{"id":"https://openalex.org/W2013127663","doi":"https://doi.org/10.1210/endo-108-5-1639","title":"Effects of Rat Urinary Arginine Esterases on Rat Kidney to Release Renin*","display_name":"Effects of Rat Urinary Arginine Esterases on Rat Kidney to Release Renin*","publication_year":1981,"publication_date":"1981-05-01","ids":{"openalex":"https://openalex.org/W2013127663","doi":"https://doi.org/10.1210/endo-108-5-1639","mag":"2013127663","pmid":"https://pubmed.ncbi.nlm.nih.gov/6163623"},"language":"en","primary_location":{"id":"doi:10.1210/endo-108-5-1639","doi":"https://doi.org/10.1210/endo-108-5-1639","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-108-5-1639","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046929921","display_name":"Shin Suzuki","orcid":"https://orcid.org/0000-0002-5358-9619","observed_orcids":["https://orcid.org/0000-0002-5358-9619"]},"institutions":[{"id":"https://openalex.org/I12057038","display_name":"University of Toledo Medical Center","ror":"https://ror.org/01600wh70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I12057038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SHIN SUZUKI","raw_affiliation_strings":["Department of Medicine, Medical College of Ohio Toledo, Ohio 43699"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Medical College of Ohio Toledo, Ohio 43699","institution_ids":["https://openalex.org/I12057038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009106651","display_name":"Roberto Franco-Saenz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12057038","display_name":"University of Toledo Medical Center","ror":"https://ror.org/01600wh70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I12057038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ROBERTO FRANCO-SAENZ","raw_affiliation_strings":["Department of Medicine, Medical College of Ohio Toledo, Ohio 43699"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Medical College of Ohio Toledo, Ohio 43699","institution_ids":["https://openalex.org/I12057038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108203436","display_name":"Patrick J. Mulrow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12057038","display_name":"University of Toledo Medical Center","ror":"https://ror.org/01600wh70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I12057038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"PATRICK J. MULROW","raw_affiliation_strings":["Department of Medicine, Medical College of Ohio Toledo, Ohio 43699"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Medical College of Ohio Toledo, Ohio 43699","institution_ids":["https://openalex.org/I12057038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062999597","display_name":"Richard P. McPartland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12057038","display_name":"University of Toledo Medical Center","ror":"https://ror.org/01600wh70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I12057038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"RICHARD P. McPARTLAND","raw_affiliation_strings":["Department of Medicine, Medical College of Ohio Toledo, Ohio 43699"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Medical College of Ohio Toledo, Ohio 43699","institution_ids":["https://openalex.org/I12057038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048944115","display_name":"Dennis L. Sustarsic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12057038","display_name":"University of Toledo Medical Center","ror":"https://ror.org/01600wh70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I12057038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DENNIS SUSTARSIC","raw_affiliation_strings":["Department of Medicine, Medical College of Ohio Toledo, Ohio 43699"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Medical College of Ohio Toledo, Ohio 43699","institution_ids":["https://openalex.org/I12057038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023480786","display_name":"John P. Rapp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12057038","display_name":"University of Toledo Medical Center","ror":"https://ror.org/01600wh70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I12057038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JOHN P. RAPP","raw_affiliation_strings":["Department of Medicine, Medical College of Ohio Toledo, Ohio 43699"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Medical College of Ohio Toledo, Ohio 43699","institution_ids":["https://openalex.org/I12057038"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I12057038"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":1.9585,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.85569828,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"108","issue":"5","first_page":"1639","last_page":"1642"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.0333000011742115,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renin-secretion","display_name":"renin secretion","score":0.8130000233650208},{"id":"https://openalex.org/keywords/kallikrein","display_name":"kallikrein","score":0.8080000281333923},{"id":"https://openalex.org/keywords/renal-cortex","display_name":"renal cortex","score":0.7400000095367432},{"id":"https://openalex.org/keywords/renin-activation","display_name":"renin activation","score":0.8040000200271606},{"id":"https://openalex.org/keywords/soybean-trypsin-inhibitor","display_name":"soybean trypsin inhibitor","score":0.8840000033378601},{"id":"https://openalex.org/keywords/aprotinin","display_name":"aprotinin","score":0.7910000085830688},{"id":"https://openalex.org/keywords/rat-kidney","display_name":"rat