{"id":"https://openalex.org/W2013178878","doi":"https://doi.org/10.1002/(sici)1096-8628(19980207)81:1<117::aid-ajmg19>3.0.co;2-m","title":"ApoE genotype is a risk factor in nonpresenilin early-onset alzheimer's disease families","display_name":"ApoE genotype is a risk factor in nonpresenilin early-onset alzheimer's disease families","publication_year":1998,"publication_date":"1998-02-07","ids":{"openalex":"https://openalex.org/W2013178878","doi":"https://doi.org/10.1002/(sici)1096-8628(19980207)81:1<117::aid-ajmg19>3.0.co;2-m","mag":"2013178878","pmid":"https://pubmed.ncbi.nlm.nih.gov/9514597"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1096-8628(19980207)81:1<117::aid-ajmg19>3.0.co;2-m","doi":"https://doi.org/10.1002/(sici)1096-8628(19980207)81:1<117::aid-ajmg19>3.0.co;2-m","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1096-8628(19980207)81:1<117::aid-ajmg19>3.0.co;2-m","pdf_url":null,"source":{"id":"https://openalex.org/S4210224978","display_name":"American Journal of Medical Genetics","issn_l":"0148-7299","issn":["0148-7299","1096-8628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Medical Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082436384","display_name":"Henry Houlden","orcid":"https://orcid.org/0000-0002-2866-7777","observed_orcids":["https://orcid.org/0000-0002-2866-7777","https://orcid.org/0000-0002-0916-7347"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Henry Houlden","raw_affiliation_strings":["Neurogenetics Laboratory, Mayo Clinic Jacksonville, Florida 32224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurogenetics Laboratory, Mayo Clinic Jacksonville, Florida 32224, USA","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079307479","display_name":"Richard Crook","orcid":"https://orcid.org/0000-0001-6782-1581","observed_orcids":["https://orcid.org/0000-0001-6782-1581"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Crook","raw_affiliation_strings":["Neurogenetics Laboratory, Birdsall Building, Mayo Clinic Jacksonville, Jacksonville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurogenetics Laboratory, Birdsall Building, Mayo Clinic Jacksonville, Jacksonville, Florida","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107347306","display_name":"H. Backhovens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149213910","display_name":"University of Antwerp","ror":"https://ror.org/008x57b05","country_code":"BE","type":"education","lineage":["https://openalex.org/I149213910"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Hubert Backhovens","raw_affiliation_strings":["Laboratory of Neurogenetics, Flanders Interuniversity Institute of Biotechnology, Born-Bunge Foundation, Department of Biochemistry, University of Antwerp, Antwerp, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurogenetics, Flanders Interuniversity Institute of Biotechnology, Born-Bunge Foundation, Department of Biochemistry, University of Antwerp, Antwerp, Belgium","institution_ids":["https://openalex.org/I149213910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022236636","display_name":"Guy Prihar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guy Prihar","raw_affiliation_strings":["Neurogenetics Laboratory, Birdsall Building, Mayo Clinic Jacksonville, Jacksonville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurogenetics Laboratory, Birdsall Building, Mayo Clinic Jacksonville, Jacksonville, Florida","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051295879","display_name":"Matt C. Baker","orcid":"https://orcid.org/0009-0001-2691-5757","observed_orcids":["https://orcid.org/0009-0001-2691-5757"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matt Baker","raw_affiliation_strings":["Neurogenetics Laboratory, Birdsall Building, Mayo Clinic Jacksonville, Jacksonville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurogenetics Laboratory, Birdsall Building, Mayo Clinic Jacksonville, Jacksonville, Florida","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109961094","display_name":"Mike Hutton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mike Hutton","raw_affiliation_strings":["Neurogenetics Laboratory, Birdsall Building, Mayo Clinic Jacksonville, Jacksonville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurogenetics Laboratory, Birdsall Building, Mayo Clinic Jacksonville, Jacksonville, Florida","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032450718","display_name":"Martin N. Rossor","orcid":"https://orcid.org/0000-0001-8215-3120","observed_orcids":["https://orcid.org/0000-0001-8215-3120"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Martin Rossor","raw_affiliation_strings":["Dementia Research Group, Department of Neurology, Imperial College of Science Technology and Medicine, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dementia Research Group, Department of Neurology, Imperial College of Science Technology and Medicine, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111443830","display_name":"Jean Jacques Martin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149213910","display_name":"University