{"id":"https://openalex.org/W2013017832","doi":"https://doi.org/10.1172/jci102311","title":"CORTISONE IN HYPERTENSIVE VASCULAR DISEASE 1","display_name":"CORTISONE IN HYPERTENSIVE VASCULAR DISEASE 1","publication_year":1950,"publication_date":"1950-06-01","ids":{"openalex":"https://openalex.org/W2013017832","doi":"https://doi.org/10.1172/jci102311","mag":"2013017832","pmid":"https://pubmed.ncbi.nlm.nih.gov/15436665","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/436112"},"language":"en","primary_location":{"id":"doi:10.1172/jci102311","doi":"https://doi.org/10.1172/jci102311","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci102311","pdf_url":"http://www.jci.org/articles/view/102311/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/102311/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069653874","display_name":"George A. Perera","orcid":"https://orcid.org/0000-0002-3239-4097","observed_orcids":["https://orcid.org/0000-0002-3239-4097"]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George A. Perera","raw_affiliation_strings":["(Froin the Departments of Medicine anid Physiology, College of Physicians anid Surgeonls, Columbia Uniiversity, anid the Presbyterian Hospital, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Froin the Departments of Medicine anid Physiology, College of Physicians anid Surgeonls, Columbia Uniiversity, anid the Presbyterian Hospital, New York","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Thomas C. Fleming","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas C. Fleming","raw_affiliation_strings":["(Froin the Departments of Medicine anid Physiology, College of Physicians anid Surgeonls, Columbia Uniiversity, anid the Presbyterian Hospital, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Froin the Departments of Medicine anid Physiology, College of Physicians anid Surgeonls, Columbia Uniiversity, anid the Presbyterian Hospital, New York","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012556799","display_name":"Kermit L. Pines","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kermit L. Pines","raw_affiliation_strings":["(Froin the Departments of Medicine anid Physiology, College of Physicians anid Surgeonls, Columbia Uniiversity, anid the Presbyterian Hospital, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Froin the Departments of Medicine anid Physiology, College of Physicians anid Surgeonls, Columbia Uniiversity, anid the Presbyterian Hospital, New York","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042530533","display_name":"Margaret Crymble","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret Crymble","raw_affiliation_strings":["(Froin the Departments of Medicine anid Physiology, College of Physicians anid Surgeonls, Columbia Uniiversity, anid the Presbyterian Hospital, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(Froin the Departments of Medicine anid Physiology, College of Physicians anid Surgeonls, Columbia Uniiversity, anid the Presbyterian Hospital, New York","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":8.726,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.9779338,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"6","first_page":"739","last_page":"744"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.5859000086784363,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.5859000086784363,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.4011000096797943,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cortisone","display_name":"cortisone","score":0.9819999933242798},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9309999942779541},{"id":"https://openalex.org/keywords/hypertensive-vascular-disease","display_name":"hypertensive vascular disease","score":0.906000018119812},{"id":"https://openalex.org/keywords/blood-pressure-reduction","display_name":"blood pressure reduction","score":0.8420000076293945},{"id":"https://openalex.org/keywords/long-term-corticosteroid-therapy","display_name":"long-term corticosteroid therapy","score":0.8320000171661377},{"id":"https://openalex.org/keywords/ambulatory-blood-pressure-monitoring","display_name":"ambulatory blood pressure monitoring","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C2780484280","wikidata":"https://www.wikidata.org/wiki/Q423185","display_name":"Cortisone","level":2,"score":0.8562430143356323},{"id":"https://openalex.org/C3019881880","wikidata":"https://www.wikidata.org/wiki/Q41861","display_name":"Hypertensive disease","level":3,"score":0.6104677319526672},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4782501757144928},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3664790391921997},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3285079896450043},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.1746966540813446}],"mesh":[{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003348","descriptor_name":"Cortisone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1172/jci102311","doi":"https://doi.org/10.1172/jci102311","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci102311","pdf_url":"http://www.jci.org/articles/view/102311/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:436112","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/436112","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:15436665","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15436665","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmid:15436806","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15436806","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.998.2876","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.998.2876","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://dm5migu4zj3pb.cloudfront.net/manuscripts/102000/102311/JCI50102311.