kidney","score":0.3479999899864197}],"concepts":[{"id":"https://openalex.org/C52853521","wikidata":"https://www.wikidata.org/wiki/Q423285","display_name":"Kallikrein","level":3,"score":0.8160606622695923},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7220089435577393},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.7075339555740356},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6781048774719238},{"id":"https://openalex.org/C2777261171","wikidata":"https://www.wikidata.org/wiki/Q418750","display_name":"Esterase","level":3,"score":0.6560168266296387},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.6021813154220581},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5196996331214905},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.48148977756500244},{"id":"https://openalex.org/C163994747","wikidata":"https://www.wikidata.org/wiki/Q2916358","display_name":"Sephadex","level":3,"score":0.4472983181476593},{"id":"https://openalex.org/C138976137","wikidata":"https://www.wikidata.org/wiki/Q7201790","display_name":"Plasma renin activity","level":4,"score":0.4252707362174988},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3737099766731262},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30705156922340393},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1957750916481018},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13011088967323303},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0447714626789093}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002265","descriptor_name":"Carboxylic Ester Hydrolases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002265","descriptor_name":"Carboxylic Ester Hydrolases","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007611","descriptor_name":"Aprotinin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007672","descriptor_name":"Kidney Cortex","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012083","descriptor_name":"Renin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014360","descriptor_name":"Trypsin Inhibitor, Kunitz Soybean","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/endo-108-5-1639","doi":"https://doi.org/10.1210/endo-108-5-1639","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-108-5-1639","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:6163623","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6163623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1482593346","https://openalex.org/W1977311294","https://openalex.org/W1984641842","https://openalex.org/W2048323907","https://openalex.org/W2049237461","https://openalex.org/W2060302745","https://openalex.org/W2062427601","https://openalex.org/W2063571166","https://openalex.org/W2067488428","https://openalex.org/W2071426158","https://openalex.org/W2071830179","https://openalex.org/W2120069566","https://openalex.org/W2311052739","https://openalex.org/W2330731689","https://openalex.org/W2346245295","https://openalex.org/W2408956696","https://openalex.org/W2422214923"],"related_works":["https://openalex.org/W2048323907","https://openalex.org/W2073345894","https://openalex.org/W2132910304","https://openalex.org/W2006490271","https://openalex.org/W7095874329","https://openalex.org/W1024032912","https://openalex.org/W2160511082","https://openalex.org/W2334279307","https://openalex.org/W2031491105","https://openalex.org/W2011619860"],"abstract_inverted_index":{"Urinary":[0],"kallikrein":[1,18,98,138],"has":[2],"been":[3],"reported":[4],"to":[5,33,77,90,171],"activate":[6],"human":[7],"plasma":[8],"inactive":[9],"renin.":[10],"Our":[11],"previous":[12],"report":[13],"suggests":[14],"that":[15,91],"rat":[16,23,41,70,78,93],"urinary":[17,94,97],"releases":[19],"active":[20],"renin":[21,58,100,115,127,143,152,180,193],"from":[22,59,68],"renal":[24,79],"cortical":[25,80],"slices.":[26,81],"Recently,":[27],"McPartland":[28],"et":[29],"al.":[30],"were":[31,66],"able":[32],"separate":[34],"the":[35,60,162,188,195],"A":[36],"esterase":[37,122,140,150,173],"activity":[38],"of":[39,85,92,159,161,179,192],"male":[40,69],"urine":[42,54,71],"into":[43],"two":[44],"components:":[45],"A1":[46,63,123,163],"and":[47,64,75,139,157,164,182,190],"A2.":[48],"To":[49],"evaluate":[50],"whether":[51],"these":[52,86],"other":[53],"arginine":[55],"esterases":[56,62,166],"release":[57,101,116,128,181,189],"kidney,":[61],"A2":[65,112,141,165,174],"isolated":[67],"using":[72],"DEAE-Sephadex":[73],"chromatography":[74],"superfused":[76],"The":[82,154],"renin-stimulating":[83],"action":[84],"enzymes":[87],"was":[88],"compared":[89],"kallikrein.":[95],"Rat":[96],"stimulated":[99,114,142],"in":[102,194],"a":[103,176],"dose-dependent":[104],"fashion":[105],"between":[106,118,131],"70--140":[107,132],"milliesterase":[108],"units":[109],"(mEU)/ml.":[110],"Esterase":[111],"dose":[113],"significantly":[117],"120--140":[119],"mEU/ml.":[120,133],"However,":[121,169],"did":[124],"not":[125],"stimulate":[126],"at":[129],"concentrations":[130],"Although":[134],"Trasylol":[135],"completely":[136],"abolished":[137],"release,":[144],"soybean":[145],"trypsin":[146],"inhibitor":[147],"blocked":[148],"only":[149],"A2-stimulated":[151],"release.":[153],"physiological":[155],"role":[156],"site":[158],"origin":[160],"is":[167,175],"unknown.":[168],"similar":[170],"kallikrein,":[172],"potent":[177],"stimulator":[178],"may":[183],"be":[184],"physiologically":[185],"important":[186],"for":[187],"activation":[191],"kidney.":[196]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}