{"id":"https://openalex.org/W2013164342","doi":"https://doi.org/10.1159/000126786","title":"Pituitary Adenyl Cyclase-Activating Peptide: A Hypophysiotropic Factor That Stimulates Proopiomelanocortin Gene Transcription, and Proopio-melanocortin-Derived Peptide Secretion in Corticotropic Cells","display_name":"Pituitary Adenyl Cyclase-Activating Peptide: A Hypophysiotropic Factor That Stimulates Proopiomelanocortin Gene Transcription, and Proopio-melanocortin-Derived Peptide Secretion in Corticotropic Cells","publication_year":2008,"publication_date":"2008-04-09","ids":{"openalex":"https://openalex.org/W2013164342","doi":"https://doi.org/10.1159/000126786","mag":"2013164342","pmid":"https://pubmed.ncbi.nlm.nih.gov/7845539"},"language":"en","primary_location":{"id":"doi:10.1159/000126786","doi":"https://doi.org/10.1159/000126786","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000126786","pdf_url":null,"source":{"id":"https://openalex.org/S84102376","display_name":"Neuroendocrinology","issn_l":"0028-3835","issn":["0028-3835","1423-0194"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroendocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004712759","display_name":"Anne\u2010Laurence Boutillier","orcid":"https://orcid.org/0000-0002-2317-9280","observed_orcids":["https://orcid.org/0000-0002-2317-9280"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anne-Laurence Boutillier","raw_affiliation_strings":["Institut de Physiologie et de Chimie Biologie, URA 1446 CNRS Neurophysiologie et Neurobiologie des Syst\u00e8mes Endocrines, Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Physiologie et de Chimie Biologie, URA 1446 CNRS Neurophysiologie et Neurobiologie des Syst\u00e8mes Endocrines, Strasbourg, France","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108418506","display_name":"Dominique Monnier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Dominique Monnier","raw_affiliation_strings":["Institut de Physiologie et de Chimie Biologie, URA 1446 CNRS Neurophysiologie et Neurobiologie des Syst\u00e8mes Endocrines, Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Physiologie et de Chimie Biologie, URA 1446 CNRS Neurophysiologie et Neurobiologie des Syst\u00e8mes Endocrines, Strasbourg, France","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111840779","display_name":"Bernard Koch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bernard Koch","raw_affiliation_strings":["Institut de Physiologie et de Chimie Biologie, URA 1446 CNRS Neurophysiologie et Neurobiologie des Syst\u00e8mes Endocrines, Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Physiologie et de Chimie Biologie, URA 1446 CNRS Neurophysiologie et Neurobiologie des Syst\u00e8mes Endocrines, Strasbourg, France","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046468115","display_name":"Jean\u2010Philippe Loeffler","orcid":"https://orcid.org/0000-0003-0166-5496","observed_orcids":["https://orcid.org/0000-0003-0166-5496"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philippe Loeffler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.722,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.64349929,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"60","issue":"5","first_page":"493","last_page":"502"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pituitary-adenylate-cyclase-activating-peptide","display_name":"pituitary adenylate cyclase-activating peptide","score":0.9620000123977661},{"id":"https://openalex.org/keywords/proopiomelanocortin","display_name":"proopiomelanocortin","score":0.9490000009536743},{"id":"https://openalex.org/keywords/acth-secretion","display_name":"ACTH secretion","score":0.8159999847412109},{"id":"https://openalex.org/keywords/att-20-cells","display_name":"AtT-20 cells","score":0.9490000009536743},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.7239999771118164},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.9710000157356262},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.7919999957084656},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9509999752044678},{"id":"https://openalex.org/keywords/rolipram","display_name":"rolipram","score":0.8109999895095825},{"id":"https://openalex.org/keywords/camp-response-element","display_name":"cAMP response element","score":0.7570000290870667},{"id":"https://openalex.org/keywords/hypophysiotropic-hormones","display_name":"hypophysiotropic hormones","score":0.7950000166893005},{"id":"https://openalex.org/keywords/corticotropin-releasing-factor","display_name":"corticotropin-releasing factor","score":0.9779999852180481}],"concepts":[{"id":"https://openalex.org/C2781309135","wikidata":"https://www.wikidata.org/wiki/Q418896","display_name":"Proopiomelanocortin","level":3,"score":0.9565422534942627},{"id":"https://openalex.org/C2779993316","wikidata":"https://www.wikidata.org/wiki/Q6591465","display_name":"Melanocortin","level":3,"score":0.7943935394287109},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7828959822654724},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7670011520385742},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5063132047653198},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.4686514735221863},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45100393891334534},{"id":"https://openalex.org/C2778491484","wikidata":"https://www.wikidata.org/wiki/Q922411","display_name":"Hypopituitarism","level":2,"score":0.4269680380821228},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4196361303329468},{"id":"https://openalex.org/C56191518","wikidata":"https://www.wikidata.org/wiki/Q416997","display_name":"Peptide