{"id":"https://openalex.org/W2013299549","doi":"https://doi.org/10.1097/00007890-199608150-00011","title":"PROGRESSIVE HISTOLOGIC INJURY IN KIDNEYS FROM HEART AND LIVER TRANSPLANT RECIPIENTS RECEIVING CYCLOSPORINE","display_name":"PROGRESSIVE HISTOLOGIC INJURY IN KIDNEYS FROM HEART AND LIVER TRANSPLANT RECIPIENTS RECEIVING CYCLOSPORINE","publication_year":1996,"publication_date":"1996-08-01","ids":{"openalex":"https://openalex.org/W2013299549","doi":"https://doi.org/10.1097/00007890-199608150-00011","mag":"2013299549","pmid":"https://pubmed.ncbi.nlm.nih.gov/8779684"},"language":"en","primary_location":{"id":"doi:10.1097/00007890-199608150-00011","doi":"https://doi.org/10.1097/00007890-199608150-00011","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199608150-00011","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110855525","display_name":"Michael E. Falkenhain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M. E. Falkenhain","raw_affiliation_strings":["Department of Internal Medicine, The Ohio State University, Columbus 43210, USA","Department of Internal Medicine","M.E. Falkenhain, MD, Division of Nephrology, The Ohio State University, N-210 Means Hall, 1654 Upham Drive, Columbus, OH 43210"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, The Ohio State University, Columbus 43210, USA","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Department of Internal Medicine","institution_ids":[]},{"raw_affiliation_string":"M.E. Falkenhain, MD, Division of Nephrology, The Ohio State University, N-210 Means Hall, 1654 Upham Drive, Columbus, OH 43210","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065623766","display_name":"Borja G. Cos\u00edo","orcid":"https://orcid.org/0000-0002-6388-8209","observed_orcids":["https://orcid.org/0000-0002-6388-8209"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. G. Cosio","raw_affiliation_strings":["Department of Internal Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024780472","display_name":"Daniel D. Sedmak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. D. Sedmak","raw_affiliation_strings":["Department of Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110855525"],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":null,"apc_paid":null,"fwci":3.2709,"has_fulltext":false,"cited_by_count":106,"citation_normalized_percentile":{"value":0.91581921,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"62","issue":"3","first_page":"364","last_page":"370"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.01899999938905239,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.906000018119812},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.906000018119812},{"id":"https://openalex.org/keywords/chronic-renal-injury","display_name":"chronic renal injury","score":0.6970000267028809},{"id":"https://openalex.org/keywords/heart-transplant-recipients","display_name":"heart transplant recipients","score":0.7070000171661377},{"id":"https://openalex.org/keywords/liver-transplant-recipients","display_name":"liver transplant recipients","score":1.0},{"id":"https://openalex.org/keywords/arteriolar-hyalinosis","display_name":"arteriolar hyalinosis","score":0.9049999713897705},{"id":"https://openalex.org/keywords/global-glomerulosclerosis","display_name":"global glomerulosclerosis","score":0.9139999747276306},{"id":"https://openalex.org/keywords/focal-glomerulosclerosis","display_name":"focal glomerulosclerosis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/interstitial-fibrosis","display_name":"interstitial fibrosis","score":0.9570000171661377},{"id":"https://openalex.org/keywords/glomerular-filtration-rate","display_name":"glomerular filtration rate","score":0.7850000262260437},{"id":"https://openalex.org/keywords/serum-creatinine","display_name":"serum creatinine","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8525758981704712},{"id":"https://openalex.org/C2777390665","wikidata":"https://www.wikidata.org/wiki/Q5571239","display_name":"Glomerulosclerosis","level":4,"score":0.8385719060897827},{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.7244862914085388},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6304529905319214},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.561614453792572},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.54208904504776},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5288143157958984},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.49104928970336914},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4881933331489563},{"id":"https://openalex.org/C2779504383","wikidata":"https://www.wikidata.org/wiki/Q41482","display_name":"Autopsy","level":2,"score":0.45427900552749634},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4060834050178528},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.34510356187820435},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.15426886081695557}