{"id":"https://openalex.org/W2012978731","doi":"https://doi.org/10.1158/1538-7445.am2014-4879","title":"Abstract 4879: Targeting the seed and the soil of cancers with selective small-molecule inhibitors of CDK8/19: Chemopotentiating, chemopreventive, anti-invasive and anti-metastatic activities","display_name":"Abstract 4879: Targeting the seed and the soil of cancers with selective small-molecule inhibitors of CDK8/19: Chemopotentiating, chemopreventive, anti-invasive and anti-metastatic activities","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W2012978731","doi":"https://doi.org/10.1158/1538-7445.am2014-4879","mag":"2012978731"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2014-4879","doi":"https://doi.org/10.1158/1538-7445.am2014-4879","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-4879","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055575813","display_name":"Donald C. Porter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157231","display_name":"Senex Biotechnology (United States)","ror":"https://ror.org/05w1q8228","country_code":"US","type":"company","lineage":["https://openalex.org/I4210157231"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald C. Porter","raw_affiliation_strings":["1Senex Biotechnology Inc., Columbia, SC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Senex Biotechnology Inc., Columbia, SC;","institution_ids":["https://openalex.org/I4210157231"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103191968","display_name":"Jiaxin Liang","orcid":"https://orcid.org/0000-0003-2129-3626","observed_orcids":["https://orcid.org/0000-0003-2129-3626"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiaxin Liang","raw_affiliation_strings":["2University of South Carolina, Columbia, SC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of South Carolina, Columbia, SC;","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043295429","display_name":"Vimala Kaza","orcid":"https://orcid.org/0009-0006-3534-5481","observed_orcids":["https://orcid.org/0009-0006-3534-5481"]},"institutions":[{"id":"https://openalex.org/I4210157231","display_name":"Senex Biotechnology (United States)","ror":"https://ror.org/05w1q8228","country_code":"US","type":"company","lineage":["https://openalex.org/I4210157231"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vimala Kaza","raw_affiliation_strings":["1Senex Biotechnology Inc., Columbia, SC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Senex Biotechnology Inc., Columbia, SC;","institution_ids":["https://openalex.org/I4210157231"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053820301","display_name":"Alexander A. Chumanevich","orcid":"https://orcid.org/0000-0002-0612-1765","observed_orcids":["https://orcid.org/0000-0002-0612-1765"]},"institutions":[{"id":"https://openalex.org/I4210157231","display_name":"Senex Biotechnology (United States)","ror":"https://ror.org/05w1q8228","country_code":"US","type":"company","lineage":["https://openalex.org/I4210157231"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander A. Chumanevich","raw_affiliation_strings":["1Senex Biotechnology Inc., Columbia, SC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Senex Biotechnology Inc., Columbia, SC;","institution_ids":["https://openalex.org/I4210157231"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050972269","display_name":"Serena Altilia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157231","display_name":"Senex Biotechnology (United States)","ror":"https://ror.org/05w1q8228","country_code":"US","type":"company","lineage":["https://openalex.org/I4210157231"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Serena Altilia","raw_affiliation_strings":["1Senex Biotechnology Inc., Columbia, SC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Senex Biotechnology Inc., Columbia, SC;","institution_ids":["https://openalex.org/I4210157231"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060960481","display_name":"Elena Farmaki","orcid":"https://orcid.org/0000-0001-5038-5875","observed_orcids":["https://orcid.org/0000-0001-5038-5875"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Elena Farmaki","raw_affiliation_strings":["3University of Athens, Athens, Greece;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3University of Athens, Athens, Greece;","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028090148","display_name":"Mengqian Chen","orcid":"https://orcid.org/0000-0003-1706-9509","observed_orcids":["https://orcid.org/0000-0003-1706-9509"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mengqian Chen","raw_affiliation_strings":["2University of South Carolina, Columbia, SC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of South Carolina, Columbia, SC;","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006355252","display_name":"Gary P. Schools","orcid":"https://orcid.org/0009-0004-3013-1260","observed_orcids":["https://orcid.org/0009-0004-3013-1260"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary P. Schools","raw_affiliation_strings":["2University of South Carolina, Columbia, SC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of South Carolina, Columbia, SC;","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033125510","display_name":"Ioulia Chatzistamou","orcid":"https://orcid.org/0000-0002-6632-8469","observed_orcids":["https://orcid.org/0000-0002-6632-8469"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Ioulia Chatzistamou","raw_affiliation_strings":["3University of Athens, Athens, Greece;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3University