{"id":"https://openalex.org/W2013247951","doi":"https://doi.org/10.1371/journal.pone.0044149","title":"Environmental Enrichment Alters Nicotine-Mediated Locomotor Sensitization and Phosphorylation of DARPP-32 and CREB in Rat Prefrontal Cortex","display_name":"Environmental Enrichment Alters Nicotine-Mediated Locomotor Sensitization and Phosphorylation of DARPP-32 and CREB in Rat Prefrontal Cortex","publication_year":2012,"publication_date":"2012-08-31","ids":{"openalex":"https://openalex.org/W2013247951","doi":"https://doi.org/10.1371/journal.pone.0044149","mag":"2013247951","pmid":"https://pubmed.ncbi.nlm.nih.gov/22952905","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3432100"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0044149","doi":"https://doi.org/10.1371/journal.pone.0044149","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0044149","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0044149&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0044149&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048513463","display_name":"Adrian M. Gomez","orcid":"https://orcid.org/0000-0002-4278-8209","observed_orcids":["https://orcid.org/0000-0002-4278-8209"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adrian M. Gomez","raw_affiliation_strings":["Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, South Carolina, USA","Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, South Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, South Carolina, USA","institution_ids":["https://openalex.org/I155781252"]},{"raw_affiliation_string":"Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, South Carolina, United States of America","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030559597","display_name":"Narasimha M. Midde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Narasimha M. Midde","raw_affiliation_strings":["Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, South Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, South Carolina, United States of America","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047436104","display_name":"Charles F. Mactutus","orcid":"https://orcid.org/0000-0002-6508-1329","observed_orcids":["https://orcid.org/0000-0002-6508-1329"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles F. Mactutus","raw_affiliation_strings":["Department of Psychology, University of South Carolina, Columbia, South Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, University of South Carolina, Columbia, South Carolina, United States of America","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029143320","display_name":"Rosemarie M. Booze","orcid":"https://orcid.org/0000-0003-3908-8313","observed_orcids":["https://orcid.org/0000-0003-3908-8313"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rosemarie M. Booze","raw_affiliation_strings":["Department of Psychology, University of South Carolina, Columbia, South Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, University of South Carolina, Columbia, South Carolina, United States of America","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083522997","display_name":"Jun Zhu","orcid":"https://orcid.org/0000-0001-9075-4866","observed_orcids":["https://orcid.org/0000-0001-9075-4866"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jun Zhu","raw_affiliation_strings":["Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, South Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, South Carolina, United States of America","institution_ids":["https://openalex.org/I155781252"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5083522997"],"corresponding_institution_ids":["https://openalex.org/I155781252"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.4498,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.77819497,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"7","issue":"8","first_page":"e44149","last_page":"e44149"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.016100000590085983,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/environmental-enrichment","display_name":"environmental enrichment","score":1.0},{"id":"https://openalex.org/keywords/nicotine","display_name":"nicotine","score":0.9200000166893005},{"id":"https://openalex.org/keywords/locomotor-sensitization","display_name":"locomotor sensitization","score":0.996999979019165},{"id":"https://openalex.org/keywords/darpp-32","display_name":"DARPP-32","score":0.9039999842643738},{"id":"https://openalex.org/keywords/creb","display_name":"CREB","score":0.9160000085830688},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.8100000023841858},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.9909999966621399},{"id":"https://openalex.org/keywords/nucleus-accumbens","display_name":"nucleus accumbens","score":0.996999979019165},{"id":"https://openalex.org/keywords/housing-conditions","display_name":"housing conditions","score":0.5239999890327454},{"id":"https://openalex.org/keywords/nicotine-dependence","display_name":"nicotine dependence","score":0.4580000042915344},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.5799999833106995},{"id":"https://openalex.org/keywords/dopaminergic-neurotransmission","display_name":"dopamine