh":[{"descriptor_ui":"D002396","descriptor_name":"Catechols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004578","descriptor_name":"Electron Spin Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005047","descriptor_name":"Etoposide","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D005047","descriptor_name":"Etoposide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010584","descriptor_name":"Bacteriophage phi X 174","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011809","descriptor_name":"Quinones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012996","descriptor_name":"Solutions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.3109/10715768809066905","doi":"https://doi.org/10.3109/10715768809066905","is_oa":false,"landing_page_url":"https://doi.org/10.3109/10715768809066905","pdf_url":null,"source":{"id":"https://openalex.org/S4210177992","display_name":"Free Radical Research Communications","issn_l":"8755-0199","issn":["8755-0199"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Research Communications","raw_type":"journal-article"},{"id":"pmid:2854106","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2854106","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free radical research communications","raw_type":"Journal Article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/1b191df3-21bc-4eb9-8880-83a2939ea74f","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/1b191df3-21bc-4eb9-8880-83a2939ea74f","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"van Maanen, J M S, Verkerk, U H, Broersen, J, Lafleur, M V M, de Vries, J, Retel, J & Pinedo, H M 1988, 'Semi Quinone formation from the catechol and ortho-quinone metabolites of the antitumor agent VP l6 213', Free radical research, vol. 4, no. 6, pp. 371-384.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dare.ubvu.vu.nl:1871/4010","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1871/4010","pdf_url":null,"source":{"id":"https://openalex.org/S4306400546","display_name":"Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I865915315","host_organization_name":"Vrije Universiteit Amsterdam","host_organization_lineage":["https://openalex.org/I865915315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article / Letter to editor"},{"id":"pmh:vu1:oai:dare.ubvu.vu.nl:1871/4010","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1871/4010","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"TITLE=None","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vumc:oai:pure.atira.dk:publications/d2c2a37b-43e6-4dff-989b-36f076ae35d0","doi":null,"is_oa":true,"landing_page_url":"https://research.vumc.nl/en/publications/d2c2a37b-43e6-4dff-989b-36f076ae35d0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Free radical research, 4(6), 371 - 384. Informa Healthcare","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/1b191df3-21bc-4eb9-8880-83a2939ea74f","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/1b191df3-21bc-4eb9-8880-83a2939ea74f","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"van Maanen, J M S, Verkerk, U H, Broersen, J, Lafleur, M V M, de Vries, J, Retel, J & Pinedo, H M 1988, 'Semi Quinone formation from the catechol and ortho-quinone metabolites of the antitumor agent VP l6 213', Free radical research, vol. 4, no. 6, pp. 371-384.","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1552750745","https://openalex.org/W1554159232","https://openalex.org/W1613283346","https://openalex.org/W1622800336","https://openalex.org/W1952290204","https://openalex.org/W1963566334","https://openalex.org/W1990034963","https://openalex.org/W2003858110","https://openalex.org/W2008738285","https://openalex.org/W2047505314","https://openalex.org/W2053078712","https://openalex.org/W2064450459","https://openalex.org/W2064636365","https://openalex.org/W2073983482","https://openalex.org/W2130663998","https://openalex.org/W2133403194","https://openalex.org/W4205273680","https://openalex.org/W4302035473"],"related_works":["https://openalex.org/W2052332489","https://openalex.org/W2056217223","https://openalex.org/W2026721580","https://openalex.org/W6996505589","https://openalex.org/W1963566334","https://openalex.org/W2067340210","https://openalex.org/W2240746254","https://openalex.org/W7056348874","https://openalex.org/W2003858110","https://openalex.org/W2028839904"],"abstract_inverted_index":{"The":[0,73],"catechol":[1,66,99,113],"metabolite":[2,14],"of":[3,11,35,47,59,76,87,103,111,122,163,171,188,190],"the":[4,9,17,36,45,48,57,65,77,84,98,101,106,112,120,123,135,138,168,178,186],"antitumor":[5],"agent":[6],"VP-16-213":[7,104],"and":[8,67,100,131],"ortho-quinone":[10,102,139,170],"VP-16-213--a":[12],"secondary":[13,93],"formed":[15,96],"from":[16,38,97],"catechol--easily":[18],"undergo":[19],"auto-oxidation":[20],"into":[21],"a":[22,92,147,183],"free":[23,49,78,148],"radical":[24,50,79,86,94,125,149,180],"at":[25],"pH":[26,37,90],"greater":[27],"than":[28,64],"or":[29],"equal":[30],"to":[31,40,134],"7.4.":[32],"By":[33],"elevation":[34],"7.4":[39],"10,":[41],"an":[42],"increase":[43],"in":[44,119,185],"production":[46],"was":[51,54,140,150],"observed,":[52],"which":[53],"accompanied":[55],"by":[56,71,152,167],"formation":[58,121],"products":[60],"with":[61,114,142,154],"higher":[62],"hydrophylicity":[63],"ortho-quinone,":[68],"as":[69,126],"found":[70],"HPLC-analysis.":[72],"hyperfine":[74],"structure":[75],"indicates":[80],"that":[81,177],"it":[82],"is":[83,95],"semi-quinone":[85,107,179],"VP-16-213.":[88],"At":[89],"12.5":[91],"besides":[105],"radical.":[108],"One-electron":[109],"oxidation":[110,133],"horseradish":[115],"peroxidase/hydrogen":[116],"peroxide":[117],"resulted":[118],"same":[124],"observed":[127],"under":[128],"alkaline":[129],"conditions":[130],"subsequent":[132],"ortho-quinone.":[136],"If":[137],"incubated":[141],"NADPH":[143],"cytochrome":[144,173],"P-450":[145,174],"reductase,":[146],"detected":[151],"spin-trapping":[153],"POBN,":[155],"but":[156],"not":[157],"without":[158],"spin-trapping.":[159],"Studies":[160],"on":[161],"inactivation":[162,189],"phi":[164],"X174":[165],"DNA":[166],"system":[169],"VP-16-213/NADPH":[172],"reductase":[175],"suggest":[176],"may":[181],"play":[182],"role":[184],"process":[187],"DNA.":[191]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}