{"id":"https://openalex.org/W2013276072","doi":"https://doi.org/10.1074/jbc.m806447200","title":"Bidirectional Regulation of Kainate Receptor Surface Expression in Hippocampal Neurons","display_name":"Bidirectional Regulation of Kainate Receptor Surface Expression in Hippocampal Neurons","publication_year":2008,"publication_date":"2008-10-28","ids":{"openalex":"https://openalex.org/W2013276072","doi":"https://doi.org/10.1074/jbc.m806447200","mag":"2013276072","pmid":"https://pubmed.ncbi.nlm.nih.gov/18955488","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2662304"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m806447200","doi":"https://doi.org/10.1074/jbc.m806447200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m806447200","pdf_url":"http://www.jbc.org/article/S0021925820496528/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820496528/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"St\u00e9phane Martin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"St\u00e9phane Martin","raw_affiliation_strings":["Department of Anatomy, Medical Research Council Centre for Synaptic Plasticity, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Medical Research Council Centre for Synaptic Plasticity, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040084516","display_name":"Tristan Bouschet","orcid":"https://orcid.org/0000-0002-7858-6115","observed_orcids":["https://orcid.org/0000-0002-7858-6115"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tristan Bouschet","raw_affiliation_strings":["Department of Anatomy, Medical Research Council Centre for Synaptic Plasticity, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Medical Research Council Centre for Synaptic Plasticity, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014643231","display_name":"Emma L. Jenkins","orcid":"https://orcid.org/0000-0001-5860-8762","observed_orcids":["https://orcid.org/0000-0001-5860-8762"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Emma L. Jenkins","raw_affiliation_strings":["Department of Anatomy, Medical Research Council Centre for Synaptic Plasticity, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Medical Research Council Centre for Synaptic Plasticity, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083648774","display_name":"Atsushi Nishimune","orcid":"https://orcid.org/0000-0003-0167-2055","observed_orcids":["https://orcid.org/0000-0003-0167-2055"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Atsushi Nishimune","raw_affiliation_strings":["Department of Anatomy, Medical Research Council Centre for Synaptic Plasticity, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Medical Research Council Centre for Synaptic Plasticity, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082068871","display_name":"Jeremy Martin Henley","orcid":"https://orcid.org/0000-0003-3589-8335","observed_orcids":["https://orcid.org/0000-0003-3589-8335"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Jeremy M. Henley","raw_affiliation_strings":["Department of Anatomy, Medical Research Council Centre for Synaptic Plasticity, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Medical Research Council Centre for Synaptic Plasticity, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom","institution_ids":["https://openalex.org/I36234482"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5082068871"],"corresponding_institution_ids":["https://openalex.org/I36234482"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.9999,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.70217985,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"283","issue":"52","first_page":"36435","last_page":"36440"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kainate-receptors","display_name":"kainate receptors","score":0.9860000014305115},{"id":"https://openalex.org/keywords/receptor-surface-expression","display_name":"receptor surface expression","score":0.8769999742507935},{"id":"https://openalex.org/keywords/bidirectional-regulation","display_name":"bidirectional regulation","score":0.7319999933242798},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.7870000004768372},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.6729999780654907},{"id":"https://openalex.org/keywords/nmda-receptor-activation","display_name":"NMDA receptor activation","score":0.6980000138282776},{"id":"https://openalex.org/keywords/heteromeric-receptor-assembly","display_name":"heteromeric receptor assembly","score":0.8560000061988831},{"id":"https://openalex.org/keywords/extrasynaptic-glutamate","display_name":"extrasynaptic glutamate","score":0.8330000042915344},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C189184402","wikidata":"https://www.wikidata.org/wiki/Q3454536","display_name":"Kainate receptor","level":5,"score":0.9409948587417603},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.5774553418159485},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.5764667391777039},{"id":"https://openalex.org/C2776108384","wikidata":"https://www.wikidata.org/wiki/Q390239","display_name":"Kainic acid","level":4,"score":0.572510838508606},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5692475438117981},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5628108978271484},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.537676990032196},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5175656676292419},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.49886345863342285},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4902637302875519},{"id":"https://openalex.org/C2779803574","wikidata":"https://www.wikidata.org/wiki/Q4386534","display_name":"CNQX","level":5,"score":0.4687621295452118},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.44767558574676514},{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.44404441118240356},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.42698484659194946},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.407988578081131},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3403415083885193},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3398978114128113},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29824280738830566}],"mesh":[{"descriptor_ui":"D000097806","descriptor_name":"GluK2 