{"id":"https://openalex.org/W2013046014","doi":"https://doi.org/10.1016/j.bpj.2009.12.398","title":"Transcription Factor Switching Dynamics Regulates Gene Activation","display_name":"Transcription Factor Switching Dynamics Regulates Gene Activation","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2013046014","doi":"https://doi.org/10.1016/j.bpj.2009.12.398","mag":"2013046014"},"language":"en","primary_location":{"id":"doi:10.1016/j.bpj.2009.12.398","doi":"https://doi.org/10.1016/j.bpj.2009.12.398","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2009.12.398","pdf_url":"http://www.cell.com/article/S0006349509022036/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0006349509022036/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028867664","display_name":"J\u00fcrgen Reingruber","orcid":"https://orcid.org/0000-0002-7167-8092","observed_orcids":["https://orcid.org/0000-0002-7167-8092"]},"institutions":[{"id":"https://openalex.org/I29607241","display_name":"\u00c9cole Normale Sup\u00e9rieure - PSL","ror":"https://ror.org/05a0dhs15","country_code":"FR","type":"other","lineage":["https://openalex.org/I2746051580","https://openalex.org/I29607241"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Juergen Reingruber","raw_affiliation_strings":["Ecole Normale Superieure, Paris, France","Ecole Normale Sup\u00e8rieure, Paris, France#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ecole Normale Superieure, Paris, France","institution_ids":["https://openalex.org/I29607241"]},{"raw_affiliation_string":"Ecole Normale Sup\u00e8rieure, Paris, France#TAB#","institution_ids":["https://openalex.org/I29607241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013042042","display_name":"Lana Bosanac","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29607241","display_name":"\u00c9cole Normale Sup\u00e9rieure - PSL","ror":"https://ror.org/05a0dhs15","country_code":"FR","type":"other","lineage":["https://openalex.org/I2746051580","https://openalex.org/I29607241"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lana Bosanac","raw_affiliation_strings":["Ecole Normale Superieure, Paris, France","Ecole Normale Sup\u00e8rieure, Paris, France#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ecole Normale Superieure, Paris, France","institution_ids":["https://openalex.org/I29607241"]},{"raw_affiliation_string":"Ecole Normale Sup\u00e8rieure, Paris, France#TAB#","institution_ids":["https://openalex.org/I29607241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071287432","display_name":"Xavier Darzacq","orcid":"https://orcid.org/0000-0003-2537-8395","observed_orcids":["https://orcid.org/0000-0003-2537-8395"]},"institutions":[{"id":"https://openalex.org/I29607241","display_name":"\u00c9cole Normale Sup\u00e9rieure - PSL","ror":"https://ror.org/05a0dhs15","country_code":"FR","type":"other","lineage":["https://openalex.org/I2746051580","https://openalex.org/I29607241"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Xavier Darzacq","raw_affiliation_strings":["Ecole Normale Superieure, Paris, France","Ecole Normale Sup\u00e8rieure, Paris, France#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ecole Normale Superieure, Paris, France","institution_ids":["https://openalex.org/I29607241"]},{"raw_affiliation_string":"Ecole Normale Sup\u00e8rieure, Paris, France#TAB#","institution_ids":["https://openalex.org/I29607241"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006152136","display_name":"David Holcman","orcid":"https://orcid.org/0000-0001-9854-5014","observed_orcids":["https://orcid.org/0000-0001-9854-5014","https://orcid.org/0000-0002-0231-3073"]},"institutions":[{"id":"https://openalex.org/I29607241","display_name":"\u00c9cole Normale Sup\u00e9rieure - PSL","ror":"https://ror.org/05a0dhs15","country_code":"FR","type":"other","lineage":["https://openalex.org/I2746051580","https://openalex.org/I29607241"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"David Holcman","raw_affiliation_strings":["Ecole Normale Superieure, Paris, France","Ecole Normale Sup\u00e8rieure, Paris, France#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ecole Normale Superieure, Paris, France","institution_ids":["https://openalex.org/I29607241"]},{"raw_affiliation_string":"Ecole Normale Sup\u00e8rieure, Paris, France#TAB#","institution_ids":["https://openalex.org/I29607241"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I29607241"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10547355,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"98","issue":"3","first_page":"70a","last_page":"70a"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.4790000021457672,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.4790000021457672,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13187","display_name":"Diffusion and Search Dynamics","score":0.41190001368522644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.031300000846385956,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p-tefb","display_name":"P-TEFb","score":0.9549999833106995},{"id":"https://openalex.org/keywords/gene-activation","display_name":"gene activation","score":0.796999990940094},{"id":"https://openalex.org/keywords/activation-time","display_name":"activation time","score":0.609000027179718},{"id":"https://openalex.org/keywords/switching-rate","display_name":"switching rate","score":0.6069999933242798},{"id":"https://openalex.org/keywords/ligand-degradation","display_name":"ligand degradation","score":0.8130000233650208},{"id":"https://openalex.org/keywords/dna-binding-affinity","display_name":"DNA binding affinity","score":0.7160000205039978},{"id":"https://openalex.org/keywords/nuclear-diffusion","display_name":"nuclear diffusion","score":0.5590000152587891},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.6349999904632568},{"id":"https://openalex.org/keywords/frap-assay","display_name":"FRAP","score":0.6159999966621399},{"id":"https://openalex.org/keywords/single-particle-tracking","display_name":"single-particle tracking","score":0.9800000190734863}],"concepts":[{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6725188493728638},{"id":"https://openalex.org/C2777841055","wikidata":"https://www.wikidata.org/wiki/Q15314917","display_name":"P-TEFb","level":5,"score":0.6465262174606323},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5929039120674133},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5213426351547241},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5094378590583801},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4707373380661011},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3763318955898285},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32113662362098694},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3138236105442047},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1812446415424347},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.07009872794151306},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.bpj.2009.12.398","doi":"https://doi.org/10.1016/j.bpj.2009.12.398","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2009.12.398","pdf_url":"http://www.cell.com/article/S0006349509022036/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.bpj.2009.12.398","doi":"https://doi.org/10.1016/j.bpj.2009.12.398","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2009.12.398","pdf_url":"http://www.cell.com/article/S0006349509022036/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2013046014.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2104269878","https://openalex.org/W2952809892","https://openalex.org/W4392443247","https://openalex.org/W2768753019","https://openalex.org/W2037147787","https://openalex.org/W2570941444","https://openalex.org/W3190839634","https://openalex.org/W4380684339","https://openalex.org/W2079587938","https://openalex.org/W6903569345"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}