{"id":"https://openalex.org/W2013303875","doi":"https://doi.org/10.1177/1535370215583799","title":"Cytoskeletal prestress regulates nuclear shape and stiffness in cardiac myocytes","display_name":"Cytoskeletal prestress regulates nuclear shape and stiffness in cardiac myocytes","publication_year":2015,"publication_date":"2015-04-23","ids":{"openalex":"https://openalex.org/W2013303875","doi":"https://doi.org/10.1177/1535370215583799","mag":"2013303875","pmid":"https://pubmed.ncbi.nlm.nih.gov/25908635","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4778402"},"language":"en","primary_location":{"id":"doi:10.1177/1535370215583799","doi":"https://doi.org/10.1177/1535370215583799","is_oa":false,"landing_page_url":"https://doi.org/10.1177/1535370215583799","pdf_url":null,"source":{"id":"https://openalex.org/S67514239","display_name":"Experimental Biology and Medicine","issn_l":"0071-3384","issn":["0071-3384","1535-3699","1535-3702"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Biology and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4778402","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001911130","display_name":"Hyungsuk Lee","orcid":"https://orcid.org/0000-0002-7873-7163","observed_orcids":["https://orcid.org/0000-0002-7873-7163"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I44142251","display_name":"Wyss Institute for Biologically Inspired Engineering","ror":"https://ror.org/008cfmj78","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Hyungsuk Lee","raw_affiliation_strings":["Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA","School of Mechanical Engineering, Yonsei University, Seoul 120-749, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]},{"raw_affiliation_string":"School of Mechanical Engineering, Yonsei University, Seoul 120-749, Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076549791","display_name":"William James Adams","orcid":"https://orcid.org/0000-0002-2350-9489","observed_orcids":["https://orcid.org/0000-0002-2350-9489"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I44142251","display_name":"Wyss Institute for Biologically Inspired Engineering","ror":"https://ror.org/008cfmj78","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William J Adams","raw_affiliation_strings":["Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009817534","display_name":"Patrick W. Alford","orcid":"https://orcid.org/0000-0002-7811-4134","observed_orcids":["https://orcid.org/0000-0002-7811-4134"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I44142251","display_name":"Wyss Institute for Biologically Inspired Engineering","ror":"https://ror.org/008cfmj78","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick W Alford","raw_affiliation_strings":["Department of Biomedical Engineering, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA","Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077454813","display_name":"Megan Laura McCain","orcid":"https://orcid.org/0000-0003-1908-6783","observed_orcids":["https://orcid.org/0000-0003-1908-6783"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I44142251","display_name":"Wyss Institute for Biologically Inspired Engineering","ror":"https://ror.org/008cfmj78","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan L McCain","raw_affiliation_strings":["Department of Biomedical Engineering, Department of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, CA 90089, USA","Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Department of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, CA 90089, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086659893","display_name":"Adam W. Feinberg","orcid":"https://orcid.org/0000-0003-3338-5456","observed_orcids":["https://orcid.org/0000-0003-3338-5456"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I44142251","display_name":"Wyss Institute for Biologically Inspired Engineering","ror":"https://ror.org/008cfmj78","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I44142251"]},{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam W Feinberg","raw_affiliation_strings":["Department of Materials Science and Engineering, Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15219, USA","Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering, Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15219, USA","institution_ids":["https://openalex.org/I74973139"]},{"raw_affiliation_string":"Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010033023","display_name":"Sean P. Sheehy","orcid":"https://orcid.org/0000-0002-1154-9854","observed_orcids":["https://orcid.org/0000-0002-1154-9854"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I44142251","display_name":"Wyss Institute for Biologically Inspired Engineering","ror":"https://ror.org/008cfmj78","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean