{"id":"https://openalex.org/W2013201944","doi":"https://doi.org/10.1016/0303-8467(94)90117-1","title":"Phenytoin parahydroxylation is not impaired in patients with young-onset Parkinson's disease","display_name":"Phenytoin parahydroxylation is not impaired in patients with young-onset Parkinson's disease","publication_year":1994,"publication_date":"1994-11-01","ids":{"openalex":"https://openalex.org/W2013201944","doi":"https://doi.org/10.1016/0303-8467(94)90117-1","mag":"2013201944","pmid":"https://pubmed.ncbi.nlm.nih.gov/7889690"},"language":"en","primary_location":{"id":"doi:10.1016/0303-8467(94)90117-1","doi":"https://doi.org/10.1016/0303-8467(94)90117-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0303-8467(94)90117-1","pdf_url":null,"source":{"id":"https://openalex.org/S165396890","display_name":"Clinical Neurology and Neurosurgery","issn_l":"0303-8467","issn":["0303-8467","1872-6968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Neurology and Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103232363","display_name":"Els A. J. Peeters","orcid":"https://orcid.org/0009-0003-5610-719X","observed_orcids":["https://orcid.org/0009-0003-5610-719X"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"E.A.J. Peeters","raw_affiliation_strings":["Department of Neurology, University Hospital Leiden, The Netherlands","Department of Neurology, University Hospital Leiden, Rijnsburgerweg 10, 2333 AA Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University Hospital Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Department of Neurology, University Hospital Leiden, Rijnsburgerweg 10, 2333 AA Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035064433","display_name":"Bastiaan R. Bloem","orcid":"https://orcid.org/0000-0002-6371-3337","observed_orcids":["https://orcid.org/0000-0002-6371-3337"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"B.R. Bloem","raw_affiliation_strings":["Department of Neurology, University Hospital Leiden, Rijnsburgerweg 10, 2333 AA Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University Hospital Leiden, Rijnsburgerweg 10, 2333 AA Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066083330","display_name":"Michael A. Kuiper","orcid":"https://orcid.org/0000-0001-6201-7332","observed_orcids":["https://orcid.org/0000-0001-6201-7332"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M.A. Kuiper","raw_affiliation_strings":["Department of Neurology, Free University, Amsterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Free University, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073406580","display_name":"Pieter Vermeij","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"P. Vermeij","raw_affiliation_strings":["Department of Clinical Chemistry, Pharmacy and Toxicology, University Hospital Leiden, Rijnsburgerweg 10, 2333 AA Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, Pharmacy and Toxicology, University Hospital Leiden, Rijnsburgerweg 10, 2333 AA Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109285877","display_name":"Frederik A. de Wolff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"F.A. de Wolff","raw_affiliation_strings":["Department of Clinical Chemistry, Pharmacy and Toxicology, University Hospital Leiden, Rijnsburgerweg 10, 2333 AA Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, Pharmacy and Toxicology, University Hospital Leiden, Rijnsburgerweg 10, 2333 AA Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017091939","display_name":"Erik Ch. Wolters","orcid":"https://orcid.org/0000-0003-4411-6892","observed_orcids":["https://orcid.org/0000-0003-4411-6892"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"E.C. Wolters","raw_affiliation_strings":["Department of Neurology, Free University, Amsterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Free University, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110103972","display_name":"R. A. C. Roos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"R.A.C. Roos","raw_affiliation_strings":["Department of Neurology, University Hospital Leiden, Rijnsburgerweg 10, 2333 AA Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University Hospital Leiden, Rijnsburgerweg 10, 2333 AA Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039941295","display_name":"Michel Dominique Ferrari","orcid":"https://orcid.org/0000-0001-9691-9449","observed_orcids":["https://orcid.org/0000-0001-9691-9449"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M.D. Ferrari","raw_affiliation_strings":["Department of Neurology, University Hospital Leiden, Rijnsburgerweg 10, 2333 AA Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University Hospital Leiden, Rijnsburgerweg 10, 2333 AA Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.11054518,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"96","issue":"4","first_page":"296","last_page":"299"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.5127000212669373,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.5127000212669373,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.46880000829696655,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenytoin","display_name":"phenytoin","score":0.8679999709129333},{"id":"https://openalex.org/keywords/early-onset-parkinson-s-disease","display_name":"early-onset