{"id":"https://openalex.org/W2013270589","doi":"https://doi.org/10.1038/bjc.2014.395","title":"Identification of chemoresistant factors by protein expression analysis with iTRAQ for head and neck carcinoma","display_name":"Identification of chemoresistant factors by protein expression analysis with iTRAQ for head and neck carcinoma","publication_year":2014,"publication_date":"2014-07-17","ids":{"openalex":"https://openalex.org/W2013270589","doi":"https://doi.org/10.1038/bjc.2014.395","mag":"2013270589","pmid":"https://pubmed.ncbi.nlm.nih.gov/25032734","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4134508"},"language":"en","primary_location":{"id":"doi:10.1038/bjc.2014.395","doi":"https://doi.org/10.1038/bjc.2014.395","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bjc.2014.395","pdf_url":"https://www.nature.com/articles/bjc2014395.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/bjc2014395.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"K Nishimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16528096","display_name":"Aichi Medical University","ror":"https://ror.org/02h6cs343","country_code":"JP","type":"education","lineage":["https://openalex.org/I16528096"]},{"id":"https://openalex.org/I4210099598","display_name":"Aichi Medical University Hospital","ror":"https://ror.org/00ztar512","country_code":"JP","type":"education","lineage":["https://openalex.org/I16528096","https://openalex.org/I4210099598"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Nishimura","raw_affiliation_strings":["Department of Otorhinolaryngology, Aichi Medical University School of Medicine, 1-1, Yazakokarimata, Nagakute, Aichi 480-1195, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology, Aichi Medical University School of Medicine, 1-1, Yazakokarimata, Nagakute, Aichi 480-1195, Japan","institution_ids":["https://openalex.org/I16528096","https://openalex.org/I4210099598"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073814175","display_name":"Yoshimasa Tsuchiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16528096","display_name":"Aichi Medical University","ror":"https://ror.org/02h6cs343","country_code":"JP","type":"education","lineage":["https://openalex.org/I16528096"]},{"id":"https://openalex.org/I4210099598","display_name":"Aichi Medical University Hospital","ror":"https://ror.org/00ztar512","country_code":"JP","type":"education","lineage":["https://openalex.org/I16528096","https://openalex.org/I4210099598"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Tsuchiya","raw_affiliation_strings":["Department of Otorhinolaryngology, Aichi Medical University School of Medicine, 1-1, Yazakokarimata, Nagakute, Aichi 480-1195, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology, Aichi Medical University School of Medicine, 1-1, Yazakokarimata, Nagakute, Aichi 480-1195, Japan","institution_ids":["https://openalex.org/I16528096","https://openalex.org/I4210099598"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112796096","display_name":"H Okamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16528096","display_name":"Aichi Medical University","ror":"https://ror.org/02h6cs343","country_code":"JP","type":"education","lineage":["https://openalex.org/I16528096"]},{"id":"https://openalex.org/I4210099598","display_name":"Aichi Medical University Hospital","ror":"https://ror.org/00ztar512","country_code":"JP","type":"education","lineage":["https://openalex.org/I16528096","https://openalex.org/I4210099598"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Okamoto","raw_affiliation_strings":["Department of Otorhinolaryngology, Aichi Medical University School of Medicine, 1-1, Yazakokarimata, Nagakute, Aichi 480-1195, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology, Aichi Medical University School of Medicine, 1-1, Yazakokarimata, Nagakute, Aichi 480-1195, Japan","institution_ids":["https://openalex.org/I16528096","https://openalex.org/I4210099598"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073417010","display_name":"Kei Ijichi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Ijichi","raw_affiliation_strings":["Department of Otolaryngology, Head and Neck Surgery, Nagoya City University Graduate School of Medical Science, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Head and Neck Surgery, Nagoya City University Graduate School of Medical Science, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052226051","display_name":"Masahiko Gosho","orcid":"https://orcid.org/0000-0002-5973-9163","observed_orcids":["https://orcid.org/0000-0002-5973-9163"]},"institutions":[{"id":"https://openalex.org/I16528096","display_name":"Aichi