P Sheehy","raw_affiliation_strings":["Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089987009","display_name":"Josue A. Goss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I44142251","display_name":"Wyss Institute for Biologically Inspired Engineering","ror":"https://ror.org/008cfmj78","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Josue A Goss","raw_affiliation_strings":["Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028204678","display_name":"Kevin Kit Parker","orcid":"https://orcid.org/0000-0002-5968-7535","observed_orcids":["https://orcid.org/0000-0002-5968-7535"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I44142251","display_name":"Wyss Institute for Biologically Inspired Engineering","ror":"https://ror.org/008cfmj78","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kevin Kit Parker","raw_affiliation_strings":["Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5028204678"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":null,"fwci":1.5904,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.82617953,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"240","issue":"11","first_page":"1543","last_page":"1554"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nuclear-mechanics","display_name":"nuclear mechanics","score":0.6679999828338623},{"id":"https://openalex.org/keywords/nuclear-shape","display_name":"nuclear shape","score":0.6949999928474426},{"id":"https://openalex.org/keywords/nuclear-stiffness","display_name":"nuclear stiffness","score":0.9729999899864197},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.9160000085830688},{"id":"https://openalex.org/keywords/chromatin-decondensation","display_name":"chromatin decondensation","score":0.9290000200271606},{"id":"https://openalex.org/keywords/nuclear-membrane-rupture","display_name":"nuclear membrane rupture","score":0.8550000190734863},{"id":"https://openalex.org/keywords/nuclear-envelope","display_name":"nuclear envelope","score":0.6629999876022339},{"id":"https://openalex.org/keywords/laminopathies","display_name":"laminopathies","score":0.7820000052452087},{"id":"https://openalex.org/keywords/myofibrils","display_name":"myofibrils","score":0.7099999785423279},{"id":"https://openalex.org/keywords/mechanical-transduction","display_name":"mechanical signal transduction","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C179093185","wikidata":"https://www.wikidata.org/wiki/Q424506","display_name":"Lamin","level":3,"score":0.9015836715698242},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.796523928642273},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6689319610595703},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.6560835242271423},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.6442939639091492},{"id":"https://openalex.org/C94912109","wikidata":"https://www.wikidata.org/wiki/Q687194","display_name":"Nuclear lamina","level":5,"score":0.5816806554794312},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5503954291343689},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.4982473850250244},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.41368532180786133},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4028233289718628},{"id":"https://openalex.org/C29512474","wikidata":"https://www.wikidata.org/wiki/Q16860021","display_name":"Nuclear protein","level":4,"score":0.329816997051239},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2129691243171692},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.1310344636440277},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12774577736854553},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009685","descriptor_name":"Nuclear Envelope","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018625","descriptor_name":"Microscopy, Atomic Force","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019245","descriptor_name":"Compressive Strength","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020342","descriptor_name":"Finite Element Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1177/1535370215583799","doi":"https://doi.org/10.1177/1535370215583799","is_oa":false,"landing_page_url":"https://doi.org/10.1177/1535370215583799","pdf_url":null,"source":{"id":"https://openalex.org/S67514239","display_name":"Experimental Biology and Medicine","issn_l":"0071-3384","issn":["0071-3384","1535-3699","1535-3702"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Biology and Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4778402","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4778402","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exp Biol Med (Maywood)","raw_type":"Text"},{"id":"pmid:25908635","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25908635","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental biology and medicine (Maywood, N.J.