{"id":"https://openalex.org/W2013227276","doi":"https://doi.org/10.1097/01.pas.0000159103.95360.e8","title":"MUC1, MUC2, MUC4, and MUC5AC Expression in Salivary Gland Mucoepidermoid Carcinoma","display_name":"MUC1, MUC2, MUC4, and MUC5AC Expression in Salivary Gland Mucoepidermoid Carcinoma","publication_year":2005,"publication_date":"2005-06-14","ids":{"openalex":"https://openalex.org/W2013227276","doi":"https://doi.org/10.1097/01.pas.0000159103.95360.e8","mag":"2013227276","pmid":"https://pubmed.ncbi.nlm.nih.gov/15958852"},"language":"en","primary_location":{"id":"doi:10.1097/01.pas.0000159103.95360.e8","doi":"https://doi.org/10.1097/01.pas.0000159103.95360.e8","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.pas.0000159103.95360.e8","pdf_url":null,"source":{"id":"https://openalex.org/S37879208","display_name":"The American Journal of Surgical Pathology","issn_l":"0147-5185","issn":["0147-5185","1532-0979"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Surgical Pathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002868222","display_name":"Adriana Handra\u2010Luca","orcid":"https://orcid.org/0000-0003-3816-058X","observed_orcids":["https://orcid.org/0000-0003-3816-058X"]},"institutions":[{"id":"https://openalex.org/I4210149664","display_name":"H\u00f4pital Jean-Verdier","ror":"https://ror.org/04pag4b70","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210149664"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Adriana Handra-Luca","raw_affiliation_strings":["Service d'anatomie et de Cytologie Pathologiques, H\u00f4pital Jean Verdier, Universit\u00e9 Paris, XIII, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'anatomie et de Cytologie Pathologiques, H\u00f4pital Jean Verdier, Universit\u00e9 Paris, XIII, Paris, France","institution_ids":["https://openalex.org/I4210149664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022953596","display_name":"Georges Lamas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Georges Lamas","raw_affiliation_strings":["Service d'Oto-rhino-laryngologie, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'Oto-rhino-laryngologie, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109989611","display_name":"Jacques-Charles Bertrand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jacques-Charles Bertrand","raw_affiliation_strings":["Service de Stomatologie et de Chirurgie Maxillo-Faciale, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Stomatologie et de Chirurgie Maxillo-Faciale, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113687083","display_name":"Pierre Jean Fouret","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre Fouret","raw_affiliation_strings":["Service d'Anatomie et de Cytologie Pathologiques 1, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Paris, France","UPRES EA 3499, Universit\u00e9 Paris VI, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'Anatomie et de Cytologie Pathologiques 1, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]},{"raw_affiliation_string":"UPRES EA 3499, Universit\u00e9 Paris VI, Paris, France","institution_ids":["https://openalex.org/I4405264447"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5002868222"],"corresponding_institution_ids":["https://openalex.org/I4210149664"],"apc_list":null,"apc_paid":null,"fwci":5.0738,"has_fulltext":false,"cited_by_count":106,"citation_normalized_percentile":{"value":0.95155905,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"29","issue":"7","first_page":"881","last_page":"889"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11035","display_name":"Salivary Gland Tumors Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11035","display_name":"Salivary Gland Tumors Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mucoepidermoid-carcinoma","display_name":"mucoepidermoid carcinoma","score":0.972000002861023},{"id":"https://openalex.org/keywords/salivary-gland-tumors","display_name":"salivary gland tumors","score":0.8999999761581421},{"id":"https://openalex.org/keywords/mucin","display_name":"mucin","score":0.7250000238418579},{"id":"https://openalex.org/keywords/muc1","display_name":"MUC1","score":1.0},{"id":"https://openalex.org/keywords/muc2","display_name":"MUC2","score":0.996999979019165},{"id":"https://openalex.org/keywords/muc4","display_name":"MUC4","score":1.0},{"id":"https://openalex.org/keywords/muc5ac","display_name":"MUC5AC","score":1.0},{"id":"https://openalex.org/keywords/tumor-grade","display_name":"tumor grade","score":0.8799999952316284},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.7820000052452087},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.7549999952316284},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma-differentiation","display_name":"squamous cell carcinoma differentiation","score":0.7950000166893005},{"id":"https://openalex.org/keywords/intermediate-cells","display_name":"intermediate cells","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C2777421810","wikidata":"https://www.wikidata.org/wiki/Q21145188","display_name":"MUC1","level":3,"score":0.9452555775642395},{"id":"https://openalex.org/C179264091","wikidata":"https://www.wikidata.org/wiki/Q410862","display_name":"Mucin","level":2,"score":0.9237926602363586},{"id":"https://openalex.org/C2780859518","wikidata":"https://www.wikidata.org/wiki/Q2736268","display_name":"Mucoepidermoid carcinoma","level":3,"score":0.7867567539215088},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6925524473190308},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.6750006079673767},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6416460275650024},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5415002107620239},{"id":"https://openalex.org/C2778937882","wikidata":"https://www.wikidata.org/wiki/Q134938","display_name":"Salivary