{"id":"https://openalex.org/W2012960448","doi":"https://doi.org/10.1016/j.ymthe.2006.08.841","title":"757. Engineered Expression of Novel TRIM5 Isoforms Inhibits HIV-1 Infection in CD34 Hematopoietic Stem Cell Derived Macrophages","display_name":"757. Engineered Expression of Novel TRIM5 Isoforms Inhibits HIV-1 Infection in CD34 Hematopoietic Stem Cell Derived Macrophages","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2012960448","doi":"https://doi.org/10.1016/j.ymthe.2006.08.841","mag":"2012960448"},"language":"en","primary_location":{"id":"doi:10.1016/j.ymthe.2006.08.841","doi":"https://doi.org/10.1016/j.ymthe.2006.08.841","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2006.08.841","pdf_url":"http://www.cell.com/article/S1525001606011038/pdf","source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.cell.com/article/S1525001606011038/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010572953","display_name":"Joseph S. Anderson","orcid":"https://orcid.org/0000-0001-6001-1156","observed_orcids":["https://orcid.org/0000-0001-6001-1156"]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph S. Anderson","raw_affiliation_strings":["Microbiology, Immunology, Pathology, Colorado State University, Fort Collins, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology, Immunology, Pathology, Colorado State University, Fort Collins, CO","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051787949","display_name":"Ramesh Akkina","orcid":"https://orcid.org/0000-0002-1577-5154","observed_orcids":["https://orcid.org/0000-0002-1577-5154"]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramesh Akkina","raw_affiliation_strings":["Microbiology, Immunology, Pathology, Colorado State University, Fort Collins, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology, Immunology, Pathology, Colorado State University, Fort Collins, CO","institution_ids":["https://openalex.org/I92446798"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I92446798"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09583762,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":"S293","last_page":"S293"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.026100000366568565,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trim5alpha","display_name":"TRIM5\u03b1","score":0.8429999947547913},{"id":"https://openalex.org/keywords/hiv-1-resistance","display_name":"HIV-1 resistance","score":0.8709999918937683},{"id":"https://openalex.org/keywords/restriction-factors","display_name":"host restriction factors","score":0.7829999923706055},{"id":"https://openalex.org/keywords/cd34-hematopoietic-stem-cells","display_name":"CD34+ hematopoietic stem cells","score":0.8870000243186951},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7620000243186951},{"id":"https://openalex.org/keywords/stem-cell-gene-therapy","display_name":"stem cell gene therapy","score":0.796999990940094},{"id":"https://openalex.org/keywords/lentiviral-vectors","display_name":"lentiviral vectors","score":0.8870000243186951},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.6690000295639038},{"id":"https://openalex.org/keywords/viral-capsid","display_name":"viral capsid","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7656135559082031},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5625835061073303},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5334845781326294},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5133163332939148},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.5103532671928406},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.5043505430221558},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.49216026067733765},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4824822247028351},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.44692960381507874},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.4368782341480255},{"id":"https://openalex.org/C129470790","wikidata":"https://www.wikidata.org/wiki/Q415718","display_name":"CXCR4","level":4,"score":0.4214383363723755},{"id":"https://openalex.org/C203233990","wikidata":"https://www.wikidata.org/wiki/Q1511135","display_name":"Multiplicity of