{"id":"https://openalex.org/W2013144840","doi":"https://doi.org/10.1177/154405910308200202","title":"Resolution of Inflammation: A New Paradigm for the Pathogenesis of Periodontal Diseases","display_name":"Resolution of Inflammation: A New Paradigm for the Pathogenesis of Periodontal Diseases","publication_year":2003,"publication_date":"2003-02-01","ids":{"openalex":"https://openalex.org/W2013144840","doi":"https://doi.org/10.1177/154405910308200202","mag":"2013144840","pmid":"https://pubmed.ncbi.nlm.nih.gov/12562878"},"language":"en","primary_location":{"id":"doi:10.1177/154405910308200202","doi":"https://doi.org/10.1177/154405910308200202","is_oa":false,"landing_page_url":"https://doi.org/10.1177/154405910308200202","pdf_url":null,"source":{"id":"https://openalex.org/S62865007","display_name":"Journal of Dental Research","issn_l":"0022-0345","issn":["0022-0345","1544-0591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Dental Research","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014230085","display_name":"Thomas E. Van Dyke","orcid":"https://orcid.org/0000-0003-0568-124X","observed_orcids":["https://orcid.org/0000-0003-0568-124X"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. E. Van Dyke","raw_affiliation_strings":["Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115;","Department of Periodontology and Oral Biology, Boston University, Goldman School of Dental Medicine, 100 East Newton Street, Boston, MA 02118; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115;","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Periodontology and Oral Biology, Boston University, Goldman School of Dental Medicine, 100 East Newton Street, Boston, MA 02118; and","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029525374","display_name":"Charles Nicholas Serhan","orcid":"https://orcid.org/0000-0003-4627-8545","observed_orcids":["https://orcid.org/0000-0003-4627-8545"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C.N. Serhan","raw_affiliation_strings":["Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115","Department of Periodontology and Oral Biology, Boston University, Goldman School of Dental Medicine, 100 East Newton Street, Boston, MA 02118; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Periodontology and Oral Biology, Boston University, Goldman School of Dental Medicine, 100 East Newton Street, Boston, MA 02118; and","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":5.3866,"has_fulltext":false,"cited_by_count":511,"citation_normalized_percentile":{"value":1.0,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"82","issue":"2","first_page":"82","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.02019999921321869,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/resolution-of-inflammation","display_name":"inflammation resolution","score":0.9369999766349792},{"id":"https://openalex.org/keywords/periodontitis","display_name":"periodontitis","score":0.8980000019073486},{"id":"https://openalex.org/keywords/periodontal-disease-pathogenesis","display_name":"periodontal disease pathogenesis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.9649999737739563},{"id":"https://openalex.org/keywords/lipoxins","display_name":"lipoxins","score":0.8479999899864197},{"id":"https://openalex.org/keywords/prostaglandins","display_name":"prostaglandins","score":0.9980000257492065},{"id":"https://openalex.org/keywords/leukotrienes","display_name":"leukotrienes","score":0.9990000128746033},{"id":"https://openalex.org/keywords/inflammation-modulation","display_name":"inflammation modulation","score":0.621999979019165},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.8526767492294312},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7923218011856079},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.7144179344177246},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6448526382446289},{"id":"https://openalex.org/C2994443828","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Host response","level":3,"score":0.542332649230957},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48208075761795044},{"id":"https://openalex.org/C3020196126","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammatory response","level":3,"score":0.4404960572719574},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.4309336841106415},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3970830738544464},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001093","descriptor_name":"Arachidonate 15-Lipoxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006893","descriptor_name":"Hydroxyeicosatetraenoic Acids","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D006893","descriptor_name":"Hydroxyeicosatetraenoic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011453","descriptor_name":"Prostaglandins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015289","descriptor_name":"Leukotrienes","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018375","descriptor_name":"Neutrophil Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044045","descriptor_name":"Lipoxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1177/154405910308200202","doi":"https://doi.org/10.1177/154405910308200202","is_oa":false,"landing_page_url":"https://doi.org/10.1177/154405910308200202","pdf_url":null,"source":{"id":"https://openalex.org/S62865007","display_name":"Journal of Dental Research","issn_l":"0022-0345","issn":["0022-0345","1544-0591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Dental Research","raw_type":"journal-article"},{"id":"pmid:12562878","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12562878","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of dental research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.502.946","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.502.946","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jdr.sagepub.com/content/82/2/82.