{"id":"https://openalex.org/W2013175490","doi":"https://doi.org/10.1097/00005344-198900132-00003","title":"Effects of Doxazosin on Lipids, Lipoprotein Lipases, and Cholesterol Synthesis in the Golden Hamster","display_name":"Effects of Doxazosin on Lipids, Lipoprotein Lipases, and Cholesterol Synthesis in the Golden Hamster","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W2013175490","doi":"https://doi.org/10.1097/00005344-198900132-00003","mag":"2013175490","pmid":"https://pubmed.ncbi.nlm.nih.gov/2471016"},"language":"en","primary_location":{"id":"doi:10.1097/00005344-198900132-00003","doi":"https://doi.org/10.1097/00005344-198900132-00003","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005344-198900132-00003","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031812273","display_name":"Hans Jansen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Hans Jansen","raw_affiliation_strings":["Department of Internal Medicine III, Erasmus University Rotterdam, The Netherlands","Departments of Internal Medicine III and Biochemistry I, Erasmus University Rotterdam, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine III, Erasmus University Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I913958620"]},{"raw_affiliation_string":"Departments of Internal Medicine III and Biochemistry I, Erasmus University Rotterdam, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I913958620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004756852","display_name":"Ronald Lammers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ronald Lammers","raw_affiliation_strings":["Departments of Internal Medicine III and Biochemistry I, Erasmus University Rotterdam, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine III and Biochemistry I, Erasmus University Rotterdam, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I913958620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034923093","display_name":"Marinus G.A. Baggen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marinus G. A. Baggen","raw_affiliation_strings":["Departments of Internal Medicine III and Biochemistry I, Erasmus University Rotterdam, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine III and Biochemistry I, Erasmus University Rotterdam, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I913958620"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112138461","display_name":"Jan C. Birkenh\u00e4ger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jan C. Birkenh\u00e4ger","raw_affiliation_strings":["Departments of Internal Medicine III and Biochemistry I, Erasmus University Rotterdam, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine III and Biochemistry I, Erasmus University Rotterdam, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I913958620"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I913958620"],"apc_list":null,"apc_paid":null,"fwci":2.7071,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.89521652,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"13","issue":null,"first_page":"S5","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.7089999914169312,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.7089999914169312,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.2703000009059906,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doxazosin","display_name":"doxazosin","score":1.0},{"id":"https://openalex.org/keywords/alpha-1-adrenergic-blockade","display_name":"alpha-1 adrenergic blockade","score":0.7239999771118164},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.7210000157356262},{"id":"https://openalex.org/keywords/serum-cholesterol","display_name":"serum cholesterol","score":0.8399999737739563},{"id":"https://openalex.org/keywords/hepatic-cholesterol-synthesis","display_name":"hepatic cholesterol synthesis","score":0.8569999933242798},{"id":"https://openalex.org/keywords/hmg-coa-reductase","display_name":"HMG-CoA reductase","score":0.9369999766349792},{"id":"https://openalex.org/keywords/lipoprotein-lipase","display_name":"lipoprotein lipase","score":0.9750000238418579},{"id":"https://openalex.org/keywords/hepatic-lipase","display_name":"hepatic lipase","score":0.9850000143051147},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.7900000214576721},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.9139999747276306},{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":0.7950000166893005},{"id":"https://openalex.org/keywords/atenolol","display_name":"atenolol","score":1.0},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.7059999704360962},{"id":"https://openalex.org/keywords/thyroid-hormones","display_name":"thyroid hormones","score":0.9679999947547913},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.7480000257492065},{"id":"https://openalex.org/keywords/syrian-hamster","display_name":"golden