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016027","descriptor_name":"Heart Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016027","descriptor_name":"Heart Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016027","descriptor_name":"Heart Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016031","descriptor_name":"Liver Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016031","descriptor_name":"Liver Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016031","descriptor_name":"Liver Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00007890-199608150-00011","doi":"https://doi.org/10.1097/00007890-199608150-00011","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199608150-00011","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},{"id":"pmid:8779684","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8779684","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8500000238418579,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W141198166","https://openalex.org/W1550111394","https://openalex.org/W1955241051","https://openalex.org/W1965486287","https://openalex.org/W2008010521","https://openalex.org/W2018051522","https://openalex.org/W2025395197","https://openalex.org/W2026899198","https://openalex.org/W2067406603","https://openalex.org/W2076896665","https://openalex.org/W2083917318","https://openalex.org/W2092762429","https://openalex.org/W2319735235","https://openalex.org/W2321199594","https://openalex.org/W2410994065","https://openalex.org/W4210657423"],"related_works":["https://openalex.org/W1965486287","https://openalex.org/W1986540696","https://openalex.org/W2416539883","https://openalex.org/W1988652338","https://openalex.org/W2025458977","https://openalex.org/W1568816258","https://openalex.org/W2411917617","https://openalex.org/W2082703773","https://openalex.org/W2102765728","https://openalex.org/W2075753506"],"abstract_inverted_index":{"Cyclosporine":[0],"(CsA)":[1],"causes":[2],"both":[3],"acute":[4],"and":[5,28,62,75,94,114,142,211,233,251],"chronic":[6,21],"nephrotoxicity.":[7],"The":[8,119,138],"goal":[9],"of":[10,19,25,48,98,121,140,164,174,186,197,207,247,258],"the":[11,17,20,39,96,172,184,205,230,245,255,261],"present":[12],"studies":[13],"was":[14,86,106,126,179],"to":[15,29,38,244,249,254],"examine":[16],"nature":[18],"renal":[22,91,187,208,225,239,265],"pathologic":[23,209],"lesions":[24,33],"CsA":[26,160,250,259],"nephrotoxicity":[27],"determine":[30],"whether":[31],"these":[32],"progress":[34],"with":[35,123],"prolonged":[36,195],"exposure":[37,248],"drug.":[40],"With":[41,80],"this":[42],"purpose,":[43],"we":[44],"examined":[45,69],"large":[46],"sections":[47,67],"kidneys":[49,139,173],"obtained":[50],"at":[51],"autopsy":[52],"from":[53],"15":[54],"heart":[55,141],"transplant":[56,60,130,222],"recipients,":[57,61],"7":[58],"liver":[59,143],"10":[63],"nontransplanted":[64],"controls.":[65],"Tissue":[66],"were":[68,200],"blindly":[70],"by":[71,280],"light":[72],"microscopy,":[73],"histomorphometry,":[74],"color":[76],"computer":[77],"image":[78],"analysis.":[79],"increasing":[81],"time":[82,246],"following":[83],"transplantation,":[84,152],"there":[85,105,178],"a":[87,107],"progressive":[88],"increase":[89,182],"in":[90,95,129,183,190,235,242,252,272,274],"arteriolar":[92,112],"hyalinosis":[93,113],"percentage":[97,120],"glomeruli":[99,122],"demonstrating":[100],"global":[101,115],"sclerosis.":[102],"In":[103,219],"addition,":[104],"statistically":[108],"significant":[109,181,202],"relationship":[110],"between":[111,204],"glomerulosclerosis":[116,125],"(r=0.61,":[117],"P<0.003).":[118],"focal":[124],"also":[127],"increased":[128],"recipients":[131,144,192,223],"followed":[132,193],"for":[133,194],"more":[134,168],"than":[135,148,171],"80":[136,149],"days.":[137],"who":[145,157],"died":[146],"less":[147],"days":[150],"after":[151],"that":[153,227,260],"is,":[154],"those":[155],"patients":[156],"received":[158],"no":[159,180,201],"or":[161,214],"low":[162],"doses":[163],"CsA,":[165],"demonstrated":[166],"significantly":[167],"interstitial":[169,188],"fibrosis":[170,189],"control":[175],"individuals.":[176],"Furthermore,":[177],"amount":[185],"allograft":[191],"periods":[196],"time.":[198],"There":[199],"relationships":[203],"severity":[206],"changes":[210,267,273],"serum":[212,281],"creatinine":[213],"systemic":[215],"blood":[216],"pressure":[217],"levels.":[218],"conclusion,":[220],"non-renal":[221],"demonstrate":[224],"damage":[226,240],"affects":[228],"primarily":[229],"preglomerular":[231],"arterioles":[232],"results":[234],"glomerular":[236,275],"obliteration.":[237],"This":[238],"increases":[241],"relation":[243,253],"total":[256],"dose":[257],"patient":[262],"receives.":[263],"These":[264],"structural":[266],"are":[268],"not":[269],"reflected":[270],"initially":[271],"filtration":[276],"rate,":[277],"as":[278],"determined":[279],"creatinine.":[282]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}
