{"id":"https://openalex.org/W2013269497","doi":"https://doi.org/10.1158/1535-7163.targ-13-a280","title":"Abstract A280: Small molecule inhibition of atypical protein kinase C iota reveals a functional basis for oncogenesis.","display_name":"Abstract A280: Small molecule inhibition of atypical protein kinase C iota reveals a functional basis for oncogenesis.","publication_year":2013,"publication_date":"2013-11-01","ids":{"openalex":"https://openalex.org/W2013269497","doi":"https://doi.org/10.1158/1535-7163.targ-13-a280","mag":"2013269497"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.targ-13-a280","doi":"https://doi.org/10.1158/1535-7163.targ-13-a280","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.targ-13-a280","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029987103","display_name":"Mark David Linch","orcid":"https://orcid.org/0000-0003-2305-8486","observed_orcids":["https://orcid.org/0000-0003-2305-8486","https://orcid.org/0000-0002-3055-873X"]},"institutions":[{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark Linch","raw_affiliation_strings":["1Royal Marsden Hospital, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Royal Marsden Hospital, London, United Kingdom","institution_ids":["https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061071386","display_name":"Marta Sanz-Garc\u00eda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marta Sanz-Garcia","raw_affiliation_strings":["2London Research Insitute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2London Research Insitute, London, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Svend Kjaer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Svend Kjaer","raw_affiliation_strings":["2London Research Insitute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2London Research Insitute, London, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004574409","display_name":"Erika Soriano","orcid":"https://orcid.org/0000-0002-2972-9386","observed_orcids":["https://orcid.org/0000-0002-2972-9386"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erika Soriano","raw_affiliation_strings":["2London Research Insitute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2London Research Insitute, London, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Philippe Riou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philippe Riou","raw_affiliation_strings":["2London Research Insitute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2London Research Insitute, London, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086104700","display_name":"Philip Knowles","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philip Knowles","raw_affiliation_strings":["2London Research Insitute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2London Research Insitute, London, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036776345","display_name":"Christian Dillon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christian Dillon","raw_affiliation_strings":["3Cancer Research Technology, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Cancer Research Technology, London, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016507822","display_name":"Jon Roffey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jon Roffey","raw_affiliation_strings":["3Cancer Research Technology, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Cancer Research Technology, London, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015511982","display_name":"Neil Q. McDonald","orcid":"https://orcid.org/0000-0003-0975-6325","observed_orcids":["https://orcid.org/0000-0003-0975-6325"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neil McDonald","raw_affiliation_strings":["2London Research Insitute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2London Research Insitute, London, United Kingdom","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000996602","display_name":"Peter J. Parker","orcid":"https://orcid.org/0000-0002-6218-2933","observed_orcids":["https://orcid.org/0000-0002-6218-2933"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Parker","raw_affiliation_strings":["2London Research Insitute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2London Research Insitute, London, United Kingdom","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"11_Supplement","first_page":"A280","last_page":"A280"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.8489999771118164},{"id":"https://openalex.org/keywords/small-molecule-kinase-inhibitors","display_name":"small-molecule kinase inhibitors","score":0.6470000147819519},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.7860000133514404},{"id":"https://openalex.org/keywords/ras-signaling","display_name":"Ras signaling","score":0.7080000042915344},{"id":"https://openalex.org/keywords/erbb2","display_name":"ERBB2","score":0.984000027179718},{"id":"https://openalex.org/keywords/epithelial-polarization","display_name":"epithelial polarization","score":0.6959999799728394},{"id":"https://openalex.org/keywords/myosin-x","display_name":"myosin