{"id":"https://openalex.org/W2013209137","doi":"https://doi.org/10.1007/s10637-005-5199-4","title":"The Wnt-dependent signaling pathways as target in oncology drug discovery","display_name":"The Wnt-dependent signaling pathways as target in oncology drug discovery","publication_year":2006,"publication_date":"2006-01-28","ids":{"openalex":"https://openalex.org/W2013209137","doi":"https://doi.org/10.1007/s10637-005-5199-4","mag":"2013209137","pmid":"https://pubmed.ncbi.nlm.nih.gov/16683072","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2780666"},"language":"en","primary_location":{"id":"doi:10.1007/s10637-005-5199-4","doi":"https://doi.org/10.1007/s10637-005-5199-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10637-005-5199-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10637-005-5199-4.pdf","source":{"id":"https://openalex.org/S6037287","display_name":"Investigational New Drugs","issn_l":"0167-6997","issn":["0167-6997","1573-0646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational New Drugs","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s10637-005-5199-4.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111976833","display_name":"Nico Janssens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149213910","display_name":"University of Antwerp","ror":"https://ror.org/008x57b05","country_code":"BE","type":"education","lineage":["https://openalex.org/I149213910"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Nico Janssens","raw_affiliation_strings":["Department of Biochemistry, University of Antwerp, Wilrijk, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Antwerp, Wilrijk, Belgium","institution_ids":["https://openalex.org/I149213910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103172709","display_name":"Michel Janicot","orcid":"https://orcid.org/0000-0002-4669-9641","observed_orcids":["https://orcid.org/0000-0002-4669-9641"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michel Janicot","raw_affiliation_strings":["Johnson & Johnson Pharmaceutical R & D, Oncology Discovery Research & Early Development, Beerse, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johnson & Johnson Pharmaceutical R & D, Oncology Discovery Research & Early Development, Beerse, Belgium","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082606383","display_name":"Tim Perera","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tim Perera","raw_affiliation_strings":["Johnson & Johnson Pharmaceutical R & D, Oncology Discovery Research & Early Development, Beerse, Belgium","Johnson & Johnson Pharmaceutical R & D, Oncology Discovery Research & Early Development, Turnhoutseweg 30, B-2340, Beerse, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johnson & Johnson Pharmaceutical R & D, Oncology Discovery Research & Early Development, Beerse, Belgium","institution_ids":[]},{"raw_affiliation_string":"Johnson & Johnson Pharmaceutical R & D, Oncology Discovery Research & Early Development, Turnhoutseweg 30, B-2340, Beerse, Belgium","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5082606383"],"corresponding_institution_ids":[],"apc_list":{"value":4690,"currency":"USD","value_usd":4690},"apc_paid":{"value":4690,"currency":"USD","value_usd":4690},"fwci":0.4635,"has_fulltext":true,"cited_by_count":72,"citation_normalized_percentile":{"value":0.37272537,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"24","issue":"4","first_page":"263","last_page":"280"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.8930000066757202},{"id":"https://openalex.org/keywords/anticancer-drug-discovery","display_name":"anticancer drug discovery","score":0.921999990940094},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8119999766349792},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.9369999766349792},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.9259999990463257},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.699999988079071},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7310000061988831},{"id":"https://openalex.org/keywords/cell-fate","display_name":"cell fate","score":0.8450000286102295},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.6340000033378601},{"id":"https://openalex.org/keywords/stem-cell-research","display_name":"stem cell