{"id":"https://openalex.org/W2013107168","doi":"https://doi.org/10.1074/jbc.m609578200","title":"SOX9 Regulates Prostaglandin D Synthase Gene Transcription in Vivo to Ensure Testis Development","display_name":"SOX9 Regulates Prostaglandin D Synthase Gene Transcription in Vivo to Ensure Testis Development","publication_year":2007,"publication_date":"2007-02-04","ids":{"openalex":"https://openalex.org/W2013107168","doi":"https://doi.org/10.1074/jbc.m609578200","mag":"2013107168","pmid":"https://pubmed.ncbi.nlm.nih.gov/17277314"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m609578200","doi":"https://doi.org/10.1074/jbc.m609578200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m609578200","pdf_url":"http://www.jbc.org/article/S0021925819577298/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2013107168"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819577298/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044931412","display_name":"Dagmar Wilhelm","orcid":"https://orcid.org/0000-0002-7757-4075","observed_orcids":["https://orcid.org/0000-0002-7757-4075"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Dagmar Wilhelm","raw_affiliation_strings":["Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld 4072, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld 4072, Australia","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032945586","display_name":"Ryuji Hiramatsu","orcid":"https://orcid.org/0000-0003-2217-6261","observed_orcids":["https://orcid.org/0000-0003-2217-6261"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryuji Hiramatsu","raw_affiliation_strings":["Department of Veterinary Anatomy, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Anatomy, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109814647","display_name":"Hirofumi Mizusaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Hirofumi Mizusaki","raw_affiliation_strings":["Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld 4072, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld 4072, Australia","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075929700","display_name":"Laura Widjaja","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Laura Widjaja","raw_affiliation_strings":["Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld 4072, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld 4072, Australia","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071979633","display_name":"Alexander N. Combes","orcid":"https://orcid.org/0000-0001-6008-8786","observed_orcids":["https://orcid.org/0000-0001-6008-8786"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Alexander N. Combes","raw_affiliation_strings":["Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld 4072, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld 4072, Australia","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032337640","display_name":"Yoshiakira Kanai","orcid":"https://orcid.org/0000-0003-2116-7806","observed_orcids":["https://orcid.org/0000-0003-2116-7806"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiakira Kanai","raw_affiliation_strings":["Department of Veterinary Anatomy, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Anatomy, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039506361","display_name":"Peter A. Koopman","orcid":"https://orcid.org/0000-0001-6939-0914","observed_orcids":["https://orcid.org/0000-0001-6939-0914"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Peter Koopman","raw_affiliation_strings":["ARC Centre of Excellence in Biotechnology and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld 4072, Australia","Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld 4072, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ARC Centre of Excellence in Biotechnology and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld 4072, Australia","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]},{"raw_affiliation_string":"Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld 4072, Australia","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5039506361"],"corresponding_institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":8.7329,"has_fulltext":true,"cited_by_count":239,"citation_normalized_percentile":{"value":0.98748457,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"282","issue":"14","first_page":"10553","last_page":"10560"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.9291999936103821,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.9291999936103821,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.06030000001192093,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sox9","display_name":"SOX9","score":0.8769999742507935},{"id":"https://openalex.org/keywords/prostaglandin-d-synthase","display_name":"prostaglandin D synthase","score":0.9150000214576721},{"id":"https://openalex.org/keywords/testicular-development","display_name":"testicular development","score":0.8330000042915344},{"id":"https://openalex.org/keywords/sertoli-cells","display_name":"Sertoli cells","score":0.8769999742507935},{"id":"https://openalex.org/keywords/sry","display_name":"SRY","score":0.7620000243186951},{"id":"https://openalex.org/keywords/male-sex-determination","display_name":"male sex determination","score":0.6840000152587891},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7450000047683716},{"id":"https://openalex.org/keywords/promoter-transactivation","display_name":"promoter transactivation","score":0.6859999895095825},{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C73456138","wikidata":"https://www.wikidata.org/wiki/Q409114","display_name":"Testis determining factor","level":4,"score":0.9750498533248901},{"id":"https://openalex.org/C2781068068","wikidata":"https://www.wikidata.org/wiki/Q195614","display_name":"Sertoli cell","level":3,"score":0.8296030163764954},{"id":"https://openalex.org/C2778486617","wikidata":"https://www.wikidata.org/wiki/Q18031654","display_name":"SOX9","level":4,"score":0.8114215135574341},{"id":"https://openalex.org/C77390185","wikidata":"https://www.wikidata.org/wiki/Q17927898","display_name":"FGF9","level":4,"score":0.7742456793785095},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7110967636108398},{"id":"https://openalex.org/C2780246931","wikidata":"https://www.wikidata.org/wiki/Q202771","display_name":"Y