{"id":"https://openalex.org/W2013261471","doi":"https://doi.org/10.1038/sj.leu.2400726","title":"The use of an all oral chemotherapy (idarubicin and etoposide) in the treatment of acute myeloid leukaemia in the elderly: a report of toxicity and efficacy","display_name":"The use of an all oral chemotherapy (idarubicin and etoposide) in the treatment of acute myeloid leukaemia in the elderly: a report of toxicity and efficacy","publication_year":1997,"publication_date":"1997-08-01","ids":{"openalex":"https://openalex.org/W2013261471","doi":"https://doi.org/10.1038/sj.leu.2400726","mag":"2013261471","pmid":"https://pubmed.ncbi.nlm.nih.gov/9264368"},"language":"en","primary_location":{"id":"doi:10.1038/sj.leu.2400726","doi":"https://doi.org/10.1038/sj.leu.2400726","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.leu.2400726","pdf_url":null,"source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.25405/ncl.34092006","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110295178","display_name":"GH Jackson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800516725","display_name":"Royal Victoria Infirmary","ror":"https://ror.org/01p19k166","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"GH Jackson","raw_affiliation_strings":["Department of Haematology, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK","institution_ids":["https://openalex.org/I2800516725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110019951","display_name":"PRA Taylor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800516725","display_name":"Royal Victoria Infirmary","ror":"https://ror.org/01p19k166","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"PRA Taylor","raw_affiliation_strings":["Department of Haematology, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK","institution_ids":["https://openalex.org/I2800516725"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A Iqbal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802921333","display_name":"Nottingham City Hospital","ror":"https://ror.org/0022b3c04","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468","https://openalex.org/I2802921333"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A Iqbal","raw_affiliation_strings":["Department of Haematology, Nottingham City Hospital, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Nottingham City Hospital, UK","institution_ids":["https://openalex.org/I2802921333"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108427492","display_name":"MJ Galloway","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800205450","display_name":"Bishop Auckland Hospital","ror":"https://ror.org/0457avm18","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800136903","https://openalex.org/I2800205450"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"MJ Galloway","raw_affiliation_strings":["Department of Haematology, Bishop Auckland General Hospital, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Bishop Auckland General Hospital, UK","institution_ids":["https://openalex.org/I2800205450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032224904","display_name":"G. S. Turner","orcid":"https://orcid.org/0000-0002-0628-7060","observed_orcids":["https://orcid.org/0000-0002-0628-7060"]},"institutions":[{"id":"https://openalex.org/I2800516725","display_name":"Royal Victoria Infirmary","ror":"https://ror.org/01p19k166","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G Turner","raw_affiliation_strings":["Department of Haematology, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK","institution_ids":["https://openalex.org/I2800516725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109250940","display_name":"Andy P. Haynes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802921333","display_name":"Nottingham City Hospital","ror":"https://ror.org/0022b3c04","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468","https://openalex.org/I2802921333"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A Haynes","raw_affiliation_strings":["Department of Haematology, Nottingham City Hospital, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Nottingham City Hospital, UK","institution_ids":["https://openalex.org/I2802921333"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110882541","display_name":"PJ Hamilton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800516725","display_name":"Royal Victoria Infirmary","ror":"https://ror.org/01p19k166","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"PJ Hamilton","raw_affiliation_strings":["Department of Haematology, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK","institution_ids":["https://openalex.org/I2800516725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035489508","display_name":"Nigel H. Russell","orcid":"https://orcid.org/0000-0003-1893-8155","observed_orcids":["https://orcid.org/0000-0003-1893-8155"]},"institutions":[{"id":"https://openalex.org/I2802921333","display_name":"Nottingham City Hospital","ror":"https://ror.org/0022b3c04","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468","https://openalex.org/I2802921333"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"N Russell","raw_affiliation_strings":["Department of Haematology, Nottingham City Hospital, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Nottingham City Hospital, UK","institution_ids":["https://openalex.org/I2802921333"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109048198","display_name":"SJ Proctor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800516725","display_name":"Royal Victoria Infirmary","ror":"https://ror.org/01p19k166","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800516725","https://openalex.org/I2801663869"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"SJ Proctor","raw_affiliation_strings":["Department of Haematology, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK","institution_ids":["https://openalex.org/I2800516725"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":2.2727,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.87307045,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"11","issue":"8","first_page":"1193","last_page":"1196"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9679999947547913},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.9570000171661377},{"id":"https://openalex.org/keywords/idarubicin","display_name":"idarubicin","score":0.9470000267028809},{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":1.0},{"id":"https://openalex.org/keywords/oral-chemotherapy","display_name":"oral chemotherapy","score":0.8349999785423279},{"id":"https://openalex.org/keywords/all-oral-regimens","display_name":"all-oral regimens","score":0.7049999833106995},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.8220000267028809},{"id":"https://openalex.org/keywords/complete-remission","display_name":"complete remission","score":0.8169999718666077},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.7739999890327454},{"id":"https://openalex.org/keywords/outpatient-care","display_name":"outpatient care","score":0.7139999866485596},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.7960000038146973}],"concepts":[{"id":"https://openalex.org/C2779117419","wikidata":"https://www.wikidata.org/wiki/Q1063862","display_name":"Idarubicin","level":4,"score":0.9814337491989136},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8637446761131287},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.7391759157180786},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6123750805854797},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6001327037811279},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.571499228477478},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5375726819038391},{"id":"https://openalex.org/C2776802502","wikidata":"https://www.wikidata.org/wiki/Q417589","display_name":"Anthracycline","level":4,"score":0.5024099349975586},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.47651374340057373},{"id":"https://openalex.org/C2778041864","wikidata":"https://www.wikidata.org/wiki/Q180983","display_name":"Cytarabine","level":3,"score":0.3635822534561157},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.35809457302093506},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.10171860456466675},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005047","descriptor_name":"Etoposide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015255","descriptor_name":"Idarubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/sj.leu.2400726","doi":"https://doi.org/10.1038/sj.leu.2400726","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.leu.2400726","pdf_url":null,"source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},{"id":"pmid:9264368","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9264368","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"Journal Article"},{"id":"doi:10.25405/ncl.34092006","doi":"https://doi.org/10.25405/ncl.34092006","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34092006","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.25405/ncl.34092006.v1","doi":"https://doi.org/10.25405/ncl.34092006.v1","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34092006.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.25405/ncl.34092006","doi":"https://doi.org/10.25405/ncl.34092006","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34092006","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2265607871","https://openalex.org/W2019360978","https://openalex.org/W2079799956","https://openalex.org/W1965870170","https://openalex.org/W2404651542","https://openalex.org/W1968838197","https://openalex.org/W2111563992","https://openalex.org/W1941946666","https://openalex.org/W2282003157","https://openalex.org/W2491195533"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}