research","score":0.7250000238418579},{"id":"https://openalex.org/keywords/retinopathy","display_name":"retinopathy","score":0.6380000114440918},{"id":"https://openalex.org/keywords/arthritis","display_name":"arthritis","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.8330039978027344},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.7449262142181396},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5179599523544312},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5110601186752319},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.48011159896850586},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4134077727794647},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4056379497051239},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3585164546966553},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3392474055290222},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33302539587020874},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.31662383675575256},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2431640326976776},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.10547414422035217}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1007/s10637-005-5199-4","doi":"https://doi.org/10.1007/s10637-005-5199-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10637-005-5199-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10637-005-5199-4.pdf","source":{"id":"https://openalex.org/S6037287","display_name":"Investigational New Drugs","issn_l":"0167-6997","issn":["0167-6997","1573-0646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational New Drugs","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2780666","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2780666","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Invest New Drugs","raw_type":"Text"},{"id":"pmid:16683072","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16683072","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational new drugs","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.356.8580","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.356.8580","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/3f/9a/Invest_New_Drugs_2006_Jul_28_24(4)_263-280.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1007/s10637-005-5199-4","doi":"https://doi.org/10.1007/s10637-005-5199-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10637-005-5199-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10637-005-5199-4.pdf","source":{"id":"https://openalex.org/S6037287","display_name":"Investigational New Drugs","issn_l":"0167-6997","issn":["0167-6997","1573-0646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational New Drugs","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2013209137.pdf","grobid_xml":"https://content.openalex.org/works/W2013209137.grobid-xml"},"referenced_works_count":202,"referenced_works":["https://openalex.org/W29630822","https://openalex.org/W73927841","https://openalex.org/W125208138","https://openalex.org/W143624314","https://openalex.org/W296450459","https://openalex.org/W1489736060","https://openalex.org/W1494249446","https://openalex.org/W1496294957","https://openalex.org/W1504655784","https://openalex.org/W1511545125","https://openalex.org/W1517653371","https://openalex.org/W1525619191","https://openalex.org/W1537657975","https://openalex.org/W1544046482","https://openalex.org/W1544465315","https://openalex.org/W1554815317","https://openalex.org/W1588334150","https://openalex.org/W1589023327","https://openalex.org/W1597512265","https://openalex.org/W1611720630","https://openalex.org/W1635607892","https://openalex.org/W1743302011","https://openalex.org/W1836452880","https://openalex.org/W1864386522","https://openalex.org/W1898755691","https://openalex.org/W1904120886","https://openalex.org/W1964064352","https://openalex.org/W1966063731","https://openalex.org/W1967053372","https://openalex.org/W1967243795","https://openalex.org/W1967803088","https://openalex.org/W1968366612","https://openalex.org/W1968406486","https://openalex.org/W1969323007","https://openalex.org/W1969808979","https://openalex.org/W1971326877","https://openalex.org/W1971621147","https://openalex.org/W1976967609","https://openalex.org/W1977789763","https://openalex.org/W1978047924","https://openalex.org/W1979201752","https://openalex.org/W1979547093","https://openalex.org/W1981957327","https://openalex.org/W1983638975","https://openalex.org/W1985146880","https://openalex.org/W1985847658","https://openalex.org/W1986381857","https://openalex.org/W1986643072","https://openalex.org/W1987678786","https://openalex.org/W1988623463","https://openalex.org/W1989662404","https://openalex.org/W1991756459","https://openalex.org/W1991939427","https://openalex.org/W1994458586","https://openalex.org/W1995377960","https://openalex.org/W1995414238","https://openalex.org/W1995824762","https://openalex.org/W1998170462","https://openalex.org/W1999019867","https://openalex.org/W2000032092","https://openalex.org/W2000352591","https://openalex.org/W2001935103","https://openalex.org/W2002272803","https://openalex.org/W2002404925","https://openalex.org/W2004350008","https://openalex.org/W2006595571","https://openalex.org/W2007251848","https://openalex.org/W2008770488","https://openalex.org/W2009028105","https://openalex.org/W2009331293","https://openalex.org/W2011434621","https://openalex.org/W2011912935","https://openalex.org/W2012904565","https://openalex.org/W2013064709","https://openalex.org/W2013116063","https://openalex.org/W2015249461","https://openalex.org/W2017531120","https://openalex.org/W2017668082","https://openalex.org/W2019074781","https://openalex.org/W2023186669","https://openalex.org/W2023865101","https://openalex.org/W2024215200","https://openalex.org/W2025406984","https://openalex.org/W2025465570","https://openalex.org/W2026650776","https://openalex.org/W2029765217","https://openalex.org/W2032307016","https://openalex.org/W2033529039","https://openalex.org/W2034133599","https://openalex.org/W2034595626","https://openalex.org/W2035192365","https://openalex.org/W2036864436","https://openalex.org/W2038084705","https://openalex.org/W2039248606","https://openalex.org/W2040263952","https://openalex.org/W2040373623","https://openalex.org/W2041369790","https://openalex.org/W2043054211","https://openalex.org/W2043450395","https://openalex.org/W2044259020","https://openalex.org/W2045438256","https://openalex.org/W2046340131","https://openalex.org/W2047425230","https://openalex.org/W2048005397","https://openalex.org/W2050414776","https://openalex.org/W2051328757","https://openalex.org/W2051788298","https://openalex.org/W2052310806","https://openalex.org/W2052444795","https://openalex.org/W2053086049","https://openalex.org/W2058559777","https://openalex.org/W2059743738","https://openalex.org/W2062096656","https://openalex.org/W2062847329","https://openalex.org/W2063112284","https://openalex.org/W2063620211","https://openalex.org/W2063620691","https://openalex.org/W2064239281","https://openalex.org/W2064346328","https://openalex.org/W2064932705","https://openalex.org/W2065852799","https://openalex.org/W2067056588","https://openalex.org/W2067310420","https://openalex.org/W2067391083","https://openalex.org/W2067973442","https://openalex.org/W2068004114","https://openalex.org/W2069347152","https://openalex.org/W2070348525","https://openalex.org/W2071397057","https://openalex.org/W2073227325","https://openalex.org/W2074974325","https://openalex.org/W2079819294","https://openalex.org/W2080480789","https://openalex.org/W2081621052","https://openalex.org/W2082668329","https://openalex.org/W2082942439","https://openalex.org/W2083080708","https://openalex.org/W2086320165","https://openalex.org/W2086694435","https://openalex.org/W2088256684","https://openalex.org/W2090071382","https://openalex.org/W2090603038","https://openalex.org/W2091259207","https://openalex.org/W2092493956","https://openalex.org/W2093945470","https://openalex.org/W2097315204","https://openalex.org/W2098387982","https://openalex.org/W2099353036","https://openalex.org/W2100070586","https://openalex.org/W2102061082","https://openalex.org/W2104204293","https://openalex.org/W2106603079","https://openalex.org/W2108631062","https://openalex.org/W2108743126","https://openalex.org/W2109069210","https://openalex.org/W2111223344","https://openalex.org/W2111814753","https://openalex.org/W2114300637","https://openalex.org/W2114921350","https://openalex.org/W2115001053","https://openalex.org/W2118899402","https://openalex.org/W2119413986","https://openalex.org/W2120487488","https://openalex.org/W2120802708","https://openalex.org