signaling","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C2776552330","wikidata":"https://www.wikidata.org/wiki/Q1476178","display_name":"Nucleus accumbens","level":3,"score":0.8688779473304749},{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.7670503854751587},{"id":"https://openalex.org/C1629964","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"CREB","level":4,"score":0.7427210807800293},{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.6461530327796936},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.585978090763092},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5118116736412048},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5017509460449219},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.494931161403656},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.474956750869751},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.47383174300193787},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.4100303053855896},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39957481622695923},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.25750261545181274},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23852282762527466},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21613368391990662},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12713167071342468},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004777","descriptor_name":"Environment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005106","descriptor_name":"Exploratory Behavior","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006185","descriptor_name":"Habituation, Psychophysiologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008124","descriptor_name":"Locomotion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009714","descriptor_name":"Nucleus Accumbens","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009714","descriptor_name":"Nucleus Accumbens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010769","descriptor_name":"Phosphothreonine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051937","descriptor_name":"Dopamine and cAMP-Regulated Phosphoprotein 32","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0044149","doi":"https://doi.org/10.1371/journal.pone.0044149","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0044149","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0044149&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3432100","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3432100","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:22952905","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22952905","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.779.4492","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.779.4492","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/45/1d/pone.0044149.PMC3432100.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:a492eef80d24471b8ec332e87b7e196f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a492eef80d24471b8ec332e87b7e196f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 8, p e44149 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0044149","doi":"https://doi.org/10.1371/journal.pone.0044149","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0044149","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0044149&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1111109279","display_name":"Role of Dopamine Transporter: HIV-1 Tat Protein and Nicotine Sensitization","funder_award_id":"R03DA026721","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G1293297433","display_name":null,"funder_award_id":"DA024275","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G1611126632","display_name":"Role of DARPP-32: Individual Responsiveness to Nicotine","funder_award_id":"R03DA024275","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G7474286536","display_name":"University of South Carolina Initiative for Maximizing Student Development","funder_award_id":"R25GM076277","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8779694026","display_name":"Maternal HIV: Developmental Neurotoxicity","funder_award_id":"R01HD043680","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G994127142","display_name":null,"funder_award_id":"DA 026721","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2013247951.pdf","grobid_xml":"https://content.openalex.org/works/W2013247951.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W1480115940","https://openalex.org/W1519847602","https://openalex.org/W1681161665","https://openalex.org/W1964284359","https://openalex.org/W1965970654","https://openalex.org/W1967592113","https://openalex.org/W1969781363","https://openalex.org/W1971653641","https://openalex.org/W1971674365","https://openalex.org/W1973371295","https://openalex.org/W1975401347","https://openalex.org/W1975580333","https://openalex.org/W1976752128","https://openalex.org/W1977855083","https://openalex.org/W1978559289","https://openalex.org/W1979708893","https://openalex.org/W1982093125","https://openalex.org/W1983285634","https://openalex.org/W1983759112","https://openalex.org/W1986782732","https://openalex.org/W1989430669","https://openalex.org/W1992595542","https://openalex.org/W2000683283","https://openalex.org/W2001195