of Antwerp","ror":"https://ror.org/008x57b05","country_code":"BE","type":"education","lineage":["https://openalex.org/I149213910"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jean Jacques Martin","raw_affiliation_strings":["Laboratory of Neuropathology, Born-Bunge Foundation, Department of Medicine, University of Antwerp, Antwerp, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuropathology, Born-Bunge Foundation, Department of Medicine, University of Antwerp, Antwerp, Belgium","institution_ids":["https://openalex.org/I149213910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039639102","display_name":"Christine Van Broeckhoven","orcid":"https://orcid.org/0000-0003-0183-7665","observed_orcids":["https://orcid.org/0000-0003-0183-7665"]},"institutions":[{"id":"https://openalex.org/I149213910","display_name":"University of Antwerp","ror":"https://ror.org/008x57b05","country_code":"BE","type":"education","lineage":["https://openalex.org/I149213910"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Christine Van Broeckhoven","raw_affiliation_strings":["Laboratory of Neurogenetics, Flanders Interuniversity Institute of Biotechnology, Born-Bunge Foundation, Department of Biochemistry, University of Antwerp, Antwerp, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurogenetics, Flanders Interuniversity Institute of Biotechnology, Born-Bunge Foundation, Department of Biochemistry, University of Antwerp, Antwerp, Belgium","institution_ids":["https://openalex.org/I149213910"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020514779","display_name":"John Hardy","orcid":"https://orcid.org/0000-0002-3122-0423","observed_orcids":["https://orcid.org/0000-0002-3122-0423"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Hardy","raw_affiliation_strings":["Neurogenetics Laboratory, Birdsall Building, Mayo Clinic Jacksonville, Jacksonville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurogenetics Laboratory, Birdsall Building, Mayo Clinic Jacksonville, Jacksonville, Florida","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5082436384"],"corresponding_institution_ids":["https://openalex.org/I4210146710"],"apc_list":null,"apc_paid":null,"fwci":2.9706,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.91217862,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"81","issue":"1","first_page":"117","last_page":"121"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.020800000056624413,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.9100000262260437},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.902999997138977},{"id":"https://openalex.org/keywords/early-onset-familial-alzheimer-s-disease","display_name":"early-onset familial Alzheimer's disease","score":0.8650000095367432},{"id":"https://openalex.org/keywords/presenilin-1-mutations","display_name":"presenilin 1 mutations","score":0.9330000281333923},{"id":"https://openalex.org/keywords/psen2","display_name":"presenilin 2","score":0.8700000047683716},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.9919999837875366},{"id":"https://openalex.org/keywords/age-of-onset","display_name":"age of onset","score":0.9399999976158142},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.9110000133514404},{"id":"https://openalex.org/keywords/genotype-phenotype-correlation","display_name":"genotype-phenotype correlation","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C175344181","wikidata":"https://www.wikidata.org/wiki/Q907198","display_name":"Presenilin","level":4,"score":0.8414219617843628},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.8393861055374146},{"id":"https://openalex.org/C2777767895","wikidata":"https://www.wikidata.org/wiki/Q4691924","display_name":"Age of onset","level":3,"score":0.663950502872467},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6602427363395691},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.6309891939163208},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5391116738319397},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.4772736430168152},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44139552116394043},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.43949103355407715},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42411917448043823},{"id":"https://openalex.org/C2781340033","wikidata":"https://www.wikidata.org/wiki/Q5326566","display_name":"Early-onset Alzheimer's disease","level":4,"score":0.4212302565574646},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.40209197998046875},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35307806730270386},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3110159635543823},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18671220541000366}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053327","descriptor_name":"Apolipoprotein