/W2124961982","https://openalex.org/W2125635238","https://openalex.org/W2125734437","https://openalex.org/W2132475598","https://openalex.org/W2137846548","https://openalex.org/W2140328069","https://openalex.org/W2142779171","https://openalex.org/W2146895097","https://openalex.org/W2146962477","https://openalex.org/W2147257521","https://openalex.org/W2147864074","https://openalex.org/W2148074532","https://openalex.org/W2148883613","https://openalex.org/W2152123530","https://openalex.org/W2152633381","https://openalex.org/W2153250061","https://openalex.org/W2155348369","https://openalex.org/W2156575042","https://openalex.org/W2157321275","https://openalex.org/W2158569397","https://openalex.org/W2161376238","https://openalex.org/W2164964874","https://openalex.org/W2165061154","https://openalex.org/W2165781463","https://openalex.org/W2166295460","https://openalex.org/W2167638513","https://openalex.org/W2167639932","https://openalex.org/W2168854825","https://openalex.org/W2169503556","https://openalex.org/W2169800047","https://openalex.org/W2171996338","https://openalex.org/W2172051772","https://openalex.org/W2219022960","https://openalex.org/W2257415324","https://openalex.org/W2316742206","https://openalex.org/W4211089574","https://openalex.org/W4237338190","https://openalex.org/W7097257549"],"related_works":["https://openalex.org/W2066266408","https://openalex.org/W1986767070","https://openalex.org/W2569366849","https://openalex.org/W4210280473","https://openalex.org/W2157869060","https://openalex.org/W2199613542","https://openalex.org/W1971085650","https://openalex.org/W2466192016","https://openalex.org/W2407399555","https://openalex.org/W2940555906"],"abstract_inverted_index":{"Our":[0],"current":[1,211],"understanding":[2],"of":[3,17,67,86,93,110,135,159,173,176,198,218],"the":[4,33,68,72,76,83,136,156,174,177,216,227],"Wnt-dependent":[5,34,77,137,178,228],"signaling":[6,35,78,138,179,229],"pathways":[7,36,49,79,88,112,139,180,204],"is":[8,80,113],"mainly":[9],"based":[10],"on":[11,195,213,226],"studies":[12,29],"performed":[13],"in":[14,75,89,145,155,184],"a":[15,90,170,196],"number":[16],"model":[18],"organisms":[19],"including,":[20],"Xenopus,":[21],"Drosophila":[22],"melanogaster,":[23],"Caenorhabditis":[24],"elegans":[25],"and":[26,41,96,108,123,125,154,181,186,209],"mammals.":[27],"These":[28],"clearly":[30],"indicate":[31],"that":[32,105,221],"are":[37],"conserved":[38],"through":[39],"evolution":[40],"control":[42],"many":[43],"events":[44],"during":[45],"embryonic":[46],"development.":[47,188],"Wnt":[48],"have":[50,222],"been":[51,103],"shown":[52,104,223],"to":[53,141,168,192],"regulate":[54],"cell":[55,62,161],"proliferation,":[56],"morphology,":[57],"motility":[58],"as":[59,61,129,148],"well":[60],"fate.":[63],"The":[64],"increasing":[65],"interest":[66],"scientific":[69],"community,":[70],"over":[71],"last":[73],"decade,":[74],"supported":[81],"by":[82],"documented":[84],"importance":[85],"these":[87,111,203],"broad":[91],"range":[92],"physiological":[94],"conditions":[95],"disease":[97,127],"states.":[98],"For":[99],"instance,":[100],"it":[101],"has":[102],"inappropriate":[106],"regulation":[107],"activation":[109],"associated":[114],"with":[115],"several":[116,133],"pathological":[117],"disorders":[118],"including":[119,215],"cancer,":[120],"retinopathy,":[121],"tetra-amelia":[122],"bone":[124],"cartilage":[126],"such":[128,147],"arthritis.":[130],"In":[131,163],"addition,":[132],"components":[134],"appear":[140],"play":[142],"important":[143],"roles":[144],"diseases":[146],"Alzheimer's":[149],"disease,":[150],"schizophrenia,":[151],"bipolar":[152],"disorder":[153],"emerging":[157],"field":[158],"stem":[160],"research.":[162],"this":[164],"review,":[165],"we":[166],"wish":[167],"present":[169],"focused":[171],"overview":[172],"function":[175],"their":[182],"role":[183],"oncogenesis":[185],"cancer":[187],"We":[189],"also":[190],"want":[191],"provide":[193],"information":[194],"selection":[197],"potential":[199],"drug":[200,207],"targets":[201],"within":[202],"for":[205],"oncology":[206],"discovery,":[208],"summarize":[210],"data":[212],"approaches,":[214],"development":[217],"small-molecule":[219],"inhibitors,":[220],"relevant":[224],"effects":[225],"pathways.":[230]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