of Athens, Athens, Greece;","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056945063","display_name":"Marj M. Pena","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marj M. Pena","raw_affiliation_strings":["2University of South Carolina, Columbia, SC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of South Carolina, Columbia, SC;","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014280044","display_name":"Lawrence T. Friedhoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157231","display_name":"Senex Biotechnology (United States)","ror":"https://ror.org/05w1q8228","country_code":"US","type":"company","lineage":["https://openalex.org/I4210157231"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence T. Friedhoff","raw_affiliation_strings":["1Senex Biotechnology Inc., Columbia, SC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Senex Biotechnology Inc., Columbia, SC;","institution_ids":["https://openalex.org/I4210157231"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000902500","display_name":"Mark P. Wentland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark P. Wentland","raw_affiliation_strings":["4Rensselaer Polytechnic Institute, Troy, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Rensselaer Polytechnic Institute, Troy, NY","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049867556","display_name":"Eugenia V. Broude","orcid":"https://orcid.org/0000-0002-9180-7111","observed_orcids":["https://orcid.org/0000-0002-9180-7111"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugenia Broude","raw_affiliation_strings":["2University of South Carolina, Columbia, SC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of South Carolina, Columbia, SC;","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032833543","display_name":"Hippokratis Kiaris","orcid":"https://orcid.org/0000-0002-8999-8289","observed_orcids":["https://orcid.org/0000-0002-8999-8289"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Hippokratis Kiaris","raw_affiliation_strings":["3University of Athens, Athens, Greece;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3University of Athens, Athens, Greece;","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006208805","display_name":"Igor B. Roninson","orcid":"https://orcid.org/0000-0002-9211-1327","observed_orcids":["https://orcid.org/0000-0002-9211-1327"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Igor B. Roninson","raw_affiliation_strings":["2University of South Carolina, Columbia, SC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of South Carolina, Columbia, SC;","institution_ids":["https://openalex.org/I155781252"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"74","issue":"19_Supplement","first_page":"4879","last_page":"4879"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.27810001373291016,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.27810001373291016,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.20520000159740448,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.15610000491142273,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/small-molecule-kinase-inhibitors","display_name":"small-molecule kinase inhibitors","score":0.871999979019165},{"id":"https://openalex.org/keywords/transcription-elongation","display_name":"transcription elongation","score":0.675000011920929},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.8450000286102295},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.8240000009536743},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8759999871253967},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7120000123977661},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.6690000295639038},{"id":"https://openalex.org/keywords/ct26-cells","display_name":"CT26 cells","score":0.6050000190734863},{"id":"https://openalex.org/keywords/kinome-profiling","display_name":"kinome profiling","score":0.7490000128746033},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C54174078","wikidata":"https://www.wikidata.org/wiki/Q3197188","display_name":"Kinome","level":3,"score":0.6452705264091492},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5818043947219849},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5762958526611328},{"id":"https://openalex.org/C124320809","wikidata":"https://www.wikidata.org/wiki/Q46292","display_name":"Cyclin-dependent kinase","level":4,"score":0.5590881109237671},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.48548558354377747},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48415571451187134},{"id":"https://openalex.org/C199649820","wikidata":"https://www.wikidata.org/wiki/Q14911762","display_name":"Cyclin-dependent kinase 6","level":5,"score":0.46104806661605835},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.43350833654403687},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40097153186798096},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.38718879222869873},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37846314907073975},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3156706690788269},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.29902464151382446},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2785307765007019},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23482054471969604},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07427191734313965}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2014-4879","doi":"https://doi.org/10.1158/1538-7445.am2014-4879","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-4879","