{"id":"https://openalex.org/W2013274122","doi":"https://doi.org/10.1158/1538-7445.am10-1504","title":"Abstract 1504: Inhibition of RNA-dependent protein kinase (PKR) enhances radiation sensitivity in lung cancer cells","display_name":"Abstract 1504: Inhibition of RNA-dependent protein kinase (PKR) enhances radiation sensitivity in lung cancer cells","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W2013274122","doi":"https://doi.org/10.1158/1538-7445.am10-1504","mag":"2013274122"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am10-1504","doi":"https://doi.org/10.1158/1538-7445.am10-1504","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-1504","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044794204","display_name":"Abujiang Pataer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abujiang Pataer","raw_affiliation_strings":["1UT M.D. Anderson Cancer Ctr., Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT M.D. Anderson Cancer Ctr., Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035715471","display_name":"Xiaolin L\u00fc","orcid":"https://orcid.org/0000-0002-6858-7587","observed_orcids":["https://orcid.org/0000-0002-6858-7587","https://orcid.org/0000-0001-5094-741X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaolin Lu","raw_affiliation_strings":["1UT M.D. Anderson Cancer Ctr., Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT M.D. Anderson Cancer Ctr., Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027152610","display_name":"Jack A. Roth","orcid":"https://orcid.org/0000-0002-8955-1313","observed_orcids":["https://orcid.org/0000-0002-8955-1313"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jack A. Roth","raw_affiliation_strings":["1UT M.D. Anderson Cancer Ctr., Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT M.D. Anderson Cancer Ctr., Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076621000","display_name":"Stephen G. Swisher","orcid":"https://orcid.org/0000-0002-3080-1920","observed_orcids":["https://orcid.org/0000-0002-3080-1920"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen G. Swisher","raw_affiliation_strings":["1UT M.D. Anderson Cancer Ctr., Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT M.D. Anderson Cancer Ctr., Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"70","issue":"8_Supplement","first_page":"1504","last_page":"1504"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.3158999979496002,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.3158999979496002,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.2777999937534332,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.07090000063180923,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-dependent-protein-kinase","display_name":"RNA-dependent protein kinase","score":0.9589999914169312},{"id":"https://openalex.org/keywords/pkr","display_name":"PKR","score":0.9800000190734863},{"id":"https://openalex.org/keywords/radioresistance-biology","display_name":"radioresistance (biology)","score":0.9390000104904175},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.6579999923706055},{"id":"https://openalex.org/keywords/akt-activation","display_name":"Akt activation","score":0.8539999723434448},{"id":"https://openalex.org/keywords/nuclear-translocation","display_name":"nuclear translocation","score":0.7419999837875366},{"id":"https://openalex.org/keywords/adenovirus-vectors","display_name":"adenoviral vector","score":0.7870000004768372},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.6930000185966492},{"id":"https://openalex.org/keywords/radiosensitivity","display_name":"radiosensitivity","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C161238802","wikidata":"https://www.wikidata.org/wiki/Q14905690","display_name":"Protein kinase R","level":5,"score":0.8940428495407104},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6256166100502014},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5765321850776672},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5321696400642395},{"id":"https://openalex.org/C2777479484","wikidata":"https://www.wikidata.org/wiki/Q5323131","display_name":"EIF-2 kinase","level":5,"score":0.49324697256088257},{"id":"https://openalex.org/C154137905","wikidata":"https://www.wikidata.org/wiki/Q17816452","display_name":"AKT1","level":4,"score":0.48854169249534607},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.47076085209846497},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.44014281034469604},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4331296682357788},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4222782552242279},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4201188087463379},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37004441022872925},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3665514588356018},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3502824902534485},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.26395219564437866},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14215001463890076},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.12899962067604065},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.06961098313331604}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am10-1504","doi":"https://doi.org/10.1158/1538-7445.am10-1504","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-1504","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2401792687","https://openalex.org/W2092886041","https://openalex.org/W3139057214","https://openalex.org/W2114677141","https://openalex.org/W2058500547","https://openalex.org/W2010453242","https://openalex.org/W2088302799","https://openalex.org/W1981177991","https://openalex.org/W7099972823","https://openalex.org/W2065147986"],"abstract_inverted_index":{"Abstract":[0],"We":[1],"have":[2],"previously":[3],"demonstrated":[4],"that":[5,42],"radiation":[6,66,97,120,141,159],"resistance":[7,160],"in":[8,12,30,56,115,151],"MEFs":[9,46,75,102],"is":[10,124],"mediated":[11],"part":[13],"through":[14,20,162],"RNA-dependent":[15],"protein":[16,166],"kinase":[17],"(PKR)":[18],"possibly":[19,161],"upregulation":[21],"of":[22,28,45,59,62,70,86,96,101,130,158,164,173,183,188],"AKT":[23,89],"and":[24,47,64,91,103,118,139,171],"NFk-B.":[25],"The":[26,68],"role":[27,148],"PKR":[29,54,81,111,133,150],"cancer":[31,49,72,105,153],"cells":[32,50,73,106,154],"has":[33],"not":[34],"been":[35],"evaluated.":[36],"In":[37],"this":[38],"study,":[39],"we":[40],"show":[41],"the":[43,94,165,169,184,189],"transduction":[44,69,100,129],"lung":[48,71,104,152],"with":[51,76,107],"adenoviral":[52,80],"wt":[53,110],"results":[55,114],"nuclear":[57,84,108],"translocation":[58,85,163],"PKR,":[60,87],"activation":[61,90,117,138,172],"AKT1/2":[63,116,137],"increased":[65,119],"resistance.":[67,98,121],"or":[74],"a":[77,146,156],"dominant":[78,131],"negative":[79,132],"vector":[82],"blocks":[83],"inhibits":[88],"leads":[92],"to":[93,168],"reversal":[95],"Plasmid":[99],"targeted":[109],"vectors":[112,134],"also":[113],"This":[122],"effect":[123],"selectively":[125],"abrogated":[126],"by":[127],"plasmid":[128],"which":[135],"inhibit":[136],"restore":[140],"sensitivity.":[142],"These":[143],"findings":[144],"suggest":[145],"novel":[147],"for":[149,192],"as":[155],"mediator":[157],"product":[167],"nucleus":[170],"AKT1/2.":[174],"Citation":[175],"Format:":[176],"{Authors}.":[177],"{Abstract":[178],"title}":[179],"[abstract].":[180],"In:":[181],"Proceedings":[182],"101st":[185],"Annual":[186],"Meeting":[187],"American":[190],"Association":[191],"Cancer":[193,203],"Research;":[194],"2010":[195],"Apr":[196],"17-21;":[197],"Washington,":[198],"DC.":[199],"Philadelphia":[200],"(PA):":[201],"AACR;":[202],"Res":[204],"2010;70(8":[205],"Suppl):Abstract":[206],"nr":[207],"1504.":[208]},"counts_by_year":[],"updated_date":"2026-10-03T13:16:28.481748","created_date":"2016-06-24T00:00:00"}