infection","level":3,"score":0.4194182753562927},{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.41409480571746826},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39261674880981445},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3925594687461853},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3351147174835205},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.29695719480514526},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20390111207962036},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.18884626030921936},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11414903402328491},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.0},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.ymthe.2006.08.841","doi":"https://doi.org/10.1016/j.ymthe.2006.08.841","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2006.08.841","pdf_url":"http://www.cell.com/article/S1525001606011038/pdf","source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.ymthe.2006.08.841","doi":"https://doi.org/10.1016/j.ymthe.2006.08.841","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2006.08.841","pdf_url":"http://www.cell.com/article/S1525001606011038/pdf","source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2012960448.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2043046109","https://openalex.org/W2080822703","https://openalex.org/W6981040375","https://openalex.org/W7097582635","https://openalex.org/W4239016843","https://openalex.org/W2013105054","https://openalex.org/W4245651163","https://openalex.org/W1715606990","https://openalex.org/W2072923704","https://openalex.org/W3082842851"],"abstract_inverted_index":{"Species":[0],"specific":[1,214],"innate":[2],"resistance":[3,62,97,223],"against":[4],"viral":[5,55,127,206],"infections":[6,43],"offers":[7],"novel":[8,184],"avenues":[9],"for":[10,233],"antiviral":[11],"therapeutic":[12],"and":[13,18,23,49,152,165],"prophylactic":[14],"approaches.":[15],"The":[16],"retroviral":[17,42],"lentiviral":[19,87],"restriction":[20,215],"factors":[21],"Ref1":[22],"Lv1":[24],"are":[25],"variants":[26],"of":[27,35,47,82,192],"the":[28,45,53,111,156,177,188,212,231],"tripartite":[29],"motif":[30],"protein,":[31],"TRIM5a,":[32],"a":[33,86,90,105,225],"component":[34],"cytoplasmic":[36],"bodies.":[37],"TRIM5a":[38,178],"severely":[39],"restricts":[40],"productive":[41],"at":[44],"level":[46],"post-entry":[48],"pre-integration":[50],"by":[51,69,181,186],"destabilizing":[52],"incoming":[54],"capsid":[56],"via":[57,85],"ubiquitination.":[58],"Using":[59],"this":[60],"approach,":[61],"to":[63,98,122,135,139,149,174,201],"HIV-1":[64,136,222],"infection":[65,137],"could":[66],"be":[67,150,202],"conferred":[68,96],"TRIM5arh":[70,84,112,129,145,217],"expression":[71,81],"in":[72,89,204,220,224,236],"otherwise":[73],"susceptible":[74],"cells.":[75,141],"Here":[76],"we":[77,172],"show":[78],"that":[79,211],"stable":[80,115],"simian":[83],"vector":[88],"permissive":[91],"cell":[92,107,227],"culture":[93],"line,":[94],"Magi-CXC4,":[95],"HIV-1.":[99],"To":[100],"translate":[101],"these":[102,169],"findings":[103],"into":[104,117],"stem":[106,226],"gene":[108,238],"therapy":[109],"setting,":[110],"transgene":[113],"was":[114],"introduced":[116],"CD34+":[118],"hematopoietic":[119],"progenitor":[120],"cells":[121],"derive":[123],"transgenic":[124],"macrophages.":[125],"Upon":[126],"challenge,":[128],"expressing":[130,144,155],"macrophages":[131,143],"were":[132,146],"highly":[133],"resistant":[134],"compared":[138],"control":[140],"Human":[142],"also":[147,198],"found":[148],"phenotypically":[151],"functionally":[153],"normal":[154],"characteristic":[157],"surface":[158],"markers":[159],"CD14,":[160],"CD4,":[161],"CCR5,":[162],"CXCR4,":[163],"MHCII,":[164],"B7.1.":[166],"Based":[167],"on":[168],"promising":[170],"results,":[171],"sought":[173],"further":[175],"improve":[176],"inhibiting":[179],"action":[180],"designing":[182],"more":[183],"constructs":[185],"modifying":[187],"native":[189],"human":[190],"isoform":[191],"TRIM5a.":[193],"These":[194,208],"modified":[195],"isoforms":[196],"have":[197],"been":[199],"shown":[200],"effective":[203,219],"conferring":[205,221],"resistance.":[207],"results":[209],"demonstrate":[210],"species":[213],"factor":[216],"is":[218],"setting":[228],"thus":[229],"paving":[230],"way":[232],"its":[234],"application":[235],"AIDS":[237],"therapy.":[239]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}
