{"id":"https://openalex.org/W2013046850","doi":"https://doi.org/10.1159/000077934","title":"Plasma Concentrations of Anxiolytic Neurosteroids in Men with Normal Anxiety Scores: A Correlation Analysis","display_name":"Plasma Concentrations of Anxiolytic Neurosteroids in Men with Normal Anxiety Scores: A Correlation Analysis","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2013046850","doi":"https://doi.org/10.1159/000077934","mag":"2013046850","pmid":"https://pubmed.ncbi.nlm.nih.gov/15179013"},"language":"en","primary_location":{"id":"doi:10.1159/000077934","doi":"https://doi.org/10.1159/000077934","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000077934","pdf_url":null,"source":{"id":"https://openalex.org/S147539111","display_name":"Neuropsychobiology","issn_l":"0302-282X","issn":["0302-282X","1423-0224"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychobiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042966185","display_name":"Fr\u0103ncesca Brambilla","orcid":"https://orcid.org/0000-0002-5100-5691","observed_orcids":["https://orcid.org/0000-0002-5100-5691"]},"institutions":[{"id":"https://openalex.org/I4210116058","display_name":"Azienda Unita' Sanitaria Locale di Parma","ror":"https://ror.org/02bjdhn90","country_code":"IT","type":"government","lineage":["https://openalex.org/I4210116058"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Brambilla","raw_affiliation_strings":["Addiction Research Center, Azienda Unit\u00e0 Sanitaria, Parma, Italy. francesca.brambilla4@tin.it","Addiction Research Center, Azienda Unit\u00e0 Sanitaria, Parma, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Addiction Research Center, Azienda Unit\u00e0 Sanitaria, Parma, Italy. francesca.brambilla4@tin.it","institution_ids":["https://openalex.org/I4210116058"]},{"raw_affiliation_string":"Addiction Research Center, Azienda Unit\u00e0 Sanitaria, Parma, and","institution_ids":["https://openalex.org/I4210116058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090509427","display_name":"Giovanni Biggio","orcid":"https://orcid.org/0000-0003-2333-5535","observed_orcids":["https://orcid.org/0000-0003-2333-5535"]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Biggio","raw_affiliation_strings":["Department of Experimental Biology 'B. Loddo', Cittadella Universitaria, Monserrato-Cagliari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Biology 'B. Loddo', Cittadella Universitaria, Monserrato-Cagliari, Italy","institution_ids":["https://openalex.org/I172446870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057965326","display_name":"Maria Giuseppina Pisu","orcid":"https://orcid.org/0000-0001-6794-7782","observed_orcids":["https://orcid.org/0000-0001-6794-7782"]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Giuseppina Pisu","raw_affiliation_strings":["Department of Experimental Biology 'B. Loddo', Cittadella Universitaria, Monserrato-Cagliari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Biology 'B. Loddo', Cittadella Universitaria, Monserrato-Cagliari, Italy","institution_ids":["https://openalex.org/I172446870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086448753","display_name":"Robert H. Purdy","orcid":"https://orcid.org/0000-0002-1853-5252","observed_orcids":["https://orcid.org/0000-0002-1853-5252"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert H. Purdy","raw_affiliation_strings":["Department of Psychiatry, Veterans Affairs Medical Center, University of California, San Diego, Calif., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Veterans Affairs Medical Center, University of California, San Diego, Calif., USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071885471","display_name":"Gilberto Gerra","orcid":"https://orcid.org/0000-0002-4987-6818","observed_orcids":["https://orcid.org/0000-0002-4987-6818"]},"institutions":[{"id":"https://openalex.org/I4210116058","display_name":"Azienda Unita' Sanitaria Locale di Parma","ror":"https://ror.org/02bjdhn90","country_code":"IT","type":"government","lineage":["https://openalex.org/I4210116058"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gilberto Gerra","raw_affiliation_strings":["Addiction Research Center, Azienda Unit\u00e0 Sanitaria, Parma, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Addiction Research Center, Azienda Unit\u00e0 Sanitaria, Parma, and","institution_ids":["https://openalex.org/I4210116058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009720051","display_name":"Amir