Medical University","ror":"https://ror.org/02h6cs343","country_code":"JP","type":"education","lineage":["https://openalex.org/I16528096"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Gosho","raw_affiliation_strings":["Unit of Biostatistics, Advanced Medical Research Center, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Biostatistics, Advanced Medical Research Center, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan","institution_ids":["https://openalex.org/I16528096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016703290","display_name":"Minoru Fukayama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16528096","display_name":"Aichi Medical University","ror":"https://ror.org/02h6cs343","country_code":"JP","type":"education","lineage":["https://openalex.org/I16528096"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Fukayama","raw_affiliation_strings":["Division of Clinical Research Promotion, Institute of Comprehensive Medical Research, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Research Promotion, Institute of Comprehensive Medical Research, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan","institution_ids":["https://openalex.org/I16528096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061277451","display_name":"Kazuhiro Yoshikawa","orcid":"https://orcid.org/0000-0002-8778-1174","observed_orcids":["https://orcid.org/0000-0002-8778-1174"]},"institutions":[{"id":"https://openalex.org/I16528096","display_name":"Aichi Medical University","ror":"https://ror.org/02h6cs343","country_code":"JP","type":"education","lineage":["https://openalex.org/I16528096"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Yoshikawa","raw_affiliation_strings":["Division of Clinical Research Promotion, Institute of Comprehensive Medical Research, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Research Promotion, Institute of Comprehensive Medical Research, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan","institution_ids":["https://openalex.org/I16528096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027057785","display_name":"Hiromi H. Ueda","orcid":"https://orcid.org/0000-0001-9586-9339","observed_orcids":["https://orcid.org/0000-0001-9586-9339"]},"institutions":[{"id":"https://openalex.org/I16528096","display_name":"Aichi Medical University","ror":"https://ror.org/02h6cs343","country_code":"JP","type":"education","lineage":["https://openalex.org/I16528096"]},{"id":"https://openalex.org/I4210099598","display_name":"Aichi Medical University Hospital","ror":"https://ror.org/00ztar512","country_code":"JP","type":"education","lineage":["https://openalex.org/I16528096","https://openalex.org/I4210099598"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Ueda","raw_affiliation_strings":["Department of Otorhinolaryngology, Aichi Medical University School of Medicine, 1-1, Yazakokarimata, Nagakute, Aichi 480-1195, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology, Aichi Medical University School of Medicine, 1-1, Yazakokarimata, Nagakute, Aichi 480-1195, Japan","institution_ids":["https://openalex.org/I16528096","https://openalex.org/I4210099598"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040159243","display_name":"Carol Rossier Bradford","orcid":"https://orcid.org/0000-0002-2768-4532","observed_orcids":["https://orcid.org/0000-0002-2768-4532"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210111446","display_name":"A. Alfred Taubman Health Care Center","ror":"https://ror.org/01rh00978","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210111446","https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C R Bradford","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Taubman Center Floor 1 Reception A, 1500 E Medical Center Drive SPC 5312, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Taubman Center Floor 1 Reception A, 1500 E Medical Center Drive SPC 5312, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210111446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076508788","display_name":"Thomas E. Carey","orcid":"https://orcid.org/0000-0002-5202-7518","observed_orcids":["https://orcid.org/0000-0002-5202-7518"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210111446","display_name":"A. Alfred Taubman Health Care Center","ror":"https://ror.org/01rh00978","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210111446","https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T E Carey","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Taubman Center Floor 1 Reception A, 1500 E Medical Center Drive SPC 5312, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Taubman