hamster","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C2777590997","wikidata":"https://www.wikidata.org/wiki/Q419939","display_name":"Doxazosin","level":3,"score":0.968829333782196},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8604421615600586},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8509366512298584},{"id":"https://openalex.org/C2776525901","wikidata":"https://www.wikidata.org/wiki/Q411325","display_name":"Atenolol","level":3,"score":0.6931156516075134},{"id":"https://openalex.org/C2778575167","wikidata":"https://www.wikidata.org/wiki/Q6573","display_name":"Hamster","level":2,"score":0.6437311768531799},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.508337676525116},{"id":"https://openalex.org/C94879076","wikidata":"https://www.wikidata.org/wiki/Q420014","display_name":"Lipoprotein lipase","level":3,"score":0.4964316487312317},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47701048851013184},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.4629787802696228},{"id":"https://openalex.org/C2778151854","wikidata":"https://www.wikidata.org/wiki/Q423364","display_name":"Propranolol","level":2,"score":0.4334242343902588},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3369271755218506},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16289618611335754},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0741889476776123}],"mesh":[{"descriptor_ui":"D000317","descriptor_name":"Adrenergic alpha-Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001262","descriptor_name":"Atenolol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002791","descriptor_name":"Cholesterol, Dietary","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008049","descriptor_name":"Lipase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008071","descriptor_name":"Lipoprotein Lipase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008647","descriptor_name":"Mesocricetus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011224","descriptor_name":"Prazosin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D011224","descriptor_name":"Prazosin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011433","descriptor_name":"Propranolol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D017292","descriptor_name":"Doxazosin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00005344-198900132-00003","doi":"https://doi.org/10.1097/00005344-198900132-00003","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005344-198900132-00003","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},{"id":"pmid:2471016","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2471016","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiovascular pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2005663409","https://openalex.org/W2030310937","https://openalex.org/W2074226179","https://openalex.org/W2061695810","https://openalex.org/W2605472243","https://openalex.org/W2066177057","https://openalex.org/W2050634459","https://openalex.org/W1979486192","https://openalex.org/W4252845586","https://openalex.org/W2015578417"],"abstract_inverted_index":{"The":[0,213],"effects":[1,214,229],"of":[2,64,185],"treatment":[3],"with":[4,168,182,202,206],"adrenoceptor":[5,170],"blockers":[6,171],"on":[7,175,220,233],"sites":[8],"regulating":[9],"lipid":[10,207],"metabolism":[11,208],"were":[12,128,191],"studied":[13],"in":[14,52,56,70,79,102,151],"golden":[15],"hamsters.":[16,105],"In":[17,135,164],"hamsters":[18,165],"fed":[19],"a":[20,40,217],"standard":[21],"chow,":[22],"doxazosin,":[23],"propranolol,":[24],"and":[25,55,73,92,115,124,153,188,222],"atenolol":[26,112],"did":[27],"not":[28,60,166],"affect":[29],"plasma":[30,45,119,152,176],"cholesterol":[31,46,84,91,122,126],"or":[32,178],"triglycerides.":[33,120],"After":[34,106],"hypercholesterolemia":[35],"was":[36,59,75,99,143,156,160],"induced":[37],"by":[38,47,62,77,133,146,158,162,193],"feeding":[39],"cholesterol-enriched":[41],"diet,":[42],"doxazosin":[43,116,203],"lowered":[44,76,101,157],"12%.":[48],"Lipoprotein":[49],"lipase":[50,68,141,149],"activity":[51,69,142,150],"adipose":[53,138],"tissue":[54,139],"the":[57,65,71,80,103],"heart":[58],"changed":[61],"any":[63],"treatments.":[66],"Hepatic":[67,83,148],"liver":[72],"blood":[74],"31%":[78],"doxazosin-treated":[81,104],"animals.":[82],"synthesis,":[85],"measured":[86],"as":[87],"acetate":[88],"incorporation":[89],"into":[90],"hydroxymethylglutaryl":[93],"coenzyme":[94],"A":[95],"(HMG-CoA)":[96],"reductase":[97],"activity,":[98],"also":[100],"norepinephrine":[107],"administration":[108],"to":[109,216],"cholesterol-fed":[110],"hamsters,":[111],"increased":[113,161,192],"(+8%)":[114],"decreased":[117],"(-35%)":[118],"Plasma":[121],"levels":[123,184],"hepatic":[125],"synthesis":[127],"no":[129,173],"longer":[130],"significantly":[131],"affected":[132],"doxazosin.":[134,147,163,194],"norepinephrine-treated":[136],"animals,":[137],"lipoprotein":[140],"enhanced":[144],"(+30%)":[145],"liver,":[154],"which":[155],"norepinephrine,":[159,169,183],"treated":[167],"had":[172],"effect":[174],"insulin":[177,187],"thyroid":[179,189],"hormone,":[180],"but":[181],"both":[186],"hormone":[190],"These":[195],"data":[196],"indicate":[197],"that":[198],"selective":[199],"alpha":[200],"1-inhibition":[201],"may":[204],"interfere":[205],"at":[209],"several":[210],"regulatory":[211],"sites.":[212],"depend":[215],"large":[218],"extent":[219],"nutritional":[221],"hormonal":[223],"status.":[224],"Doxazosin":[225],"might":[226],"exert":[227],"these":[228],"partly":[230],"via":[231],"influences":[232],"other":[234],"hormones.":[235]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
