{"id":"https://openalex.org/W2013011979","doi":"https://doi.org/10.1016/0168-3659(94)90030-2","title":"Calcium-alginate beads for the oral delivery of transforming growth factor-\u03b21 (TGF-\u03b21): stabilization of TGF-\u03b21 by the addition of polyacrylic acid within acid-treated beads","display_name":"Calcium-alginate beads for the oral delivery of transforming growth factor-\u03b21 (TGF-\u03b21): stabilization of TGF-\u03b21 by the addition of polyacrylic acid within acid-treated beads","publication_year":1994,"publication_date":"1994-07-01","ids":{"openalex":"https://openalex.org/W2013011979","doi":"https://doi.org/10.1016/0168-3659(94)90030-2","mag":"2013011979"},"language":"en","primary_location":{"id":"doi:10.1016/0168-3659(94)90030-2","doi":"https://doi.org/10.1016/0168-3659(94)90030-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0168-3659(94)90030-2","pdf_url":null,"source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2013011979"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110331564","display_name":"Russell J. Mumper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Russell J. Mumper","raw_affiliation_strings":["Center for Bioengineering, University of Washington, Seattle, WA 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Bioengineering, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064675543","display_name":"Allan S. Huffman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allan S. Huffman","raw_affiliation_strings":["Center for Bioengineering, University of Washington, Seattle, WA 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Bioengineering, University of Washington, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034799855","display_name":"Pauli Antero Puolakkainen","orcid":"https://orcid.org/0000-0003-2489-4371","observed_orcids":["https://orcid.org/0000-0003-2489-4371"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pauli A. Puolakkainen","raw_affiliation_strings":["Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076787645","display_name":"Lisa S. Bouchard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa S. Bouchard","raw_affiliation_strings":["Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044698737","display_name":"Wayne R. Gombotz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wayne R. Gombotz","raw_affiliation_strings":["Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121, USA","institution_ids":["https://openalex.org/I4210091812"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044698737"],"corresponding_institution_ids":["https://openalex.org/I4210091812"],"apc_list":{"value":4440,"currency":"USD","value_usd":4440},"apc_paid":null,"fwci":2.3389,"has_fulltext":false,"cited_by_count":200,"citation_normalized_percentile":{"value":0.85136612,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"30","issue":"3","first_page":"241","last_page":"251"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.019300000742077827,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9089999794960022},{"id":"https://openalex.org/keywords/alginate-beads","display_name":"alginate beads","score":0.7799999713897705},{"id":"https://openalex.org/keywords/oral-drug-delivery","display_name":"oral drug delivery","score":0.9710000157356262},{"id":"https://openalex.org/keywords/poly-acrylic-acid","display_name":"poly(acrylic acid)","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cytoprotection","display_name":"cytoprotection","score":0.7310000061988831},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C2780312654","wikidata":"https://www.wikidata.org/wiki/Q409762","display_name":"Polyacrylic acid","level":3,"score":0.8365828990936279},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.710390567779541},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6326168775558472},{"id":"https://openalex.org/C2778713300","wikidata":"https://www.wikidata.org/wiki/Q2034064","display_name":"Calcium alginate","level":3,"score":0.6316803693771362},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5005755424499512},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44416069984436035},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.4406081736087799},{"id":"https://openalex.org/C2776648616","wikidata":"https://www.wikidata.org/wiki/Q409216","display_name":"Glucuronic acid","level":3,"score":0.42826446890830994},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4125514030456543},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.19153183698654175},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18960711359977722},{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.12046599388122559},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0860251784324646},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/0168-3659(94)90030-2","doi":"https://doi.org/10.1016/0168-3659(94)90030-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0168-3659(94)90030-2","pdf_url":null,"source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1970922742","https://openalex.org/W1974025968","https://openalex.org/W1978514667","https://openalex.org/W1984197570","https://openalex.org/W1987408592","https://openalex.org/W2007768242","https://openalex.org/W2010215470","https://openalex.org/W2011954808","https://openalex.org/W2024141571","https://openalex.org/W2025501818","https://openalex.org/W2030334823","https://openalex.org/W2042435016","https://openalex.org/W2048652797","https://openalex.org/W2048935869","https://openalex.org/W2049877229","https://openalex.org/W2057362324","https://openalex.org/W2061880077","https://openalex.org/W2065367851","https://openalex.org/W2071131056","https://openalex.org/W2071379329","https://openalex.org/W2072230022","https://openalex.org/W2087863947","https://openalex.org/W2090437823","https://openalex.org/W2117725038","https://openalex.org/W2145293649","https://openalex.org/W2161083992","https://openalex.org/W2312208584","https://openalex.org/W2318703804","https://openalex.org/W2320203601","https://openalex.org/W2408960444","https://openalex.org/W4231715521"],"related_works":["https://openalex.org/W2096379426","https://openalex.org/W1984197570","https://openalex.org/W1981471365","https://openalex.org/W2483741760","https://openalex.org/W2901747676","https://openalex.org/W1856378466","https://openalex.org/W2010926909","https://openalex.org/W4411011526","https://openalex.org/W2002956045","https://openalex.org/W4289551097"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}