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5413099037","display_name":"MOLECULAR MECHANISMS IN LEUKOCYTE-MEDIATED TISSUE INJURY","funder_award_id":"P01DE013499","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":91,"referenced_works":["https://openalex.org/W140981747","https://openalex.org/W310140967","https://openalex.org/W402711438","https://openalex.org/W1497700962","https://openalex.org/W1508470956","https://openalex.org/W1521799099","https://openalex.org/W1546975150","https://openalex.org/W1558560534","https://openalex.org/W1565755899","https://openalex.org/W1601002338","https://openalex.org/W1773327886","https://openalex.org/W1834117453","https://openalex.org/W1869980306","https://openalex.org/W1966143034","https://openalex.org/W1966274839","https://openalex.org/W1967032130","https://openalex.org/W1974066136","https://openalex.org/W1976296292","https://openalex.org/W1976485820","https://openalex.org/W1982763176","https://openalex.org/W1986483382","https://openalex.org/W1988169047","https://openalex.org/W1989070839","https://openalex.org/W1989227796","https://openalex.org/W1989856248","https://openalex.org/W1990873626","https://openalex.org/W1998377876","https://openalex.org/W1999976727","https://openalex.org/W2009033177","https://openalex.org/W2011735944","https://openalex.org/W2012967151","https://openalex.org/W2014518284","https://openalex.org/W2016870714","https://openalex.org/W2016878697","https://openalex.org/W2020756182","https://openalex.org/W2024176341","https://openalex.org/W2035007443","https://openalex.org/W2035256366","https://openalex.org/W2037179116","https://openalex.org/W2045825531","https://openalex.org/W2045962676","https://openalex.org/W2053481310","https://openalex.org/W2053972308","https://openalex.org/W2054798367","https://openalex.org/W2056570539","https://openalex.org/W2059429399","https://openalex.org/W2063973431","https://openalex.org/W2065139852","https://openalex.org/W2065376096","https://openalex.org/W2065803353","https://openalex.org/W2068210705","https://openalex.org/W2069967627","https://openalex.org/W2070579108","https://openalex.org/W2070609164","https://openalex.org/W2071201771","https://openalex.org/W2072796605","https://openalex.org/W2076657256","https://openalex.org/W2078805812","https://openalex.org/W2079341705","https://openalex.org/W2079394877","https://openalex.org/W2080085786","https://openalex.org/W2086972104","https://openalex.org/W2087715055","https://openalex.org/W2091953555","https://openalex.org/W2096765413","https://openalex.org/W2098965240","https://openalex.org/W2106223276","https://openalex.org/W2109400519","https://openalex.org/W2120782801","https://openalex.org/W2129806307","https://openalex.org/W2133075832","https://openalex.org/W2135441296","https://openalex.org/W2136561424","https://openalex.org/W2139357620","https://openalex.org/W2149110454","https://openalex.org/W2152874793","https://openalex.org/W2154746915","https://openalex.org/W2155474314","https://openalex.org/W2156645056","https://openalex.org/W2159976029","https://openalex.org/W2162382352","https://openalex.org/W2169470519","https://openalex.org/W2174934515","https://openalex.org/W2318925269","https://openalex.org/W2410642808","https://openalex.org/W2428646202","https://openalex.org/W2443199170","https://openalex.org/W2897032515","https://openalex.org/W4210968828","https://openalex.org/W4214589643","https://openalex.org/W4239145975"],"related_works":["https://openalex.org/W1525541518","https://openalex.org/W2060975886","https://openalex.org/W4206748225","https://openalex.org/W7094999503","https://openalex.org/W2006496304","https://openalex.org/W2980243142","https://openalex.org/W1820232851","https://openalex.org/W1597826715","https://openalex.org/W1562573622","https://openalex.org/W4388621661"],"abstract_inverted_index":{"The":[0,128],"periodontal":[1,20,35],"diseases":[2,5,21,96,163],"are":[3,87,115],"infectious":[4,48],"caused":[6,38],"by":[7,39,46,117,121],"predominantly":[8],"Gram-negative":[9],"bacteria.":[10],"However,":[11],"as":[12,98,111,141],"our":[13],"understanding":[14],"of":[15,18,29,55,57,72,91,106,124,130,137,145,148,157],"the":[16,19,30,40,47,53,64,80,92,133,143,146,153],"pathogenesis":[17],"grows,":[22],"it":[23],"is":[24,37,139,142],"becoming":[25],"clear":[26],"that":[27,33,63,86],"most":[28],"tissue":[31,59,159],"damage":[32],"characterizes":[34],"disease":[36],"host":[41,73],"response":[42,94],"to":[43],"infection,":[44],"not":[45],"agent":[49],"directly.":[50],"Investigation":[51],"into":[52],"mechanism":[54],"action":[56],"host-mediated":[58],"injury":[60,160],"has":[61],"revealed":[62],"neutrophil":[65],"plays":[66],"an":[67],"important":[68],"role":[69,129],"in":[70,95,132,161],"destruction":[71],"tissues.":[74],"In":[75],"this":[76],"paper,":[77],"we":[78],"review":[79],"biochemical":[81],"pathways":[82],"and":[83,113,135,155],"molecular":[84],"mediators":[85,105],"responsible":[88],"for":[89,152],"regulation":[90],"inflammatory":[93,162],"such":[97,110],"periodontitis,":[99],"with":[100],"a":[101,122],"focus":[102],"on":[103],"lipid":[104],"inflammation.":[107],"Pro-inflammatory":[108],"mediators,":[109],"prostaglandins":[112],"leukotrienes,":[114],"balanced":[116],"counter-regulatory":[118],"signals":[119],"provided":[120],"class":[123],"molecules":[125],"called":[126],"lipoxins.":[127],"lipoxins":[131],"control":[134,154],"resolution":[136],"inflammation":[138],"discussed,":[140],"possibility":[144],"development":[147],"new":[149],"therapeutic":[150],"strategies":[151],"prevention":[156],"neutrophil-mediated":[158],"like":[164],"periodontitis.":[165]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":24},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":27},{"year":2018,"cited_by_count":20},{"year":2017,"cited_by_count":23},{"year":2016,"cited_by_count":20},{"year":2015,"cited_by_count":29},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":37},{"year":2012,"cited_by_count":22}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}