{"id":"https://openalex.org/W2013287777","doi":"https://doi.org/10.1097/00005344-198007000-00007","title":"Relative Effects of Sulfinpyrazone and Ibuprofen on Canine Platelet Function and Prostaglandin-Mediated Coronary Vasodilation","display_name":"Relative Effects of Sulfinpyrazone and Ibuprofen on Canine Platelet Function and Prostaglandin-Mediated Coronary Vasodilation","publication_year":1980,"publication_date":"1980-07-01","ids":{"openalex":"https://openalex.org/W2013287777","doi":"https://doi.org/10.1097/00005344-198007000-00007","mag":"2013287777","pmid":"https://pubmed.ncbi.nlm.nih.gov/6156338"},"language":"en","primary_location":{"id":"doi:10.1097/00005344-198007000-00007","doi":"https://doi.org/10.1097/00005344-198007000-00007","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005344-198007000-00007","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052964243","display_name":"Robert E. Goldstein","orcid":"https://orcid.org/0000-0003-1780-6898","observed_orcids":["https://orcid.org/0000-0003-1780-6898"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert E. Goldstein","raw_affiliation_strings":["Cardiology Branch, National Heart, Lung, and Blood Institute, and Clinical Hematology Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Branch, National Heart, Lung, and Blood Institute, and Clinical Hematology Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005675562","display_name":"Nancy J. Davenport","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy J. Davenport","raw_affiliation_strings":["Cardiology Branch, National Heart, Lung, and Blood Institute, and Clinical Hematology Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Branch, National Heart, Lung, and Blood Institute, and Clinical Hematology Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079738724","display_name":"Norine L. Capurro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Norine L. Capurro","raw_affiliation_strings":["Cardiology Branch, National Heart, Lung, and Blood Institute, and Clinical Hematology Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Branch, National Heart, Lung, and Blood Institute, and Clinical Hematology Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067687085","display_name":"Lewis C. Lipson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lewis C. Lipson","raw_affiliation_strings":["Cardiology Branch, National Heart, Lung, and Blood Institute, and Clinical Hematology Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Branch, National Heart, Lung, and Blood Institute, and Clinical Hematology Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028576363","display_name":"Robert O. Bonow","orcid":"https://orcid.org/0000-0003-2277-3605","observed_orcids":["https://orcid.org/0000-0003-2277-3605","https://orcid.org/0000-0003-1458-1515"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert O. Bonow","raw_affiliation_strings":["Cardiology Branch, National Heart, Lung, and Blood Institute, and Clinical Hematology Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Branch, National Heart, Lung, and Blood Institute, and Clinical Hematology Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109311831","display_name":"N. Raphael Shulman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Raphael Shulman","raw_affiliation_strings":["Cardiology Branch, National Heart, Lung, and Blood Institute, and Clinical Hematology Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Branch, National Heart, Lung, and Blood Institute, and Clinical Hematology Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107838634","display_name":"Stephen E. Epstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen E. Epstein","raw_affiliation_strings":["Cardiology Branch, National Heart, Lung, and Blood Institute, and Clinical Hematology Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Branch, National Heart, Lung, and Blood Institute, and Clinical Hematology Branch, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.713,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.83128621,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"4","first_page":"399","last_page":"410"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.44510000944137573,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.44510000944137573,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.4284999966621399,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.09449999779462814,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sulfinpyrazone","display_name":"sulfinpyrazone","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ibuprofen","display_name":"ibuprofen","score":0.9990000128746033},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.7760000228881836},{"id":"https://openalex.org/keywords/coronary-vasodilation","display_name":"coronary vasodilation","score":0.9549999833106995},{"id":"https://openalex.org/keywords/prostaglandins","display_name":"prostaglandins","score":0.8960000276565552},{"id":"https://openalex.org/keywords/arachidonic-acid","display_name":"arachidonic acid","score":0.9909999966621399},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9240000247955322},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.7540000081062317},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.6830000281333923},{"id":"https://openalex.org/keywords/canine-model","display_name":"canine model","score":0.44600000977516174},{"id":"https://openalex.org/keywords/antiplatelet-drugs","display_name":"antiplatelet agents","score":0.7269999980926514},{"id":"https://openalex.org/keywords/adenosine-diphosphate","display_name":"adenosine