{"id":"https://openalex.org/W2013074077","doi":"https://doi.org/10.1016/s0165-5728(01)00337-x","title":"Chronic morphine potentiates the inflammatory response by disrupting interleukin-1\u03b2 modulation of the hypothalamic\u2013pituitary\u2013adrenal axis","display_name":"Chronic morphine potentiates the inflammatory response by disrupting interleukin-1\u03b2 modulation of the hypothalamic\u2013pituitary\u2013adrenal axis","publication_year":2001,"publication_date":"2001-08-30","ids":{"openalex":"https://openalex.org/W2013074077","doi":"https://doi.org/10.1016/s0165-5728(01)00337-x","mag":"2013074077","pmid":"https://pubmed.ncbi.nlm.nih.gov/11498262"},"language":"en","primary_location":{"id":"doi:10.1016/s0165-5728(01)00337-x","doi":"https://doi.org/10.1016/s0165-5728(01)00337-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0165-5728(01)00337-x","pdf_url":null,"source":{"id":"https://openalex.org/S137419829","display_name":"Journal of Neuroimmunology","issn_l":"0165-5728","issn":["0165-5728","1872-8421"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroimmunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113500635","display_name":"Steven D. House","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12524447","display_name":"Seton Hall University","ror":"https://ror.org/007tn5k56","country_code":"US","type":"education","lineage":["https://openalex.org/I12524447"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"S House","raw_affiliation_strings":["Department of Biology, Seton Hall University, 400 South Orange Avenue, South Orange, NJ 07079, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Seton Hall University, 400 South Orange Avenue, South Orange, NJ 07079, USA","institution_ids":["https://openalex.org/I12524447"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113500635"],"corresponding_institution_ids":["https://openalex.org/I12524447"],"apc_list":{"value":3360,"currency":"USD","value_usd":3360},"apc_paid":null,"fwci":0.902,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.65120968,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"118","issue":"2","first_page":"277","last_page":"285"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.5005000233650208,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.5005000233650208,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.4447999894618988,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-morphine","display_name":"chronic morphine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8690000176429749},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/corticotropin-releasing-factor","display_name":"corticotropin-releasing factor","score":0.9290000200271606},{"id":"https://openalex.org/keywords/corticosterone","display_name":"corticosterone","score":0.9440000057220459},{"id":"https://openalex.org/keywords/leukocyte-endothelial-adhesion","display_name":"leukocyte-endothelial adhesion","score":0.9869999885559082},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5189999938011169},{"id":"https://openalex.org/keywords/fmlp","display_name":"fMLP","score":0.7699999809265137},{"id":"https://openalex.org/keywords/opioid-analgesia","display_name":"opioid analgesia","score":0.6600000262260437},{"id":"https://openalex.org/keywords/mesenteric-venules","display_name":"mesenteric venules","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.8272292613983154},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6478491425514221},{"id":"https://openalex.org/C2777389121","wikidata":"https://www.wikidata.org/wiki/Q81225","display_name":"Morphine","level":2,"score":0.6431763172149658},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6260346174240112},{"id":"https://openalex.org/C2780352252","wikidata":"https://www.wikidata.org/wiki/Q422543","display_name":"Corticosterone","level":3,"score":0.6106260418891907},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.519818902015686},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.44647422432899475},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.4197222888469696},{"id":"https://openalex.org/C2779146795","wikidata":"https://www.wikidata.org/wiki/Q1369123","display_name":"Hypothalamic\u2013pituitary\u2013adrenal axis","level":3,"score":0.41471344232559204},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35636091232299805},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.20735213160514832},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.1639859974384308}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003345","descriptor_name":"Corticosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003346","descriptor_name":"Corticotropin-Releasing Hormone","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D003346","descriptor_name":"Corticotropin-Releasing Hormone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007030","descriptor_name":"Hypothalamo-Hypophyseal System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007030","descriptor_name":"Hypothalamo-Hypophyseal System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007276","descriptor_name":"Injections, Intraventricular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008643","descriptor_name":"Mesentery","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008643","descriptor_name":"Mesentery","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009020","descriptor_name":"Morphine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D009240","descriptor_name":"N-Formylmethionine Leucyl-Phenylalanine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010913","descriptor_name":"Pituitary-Adrenal System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010913","descriptor_name":"Pituitary-Adrenal System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014699","descriptor_name":"Venules","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014699","descriptor_name":"Venules","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0165-5728(01)00337-x","doi":"https://doi.org/10.1016/s0165-5728(01)00337-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0165-5728(01)00337-x","pdf_url":null,"source":{"id":"https://openalex.org/S137419829","display_name":"Journal of Neuroimmunology","issn_l":"0165-5728","issn":["0165-5728","1872-8421"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroimmunology","raw_type":"journal-article"},{"id":"pmid:11498262","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11498262","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuroimmunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5357776274","display_name":"Morphine Actions on the Immune System","funder_award_id":"R01DA007058","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G8098658647","display_name":"MICROVASCULAR CELL DYNAMICS IN THE INFLAMMATORY PROCESS","funder_award_id":"R29HL044914","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W43824224","https://openalex.org/W574438526","https://openalex.org/W1969606885","https://openalex.org/W1972293054","https://openalex.org/W1975280088","https://openalex.org/W1983549737","https://openalex.org/W1984978977","https://openalex.org/W1985205546","https://openalex.org/W1998257423","https://openalex.org/W1998343268","https://openalex.org/W2000956334","https://openalex.org/W2002283782","https://openalex.org/W2009415328","https://openalex.org/W2018045446","https://openalex.org/W2023023053","https://openalex.org/W2023138187","https://openalex.org/W2025579398","https://openalex.org/W2033070005","https://openalex.org/W2033239296","https://openalex.org/W2034002488","https://openalex.org/W2034902455","https://openalex.org/W2035335405","https://openalex.org/W2036062598","https://openalex.org/W2038297164","https://openalex.org/W2039470219","https://openalex.org/W2040867224","https://openalex.org/W2048513472","https://openalex.org/W2049181771","https://openalex.org/W2054920775","https://openalex.org/W2056330384","https://openalex.org/W2059322449","https://openalex.org/W2072485458","https://openalex.org/W2074591458","https://openalex.org/W2079912778","https://openalex.org/W2081534285","https://openalex.org/W2083497024","https://openalex.org/W2084761575","https://openalex.org/W2090327897","https://openalex.org/W2099405772","https://openalex.org/W2106384168","https://openalex.org/W2114882367","https://openalex.org/W2135814745","https://openalex.org/W2140839085","https://openalex.org/W2145890122","https://openalex.org/W2155081197","https://openalex.org/W2159822998","https://openalex.org/W2168364487","https://openalex.org/W2311561164","https://openalex.org/W2396307115"],"related_works":["https://openalex.org/W2075547547","https://openalex.org/W2039351166","https://openalex.org/W199781670","https://openalex.org/W2084464257","https://openalex.org/W25384397","https://openalex.org/W27257023","https://openalex.org/W2411447581","https://openalex.org/W2021951630","https://openalex.org/W2081375168","https://openalex.org/W1963602953"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}