{"id":"https://openalex.org/W2013189085","doi":"https://doi.org/10.1210/jc.2008-1461","title":"The Role of Human Chorionic Gonadotropin as a Thyroid Stimulator in Normal Pregnancy","display_name":"The Role of Human Chorionic Gonadotropin as a Thyroid Stimulator in Normal Pregnancy","publication_year":2008,"publication_date":"2008-09-01","ids":{"openalex":"https://openalex.org/W2013189085","doi":"https://doi.org/10.1210/jc.2008-1461","mag":"2013189085","pmid":"https://pubmed.ncbi.nlm.nih.gov/18772462"},"language":"en","primary_location":{"id":"doi:10.1210/jc.2008-1461","doi":"https://doi.org/10.1210/jc.2008-1461","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2008-1461","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108455606","display_name":"Jerome M. Hershman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210156876","display_name":"VA Greater Los Angeles Healthcare System","ror":"https://ror.org/05xcarb80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138663","https://openalex.org/I4210156876"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jerome M. Hershman","raw_affiliation_strings":["Veterans Affairs Greater Los Angeles Healthcare System, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Affairs Greater Los Angeles Healthcare System, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210156876"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5108455606"],"corresponding_institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210156876"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":54,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"93","issue":"9","first_page":"3305","last_page":"3306"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12587","display_name":"Gestational Trophoblastic Disease Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-chorionic-gonadotropin","display_name":"human chorionic gonadotropin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/thyroid-stimulating-activity","display_name":"thyroid-stimulating activity","score":0.781000018119812},{"id":"https://openalex.org/keywords/normal-pregnancy","display_name":"normal pregnancy","score":0.7860000133514404},{"id":"https://openalex.org/keywords/gestational-thyrotoxicosis","display_name":"gestational thyrotoxicosis","score":0.9070000052452087},{"id":"https://openalex.org/keywords/placental-tumors","display_name":"placental tumors","score":0.6370000243186951},{"id":"https://openalex.org/keywords/hydatidiform-mole","display_name":"hydatidiform mole","score":0.9309999942779541},{"id":"https://openalex.org/keywords/choriocarcinoma","display_name":"choriocarcinoma","score":0.9660000205039978},{"id":"https://openalex.org/keywords/hyperthyroidism","display_name":"hyperthyroidism","score":0.8790000081062317}],"concepts":[{"id":"https://openalex.org/C2775948956","wikidata":"https://www.wikidata.org/wiki/Q407172","display_name":"Human chorionic gonadotropin","level":3,"score":0.7627769708633423},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7187565565109253},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6753603219985962},{"id":"https://openalex.org/C104488531","wikidata":"https://www.wikidata.org/wiki/Q864212","display_name":"Bioassay","level":2,"score":0.6625465750694275},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.6199198961257935},{"id":"https://openalex.org/C2778782382","wikidata":"https://www.wikidata.org/wiki/Q409770","display_name":"Gonadotropin","level":3,"score":0.5416496396064758},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4945809543132782},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.48874783515930176},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.483605295419693},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.4676945209503174},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.42813345789909363},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37808454036712646},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.375849187374115},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3531377911567688},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.22352668642997742},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11231157183647156},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006063","descriptor_name":"Chorionic Gonadotropin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009325","descriptor_name":"Nausea","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009325","descriptor_name":"Nausea","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/jc.2008-1461","doi":"https://doi.org/10.1210/jc.2008-1461","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2008-1461","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},{"id":"pmid:18772462","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18772462","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Comment"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1964693382","https://openalex.org/W1967375819","https://openalex.org/W2005144687","https://openalex.org/W2006444741","https://openalex.org/W2016408036","https://openalex.org/W2019005474","https://openalex.org/W2023829594","https://openalex.org/W2027786544","https://openalex.org/W2030962379","https://openalex.org/W2031402418","https://openalex.org/W2074511143","https://openalex.org/W2076719524","https://openalex.org/W2096594977"],"related_works":["https://openalex.org/W1998414543","https://openalex.org/W1967375819","https://openalex.org/W8530111","https://openalex.org/W1988457498","https://openalex.org/W3094777490","https://openalex.org/W1973556660","https://openalex.org/W2023553902","https://openalex.org/W1966825113","https://openalex.org/W2006444741","https://openalex.org/W2065357384"],"abstract_inverted_index":{"The":[0],"first":[1],"clinical":[2],"reports":[3],"of":[4,21,64,103,127],"a":[5,52,116,149,184],"placental":[6,14,180],"thyroid":[7],"stimulator":[8],"arose":[9,176],"from":[10,177,183],"studies":[11,174],"indicating":[12],"that":[13,16,44,63,68,79],"tumors":[15,181],"secrete":[17],"very":[18],"large":[19],"amount":[20],"human":[22],"chorionic":[23],"gonadotropin":[24],"(hCG),":[25],"hydatidiform":[26],"moles":[27],"and":[28,37,62,162],"choriocarcinomas,":[29],"were":[30],"associated":[31,190],"with":[32,179,187,191],"hyperthyroidism":[33],"[summarized":[34],"by":[35],"Yoshimura":[36],"Hershman":[38],"(1)].":[39],"In":[40],"1967,":[41],"Burger":[42],"reported":[43,67],"impure,":[45],"commercial":[46],"hCG":[47,71,84,87,106,122,128,142,147,193],"had":[48,72],"thyroid-stimulating":[49],"activity":[50,73],"in":[51,74,89,98,132,152,170],"mouse":[53],"bioassay":[54],"(2).":[55],"Several":[56],"years":[57],"later":[58],"my":[59],"laboratory":[60],"(3)":[61],"Nisula":[65],"(4)":[66],"highly":[69],"purified":[70],"this":[75,163],"bioassay.":[76],"We":[77],"found":[78],"the":[80,101,135,145,153,156],"molar":[81],"TSH":[82,119,136],"was":[83],"(4).":[85],"Because":[86],"varies":[88],"its":[90,108],"carbohydrate":[91],"composition,":[92],"there":[93],"has":[94,148],"been":[95],"considerable":[96],"controversy":[97],"regard":[99],"to":[100,134,166],"potency":[102,169],"these":[104],"variants.":[105],"lacking":[107],"C-terminal":[109],"tail,":[110],"therefore":[111],"closely":[112],"resembling":[113],"LH,":[114],"is":[115],"more":[117,130,157],"potent":[118,131],"than":[120,138,155],"native":[121],"(5).":[123],"Desialylated":[124],"basic":[125,158],"variants":[126],"are":[129],"binding":[133],"receptor":[137],"fully":[139],"sialylated":[140],"acidic":[141,146],"(6).":[143],"However,":[144],"longer":[150],"half-life":[151],"circulation":[154],"partially":[159],"desialylated":[160],"hCG,":[161],"may":[164],"contribute":[165],"greater":[167],"thyrotropic":[168],"humans":[171],"(7).":[172],"These":[173],"mainly":[175],"patients":[178,186],"or":[182],"few":[185],"gestational":[188],"thyrotoxicosis":[189],"high":[192],"levels.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}