chromosome","level":3,"score":0.5349582433700562},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.4824410080909729},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4736308455467224},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.38741418719291687},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3852434456348419},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.35219353437423706},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.34925419092178345},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.3214598298072815},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28837496042251587},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.19570335745811462},{"id":"https://openalex.org/C123765429","wikidata":"https://www.wikidata.org/wiki/Q36961","display_name":"Spermatogenesis","level":2,"score":0.14385685324668884}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006609","descriptor_name":"High Mobility Group Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006609","descriptor_name":"High Mobility Group Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012708","descriptor_name":"Sertoli Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012708","descriptor_name":"Sertoli Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014998","descriptor_name":"Y Chromosome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015230","descriptor_name":"Prostaglandin D2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019746","descriptor_name":"Intramolecular Oxidoreductases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D019746","descriptor_name":"Intramolecular Oxidoreductases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020218","descriptor_name":"Response Elements","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051876","descriptor_name":"Sex-Determining Region Y Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051876","descriptor_name":"Sex-Determining Region Y Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054834","descriptor_name":"Lipocalins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055758","descriptor_name":"SOX9 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m609578200","doi":"https://doi.org/10.1074/jbc.m609578200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m609578200","pdf_url":"http://www.jbc.org/article/S0021925819577298/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:17277314","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17277314","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m609578200","doi":"https://doi.org/10.1074/jbc.m609578200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m609578200","pdf_url":"http://www.jbc.org/article/S0021925819577298/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4000000059604645}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334704","display_name":"Australian Research Council","ror":"https://ror.org/05mmh0f86"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2013107168.pdf","grobid_xml":"https://content.openalex.org/works/W2013107168.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1486895198","https://openalex.org/W1529357388","https://openalex.org/W1570696801","https://openalex.org/W1600280267","https://openalex.org/W1851481002","https://openalex.org/W1965927288","https://openalex.org/W1973295687","https://openalex.org/W1991182179","https://openalex.org/W1992668049","https://openalex.org/W1994015599","https://openalex.org/W1996223704","https://openalex.org/W1999183933","https://openalex.org/W2007969716","https://openalex.org/W2014998600","https://openalex.org/W2017288138","https://openalex.org/W2019701459","https://openalex.org/W2021719160","https://openalex.org/W2024110331","https://openalex.org/W2026242783","https://openalex.org/W2027573073","https://openalex.org/W2037313882","https://openalex.org/W2046418478","https://openalex.org/W2052697305","https://openalex.org/W2062259323","https://openalex.org/W2062418948","https://openalex.org/W2072937904","https://openalex.org/W2073688806","https://openalex.org/W2078111266","https://openalex.org/W2081087045","https://openalex.org/W2086013207","https://openalex.org/W2088120545","https://openalex.org/W2089558187","https://openalex.org/W2094207651","https://openalex.org/W2097890006","https://openalex.org/W2099021510","https://openalex.org/W2103335643","https://openalex.org/W2105344558","https://openalex.org/W2119642891","https://openalex.org/W2133210794","https://openalex.org/W2146213727","https://openalex.org/W2147788240","https://openalex.org/W2154969680","https://openalex.org/W2157259126","https://openalex.org/W2159231404","https://openalex.org/W2160416416","https://openalex.org/W2162704758","https://openalex.org/W2163979723","https://openalex.org/W2166820565","https://openalex.org/W2169912077"],"related_works":["https://openalex.org/W2072937904","https://openalex.org/W2021864916","https://openalex.org/W2037085982","https://openalex.org/W1986959279","https://openalex.org/W1496920","https://openalex.org/W2611918196","https://openalex.org/W413327970","https://openalex.org/W1991758223","https://openalex.org/W2046418478"],"abstract_inverted_index":{"In":[0,154],"mammals,":[1],"male":[2],"sex":[3],"is":[4,108,166],"determined":[5],"by":[6,169],"the":[7,31,37,50,72,83,96,103,115,151,184],"Y-chromosomal":[8],"gene":[9,26,97],"Sry":[10,19,171],"(sex-determining":[11],"region":[12],"of":[13,18,30,39,52,82,117],"Y":[14],"chromosome).":[15],"The":[16],"expression":[17,165],"and":[20,124,136,149],"subsequently":[21],"Sox9":[22,118],"(SRY":[23],"box":[24],"containing":[25],"9)":[27],"in":[28,36,47,64,110,122,125,187],"precursors":[29],"supporting":[32,84],"cell":[33,56,85,90],"lineage":[34,86],"results":[35],"differentiation":[38],"these":[40],"cells":[41,46,62,81,112],"into":[42],"Sertoli":[43,45,61,89,111],"cells.":[44],"turn":[48],"orchestrate":[49],"development":[51],"all":[53],"other":[54],"male-specific":[55],"types.":[57],"To":[58],"ensure":[59],"that":[60,95,105,163,177],"differentiate":[63],"sufficient":[65],"numbers":[66],"to":[67,87,141,146,183],"induce":[68],"normal":[69],"testis":[70,74],"development,":[71],"early":[73],"produces":[75,106],"prostaglandin":[76,99],"D(2)":[77],"(PGD(2)),":[78],"which":[79],"recruits":[80],"a":[88,128,144,158],"fate.":[91],"Here":[92],"we":[93],"show":[94],"encoding":[98],"D":[100],"synthase":[101],"(Pgds),":[102],"enzyme":[104],"PGD(2),":[107],"expressed":[109],"immediately":[113],"after":[114],"onset":[116],"expression.":[119,172],"Promoter":[120],"analysis":[121],"silico":[123],"vitro":[126],"identified":[127],"paired":[129],"SOX/SRY":[130],"binding":[131],"site.":[132],"Interestingly,":[133],"only":[134],"SOX9,":[135],"not":[137,167,180],"SRY,":[138],"was":[139],"able":[140],"bind":[142],"as":[143],"dimer":[145],"this":[147],"site":[148],"transactivate":[150],"Pgds":[152,164,185],"promoter.":[153],"line":[155],"with":[156],"this,":[157],"transgenic":[159],"mouse":[160],"model":[161],"showed":[162],"affected":[168],"ectopic":[170],"Finally,":[173],"chromatin":[174],"immunoprecipitation":[175],"proved":[176],"SOX9":[178],"but":[179],"SRY":[181],"binds":[182],"promoter":[186],"vivo.":[188]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":22},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}