Zaimovich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116058","display_name":"Azienda Unita' Sanitaria Locale di Parma","ror":"https://ror.org/02bjdhn90","country_code":"IT","type":"government","lineage":["https://openalex.org/I4210116058"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Amir Zaimovich","raw_affiliation_strings":["Addiction Research Center, Azienda Unit\u00e0 Sanitaria, Parma, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Addiction Research Center, Azienda Unit\u00e0 Sanitaria, Parma, and","institution_ids":["https://openalex.org/I4210116058"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028115615","display_name":"Mariangela Serra","orcid":"https://orcid.org/0000-0002-6908-4228","observed_orcids":["https://orcid.org/0000-0002-6908-4228"]},"institutions":[{"id":"https://openalex.org/I4210116058","display_name":"Azienda Unita' Sanitaria Locale di Parma","ror":"https://ror.org/02bjdhn90","country_code":"IT","type":"government","lineage":["https://openalex.org/I4210116058"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mariangela Serra","raw_affiliation_strings":["Addiction Research Center, Azienda Unit\u00e0 Sanitaria, Parma, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Addiction Research Center, Azienda Unit\u00e0 Sanitaria, Parma, and","institution_ids":["https://openalex.org/I4210116058"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7487,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.80941176,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"50","issue":"1","first_page":"6","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.020500000566244125,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurosteroids","display_name":"neurosteroids","score":0.9819999933242798},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.7990000247955322},{"id":"https://openalex.org/keywords/plasma-steroid-levels","display_name":"plasma steroid levels","score":0.6809999942779541},{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.9580000042915344},{"id":"https://openalex.org/keywords/allopregnanolone","display_name":"allopregnanolone","score":0.925000011920929},{"id":"https://openalex.org/keywords/pregnenolone","display_name":"pregnenolone","score":0.9769999980926514},{"id":"https://openalex.org/keywords/tetrahydrodeoxycorticosterone","display_name":"tetrahydrodeoxycorticosterone","score":0.9980000257492065},{"id":"https://openalex.org/keywords/state-anxiety","display_name":"state anxiety","score":0.9599999785423279},{"id":"https://openalex.org/keywords/trait-anxiety","display_name":"trait anxiety","score":0.9980000257492065},{"id":"https://openalex.org/keywords/men","display_name":"men","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C44796713","wikidata":"https://www.wikidata.org/wiki/Q2659374","display_name":"Neuroactive steroid","level":4,"score":0.9707179069519043},{"id":"https://openalex.org/C2778338918","wikidata":"https://www.wikidata.org/wiki/Q2482223","display_name":"Allopregnanolone","level":5,"score":0.9032145738601685},{"id":"https://openalex.org/C2777765862","wikidata":"https://www.wikidata.org/wiki/Q62903","display_name":"Anxiolytic","level":3,"score":0.8569697141647339},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.7910118699073792},{"id":"https://openalex.org/C2780193516","wikidata":"https://www.wikidata.org/wiki/Q412158","display_name":"Pregnenolone","level":4,"score":0.788272500038147},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6129236817359924},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5431891679763794},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5294565558433533},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.463588684797287},{"id":"https://openalex.org/C2992367442","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Trait anxiety","level":3,"score":0.4335312843322754},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.3441665768623352},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.24221068620681763},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.22270706295967102},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.21812239289283752},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19147512316703796},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0730733871459961}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003900","descriptor_name":"Desoxycorticosterone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003900","descriptor_name":"Desoxycorticosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003900","descriptor_name":"Desoxycorticosterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011280","descriptor_name":"Pregnanolone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011280","descriptor_name":"Pregnanolone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011284","descriptor_name":"Pregnenolone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011284","descriptor_name":"Pregnenolone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011569","descriptor_name":"Psychiatric