X","score":0.9459999799728394},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.6000000238418579},{"id":"https://openalex.org/keywords/dysplasia","display_name":"dysplasia","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.649797797203064},{"id":"https://openalex.org/C2778608917","wikidata":"https://www.wikidata.org/wiki/Q6787805","display_name":"Matrigel","level":3,"score":0.6047108173370361},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5554783344268799},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5361267328262329},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.47409045696258545},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4245273172855377},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.411271333694458},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.37106478214263916},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17704200744628906},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1642839014530182},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08581119775772095}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.targ-13-a280","doi":"https://doi.org/10.1158/1535-7163.targ-13-a280","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.targ-13-a280","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2116422989","https://openalex.org/W1585228699","https://openalex.org/W7061610326","https://openalex.org/W2033641476","https://openalex.org/W2002730599","https://openalex.org/W2774933652","https://openalex.org/W1977253863","https://openalex.org/W1972758313","https://openalex.org/W2079880410","https://openalex.org/W6998768931"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Atypical":[2],"protein":[3,360],"kinase":[4,11,190,361],"C":[5,362],"iota":[6,363],"(PKC\u03b9)":[7],"is":[8,29,240,265,308,318],"a":[9,17,112,194,221,227,243,319,365],"serine/threonine":[10],"that":[12,250,264,286,316],"has":[13],"been":[14],"implicated":[15],"in":[16,31,59,130,226,267,310],"variety":[18],"of":[19,97,114,145,188,224,229,234,248,258,358,373],"cellular":[20],"processes":[21],"including":[22,200],"polarity,":[23],"migration,":[24],"proliferation":[25],"and":[26,43,61,67,92,122,135,147,191,202,236,246,273,300,380],"survival.":[27],"PKC\u03b9":[28,69,84,109,164,211,238,255,287,306,317],"amplified":[30],"many":[32],"cancers":[33],"correlating":[34],"with":[35,74,78,166,242,271],"poor":[36],"prognosis,":[37],"however":[38,132],"the":[39,143,185,189,259,374],"upstream":[40,297],"activating":[41],"inputs":[42,107,299],"downstream":[44],"effectors":[45],"are":[46],"not":[47,150,291],"well":[48],"defined.":[49],"Experimental":[50],"Procedures:":[51],"3D":[52,311],"MDCK":[53,116,125,137,152],"epithelial":[54,282],"cell":[55],"spheroids":[56],"were":[57],"grown":[58],"Matrigel":[60],"used":[62],"to":[63,207,212],"assess":[64],"polarized":[65,128,155,214],"morphogenesis":[66,156],"growth.":[68],"was":[70,87,205],"manipulated":[71],"by":[72,89,94,160,254,293,296],"inhibition":[73,165,357],"CRT0066854,":[75],"or":[76,80,99,162],"transfection":[77],"siRNA":[79],"cDNA":[81],"variants.":[82],"A":[83],"binding":[85,100,178,218,262],"interface":[86],"identified":[88,183],"X-ray":[90],"crystallography":[91],"interrogated":[93],"mass":[95],"spectrometry":[96],"wildtype":[98],"mutant":[101,324],"immunocomplexes.":[102],"Results:":[103],"To":[104],"identify":[105],"potential":[106],"into":[108],"we":[110],"assessed":[111],"panel":[113],"transformed":[115,173],"cells;":[117],"p110\u03b1,":[118],"Src,":[119],"Ras,":[120,133],"ErbB2":[121,134],"Raf.":[123],"Parental":[124],"cells":[126,138,174],"form":[127],"cysts":[129],"Matrigel,":[131],"p110\u03b1":[136,151],"formed":[139],"dysplastic":[140,281],"spheroids.":[141,283],"In":[142],"case":[144],"Ras":[146,235,323],"ErbB2,":[148,237],"but":[149,295],"spheroids,":[153],"normal":[154],"could":[157],"be":[158,208,252],"rescued":[159,253],"siRNA-PKC\u03b9":[161],"partial":[163],"decreased":[167],"spheroid":[168],"size":[169],"seen":[170],"for":[171,197,210,322,368],"all":[172],"lines.":[175],"An":[176],"effector":[177,261],"site":[179,196],"(PKC\u03b9":[180],"RIPR":[181],"motif)":[182],"from":[184],"crystal":[186],"structure":[187],"characterized":[192],"as":[193,279],"recruitment":[195],"select":[198],"targets":[199],"LLGL2":[201,272],"Myosin":[203],"X,":[204],"found":[206,266],"critical":[209],"confer":[213],"morphogenesis.":[215],"Interestingly":[216],"this":[217],"motif":[219,263],"shows":[220],"low":[222],"frequency":[223],"mutation":[225],"subset":[228],"human":[230],"tumors.":[231,325],"Conclusions:":[232],"Downstream":[233],"activity":[239],"enhanced":[241],"resulting":[244],"dysplasia":[245],"loss":[247],"polarization,":[249],"can":[251],"inhibition.":[256],"Mutation":[257],"PKC\u03b9-RIPR":[260],"cancer,":[268,290],"prevents":[269],"interaction":[270],"its":[274],"expression":[275],"also":[276],"elicits":[277],"growth":[278],"non-polarized,":[280],"This":[284],"indicates":[285],"may":[288],"promote":[289],"only":[292],"amplification,":[294],"oncogenic":[298],"somatic":[301],"mutation.":[302],"The":[303],"oncogene":[304],"dependent":[305],"hyperactivation":[307],"pro-proliferative":[309],"culture,":[312],"providing":[313],"compelling":[314],"evidence":[315],"good":[320],"target":[321],"Citation":[326,333],"Information:":[327],"Mol":[328,391],"Cancer":[329,381,392],"Ther":[330,393],"2013;12(11":[331,394],"Suppl):A280.":[332],"Format:":[334],"Mark":[335],"Linch,":[336],"Marta":[337],"Sanz-Garcia,":[338],"Svend":[339],"Kjaer,":[340],"Erika":[341],"Soriano,":[342],"Philippe":[343],"Riou,":[344],"Philip":[345],"Knowles,":[346],"Christian":[347],"Dillon,":[348],"Jon":[349],"Roffey,":[350],"Neil":[351],"McDonald,":[352],"Peter":[353],"Parker.":[354],"Small":[355],"molecule":[356],"atypical":[359],"reveals":[364],"functional":[366],"basis":[367],"oncogenesis.":[369],"[abstract].":[370],"In:":[371],"Proceedings":[372],"AACR-NCI-EORTC":[375],"International":[376],"Conference:":[377],"Molecular":[378],"Targets":[379],"Therapeutics;":[382],"2013":[383],"Oct":[384],"19-23;":[385],"Boston,":[386],"MA.":[387],"Philadelphia":[388],"(PA):":[389],"AACR;":[390],"Suppl):Abstract":[395],"nr":[396],"A280.":[397]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