Parkinson's disease","score":0.984000027179718},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.9259999990463257},{"id":"https://openalex.org/keywords/hepatic-drug-metabolism","display_name":"hepatic drug metabolism","score":0.8360000252723694}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8937357068061829},{"id":"https://openalex.org/C2778337148","wikidata":"https://www.wikidata.org/wiki/Q410400","display_name":"Phenytoin","level":3,"score":0.722953200340271},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.660850465297699},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.60494464635849},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5700735449790955},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.5684055089950562},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.5398302674293518},{"id":"https://openalex.org/C2777767895","wikidata":"https://www.wikidata.org/wiki/Q4691924","display_name":"Age of onset","level":3,"score":0.44262921810150146},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.42763853073120117},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.4270574152469635},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4214913845062256},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.18445786833763123},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.07831314206123352}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006900","descriptor_name":"Hydroxylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008658","descriptor_name":"Inactivation, Metabolic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010672","descriptor_name":"Phenytoin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D010672","descriptor_name":"Phenytoin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/0303-8467(94)90117-1","doi":"https://doi.org/10.1016/0303-8467(94)90117-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0303-8467(94)90117-1","pdf_url":null,"source":{"id":"https://openalex.org/S165396890","display_name":"Clinical Neurology and Neurosurgery","issn_l":"0303-8467","issn":["0303-8467","1872-6968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Neurology and Neurosurgery","raw_type":"journal-article"},{"id":"pmid:7889690","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7889690","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical neurology and neurosurgery","raw_type":"Journal Article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/2d8bc6b9-81eb-4d7c-9077-ea650fa97498","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/2d8bc6b9-81eb-4d7c-9077-ea650fa97498","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Peeters, E A, Bloem, B R, Kuiper, M A, Vermeij, P, de Wolff, F A, Wolters, E C, Roos, R A & Ferrari, M D 1994, 'Phenytoin parahydroxylation is not impaired in patients with young-onset Parkinson's disease', Clinical neurology and neurosurgery, vol. 96, no. 4, pp. 296-299. https://doi.org/10.1016/0303-8467(94)90117-1","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/8bce1653-e23c-42a7-9dbf-1194a5846c22","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/phenytoin-parahydroxylation-is-not-impaired-in-patients-with-youngonset-parkinsons-disease(8bce1653-e23c-42a7-9dbf-1194a5846c22).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical neurology and neurosurgery, 96(4), 296 - 299. Elsevier","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1969800514","https://openalex.org/W1980585130","https://openalex.org/W1981347206","https://openalex.org/W1986606436","https://openalex.org/W2002387779","https://openalex.org/W2003972599","https://openalex.org/W2007964603","https://openalex.org/W2013407711","https://openalex.org/W2022208588","https://openalex.org/W2030084106","https://openalex.org/W2031736446","https://openalex.org/W2035034982","https://openalex.org/W2035786828","https://openalex.org/W2038413168","https://openalex.org/W2039727503","https://openalex.org/W2048266571","https://openalex.org/W2055568229","https://openalex.org/W2057649946","https://openalex.org/W2067815168","https://openalex.org/W2071332031","https://openalex.org/W2094602388","https://openalex.org/W2094906736","https://openalex.org/W2126704418","https://openalex.org/W2150961005","https://openalex.org/W2160131033","https://openalex.org/W2224311781","https://openalex.org/W4285719527","https://openalex.org/W6683833792"],"related_works":["https://openalex.org/W2224311781","https://openalex.org/W2150961005","https://openalex.org/W2068561504","https://openalex.org/W2015769536","https://openalex.org/W1918218212","https://openalex.org/W2010345624","https://openalex.org/W4389447769","https://openalex.org/W1986606436","https://openalex.org/W2171041632","https://openalex.org/W2032641344"],"abstract_inverted_index":null,"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