Status Rating Scales","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000077934","doi":"https://doi.org/10.1159/000077934","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000077934","pdf_url":null,"source":{"id":"https://openalex.org/S147539111","display_name":"Neuropsychobiology","issn_l":"0302-282X","issn":["0302-282X","1423-0224"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychobiology","raw_type":"journal-article"},{"id":"pmid:15179013","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15179013","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychobiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6800000071525574}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W33406674","https://openalex.org/W83640801","https://openalex.org/W204867062","https://openalex.org/W598007856","https://openalex.org/W1575526572","https://openalex.org/W1607171655","https://openalex.org/W1966627384","https://openalex.org/W1976512352","https://openalex.org/W1988911904","https://openalex.org/W1992498831","https://openalex.org/W1994924064","https://openalex.org/W2000712333","https://openalex.org/W2021702792","https://openalex.org/W2024015272","https://openalex.org/W2024181736","https://openalex.org/W2028466691","https://openalex.org/W2030617245","https://openalex.org/W2036583721","https://openalex.org/W2041635772","https://openalex.org/W2056224205","https://openalex.org/W2061449969","https://openalex.org/W2072517364","https://openalex.org/W2073796833","https://openalex.org/W2083973091","https://openalex.org/W2088290994","https://openalex.org/W2088880330","https://openalex.org/W2115583232","https://openalex.org/W2135886148","https://openalex.org/W2159011576","https://openalex.org/W2168559252","https://openalex.org/W2242530628","https://openalex.org/W4239267568"],"related_works":["https://openalex.org/W7070594802","https://openalex.org/W2794725822","https://openalex.org/W2036583721","https://openalex.org/W7098710365","https://openalex.org/W1964069126","https://openalex.org/W204867062","https://openalex.org/W2162028023","https://openalex.org/W7140239708","https://openalex.org/W2112445335","https://openalex.org/W1484579537"],"abstract_inverted_index":{"Neurosteroids":[0],"are":[1,11],"physiological":[2],"regulators":[3,46],"of":[4,20,26,32,55,101,108,113],"anxiety":[5,45,71,99,125,135],"in":[6,47,52,138,143],"experimental":[7,48,139],"animals,":[8,49],"but":[9,141],"there":[10],"no":[12],"data":[13,112,128],"for":[14],"humans":[15],"about":[16],"the":[17,21,76,84,88,98,102,106,114],"modulatory":[18],"effects":[19],"hormones":[22],"on":[23],"normal":[24,60],"aspects":[25],"this":[27],"emotional":[28],"parameter.":[29],"Plasma":[30],"concentrations":[31,96,120],"four":[33],"neurosteroids,":[34],"pregnenolone,":[35],"progesterone":[36],"(PROG),":[37],"allopregnanolone":[38],"and":[39,58,68,87,97,116],"tetrahydrodeoxycorticosterone,":[40],"suggested":[41],"to":[42,111],"be":[43],"major":[44],"were":[50,73,91,104],"measured":[51,74],"a":[53],"group":[54],"58":[56],"physically":[57],"psychologically":[59],"adult":[61],"male":[62],"subjects.":[63],"In":[64],"parallel,":[65],"trait":[66],"(genotypical)":[67],"state":[69,124],"(phenotypical)":[70],"scores":[72,100],"by":[75],"State-Trait":[77],"Anxiety":[78],"Inventory.":[79],"The":[80,94],"possible":[81],"correlations":[82],"between":[83],"hormonal":[85],"secretions":[86],"psychological":[89],"parameters":[90],"statistically":[92],"analyzed.":[93],"neurosteroid":[95],"probands":[103],"within":[105],"ranges":[107],"normality":[109],"according":[110],"literature":[115],"our":[117],"own.":[118],"PROG":[119],"correlated":[121],"significantly":[122],"with":[123],"scores.":[126],"These":[127],"suggest":[129],"that":[130],"neurosteroids":[131],"may":[132],"physiologically":[133],"modulate":[134],"not":[136],"only":[137],"animals":[140],"also":[142],"humans.":[144]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