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1172/jci102311","doi":"https://doi.org/10.1172/jci102311","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci102311","pdf_url":"http://www.jci.org/articles/view/102311/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2013017832.pdf","grobid_xml":"https://content.openalex.org/works/W2013017832.grobid-xml"},"referenced_works_count":6,"referenced_works":["https://openalex.org/W1971714645","https://openalex.org/W2070441038","https://openalex.org/W2074367741","https://openalex.org/W2275340282","https://openalex.org/W2333065188","https://openalex.org/W4256341523"],"related_works":["https://openalex.org/W1993273114","https://openalex.org/W1984413704","https://openalex.org/W2395678372","https://openalex.org/W2156745991","https://openalex.org/W2410104727","https://openalex.org/W2328359170","https://openalex.org/W3090124546","https://openalex.org/W6981342484","https://openalex.org/W2413958157","https://openalex.org/W2418772474"],"abstract_inverted_index":{"Previous":[0],"observations":[1],"have":[2],"indicated":[3],"that":[4],"the":[5,27,45,55,78,82,144,168,174,184,193,215,248,251,260,278,282],"administration":[6],"of":[7,57,65,81,86,89,106,127,146,167,191,217,250],"cortisone":[8],"may":[9],"be":[10],"associated":[11],"with":[12,20],"a":[13,62,71,124,188,218,244],"decline":[14],"in":[15,18,29,35,200,226,277],"blood":[16,125,149,230,233,271],"pressure":[17,126,155,234],"patients":[19],"uncom-plicated":[21],"hypertensive":[22],"vascular":[23],"disease":[24],"(1).":[25],"As":[26],"changes":[28],"arterial":[30],"tension":[31],"were":[32,156,163,182,236,273],"comparatively":[33],"small":[34],"these":[36],"short-term":[37],"studies,":[38],"and":[39,93,129,133,153,173,203,232,238],"usually":[40],"took":[41],"place":[42],"immediately":[43],"after":[44,229],"steroid":[46],"had":[47],"been":[48],"dis-continued,":[49],"it":[50],"seemed":[51],"desirable":[52],"to":[53,77,187],"record":[54],"effects":[56],"increased":[58],"dosage":[59],"given":[60],"for":[61,96,123,267],"longer":[63],"period":[64,145],"time.":[66],"CASE":[67],"REPORT":[68],"M.":[69],"J.,":[70],"37-year-old":[72],"Negro":[73],"housewife,":[74],"was":[75,100,119,141,196,207,224,241,254,265,288],"admitted":[76],"metabolism":[79],"ward":[80],"Presbyterian":[83],"Hospital":[84],"because":[85],"occasional":[87],"headaches":[88],"moderate":[90],"intensity,":[91],"palpita-tions":[92],"hypertension":[94],"known":[95],"five":[97],"years.":[98],"There":[99],"neither":[101],"past":[102],"nor":[103],"present":[104],"evidence":[105],"cardiac":[107],"pain,":[108],"con-gestive":[109],"failure,":[110],"renal,":[111],"cerebral":[112],"or":[113],"obvious":[114],"endocrine":[115],"dis-ease.":[116],"Physical":[117],"examination":[118],"not":[120,164,213],"remarkable":[121],"except":[122],"210/128":[128],"slight":[130],"arteriolar":[131],"narrowing":[132],"arteriovenous":[134],"compression":[135],"on":[136,259],"funduscopic":[137],"examination.":[138],"The":[139,222],"patient":[140,223],"afebrile":[142],"throughout":[143],"ob-servation.":[147],"Complete":[148],"count,":[150],"circulation":[151],"time":[152],"venous":[154],"within":[157],"normal":[158],"limits.":[159],"Popliteal":[160],"ar-terial":[161],"pressures":[162,272],"reduced.":[165],"X-ray":[166],"heart":[169],"dis-closed":[170],"no":[171,177],"hypertrophy":[172],"electrocardiogram":[175],"showed":[176],"significant":[178],"abnormalities.":[179],"Repeated":[180],"urinalyses":[181],"negative;":[183],"urine":[185],"concentrated":[186],"specific":[189],"gravity":[190],"1.022;":[192],"phenolsulfonphthalein":[194],"excretion":[195],"80":[197],"per":[198],"cent":[199],"two":[201],"hours;":[202],"an":[204],"intravenous":[205],"pyelogram":[206],"nor-mal.":[208],"A":[209],"benzodioxane":[210],"test":[211],"did":[212],"suggest":[214],"presence":[216],"pheochromocytoma":[219],"(2).":[220],"METHODS":[221],"kept":[225],"bed":[227],"until":[228],"studies":[231],"measurements":[235],"made,":[237],"am-bulatory":[239],"activity":[240],"standardized":[242],"at":[243],"constant":[245],"level":[246],"dur-ing":[247],"rest":[249],"day.":[252],"She":[253],"weighed":[255],"daily":[256],"before":[257],"breakfast":[258],"same":[261,279,283],"scales.":[262],"Distilled":[263],"water":[264],"sup-plied":[266],"drinking.":[268],"\"Resting":[269],"\"":[270],"meas-ured":[274],"each":[275],"morning":[276],"arm":[280],"by":[281,292],"observer,":[284],"1":[285],"This":[286],"investigation":[287],"supported":[289],"(in":[290],"part)":[291],"re-":[293]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
