{"id":"https://openalex.org/W2013159264","doi":"https://doi.org/10.1097/00006231-199601000-00014","title":"Radiochemical and radioimmunological data of 99Tcm-anti-CEA labelled by two diverse methods","display_name":"Radiochemical and radioimmunological data of 99Tcm-anti-CEA labelled by two diverse methods","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W2013159264","doi":"https://doi.org/10.1097/00006231-199601000-00014","mag":"2013159264","pmid":"https://pubmed.ncbi.nlm.nih.gov/8692479"},"language":"en","primary_location":{"id":"doi:10.1097/00006231-199601000-00014","doi":"https://doi.org/10.1097/00006231-199601000-00014","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00006231-199601000-00014","pdf_url":null,"source":{"id":"https://openalex.org/S108023290","display_name":"Nuclear Medicine Communications","issn_l":"0143-3636","issn":["0143-3636","1473-5628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nuclear Medicine Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041204996","display_name":"Alexandra D. Varvarigou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203474044","display_name":"National Centre of Scientific Research \"Demokritos\"","ror":"https://ror.org/038jp4m40","country_code":"GR","type":"facility","lineage":["https://openalex.org/I203474044"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"A. D. VARVARIGOU","raw_affiliation_strings":["Institute of Radiodiagnostics, National Centre for Scientific Research Demokritos, Aghia Paraskevi Attikis, Greece","Institute of Radiodiagnostics, National Centre for Scientific Research 'Demokritos', PO Box 60228, Aghia Paraskevi Attikis 15310 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Radiodiagnostics, National Centre for Scientific Research Demokritos, Aghia Paraskevi Attikis, Greece","institution_ids":["https://openalex.org/I203474044"]},{"raw_affiliation_string":"Institute of Radiodiagnostics, National Centre for Scientific Research 'Demokritos', PO Box 60228, Aghia Paraskevi Attikis 15310 and","institution_ids":["https://openalex.org/I203474044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5096863438","display_name":"S. C. ARCHIMANDRITE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203474044","display_name":"National Centre of Scientific Research \"Demokritos\"","ror":"https://ror.org/038jp4m40","country_code":"GR","type":"facility","lineage":["https://openalex.org/I203474044"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"S. C. ARCHIMANDRITE","raw_affiliation_strings":["Institute of Radiodiagnostics, National Centre for Scientific Research 'Demokritos', PO Box 60228, Aghia Paraskevi Attikis 15310 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Radiodiagnostics, National Centre for Scientific Research 'Demokritos', PO Box 60228, Aghia Paraskevi Attikis 15310 and","institution_ids":["https://openalex.org/I203474044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028048836","display_name":"Kalliope E. Sekeri\u2010Pataryas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203474044","display_name":"National Centre of Scientific Research \"Demokritos\"","ror":"https://ror.org/038jp4m40","country_code":"GR","type":"facility","lineage":["https://openalex.org/I203474044"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"K. SEKERI-PATARYAS","raw_affiliation_strings":["Institute of Radiodiagnostics, National Centre for Scientific Research 'Demokritos', PO Box 60228, Aghia Paraskevi Attikis 15310 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Radiodiagnostics, National Centre for Scientific Research 'Demokritos', PO Box 60228, Aghia Paraskevi Attikis 15310 and","institution_ids":["https://openalex.org/I203474044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018949280","display_name":"Thomae G. Sourlingas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203474044","display_name":"National Centre of Scientific Research \"Demokritos\"","ror":"https://ror.org/038jp4m40","country_code":"GR","type":"facility","lineage":["https://openalex.org/I203474044"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"T. G. SOURLINGAS","raw_affiliation_strings":["Institute of Radiodiagnostics, National Centre for Scientific Research 'Demokritos', PO Box 60228, Aghia Paraskevi Attikis 15310 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Radiodiagnostics, National Centre for Scientific Research 'Demokritos', PO Box 60228, Aghia Paraskevi Attikis 15310 and","institution_ids":["https://openalex.org/I203474044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029346532","display_name":"Gregory B. Sivolapenko","orcid":"https://orcid.org/0000-0003-2388-362X","observed_orcids":["https://orcid.org/0000-0003-2388-362X","https://orcid.org/0000-0002-2575-3565"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. SIVOLAPENKO","raw_affiliation_strings":["'Encephalos' Diagnostics and Therapeutics Institute, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"'Encephalos' Diagnostics and Therapeutics Institute, Athens, Greece","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091335874","display_name":"Ekaterine Paschali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203474044","display_name":"National Centre of Scientific Research \"Demokritos\"","ror":"https://ror.org/038jp4m40","country_code":"GR","type":"facility","lineage":["https://openalex.org/I203474044"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"E. PASCHALI","raw_affiliation_strings":["Institute of Radiodiagnostics, National Centre for Scientific Research 'Demokritos', PO Box 60228, Aghia Paraskevi Attikis 15310 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Radiodiagnostics, National