Kainate Receptor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007608","descriptor_name":"Kainic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012845","descriptor_name":"Sindbis Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016202","descriptor_name":"N-Methylaspartate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018092","descriptor_name":"Kainic Acid Receptors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018092","descriptor_name":"Kainic Acid Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1074/jbc.m806447200","doi":"https://doi.org/10.1074/jbc.m806447200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m806447200","pdf_url":"http://www.jbc.org/article/S0021925820496528/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2662304","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2662304","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:18955488","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18955488","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-05745099v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05745099","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Biological Chemistry, 2008, 283 (52), pp.36435-36440. ⟨10.1074/jbc.M806447200⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/163921","doi":null,"is_oa":true,"landing_page_url":"https://dipot.ulb.ac.be/dspace/bitstream/2013/163921/3/doi_147551.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Journal of biological chemistry, 283 (52","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:research-information.bris.ac.uk:openaire_cris_publications/2369a20a-b918-4b83-a4d8-e55df298bc93","doi":null,"is_oa":false,"landing_page_url":"https://research-information.bris.ac.uk/en/publications/2369a20a-b918-4b83-a4d8-e55df298bc93","pdf_url":null,"source":{"id":"https://openalex.org/S4306400895","display_name":"Bristol Research (University of Bristol)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I36234482","host_organization_name":"University of Bristol","host_organization_lineage":["https://openalex.org/I36234482"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Martin, SG, Bouschet, T, Jenkins, EL, Nishimune, A & Henley, JM 2008, 'Bidirectional regulation of kainate receptor surface expression in hippocampal neurons', Journal of Biological Chemistry, vol. 283(52), pp. 36435 - 36440. https://doi.org/10.1074/jbc.M806447200","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m806447200","doi":"https://doi.org/10.1074/jbc.m806447200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m806447200","pdf_url":"http://www.jbc.org/article/S0021925820496528/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7601316075","display_name":"Kainate receptor trafficking in neurones.","funder_award_id":"083721","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2013276072.pdf","grobid_xml":"https://content.openalex.org/works/W2013276072.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1964165361","https://openalex.org/W1965226335","https://openalex.org/W1965772734","https://openalex.org/W1978323848","https://openalex.org/W1982726026","https://openalex.org/W1989244218","https://openalex.org/W1997257842","https://openalex.org/W2002110360","https://openalex.org/W2008376911","https://openalex.org/W2016166286","https://openalex.org/W2039692671","https://openalex.org/W2041826924","https://openalex.org/W2052163927","https://openalex.org/W2052495973","https://openalex.org/W2060411448","https://openalex.org/W2064209065","https://openalex.org/W2129777420","https://openalex.org/W2146333273","https://openalex.org/W2149390741","https://openalex.org/W2162642602"],"related_works":["https://openalex.org/W1594523421","https://openalex.org/W7096771876","https://openalex.org/W1978323848","https://openalex.org/W3195666397","https://openalex.org/W2028461806","https://openalex.org/W1982915021","https://openalex.org/W2091497666","https://openalex.org/W1595557903","https://openalex.org/W3011614831","https://openalex.org/W1497328060"],"abstract_inverted_index":{"Kainate":[0],"receptors":[1],"(KARs)":[2],"are":[3],"crucial":[4],"for":[5,149],"the":[6,19,91,117],"regulation":[7],"of":[8,83,94],"both":[9],"excitatory":[10],"and":[11,134,163],"inhibitory":[12],"neurotransmission,":[13],"but":[14],"little":[15],"is":[16,63,140],"known":[17],"regarding":[18],"mechanisms":[20],"controlling":[21],"KAR":[22,31,39,53,86,132,137],"surface":[23,40,85,95,138],"expression.":[24],"We":[25],"used":[26],"super":[27],"ecliptic":[28],"pHluorin":[29],"(SEP)-tagged":[30],"subunit":[32],"GluR6a":[33],"to":[34,55,109,116,152,158],"investigate":[35],"real-time":[36],"changes":[37,159],"in":[38,42,79,106,160],"expression":[41,139],"hippocampal":[43,150],"neurons.":[44],"Sindbis":[45],"virus-expressed":[46],"SEP-GluR6":[47,62],"subunits":[48,54],"efficiently":[49],"co-assembled":[50],"with":[51],"native":[52],"form":[56],"heteromeric":[57],"receptors.":[58],"Diffuse":[59],"surface-expressed":[60,107],"dendritic":[61],"rapidly":[64],"internalized":[65],"following":[66,90],"either":[67],"N-methyl-d-aspartate":[68,76],"or":[69,74],"kainate":[70,73,99],"application.":[71],"Sustained":[72],"transient":[75,127],"application":[77,100],"resulted":[78],"a":[80,97,102,147],"slow":[81],"decrease":[82],"base-line":[84],"levels.":[87],"Surprisingly,":[88],"however,":[89],"initial":[92,125],"loss":[93],"receptors,":[96],"short":[98],"caused":[101],"long":[103],"lasting":[104],"increase":[105],"KARs":[108],"levels":[110],"significantly":[111],"greater":[112],"than":[113],"those":[114],"prior":[115],"agonist":[118,128],"challenge.":[119],"These":[120],"data":[121],"suggest":[122],"that":[123,136],"after":[124],"endocytosis,":[126],"activation":[129,162],"evokes":[130],"increased":[131],"exocytosis":[133],"reveal":[135],"bidirectionally":[141],"regulated.":[142],"This":[143],"process":[144],"may":[145],"provide":[146],"mechanism":[148],"neurons":[151],"differentially":[153],"adapt":[154],"their":[155],"physiological":[156],"responses":[157],"synaptic":[161],"extrasynaptic":[164],"glutamate":[165],"concentration.":[166]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}