gland","level":2,"score":0.4583866000175476},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.4281925559043884},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.41897666454315186},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22156429290771484}],"mesh":[{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009077","descriptor_name":"Mucins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012468","descriptor_name":"Salivary Gland Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012468","descriptor_name":"Salivary Gland Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D012468","descriptor_name":"Salivary Gland Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018277","descriptor_name":"Carcinoma, Mucoepidermoid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018277","descriptor_name":"Carcinoma, Mucoepidermoid","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D018277","descriptor_name":"Carcinoma, Mucoepidermoid","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/01.pas.0000159103.95360.e8","doi":"https://doi.org/10.1097/01.pas.0000159103.95360.e8","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.pas.0000159103.95360.e8","pdf_url":null,"source":{"id":"https://openalex.org/S37879208","display_name":"The American Journal of Surgical Pathology","issn_l":"0147-5185","issn":["0147-5185","1532-0979"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Surgical Pathology","raw_type":"journal-article"},{"id":"pmid:15958852","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15958852","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of surgical pathology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321837","display_name":"Ministerio de Econom\u00eda y Competitividad","ror":"https://ror.org/034900433"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1533823485","https://openalex.org/W1973625629","https://openalex.org/W1973955814","https://openalex.org/W1982941891","https://openalex.org/W1994708622","https://openalex.org/W2008343864","https://openalex.org/W2012403833","https://openalex.org/W2014428384","https://openalex.org/W2016124696","https://openalex.org/W2021288438","https://openalex.org/W2023761151","https://openalex.org/W2029763476","https://openalex.org/W2031933232","https://openalex.org/W2032972690","https://openalex.org/W2047801916","https://openalex.org/W2058382351","https://openalex.org/W2065867251","https://openalex.org/W2072776268","https://openalex.org/W2083249852","https://openalex.org/W2087189971","https://openalex.org/W2089873075","https://openalex.org/W2092559728","https://openalex.org/W2122386490","https://openalex.org/W2139144874","https://openalex.org/W2139699855","https://openalex.org/W2146531459","https://openalex.org/W2150312232","https://openalex.org/W2313653458","https://openalex.org/W4230985621","https://openalex.org/W4298209788","https://openalex.org/W6681516876"],"related_works":["https://openalex.org/W4313455067","https://openalex.org/W3087674469","https://openalex.org/W2012403833","https://openalex.org/W2777392506","https://openalex.org/W2135882096","https://openalex.org/W4311544880","https://openalex.org/W2024898443","https://openalex.org/W2171827024","https://openalex.org/W7201863040","https://openalex.org/W2108130616"],"abstract_inverted_index":{"We":[0,17],"determined":[1],"whether":[2],"immunostaining":[3],"for":[4,23,156,159,162,166,225,233],"mucins":[5,153],"could":[6],"provide":[7],"a":[8,251],"better":[9],"characterization":[10],"of":[11,65,73,88,117,150],"salivary":[12,52,204],"gland":[13],"mucoepidermoid":[14],"carcinoma":[15],"(MEC).":[16],"investigated":[18],"63":[19],"MECs":[20],"by":[21],"immunohistochemistry":[22],"MUC1,":[24,98,157],"MUC2,":[25,109,160],"MUC4,":[26,163],"and":[27,33,56,59,69,76,81,91,131,164,169,210,217,219],"MUC5AC.":[28,167],"Mucin":[29],"expressing":[30,152],"cell":[31,215,239],"types":[32],"labeling":[34],"patterns":[35],"were":[36,40,83,124,133,154,171],"recorded.":[37],"The":[38,148],"results":[39],"compared":[41],"with":[42,102,127,135,144,187],"microscopic":[43],"grade,":[44],"tumor-associated":[45,136,145],"lymphoid":[46,137,146],"infiltrate,":[47],"mucin":[48,196],"expression":[49,100,185,197,249],"in":[50,85,113,175,178,198,203,221,227],"surrounding":[51,179],"glands,":[53],"clinical":[54],"features,":[55],"outcome.":[57],"MUC1":[58,130,168,184,209,248],"MUC4":[60,99,211,242],"labeled":[61],"the":[62,70,86],"apical":[63],"membrane":[64,72],"glandular":[66],"tumor":[67,78,93,103,246],"cells":[68,207],"entire":[71],"intermediate,":[74],"clear,":[75],"epidermoid":[77],"cells.":[79,94],"MUC2":[80,218],"MUC5AC":[82,110,132,170,220,226],"expressed":[84,112,174],"cytoplasm":[87],"glandular,":[89],"mucous,":[90],"intermediate":[92],"In":[95,194],"contrast":[96],"to":[97,245],"decreased":[101],"grade":[104],"(P":[105,139,181,191],"<":[106,140,182,192],"0.01).":[107],"Unlike":[108],"was":[111],"more":[114,172],"than":[115,177],"50%":[116],"high-grade":[118,228,235],"tumors,":[119],"including":[120],"2":[121],"cases":[122],"that":[123,202],"not":[125,143],"stained":[126],"Alcian":[128],"blue.":[129],"associated":[134],"infiltrates":[138],"0.05),":[141],"but":[142],"follicles.":[147],"proportions":[149],"tumors":[151,176,229],"71%":[155],"21%":[158],"79%":[161],"68%":[165],"frequently":[173],"glands":[180],"0.0001).":[183],"correlated":[186],"shorter":[188],"progression-free":[189],"survival":[190],"0.05).":[193],"conclusion,":[195],"MEC":[199,236],"differs":[200],"from":[201,237],"glands.":[205],"Intermediate":[206],"express":[208],"all":[212],"along":[213],"their":[214,222],"surface":[216],"cytoplasm.":[223],"Staining":[224],"can":[230],"be":[231],"helpful":[232],"distinguishing":[234],"squamous":[238],"carcinoma.":[240],"While":[241],"is":[243],"related":[244],"differentiation,":[247],"indicates":[250],"worse":[252],"prognosis.":[253]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}