{"id":"https://openalex.org/W2013161595","doi":"https://doi.org/10.1016/0198-8859(93)90142-n","title":"HLA-DR\u03b2 chain residues that are predicted to be located in the floor of the peptide-binding groove contribute to antibody-binding epitopes","display_name":"HLA-DR\u03b2 chain residues that are predicted to be located in the floor of the peptide-binding groove contribute to antibody-binding epitopes","publication_year":1993,"publication_date":"1993-05-01","ids":{"openalex":"https://openalex.org/W2013161595","doi":"https://doi.org/10.1016/0198-8859(93)90142-n","mag":"2013161595","pmid":"https://pubmed.ncbi.nlm.nih.gov/7690741"},"language":"en","primary_location":{"id":"doi:10.1016/0198-8859(93)90142-n","doi":"https://doi.org/10.1016/0198-8859(93)90142-n","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0198-8859(93)90142-n","pdf_url":null,"source":{"id":"https://openalex.org/S6860681","display_name":"Human Immunology","issn_l":"0198-8859","issn":["0198-8859","1879-1166"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088117123","display_name":"Ellen Klohe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210135841","display_name":"Iowa City VA Medical Center","ror":"https://ror.org/03r9k1585","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210132647","https://openalex.org/I4210135841","https://openalex.org/I4210159720"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellen Klohe","raw_affiliation_strings":["Department of Veterans Affairs Medical Center, Iowa City, Iowa","Department of Veterans Affairs Medical Center and the Department of Internal Medicine, University of Iowa College of Medicine Iowa City, Iowa, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterans Affairs Medical Center, Iowa City, Iowa","institution_ids":["https://openalex.org/I4210135841"]},{"raw_affiliation_string":"Department of Veterans Affairs Medical Center and the Department of Internal Medicine, University of Iowa College of Medicine Iowa City, Iowa, USA","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210135841"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xin-ting Fu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210135841","display_name":"Iowa City VA Medical Center","ror":"https://ror.org/03r9k1585","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210132647","https://openalex.org/I4210135841","https://openalex.org/I4210159720"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin-ting Fu","raw_affiliation_strings":["Department of Veterans Affairs Medical Center and the Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterans Affairs Medical Center and the Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa, USA","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210135841"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000309481","display_name":"Manfred Ballas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I2801931480","display_name":"German Red Cross","ror":"https://ror.org/02y3dtg29","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801931480"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Manfred Ballas","raw_affiliation_strings":["Department of Transplantation Immunology, Red Cross Blood Bank and the Department of Transfusion Medicine, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Transplantation Immunology, Red Cross Blood Bank and the Department of Transfusion Medicine, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I2801931480"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049654907","display_name":"Robert W. Karr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210135841","display_name":"Iowa City VA Medical Center","ror":"https://ror.org/03r9k1585","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210132647","https://openalex.org/I4210135841","https://openalex.org/I4210159720"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert W. Karr","raw_affiliation_strings":["Department of Veterans Affairs Medical Center and the Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterans Affairs Medical Center and the Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa, USA","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210135841"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5049654907"],"corresponding_institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210135841"],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":0.9802,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.72852596,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"37","issue":"1","first_page":"51","last_page":"58"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hla-dr-beta-chain","display_name":"HLA-DR beta chain","score":0.8759999871253967},{"id":"https://openalex.org/keywords/hla-drw52","display_name":"HLA-DRw52","score":0.8880000114440918},{"id":"https://openalex.org/keywords/antibody-epitopes","display_name":"antibody epitopes","score":0.8500000238418579},{"id":"https://openalex.org/keywords/peptide-binding-groove","display_name":"peptide binding