Center Floor 1 Reception A, 1500 E Medical Center Drive SPC 5312, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210111446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028090784","display_name":"Tetsuya Ogawa","orcid":"https://orcid.org/0000-0003-4093-9533","observed_orcids":["https://orcid.org/0000-0003-4093-9533"]},"institutions":[{"id":"https://openalex.org/I16528096","display_name":"Aichi Medical University","ror":"https://ror.org/02h6cs343","country_code":"JP","type":"education","lineage":["https://openalex.org/I16528096"]},{"id":"https://openalex.org/I4210099598","display_name":"Aichi Medical University Hospital","ror":"https://ror.org/00ztar512","country_code":"JP","type":"education","lineage":["https://openalex.org/I16528096","https://openalex.org/I4210099598"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"T Ogawa","raw_affiliation_strings":["Department of Otorhinolaryngology, Aichi Medical University School of Medicine, 1-1, Yazakokarimata, Nagakute, Aichi 480-1195, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology, Aichi Medical University School of Medicine, 1-1, Yazakokarimata, Nagakute, Aichi 480-1195, Japan","institution_ids":["https://openalex.org/I16528096","https://openalex.org/I4210099598"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5028090784"],"corresponding_institution_ids":["https://openalex.org/I16528096","https://openalex.org/I4210099598"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":1.2857,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.79916234,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"111","issue":"4","first_page":"799","last_page":"806"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.4147999882698059,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.4147999882698059,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.3158999979496002,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.11420000344514847,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.8960000276565552},{"id":"https://openalex.org/keywords/cisplatin-resistance","display_name":"cisplatin resistance","score":0.8920000195503235},{"id":"https://openalex.org/keywords/5-fluorouracil-resistance","display_name":"5-fluorouracil resistance","score":0.9700000286102295},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/enolase-1","display_name":"alpha-enolase","score":0.7599999904632568},{"id":"https://openalex.org/keywords/multidrug-resistance-protein","display_name":"multidrug resistance protein","score":0.9279999732971191},{"id":"https://openalex.org/keywords/protein-expression-profiling","display_name":"protein expression profiling","score":0.7049999833106995},{"id":"https://openalex.org/keywords/itraq","display_name":"iTRAQ","score":0.7379999756813049},{"id":"https://openalex.org/keywords/resistance-biomarkers","display_name":"resistance biomarkers","score":0.7459999918937683},{"id":"https://openalex.org/keywords/cancer-therapy-targets","display_name":"cancer therapy targets","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.9186089634895325},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.6345667243003845},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.6227902770042419},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5881542563438416},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5098564028739929},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.46263593435287476},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44479674100875854},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.432331383228302},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39447200298309326},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3931315541267395},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.3649413287639618},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2976900339126587},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.15631002187728882},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13024955987930298},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08040371537208557},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010751","descriptor_name":"Phosphopyruvate Hydratase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010751","descriptor_name":"Phosphopyruvate Hydratase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051881","descriptor_name":"Receptor, Notch1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/bjc.2014.395","doi":"https://doi.org/10.1038/bjc.2014.395","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bjc.2014.395","pdf_url":"https://www.nature.com/articles/bjc2014395.