Centre for Scientific Research 'Demokritos', PO Box 60228, Aghia Paraskevi Attikis 15310 and","institution_ids":["https://openalex.org/I203474044"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1255,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.77206995,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"17","issue":"1","first_page":"80","last_page":"88"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13561","display_name":"Chemical Reactions and Isotopes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/technetium-99m","display_name":"technetium-99m","score":0.9240000247955322},{"id":"https://openalex.org/keywords/anti-cea-monoclonal-antibody","display_name":"anti-CEA monoclonal antibody","score":0.9269999861717224},{"id":"https://openalex.org/keywords/antibody-labeling","display_name":"antibody labeling","score":0.7070000171661377},{"id":"https://openalex.org/keywords/2-mercaptoethanol-reduction","display_name":"2-mercaptoethanol reduction","score":0.9380000233650208},{"id":"https://openalex.org/keywords/2-iminothiolane","display_name":"2-iminothiolane","score":0.9200000166893005},{"id":"https://openalex.org/keywords/antibody-stability","display_name":"antibody stability","score":0.7110000252723694},{"id":"https://openalex.org/keywords/tumour-cell-targeting","display_name":"tumour cell targeting","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C2780523633","wikidata":"https://www.wikidata.org/wiki/Q380709","display_name":"Labelling","level":2,"score":0.9438981413841248},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8344006538391113},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.606870710849762},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5627444386482239},{"id":"https://openalex.org/C177322064","wikidata":"https://www.wikidata.org/wiki/Q750955","display_name":"Radiochemistry","level":1,"score":0.5517117381095886},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4383798837661743},{"id":"https://openalex.org/C522557706","wikidata":"https://www.wikidata.org/wiki/Q1054","display_name":"Technetium","level":2,"score":0.4238792955875397},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4063226580619812},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3241194486618042},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.13981184363365173},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1145969033241272},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08692747354507446},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002272","descriptor_name":"Carcinoembryonic Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007202","descriptor_name":"Indicators and Reagents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007553","descriptor_name":"Isotope Labeling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013667","descriptor_name":"Technetium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00006231-199601000-00014","doi":"https://doi.org/10.1097/00006231-199601000-00014","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00006231-199601000-00014","pdf_url":null,"source":{"id":"https://openalex.org/S108023290","display_name":"Nuclear Medicine Communications","issn_l":"0143-3636","issn":["0143-3636","1473-5628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nuclear Medicine Communications","raw_type":"journal-article"},{"id":"pmid:8692479","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8692479","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nuclear medicine communications","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4298064385","https://openalex.org/W2380725795","https://openalex.org/W2064453375","https://openalex.org/W2036549718","https://openalex.org/W2030924957","https://openalex.org/W1997956196","https://openalex.org/W2411167839","https://openalex.org/W2183858021","https://openalex.org/W2396763205","https://openalex.org/W2386688995"],"abstract_inverted_index":{"The":[0,64],"aim":[1],"of":[2,11,21,37,69,78,85,93],"this":[3],"study":[4],"was":[5,48,59,101],"to":[6,50,95],"make":[7],"a":[8,12,55,111],"comparative":[9],"evaluation":[10],"direct":[13,28],"and":[14,66,115,119,125],"an":[15],"indirect":[16,44],"method":[17],"for":[18,61,103,139],"the":[19,27,35,43,46,70,76,79,83,91,104,131,140],"labelling":[20,80,106,113],"anti-CEA":[22],"with":[23,42],"technetium-99m":[24],"(99Tcm).":[25],"With":[26],"method,":[29,45],"disulphide":[30],"bridges":[31],"were":[32,73],"cleaved":[33],"by":[34],"use":[36],"2-mercaptoethanol":[38,141],"as":[39,88,90,128,130],"reductant,":[40],"whereas":[41],"antibody":[47],"coupled":[49],"2-iminothiolane.":[51],"In":[52],"both":[53],"cases,":[54],"preformed":[56],"intermediate":[57],"chelate":[58],"used":[60],"99Tcm":[62],"exchange.":[63],"radiochemical":[65,126],"radiobiological":[67],"behaviour":[68],"99Tcm-labelled":[71],"species":[72],"studied.":[74],"Furthermore,":[75],"influence":[77],"systems":[81],"on":[82],"integrity":[84],"monoclonal":[86],"antibodies,":[87],"well":[89,129],"ability":[92],"99Tcm-anti-CEA":[94],"tag":[96],"onto":[97],"human":[98],"cancer":[99],"cells,":[100],"investigated":[102],"two":[105],"systems.":[107],"Both":[108],"methods":[109],"showed":[110],"high":[112],"yield":[114],"resulted":[116],"in":[117],"immunoreactive":[118],"stable":[120],"derivatives.":[121],"However,":[122],"detailed":[123],"electrophoretical":[124],"data,":[127],"cysteine":[132],"challenge":[133],"trial,":[134],"indicated":[135],"relatively":[136],"greater":[137],"stability":[138],"reduction":[142],"procedure.":[143]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
