{"id":"https://openalex.org/W2013201889","doi":"https://doi.org/10.1093/carcin/11.11.1971","title":"Fluorine probes for investigating the mechanism of activation of indeno [1,2,3-cd]pyrene to a tumorigenic agent","display_name":"Fluorine probes for investigating the mechanism of activation of indeno [1,2,3-cd]pyrene to a tumorigenic agent","publication_year":1990,"publication_date":"1990-01-01","ids":{"openalex":"https://openalex.org/W2013201889","doi":"https://doi.org/10.1093/carcin/11.11.1971","mag":"2013201889","pmid":"https://pubmed.ncbi.nlm.nih.gov/2225328"},"language":"en","primary_location":{"id":"doi:10.1093/carcin/11.11.1971","doi":"https://doi.org/10.1093/carcin/11.11.1971","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/11.11.1971","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085055148","display_name":"Joseph E. Rice","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph E. Rice","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, College of Pharmacy, Rutgers-The State University of New Jersey, Piscataway 08855"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, College of Pharmacy, Rutgers-The State University of New Jersey, Piscataway 08855","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082003644","display_name":"Eric H. Weyand","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric H. Weyand","raw_affiliation_strings":["Naylor Dana Institute for Disease Prevention Valhalla, NY 10595, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Naylor Dana Institute for Disease Prevention Valhalla, NY 10595, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052367938","display_name":"Christine Burrill","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christine Burrill","raw_affiliation_strings":["Naylor Dana Institute for Disease Prevention Valhalla, NY 10595, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Naylor Dana Institute for Disease Prevention Valhalla, NY 10595, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110337003","display_name":"Edmond J. La Voie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edmond J. La Voie","raw_affiliation_strings":["Naylor Dana Institute for Disease Prevention Valhalla, NY 10595, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Naylor Dana Institute for Disease Prevention Valhalla, NY 10595, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4835,"currency":"USD","value_usd":4835},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.10997305,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"11","issue":"11","first_page":"1971","last_page":"1974"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.01679999940097332,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/indeno-1-2-3-cd-pyrene","display_name":"indeno[1,2,3-cd]pyrene","score":0.9980000257492065},{"id":"https://openalex.org/keywords/metabolic-activation","display_name":"metabolic activation","score":0.7850000262260437},{"id":"https://openalex.org/keywords/skin-carcinogenesis","display_name":"skin carcinogenesis","score":0.5820000171661377},{"id":"https://openalex.org/keywords/dna-adducts","display_name":"DNA adducts","score":0.7739999890327454},{"id":"https://openalex.org/keywords/32p-postlabeling","display_name":"32P-postlabeling","score":0.7820000052452087}],"concepts":[{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.5170167684555054},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.334119975566864},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1455228328704834}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005461","descriptor_name":"Fluorine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D011721","descriptor_name":"Pyrenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015197","descriptor_name":"Carcinogenicity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/carcin/11.11.1971","doi":"https://doi.org/10.1093/carcin/11.11.1971","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/11.11.1971","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},{"id":"pmid:2225328","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2225328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.800000011920929,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1685782788","display_name":null,"funder_award_id":"ES02030","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1567792310","https://openalex.org/W1818735208","https://openalex.org/W2121762929","https://openalex.org/W2015123985","https://openalex.org/W1994732776","https://openalex.org/W1976138981","https://openalex.org/W2077792423","https://openalex.org/W2029233744","https://openalex.org/W2058063530","https://openalex.org/W1988922565"],"abstract_inverted_index":{"Indeno[1,2,3-cd]pyrene":[0],"(IP)":[1],"is":[2,16,207],"a":[3,102,131,144],"non-alternant":[4],"polycyclic":[5],"aromatic":[6],"hydrocarbon":[7],"that":[8,29,191,199,259,290],"has":[9],"tumor-initiating":[10,60],"activity":[11,61,74],"on":[12,62],"mouse":[13,42,63],"skin":[14,111],"and":[15,21,31,33,45,66,96,174,241],"carcinogenic":[17],"in":[18,22,39,41,51,113,147,209,309],"newborn":[19],"mice":[20,136,157,210,236],"rat":[23],"lungs.":[24],"Previous":[25],"studies":[26],"have":[27,83],"shown":[28],"8-":[30],"9-hydroxyIP":[32],"IP-1,2-diol":[34,65,240,248],"are":[35,47,296],"major":[36,195,219,251],"metabolites":[37,53],"formed":[38,231,291],"vivo":[40,52],"skin.":[43,183],"8-HydroxyIP-1,2-diol":[44],"9-hydroxyIP-1,2-diol":[46],"also":[48],"observed":[49,260],"as":[50,75,226],"of":[54,90,99,106,115,122,134,149,167,171,182,186,270,277],"IP.":[55,76,100,233],"Although":[56],"8-hydroxyIP":[57],"had":[58,71,286],"marginal":[59],"skin,":[64],"its":[67],"epoxide":[68],"precursor,":[69],"IP-1,2-oxide,":[70],"similar":[72,257,288],"tumorigenic":[73,145],"In":[77,140,214],"the":[78,88,94,116,126,150,165,168,172,179,187,203,229,262,275,278,315],"present":[79],"study":[80],"fluorine":[81],"probes":[82],"been":[84],"employed":[85],"to":[86,202,245,258,289],"investigate":[87],"contribution":[89],"metabolic":[91,301],"activation":[92,302],"at":[93,164,303,314],"1,2":[95,316],"7-10":[97,305],"positions":[98,304],"At":[101,125],"total":[103],"initiating":[104],"dose":[105],"4.0":[107],"mumol,":[108],"2-fluoroIP":[109,216],"induced":[110,130],"tumors":[112],"76%":[114],"treated":[117,151,180,211,237],"animals":[118,152],"with":[119,137,153,212,222,228,239,255,298,311],"an":[120,267],"average":[121],"3.9":[123],"tumors/mouse.":[124,139],"same":[127],"dose,":[128],"IP":[129,192,299],"72%":[132],"incidence":[133],"tumor-bearing":[135],"2.1":[138],"contrast,":[141,215],"8,9-difluoroIP":[142],"elicited":[143],"response":[146],"40%":[148],"0.6":[154],"tumors/animal.":[155],"Five":[156],"from":[158,178,232,235,292],"each":[159],"experimental":[160],"group":[161],"were":[162,283],"killed":[163],"conclusion":[166],"initiation":[169],"phase":[170],"bioassay":[173],"DNA":[175,189,197,234,252,271],"was":[176,243],"isolated":[177],"areas":[181],"32P-Postlabeling":[184],"analysis":[185],"hydrolyzed":[188],"indicated":[190],"forms":[193,217,249],"one":[194,218,250],"detectable":[196],"adduct":[198,206,220,230,253],"migrates":[200],"close":[201],"origin.":[204],"This":[205],"absent":[208],"8,9-difluoroIP.":[213],"spot":[221,254],"different":[223],"retention":[224],"behavior":[225],"compared":[227],"topically":[238],"IP-1,2-oxide":[242,265],"subjected":[244],"32P-postlabeling":[246],"analysis.":[247],"mobility":[256,287],"for":[261],"IP-DNA":[263,279],"adduct.":[264,280],"displayed":[266],"intense":[268],"pattern":[269],"adducts":[272,282],"centered":[273],"around":[274],"location":[276],"No":[281],"detected":[284],"which":[285],"2-fluoroIP.":[293],"These":[294],"results":[295],"consistent":[297],"undergoing":[300],"either":[306],"alone":[307],"or":[308],"conjunction":[310],"dihydrodiol":[312],"formation":[313],"position.":[317]},"counts_by_year":[{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}