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4778402","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4778402","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exp Biol Med (Maywood)","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4043000042438507}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6295293734","display_name":"Myocyte Shape in Myofibril Patterning and Contraction","funder_award_id":"R01HL079126","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1549239847","https://openalex.org/W1556965300","https://openalex.org/W1974670138","https://openalex.org/W1977428652","https://openalex.org/W1985331773","https://openalex.org/W1987371172","https://openalex.org/W1993004731","https://openalex.org/W2013266615","https://openalex.org/W2023649556","https://openalex.org/W2028672310","https://openalex.org/W2033465506","https://openalex.org/W2036145275","https://openalex.org/W2036422131","https://openalex.org/W2050455213","https://openalex.org/W2051209391","https://openalex.org/W2051896127","https://openalex.org/W2052373675","https://openalex.org/W2054635074","https://openalex.org/W2061801043","https://openalex.org/W2064019624","https://openalex.org/W2080751777","https://openalex.org/W2082067280","https://openalex.org/W2085646733","https://openalex.org/W2087061669","https://openalex.org/W2093651431","https://openalex.org/W2105002450","https://openalex.org/W2106294826","https://openalex.org/W2109707676","https://openalex.org/W2113153325","https://openalex.org/W2114063466","https://openalex.org/W2119999870","https://openalex.org/W2126531317","https://openalex.org/W2132917470","https://openalex.org/W2133622971","https://openalex.org/W2135745724","https://openalex.org/W2147086117","https://openalex.org/W2149449254","https://openalex.org/W2149814027","https://openalex.org/W2156289700","https://openalex.org/W2161384527","https://openalex.org/W2161870945","https://openalex.org/W2163355774","https://openalex.org/W2163504716","https://openalex.org/W4247425028"],"related_works":["https://openalex.org/W1985331773","https://openalex.org/W2796938633","https://openalex.org/W2531091055","https://openalex.org/W2724883999","https://openalex.org/W2803327635","https://openalex.org/W3214741807","https://openalex.org/W2265708655","https://openalex.org/W2571383784","https://openalex.org/W2155003718","https://openalex.org/W4405186417"],"abstract_inverted_index":{"Mechanical":[0],"stresses":[1],"on":[2,40,66,106,114],"the":[3,27,41,48,52,62,92,107,111,115,119,122,143,173,186,192,207],"myocyte":[4,203],"nucleus":[5,144],"have":[6,33,38],"been":[7,34],"associated":[8],"with":[9],"several":[10],"diseases":[11],"and":[12,30,55,64,76,89,121,127,137,152,155,180,205],"potentially":[13],"transduce":[14],"mechanical":[15,42,59],"stimuli":[16],"into":[17],"cellular":[18],"responses.":[19],"Although":[20],"a":[21,96,101,161,169],"number":[22],"of":[23,44,47,87,91,99,103,124,134,163,172,202,209],"physical":[24],"links":[25],"between":[26,61],"nuclear":[28,53,67,80,93,187],"envelope":[29,54],"cytoplasmic":[31],"filaments":[32],"identified,":[35],"previous":[36],"studies":[37,190],"focused":[39],"properties":[43],"individual":[45],"components":[46],"nucleus,":[49,116,175],"such":[50],"as":[51],"lamin":[56,212],"network.":[57],"The":[58],"interaction":[60],"cytoskeleton":[63],"chromatin":[65,77,88,138,181],"deformability":[68,157],"remains":[69],"elusive.":[70],"Here,":[71],"we":[72,117,176],"investigated":[73],"how":[74],"cytoskeletal":[75,179],"structures":[78],"influence":[79],"mechanics":[81,201],"in":[82,129,145,185,200,206],"cardiac":[83],"myocytes.":[84],"Rapid":[85],"decondensation":[86],"rupture":[90],"membrane":[94],"caused":[95],"sudden":[97],"expansion":[98],"DNA,":[100],"consequence":[102],"prestress":[104,112,154],"exerted":[105,113],"nucleus.":[108],"To":[109],"characterize":[110],"measured":[118],"shape":[120],"stiffness":[123],"isolated":[125],"nuclei":[126,128],"living":[130],"myocytes":[131,146],"during":[132],"disruption":[133],"cytoskeletal,":[135],"myofibrillar,":[136],"structure.":[139],"We":[140],"found":[141],"that":[142,178],"is":[147,158],"subject":[148],"to":[149],"both":[150],"tensional":[151],"compressional":[153],"its":[156],"determined":[159],"by":[160,211],"balance":[162],"those":[164],"opposing":[165],"forces.":[166],"By":[167],"developing":[168],"computational":[170],"model":[171],"prestressed":[174],"showed":[177],"prestresses":[182],"create":[183],"vulnerability":[184],"envelope.":[188],"Our":[189],"suggest":[191],"cytoskeletal-nuclear-chromatin":[193],"interconnectivity":[194],"may":[195],"play":[196],"an":[197],"important":[198],"role":[199],"contraction":[204],"development":[208],"laminopathies":[210],"mutations.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}