E4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053764","descriptor_name":"Presenilin-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053766","descriptor_name":"Presenilin-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/(sici)1096-8628(19980207)81:1<117::aid-ajmg19>3.0.co;2-m","doi":"https://doi.org/10.1002/(sici)1096-8628(19980207)81:1<117::aid-ajmg19>3.0.co;2-m","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1096-8628(19980207)81:1<117::aid-ajmg19>3.0.co;2-m","pdf_url":null,"source":{"id":"https://openalex.org/S4210224978","display_name":"American Journal of Medical Genetics","issn_l":"0148-7299","issn":["0148-7299","1096-8628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Medical Genetics","raw_type":"journal-article"},{"id":"pmid:9514597","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9514597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of medical genetics","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:155805","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/155805/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"AM J MED GENET , 81 (1) 117 - 121. (1998)","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G3104868179","display_name":"APP TRANSFECTION TO STUDY ALPHA- AND BETA- SECRETASES","funder_award_id":"R01AG012028","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4649074975","display_name":null,"funder_award_id":"AG-11871","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5836025684","display_name":"GENETICS OF EARLY-ONSET ALZHEIMER'S DISEASE","funder_award_id":"R01AG011871","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G704999138","display_name":null,"funder_award_id":"AG 12028","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1983453007","https://openalex.org/W1985253611","https://openalex.org/W1996623888","https://openalex.org/W1999631936","https://openalex.org/W1999902101","https://openalex.org/W2006014092","https://openalex.org/W2011199056","https://openalex.org/W2011924331","https://openalex.org/W2013669235","https://openalex.org/W2017568059","https://openalex.org/W2019251951","https://openalex.org/W2029486567","https://openalex.org/W2033325438","https://openalex.org/W2036362108","https://openalex.org/W2046209489","https://openalex.org/W2058723245","https://openalex.org/W2071867775","https://openalex.org/W2083633251","https://openalex.org/W2091149745","https://openalex.org/W2098546816","https://openalex.org/W2113539936","https://openalex.org/W2135475959","https://openalex.org/W2139930052","https://openalex.org/W2155961722","https://openalex.org/W2156220037","https://openalex.org/W2621518294"],"related_works":["https://openalex.org/W218339917","https://openalex.org/W2006014092","https://openalex.org/W2415219697","https://openalex.org/W2349827052","https://openalex.org/W2033146894","https://openalex.org/W2415270303","https://openalex.org/W1999902101","https://openalex.org/W2075219817","https://openalex.org/W1892157526","https://openalex.org/W4388097413"],"abstract_inverted_index":{"The":[0,69,103],"apolipoprotein":[1],"E":[2],"(ApoE)":[3],"genotype":[4,27,71],"is":[5,72,210],"a":[6,37,50,84,106,168,211,225],"significant":[7,212],"risk":[8,213],"factor":[9,214],"and":[10,47,58,90,154,177,186,192,201,205,222],"modulator":[11],"of":[12,14,16,24,79,105,109,113,127,172,218,231],"age":[13,78,112],"onset":[15,80,114],"Alzheimer's":[17],"disease":[18],"(AD).":[19],"We":[20],"analyzed":[21],"the":[22,25,40,54,59,87,98,119,125,133,151,157,178,196,207,216,229],"effect":[23],"ApoE":[26,70],"in":[28,39,53,81,86,96,118,132,143,156,199,215,228],"two":[29],"distinct":[30],"early-onset":[31,66,161,203,220],"familial":[32,67],"AD":[33,121,155,162,180,197,221],"groups:":[34],"families":[35,48,82,91,122,163],"with":[36,83,92],"mutation":[38,51,85],"presenilin-1":[41],"gene":[42,64,89],"(PS-1)":[43],"on":[44,111],"chromosome":[45],"14,":[46],"without":[49],"detectable":[52,95],"PS-1,":[55],"presenilin-2":[56],"(PS-2),":[57],"amyloid":[60],"precursor":[61],"protein":[62],"(APP)":[63],"(non-PS":[65],"AD).":[68],"clearly":[73],"shown":[74,165],"not":[75,116],"to":[76,124,140,166,175],"modulate":[77],"PS-1":[88,120,158,179,200],"no":[93,148],"lesion":[94],"either":[97],"presenilin":[99],"or":[100],"APP":[101],"gene.":[102],"effects":[104],"double":[107],"dose":[108],"ApoE4":[110,130,152,173,208],"were":[115,164],"assessed":[117,142],"due":[123],"lack":[126],"any":[128],"affected":[129],"homozygotes":[131],"sample":[134],"set;":[135],"this":[136],"insufficiency":[137],"will":[138,223],"need":[139],"be":[141,224],"further":[144],"studies.":[145],"There":[146],"was":[147],"association":[149],"between":[150],"allele":[153,209],"families.":[159],"Non-PS":[160],"have":[167],"significantly":[169],"higher":[170],"frequency":[171],"compared":[174],"controls":[176],"group.":[181],"These":[182],"observations":[183],"are":[184],"important":[185],"suggest":[187],"that":[188],"1)":[189],"other":[190],"genetic":[191],"environmental":[193],"factors":[194],"modify":[195],"phenotype":[198],"non-PS":[202,219],"families;":[204],"2)":[206],"etiology":[217],"useful":[226],"adjunct":[227],"diagnosis":[230],"unaffected":[232],"family":[233],"members.":[234]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