hormone","level":3,"score":0.4160807430744171},{"id":"https://openalex.org/C2777658017","wikidata":"https://www.wikidata.org/wiki/Q156871","display_name":"Pituitary gland","level":3,"score":0.4129076600074768},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4104993939399719},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36041519045829773},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3033197224140167},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1361936628818512},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12850356101989746},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07106533646583557}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000324","descriptor_name":"Adrenocorticotropic Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010911","descriptor_name":"Pituitary Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011333","descriptor_name":"Pro-Opiomelanocortin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011333","descriptor_name":"Pro-Opiomelanocortin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012045","descriptor_name":"Regulatory Sequences, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015500","descriptor_name":"Chloramphenicol O-Acetyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051219","descriptor_name":"Pituitary Adenylate Cyclase-Activating Polypeptide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000126786","doi":"https://doi.org/10.1159/000126786","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000126786","pdf_url":null,"source":{"id":"https://openalex.org/S84102376","display_name":"Neuroendocrinology","issn_l":"0028-3835","issn":["0028-3835","1423-0194"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroendocrinology","raw_type":"journal-article"},{"id":"pmid:7845539","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7845539","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroendocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2145054067","https://openalex.org/W7095393657","https://openalex.org/W1966809567","https://openalex.org/W2000181594","https://openalex.org/W2091571505","https://openalex.org/W1990189762","https://openalex.org/W2042641385","https://openalex.org/W2078243645","https://openalex.org/W1982565891","https://openalex.org/W1965135980"],"abstract_inverted_index":{"The":[0,57],"biological":[1],"effects":[2,59],"of":[3,28,60,140,147,154,166],"pituitary":[4],"adenylate":[5],"cyclase-activating":[6],"peptide":[7,13],"(PACAP)":[8],"27":[9],"and":[10,15,42,84],"38":[11],"on":[12,156,200],"secretion":[14],"gene":[16,69,115],"regulation":[17],"were":[18,62],"studied":[19],"in":[20,39,45],"the":[21,46,85,95,117,132,152,163,173],"mouse":[22],"corticotrope-derived":[23],"cell":[24],"line":[25],"AtT20.":[26],"Treatment":[27],"these":[29,180],"cells":[30,91],"with":[31,48,94],"PACAP":[32,61,77,122,155,169,184],"27/38":[33,78],"led":[34],"to":[35,54],"a":[36,67,71,113,143,186],"dose-dependent":[37],"increase":[38],"cAMP":[40,72],"content":[41],"ACTH":[43],"accumulation":[44],"medium":[47],"an":[49],"apparent":[50],"ED50":[51],"value":[52],"close":[53],"10(-9)":[55],"M.":[56],"genomic":[58],"first":[63],"investigated":[64],"by":[65,102,111,131,142,168,172],"using":[66,112],"reporter":[68,114],"containing":[70,116],"responsive":[73],"element":[74],"(CRE:":[75],"TGACGTCA)":[76],"stimulate":[79],"transcription":[80],"from":[81],"this":[82,148],"construction":[83],"effect":[86,153],"is":[87,129,170,185],"further":[88],"increased":[89],"when":[90],"are":[92],"cotreated":[93],"phosphodiesterase":[96],"inhibitor":[97],"rolipram.":[98],"Furthermore,":[99],"we":[100,160],"show":[101,161],"measuring":[103],"nuclear":[104],"heterologous":[105],"proopiomelanocortin":[106],"(POMC)":[107],"RNA":[108],"levels":[109],"or":[110],"POMC":[118,124,157,167],"promoter":[119],"region,":[120],"that":[121,162,183,189],"stimulates":[123],"transcription.":[125,158],"This":[126],"transcriptional":[127,164],"stimulation":[128,165],"mediated":[130],"cAMP-dependent":[133],"protein":[134],"kinase":[135],"(PKA)":[136],"since":[137],"genetic":[138],"inactivation":[139],"PKA":[141],"dominant":[144],"inhibitory":[145],"mutant":[146],"enzyme":[149],"completely":[150],"abolished":[151],"Finally,":[159],"repressed":[171],"glucocorticoid":[174],"receptor":[175],"agonist":[176],"dexamethasone.":[177],"Taken":[178],"together,":[179],"data":[181],"suggest":[182],"hypophysiotropic":[187],"hormone":[188,198],"exert":[190],"similar":[191],"if":[192],"not":[193],"identical":[194],"functions":[195],"as":[196],"corticotropin-releasing":[197],"(CRH)":[199],"corticotrope":[201],"cells.":[202]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}