groove","score":0.871999979019165},{"id":"https://openalex.org/keywords/alpha-helix","display_name":"alpha-helix","score":0.5339999794960022},{"id":"https://openalex.org/keywords/solvent-accessible-surface","display_name":"solvent accessible surface","score":0.7900000214576721},{"id":"https://openalex.org/keywords/hla-class-ii","display_name":"HLA class II","score":0.4729999899864197},{"id":"https://openalex.org/keywords/epitope-mapping","display_name":"epitope mapping","score":0.5910000205039978},{"id":"https://openalex.org/keywords/amino-acid-substitutions","display_name":"amino acid substitutions","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.7995903491973877},{"id":"https://openalex.org/C2779472054","wikidata":"https://www.wikidata.org/wiki/Q2377973","display_name":"Groove (engineering)","level":2,"score":0.7882457971572876},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6165976524353027},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.585782527923584},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5321342945098877},{"id":"https://openalex.org/C84613547","wikidata":"https://www.wikidata.org/wiki/Q17037912","display_name":"Heavy chain","level":3,"score":0.42347198724746704},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.42150068283081055},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42074090242385864},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3643668591976166},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31378602981567383},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2610603868961334},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24013623595237732},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.22800219058990479},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.06731283664703369},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001666","descriptor_name":"Binding Sites, Antibody","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006684","descriptor_name":"HLA-DR Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006684","descriptor_name":"HLA-DR Antigens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0198-8859(93)90142-n","doi":"https://doi.org/10.1016/0198-8859(93)90142-n","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0198-8859(93)90142-n","pdf_url":null,"source":{"id":"https://openalex.org/S6860681","display_name":"Human Immunology","issn_l":"0198-8859","issn":["0198-8859","1879-1166"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Immunology","raw_type":"journal-article"},{"id":"pmid:7690741","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7690741","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.46810001134872437,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7567427","display_name":"CORE CENTER--DIABETES AND ENDOCRINOLOGY","funder_award_id":"P30DK025295","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7942606083","display_name":"MOLECULAR CLONING OF THE DR7-ASSOCIATED IA GENES","funder_award_id":"R01AI024138","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320310223","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1483035379","https://openalex.org/W1512778880","https://openalex.org/W1524255723","https://openalex.org/W1552176172","https://openalex.org/W1553916036","https://openalex.org/W1561644389","https://openalex.org/W1566671100","https://openalex.org/W1577159905","https://openalex.org/W1735446002","https://openalex.org/W1910839921","https://openalex.org/W1913223397","https://openalex.org/W1918119607","https://openalex.org/W1949345268","https://openalex.org/W1965372133","https://openalex.org/W1971018049","https://openalex.org/W1973088414","https://openalex.org/W1983264215","https://openalex.org/W1987457781","https://openalex.org/W1993129154","https://openalex.org/W1998371945","https://openalex.org/W2002586862","https://openalex.org/W2003870859","https://openalex.org/W2011293221","https://openalex.org/W2019332302","https://openalex.org/W2037624920","https://openalex.org/W2046437067","https://openalex.org/W2056927502","https://openalex.org/W2058428642","https://openalex.org/W2060913542","https://openalex.org/W2065108029","https://openalex.org/W2071512798","https://openalex.org/W2074103669","https://openalex.org/W2077578546","https://openalex.org/W2081530158","https://openalex.org/W2099028937","https://openalex.org/W2111441225","https://openalex.org/W2121731183","https://openalex.org/W2128523355","https://openalex.org/W2130228082","https://openalex.org/W2151053360","https://openalex.org/W2171196230","https://openalex.org/W2278026865","https://openalex.org/W2531561153","https://openalex.org/W4299692183","https://openalex.org/W4313448311","https://openalex.org/W4322378205"],"related_works":["https://openalex.org/W1967985283","https://openalex.org/W1976763803","https://openalex.org/W1998371945","https://openalex.org/W2044557554","https://openalex.org/W1835297465","https://openalex.org/W1981008739","https://openalex.org/W1524255723","https://openalex.org/W2120661419","https://openalex.org/W1995907576","https://openalex.org/W2002586862"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