560","https://openalex.org/W2003339289","https://openalex.org/W2004618736","https://openalex.org/W2011415448","https://openalex.org/W2012206046","https://openalex.org/W2012806030","https://openalex.org/W2018040130","https://openalex.org/W2018659080","https://openalex.org/W2018690806","https://openalex.org/W2020171179","https://openalex.org/W2020174502","https://openalex.org/W2027606489","https://openalex.org/W2032524727","https://openalex.org/W2034769991","https://openalex.org/W2034864387","https://openalex.org/W2036880872","https://openalex.org/W2039772431","https://openalex.org/W2040790125","https://openalex.org/W2042287552","https://openalex.org/W2042905107","https://openalex.org/W2045129849","https://openalex.org/W2046545299","https://openalex.org/W2048298631","https://openalex.org/W2049946106","https://openalex.org/W2049981427","https://openalex.org/W2050667075","https://openalex.org/W2050752277","https://openalex.org/W2053058520","https://openalex.org/W2054668681","https://openalex.org/W2055984987","https://openalex.org/W2057749702","https://openalex.org/W2057905064","https://openalex.org/W2061575992","https://openalex.org/W2068549908","https://openalex.org/W2075370186","https://openalex.org/W2076342500","https://openalex.org/W2077172541","https://openalex.org/W2078530990","https://openalex.org/W2078962110","https://openalex.org/W2083438995","https://openalex.org/W2089824490","https://openalex.org/W2090351327","https://openalex.org/W2091612414","https://openalex.org/W2095889446","https://openalex.org/W2097875012","https://openalex.org/W2106862702","https://openalex.org/W2111304405","https://openalex.org/W2114207481","https://openalex.org/W2122592499","https://openalex.org/W2130299724","https://openalex.org/W2133711068","https://openalex.org/W2151137320","https://openalex.org/W2156927636","https://openalex.org/W2163805252","https://openalex.org/W2165909414","https://openalex.org/W4213265599"],"related_works":["https://openalex.org/W2032859446","https://openalex.org/W2297747635","https://openalex.org/W1977855083","https://openalex.org/W2048298631","https://openalex.org/W2147059192","https://openalex.org/W2001364619","https://openalex.org/W21605745","https://openalex.org/W2273572237","https://openalex.org/W1817641483","https://openalex.org/W2794129452"],"abstract_inverted_index":{"Exposure":[0],"within":[1],"an":[2],"environmental":[3],"enrichment":[4],"paradigm":[5],"results":[6],"in":[7,38,41,72,79,147,155,169,175,180,200,215,221,249,257],"neurobiological":[8],"adaptations":[9],"and":[10,25,28,35,46,84,133,151,154,202,208,229,255],"decreases":[11],"the":[12,58,61,73,109,138,162,212,243,250,258],"baseline":[13,94],"of":[14,22,53,65,149,158,164,172,195,223,242,246,253,260],"locomotor":[15,36,102,111],"activity.":[16],"The":[17],"current":[18],"study":[19],"determined":[20],"activation":[21],"DARPP-32":[23,66],"(dopamine-":[24],"cAMP-regulated":[26],"phosphoprotein-32)":[27],"CREB":[29,196],"(cAMP":[30],"response":[31],"element":[32],"binding":[33],"protein),":[34],"activity":[37,112],"rats":[39,125,153,182,189,225],"raised":[40],"enriched":[42],"(EC),":[43],"impoverished":[44],"(IC),":[45],"standard":[47],"(SC)":[48],"conditions":[49,107],"following":[50],"repeated":[51,141],"administration":[52],"nicotine":[54,97,130,142],"or":[55],"saline.":[56],"In":[57],"saline-control":[59],"group,":[60],"basal":[62,192],"phosphorylation":[63,193],"state":[64],"at":[67,197],"Threonine-34":[68],"site":[69],"(pDARPP-32":[70],"Thr34)":[71],"prefrontal":[74],"cortex":[75],"(PFC)":[76],"was":[77,88,113,177,218],"lower":[78,191],"EC":[80,124,150,159,181,188,224],"compared":[81,205],"to":[82,129,184,206,227],"IC":[83,132,152,185,207,228],"SC":[85,134,209,230],"rats,":[86,210],"which":[87],"positively":[89],"correlated":[90],"with":[91,137],"their":[92,120],"respective":[93,121],"activities.":[95],"While":[96],"(0.35":[98],"mg/kg,":[99],"freebase)":[100],"produced":[101],"sensitization":[103,128],"across":[104],"all":[105],"housing":[106],"when":[108],"nicotine-mediated":[110],"expressed":[114],"as":[115],"a":[116],"percent":[117],"change":[118,165],"from":[119,166],"saline":[122,167],"control,":[123],"displayed":[126],"greater":[127],"than":[131],"rats.":[135,186,231],"Consistent":[136],"behavioral":[139],"findings,":[140],"injection":[143],"increased":[144,179],"pDARPP-32":[145,173],"Thr34":[146,174],"PFC":[148,176,201,222],"nucleus":[156,203],"accumbens":[157,204],"rats;":[160],"however,":[161],"magnitude":[163],"control":[168],"nicotine-induced":[170,213],"enhancement":[171],"strikingly":[178],"relative":[183,226],"Moreover,":[187],"had":[190],"levels":[194],"serine":[198],"133":[199],"whereas":[211],"increase":[214],"phosphorylated":[216],"CREB-Ser133":[217],"more":[219],"pronounced":[220],"Collectively,":[232],"these":[233],"findings":[234],"suggest":[235],"innovative":[236],"insights":[237],"into":[238],"advancing":[239],"our":[240],"understanding":[241],"molecular":[244],"mechanisms":[245],"enrichment-induced":[247],"changes":[248],"motivational":[251],"effects":[252],"nicotine,":[254],"aiding":[256],"identification":[259],"new":[261],"therapeutic":[262],"strategies":[263],"for":[264],"tobacco":[265],"smokers.":[266]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}