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1979185488","https://openalex.org/W6999932289","https://openalex.org/W4396561742","https://openalex.org/W2084115244","https://openalex.org/W2740267586","https://openalex.org/W2935839272","https://openalex.org/W2500944099","https://openalex.org/W388820836","https://openalex.org/W2119392066","https://openalex.org/W7019728590"],"abstract_inverted_index":{"Abstract":[0],"Cyclin-dependent":[1],"kinase":[2],"8":[3],"(CDK8),":[4],"along":[5],"with":[6,143,206,386],"its":[7],"closely":[8],"related":[9],"paralog":[10],"CDK19,":[11],"are":[12,31],"transcription-regulating":[13],"kinases":[14],"that,":[15],"unlike":[16],"some":[17],"other":[18],"members":[19],"of":[20,37,42,58,66,68,78,84,95,113,180,196,203,213,244,265,275,283,296,330,384,390,401,406],"the":[21,35,43,56,64,76,79,114,211,233,241,257,286,300,311,336,379,382,402,407],"CDK":[22],"family,":[23],"do":[24],"not":[25,32],"regulate":[26],"cell":[27,45],"cycle":[28],"progression":[29,334],"and":[30,86,98,135,158,199,324,381,395],"required":[33],"for":[34,187,410],"growth":[36,198,212,255,298,309],"normal":[38,99,234],"cells":[39,100,218],"or":[40],"most":[41],"tumor":[44,97,197,293,308,333],"types.":[46],"CDK8":[47,290],"has":[48,184],"been":[49,185],"identified":[50],"as":[51,138,148,289],"an":[52,118,139,261],"oncogene":[53],"that":[54,170,318],"enhances":[55],"activity":[57],"several":[59,190],"tumor-promoting":[60,92],"transcription":[61,67],"factors,":[62],"mediating":[63],"elongation":[65],"newly":[69],"activated":[70],"genes.":[71],"We":[72,108],"have":[73],"previously":[74],"reported":[75],"discovery":[77],"first":[80],"selective":[81,387],"small-molecule":[82,388],"inhibitors":[83,389],"CDK8/19":[85,128,319],"their":[87],"ability":[88],"to":[89,223],"block":[90],"chemotherapy-induced":[91],"paracrine":[93],"activities":[94],"both":[96],"(Porter":[101],"et":[102],"al.,":[103],"PNAS":[104],"109,":[105],"13799,":[106],"2012).":[107],"now":[109],"conducted":[110],"chemical":[111],"optimization":[112],"original":[115],"inhibitors,":[116],"yielding":[117],"optimized":[119],"preclinical":[120],"lead":[121],"compound,":[122],"Senexin":[123,125,182,207,224,238,251,280],"B.":[124,376],"B":[126,183,208,225,239,252,281],"inhibits":[127],"in":[129,133,136,166,189,260,292,299,310,327],"low":[130],"nanomolar":[131],"range":[132],"vitro":[134],"vivo":[137],"ATP":[140],"pocket":[141],"binder,":[142],"very":[144],"high":[145],"target":[146],"selectivity":[147],"indicated":[149],"by":[150,177],"kinome":[151],"profiling.":[152],"It":[153],"is":[154],"highly":[155],"water-soluble,":[156],"bioavailable,":[157],"produces":[159,321],"no":[160],"limiting":[161],"toxicity":[162],"upon":[163],"prolonged":[164],"administration":[165],"mice,":[167],"at":[168,335],"doses":[169],"yield":[171],"plasma":[172],"concentrations":[173],"exceeding":[174],"cellular":[175],"IC50":[176],"2-3":[178],"orders":[179],"magnitude.":[181],"tested":[186],"efficacy":[188],"animal":[191],"models":[192],"addressing":[193],"different":[194,328],"aspects":[195],"progression.":[200],"(i)":[201],"Pretreatment":[202],"tumor-free":[204],"mice":[205,221,284],"significantly":[209],"inhibited":[210,253],"triple-negative":[214],"breast":[215],"cancer":[216],"(TNBC)":[217],"inoculated":[219],"into":[220,256],"subsequently":[222],"administration,":[226],"indicating":[227],"a":[228,271,303],"general":[229],"chemopreventive":[230,323],"effect":[231,243,288,305],"on":[232,246,306],"tissue":[235],"\u201csoil\u201d.":[236],"(ii)":[237],"potentiated":[240],"tumor-suppressive":[242],"doxorubicin":[245],"established":[247],"TNBC":[248,267],"xenografts.":[249],"(iii)":[250],"invasive":[254],"muscle":[258],"layer":[259],"orthotopic":[262],"xenograft":[263],"model":[264,274],"MDA-MB-468":[266],"cells.":[268],"(iv)":[269],"In":[270],"spleen-to-liver":[272],"metastasis":[273],"syngeneic":[276],"mouse":[277],"CT26":[278],"tumors,":[279],"treatment":[282],"had":[285],"same":[287],"knockdown":[291],"cells:":[294],"suppression":[295],"metastatic":[297],"liver":[301],"without":[302],"significant":[304],"primary":[307],"spleen.":[312],"Taken":[313],"together,":[314],"these":[315],"results":[316],"indicate":[317],"inhibition":[320],"chemopotentiating,":[322],"anti-metastatic":[325,396],"effects":[326],"types":[329],"cancer,":[331],"inhibiting":[332],"organismal":[337],"level.":[338],"Citation":[339],"Format:":[340],"Donald":[341],"C.":[342],"Porter,":[343],"Jiaxin":[344],"Liang,":[345],"Vimala":[346],"Kaza,":[347],"Alexander":[348],"A.":[349],"Chumanevich,":[350],"Serena":[351],"Altilia,":[352],"Elena":[353],"Farmaki,":[354],"Mengqian":[355],"Chen,":[356],"Gary":[357],"P.":[358,369],"Schools,":[359],"Ioulia":[360],"Chatzistamou,":[361],"Marj":[362],"M.":[363],"Pena,":[364],"Lawrence":[365],"T.":[366],"Friedhoff,":[367],"Mark":[368],"Wentland,":[370],"Eugenia":[371],"Broude,":[372],"Hippokratis":[373],"Kiaris,":[374],"Igor":[375],"Roninson.":[377],"Targeting":[378],"seed":[380],"soil":[383],"cancers":[385],"CDK8/19:":[391],"Chemopotentiating,":[392],"chemopreventive,":[393],"anti-invasive":[394],"activities.":[397],"[abstract].":[398],"In:":[399],"Proceedings":[400],"105th":[403],"Annual":[404],"Meeting":[405],"American":[408],"Association":[409],"Cancer":[411,422],"Research;":[412],"2014":[413],"Apr":[414],"5-9;":[415],"San":[416],"Diego,":[417],"CA.":[418],"Philadelphia":[419],"(PA):":[420],"AACR;":[421],"Res":[423],"2014;74(19":[424],"Suppl):Abstract":[425],"nr":[426],"4879.":[427],"doi:10.1158/1538-7445.AM2014-4879":[428]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}