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4134508","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4134508","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer","raw_type":"Text"},{"id":"pmid:25032734","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25032734","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/bjc.2014.395","doi":"https://doi.org/10.1038/bjc.2014.395","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bjc.2014.395","pdf_url":"https://www.nature.com/articles/bjc2014395.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8600000143051147}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2013270589.pdf","grobid_xml":"https://content.openalex.org/works/W2013270589.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W33386600","https://openalex.org/W1514403557","https://openalex.org/W1573959016","https://openalex.org/W1605102643","https://openalex.org/W1891733505","https://openalex.org/W1945650577","https://openalex.org/W1961406038","https://openalex.org/W1972070154","https://openalex.org/W1986311875","https://openalex.org/W1997824196","https://openalex.org/W2001143464","https://openalex.org/W2001578335","https://openalex.org/W2010533066","https://openalex.org/W2012108057","https://openalex.org/W2021709131","https://openalex.org/W2042440620","https://openalex.org/W2050847569","https://openalex.org/W2070718488","https://openalex.org/W2076944509","https://openalex.org/W2083434578","https://openalex.org/W2111159494","https://openalex.org/W2113274055","https://openalex.org/W2128961154","https://openalex.org/W2153271048","https://openalex.org/W2159169166","https://openalex.org/W2159197493","https://openalex.org/W2164300744","https://openalex.org/W2165577181","https://openalex.org/W2167391679","https://openalex.org/W2399070651","https://openalex.org/W2406213538","https://openalex.org/W2418452311"],"related_works":["https://openalex.org/W3095717728","https://openalex.org/W2885417931","https://openalex.org/W4308712274","https://openalex.org/W2047480148","https://openalex.org/W2988266807","https://openalex.org/W2022152336","https://openalex.org/W4392740152","https://openalex.org/W2056368263","https://openalex.org/W2612594791","https://openalex.org/W2028375501"],"abstract_inverted_index":{"BACKGROUND:":[0],"Cisplatin":[1],"and":[2,13,67,79,95,129,153,176,196],"other":[3],"anticancer":[4,169,193],"drugs":[5],"are":[6],"important":[7],"in":[8,127,151,155,159],"the":[9,46],"treatment":[10],"of":[11,124,199],"head":[12],"neck":[14],"squamous":[15],"cell":[16,53,131],"carcinoma;":[17],"however,":[18],"some":[19],"tumours":[20],"develop":[21],"drug":[22,32,170],"resistance.":[23,72,87],"If":[24],"chemoresistance":[25,40,183],"could":[26,187],"be":[27,35,188],"determined":[28],"before":[29],"treatment,":[30],"unnecessary":[31],"administration":[33],"would":[34],"avoided.":[36],"Here,":[37],"we":[38],"investigated":[39],"factors":[41],"by":[42,81,92,135,142],"comprehensive":[43],"analyses":[44],"at":[45],"protein":[47],"level.":[48],"METHODS:":[49],"Four":[50],"human":[51],"carcinoma":[52],"lines":[54,132],"were":[55,75,108],"used:":[56],"cisplatin-sensitive":[57],"UM-SCC-23,":[58],"UM-SCC-23-CDDPR":[59,156],"with":[60,69,77,115],"acquired":[61,70],"cisplatin":[62,146,182],"resistance,":[63],"naturally":[64],"cisplatin-resistant":[65,128],"UM-SCC-81B,":[66],"UM-SCC-23/WR":[68,160],"5-fluorouracil":[71],"Extracted":[73],"proteins":[74,107,114,126,165,186],"labelled":[76],"iTRAQ":[78],"analysed":[80],"tandem":[82],"mass":[83],"spectrometry":[84],"to":[85,118,167],"identify":[86],"Protein":[88],"expression":[89,123],"was":[90,98,133,149],"confirmed":[91,134],"western":[93,136],"blotting":[94],"functional":[96],"analysis":[97,139],"carried":[99],"out":[100],"using":[101,172],"siRNA.":[102],"RESULTS:":[103],"Thirteen":[104],"multiple-drug":[105],"resistance":[106,117,171,195],"identified,":[109],"as":[110,112,179,190,197],"well":[111],"seven":[113],"specific":[116],"cisplatin,":[119],"including":[120],"\u03b1-enolase.":[121],"Differential":[122],"these":[125],"-sensitive":[130],"blotting.":[137],"Functional":[138],"for":[140,192],"\u03b1-enolase":[141,178],"siRNA":[143],"showed":[144],"that":[145],"sensitivity":[147],"significantly":[148],"increased":[150],"UM-SCC-81B":[152],"slightly":[154],"but":[157],"not":[158],"cells.":[161],"CONCLUSIONS:":[162],"We":[163],"identified":[164,177],"thought":[166],"mediate":[168],"recent":[173],"proteome":[174],"technology":[175],"a":[180],"true":[181],"factor.":[184],"Such":[185],"used":[189],"biomarkers":[191],"agent":[194],"targets":[198],"cancer":[200],"therapy.":[201]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