diphosphate","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C2777738910","wikidata":"https://www.wikidata.org/wiki/Q3790542","display_name":"Sulfinpyrazone","level":3,"score":0.9952234625816345},{"id":"https://openalex.org/C2779944601","wikidata":"https://www.wikidata.org/wiki/Q186969","display_name":"Ibuprofen","level":2,"score":0.8089529871940613},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6066477298736572},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.603023111820221},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.6027888655662537},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.5534430742263794},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.543048083782196},{"id":"https://openalex.org/C2909076160","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Coronary vasodilator","level":3,"score":0.5195044279098511},{"id":"https://openalex.org/C2776890861","wikidata":"https://www.wikidata.org/wiki/Q419374","display_name":"Dipyridamole","level":2,"score":0.47336313128471375},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.44163984060287476},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.4267120957374573},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39327147603034973},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32478708028793335},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18733453750610352},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11666399240493774}],"mesh":[{"descriptor_ui":"D000244","descriptor_name":"Adenosine Diphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001095","descriptor_name":"Arachidonic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001095","descriptor_name":"Arachidonic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003326","descriptor_name":"Coronary Circulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007052","descriptor_name":"Ibuprofen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011453","descriptor_name":"Prostaglandins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013442","descriptor_name":"Sulfinpyrazone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/00005344-198007000-00007","doi":"https://doi.org/10.1097/00005344-198007000-00007","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005344-198007000-00007","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},{"id":"pmid:6156338","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6156338","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiovascular pharmacology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2025199802","https://openalex.org/W1976777885","https://openalex.org/W2085762798","https://openalex.org/W2944871113","https://openalex.org/W2009166270","https://openalex.org/W1989698550","https://openalex.org/W1980795734","https://openalex.org/W7097704795","https://openalex.org/W2056145852","https://openalex.org/W2168527958"],"abstract_inverted_index":{"Recent":[0],"evidence":[1],"suggests":[2],"that":[3,37,272],"the":[4,89,111,127,164],"platelet-inhibitory":[5],"drugs":[6,21],"sulfin-pyrazone":[7],"and":[8,132,147,175,200,224,235],"ibuprofen":[9,133,236],"may":[10,41],"have":[11,268],"value":[12],"in":[13,46,122,126,138,163,273],"treatment":[14],"of":[15,35,71,91,155,245],"coronary":[16,58,248],"artery":[17],"disease.":[18],"However,":[19],"these":[20],"do":[22],"not":[23,67],"only":[24],"block":[25,30],"platelet":[26,64,124,206,231,239],"aggregation,":[27],"but":[28,66],"also":[29,117,241],"synthesis":[31,70],"by":[32,110,193,209,251],"blood":[33,44],"vessels":[34,45],"prostaglandins":[36],"promote":[38],"vasodilation.":[39],"Platelets":[40],"differ":[42],"from":[43],"their":[47],"sensitivity":[48],"to":[49,82,167,229,257,267],"sulfinpyrazone":[50,131,194,234,261],"or":[51,99,195],"ibuprofen.":[52,196],"In":[53],"theory,":[54],"optimal":[55,85],"doses":[56,86,237],"for":[57,161,219],"disease":[59],"would":[60],"inhibit":[61],"potentially":[62],"deleterious":[63],"aggregation":[65,125,207],"interfere":[68],"with":[69,253],"possibly":[72],"beneficial":[73],"vasodilator":[74,165,258],"prostaglandins.":[75,259],"To":[76],"determine":[77],"whether":[78],"it":[79],"was":[80,191],"possible":[81],"identify":[83],"such":[84],"we":[87],"measured":[88],"effects":[90,120,182],"intravenous":[92],"sulfinpyrazone,":[93],"0.3\u2013100":[94],"mg/kg":[95,103],"(n":[96,104],"=":[97,105],"9),":[98],"sodium":[100],"ibuprofen,":[101,148,176,201,225,263],"0.1\u20133":[102],"7),":[106],"on":[107,121,183],"vasodilation":[108],"induced":[109,208],"protaglandin":[112],"precursor":[113],"arachidonic":[114,142,170,246,254],"acid.":[115,143,171],"We":[116],"assessed":[118],"drug":[119],"vitro":[123],"same":[128],"animals.":[129],"Both":[130],"caused":[134],"a":[135,152],"dose-related":[136],"reduction":[137,154],"flow":[139],"increment":[140],"after":[141,187],"Sulfinpyrazone,":[144,172,197,221],"\u226510":[145,198],"mg/kg,":[146,150,174,178,199,203,223,227],"\u22651":[149,202],"produced":[151,242],"mean":[153],"least":[156],"60%":[157],"(p":[158,216],"<":[159,217],"0.02":[160],"each)":[162],"response":[166],"1":[168],"mg":[169],"0.3":[173,222],"0.1":[177,226],"had":[179],"no":[180],"consistent":[181],"flow.":[184],"Flow":[185],"rise":[186],"intracoronary":[188],"prostaglandin":[189],"E2":[190],"undiminished":[192],"markedly":[204],"inhibited":[205],"adenosine":[210],"diphosphate,":[211],"2.3":[212],"x":[213],"10-5":[214],"M":[215],"0.01":[218],"each).":[220],"failed":[228],"alter":[230],"aggregation.":[232],"Hence,":[233],"inhibiting":[238],"function":[240],"comparable":[243],"inhibition":[244],"acid-induced":[247],"vasodilation,":[249],"presumably":[250],"interfering":[252],"acid":[255],"conversion":[256],"Neither":[260],"nor":[262],"administered":[264],"acutely,":[265],"appears":[266],"an":[269],"\u201coptimal\u201d":[270],"dose":[271]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
