{"id":"https://openalex.org/W2012934080","doi":"https://doi.org/10.1097/00005072-199809000-00004","title":"Cell-Type-Specific Enhancement of Amyloid-\u03b2 Deposition in a Novel Presenilin-1 Mutation (P117L)","display_name":"Cell-Type-Specific Enhancement of Amyloid-\u03b2 Deposition in a Novel Presenilin-1 Mutation (P117L)","publication_year":1998,"publication_date":"1998-09-01","ids":{"openalex":"https://openalex.org/W2012934080","doi":"https://doi.org/10.1097/00005072-199809000-00004","mag":"2012934080","pmid":"https://pubmed.ncbi.nlm.nih.gov/9737546"},"language":"en","primary_location":{"id":"doi:10.1097/00005072-199809000-00004","doi":"https://doi.org/10.1097/00005072-199809000-00004","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005072-199809000-00004","pdf_url":null,"source":{"id":"https://openalex.org/S38023437","display_name":"Journal of Neuropathology & Experimental Neurology","issn_l":"0022-3069","issn":["0022-3069","1554-6578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuropathology and Experimental Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006030271","display_name":"Jerzy W\u0119giel","orcid":"https://orcid.org/0000-0002-3685-0694","observed_orcids":["https://orcid.org/0000-0002-3685-0694"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jerzy Wegiel","raw_affiliation_strings":["New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109936852","display_name":"Henryk M. W\u00edsniewski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Henryk M. Wisniewski","raw_affiliation_strings":["New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091226042","display_name":"Izabela Kuchna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Izabela Kuchna","raw_affiliation_strings":["Medical Research Center, Polish Academy of Sciences, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Center, Polish Academy of Sciences, Warsaw, Poland","institution_ids":["https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097506771","display_name":"Michal Taranawski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michal Taranawski","raw_affiliation_strings":["New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082335313","display_name":"Eulalia Badmajew","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eulalia Badmajew","raw_affiliation_strings":["New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052872013","display_name":"E. R. Popovitch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eirene Popovitch","raw_affiliation_strings":["New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038220957","display_name":"Jerzy Kulczycki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153937","display_name":"Institute of Psychiatry and Neurology","ror":"https://ror.org/0468k6j36","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210153937"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Jerzy Kulczycki","raw_affiliation_strings":["Institute of Psychiatry and Neurology, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Psychiatry and Neurology, Warsaw, Poland","institution_ids":["https://openalex.org/I4210153937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007320348","display_name":"Wieslaw K. Dowjat","orcid":"https://orcid.org/0000-0002-5752-4628","observed_orcids":["https://orcid.org/0000-0002-5752-4628"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wieslaw K. Dowjat","raw_affiliation_strings":["New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060656369","display_name":"Thomas W\u0131sn\u0131ewsk\u0131","orcid":"https://orcid.org/0000-0002-3379-8966","observed_orcids":["https://orcid.org/0000-0002-3379-8966"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Wisniewski","raw_affiliation_strings":["Department of Neurology and Pathology, New York University Medical Center, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Pathology, New York University Medical Center, New York","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5036,"currency":"USD","value_usd":5036},"apc_paid":null,"fwci":0.825,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.66468338,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"57","issue":"9","first_page":"831","last_page":"838"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/presenilin-1","display_name":"presenilin 1","score":0.8999999761581421},{"id":"https://openalex.org/keywords/familial-alzheimer-s-disease","display_name":"familial Alzheimer's disease","score":0.8650000095367432},{"id":"https://openalex.org/keywords/amyloid-beta-deposition","display_name":"amyloid-beta deposition","score":0.9089999794960022},{"id":"https://openalex.org/keywords/vascular-amyloid","display_name":"vascular amyloid","score":0.7559999823570251},{"id":"https://openalex.org/keywords/down-syndrome","display_name":"Down syndrome","score":0.7710000276565552},{"id":"https://openalex.org/keywords/amyloid-precursor-protein-overexpression","display_name":"amyloid precursor protein overexpression","score":0.7900000214576721},{"id":"https://openalex.org/keywords/entorhinal-cortex","display_name":"entorhinal cortex","score":0.8479999899864197},{"id":"https://openalex.org/keywords/neuropathology","display_name":"neuropathology","score":0.609000027179718},{"id":"https://openalex.org/keywords/polish-families","display_name":"Polish families","score":0.3580000102519989}],"concepts":[{"id":"https://openalex.org/C175344181","wikidata":"https://www.wikidata.org/wiki/Q907198","display_name":"Presenilin","level":4,"score":0.8787941336631775},{"id":"https://openalex.org/C2780130745","wikidata":"https://www.wikidata.org/wiki/Q1650750","display_name":"Neuropathology","level":3,"score":0.7113876342773438},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5715036392211914},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5220922231674194},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4566269814968109},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4559382498264313},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.4532817006111145},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4424282908439636},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.43900150060653687},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43653547763824463},{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.42200767993927},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4174530804157257},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3555556833744049},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30844569206237793},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1834930181503296},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14587906002998352}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004314","descriptor_name":"Down Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004314","descriptor_name":"Down Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011044","descriptor_name":"Poland","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018728","descriptor_name":"Entorhinal Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018891","descriptor_name":"Dentate Gyrus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D053764","descriptor_name":"Presenilin-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00005072-199809000-00004","doi":"https://doi.org/10.1097/00005072-199809000-00004","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005072-199809000-00004","pdf_url":null,"source":{"id":"https://openalex.org/S38023437","display_name":"Journal of Neuropathology & Experimental Neurology","issn_l":"0022-3069","issn":["0022-3069","1554-6578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuropathology and Experimental Neurology","raw_type":"journal-article"},{"id":"pmid:9737546","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9737546","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuropathology and experimental neurology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3144556427","display_name":"Aging and Dementia in Adults with Down Syndrome","funder_award_id":"P01HD035897","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G4260073904","display_name":"AMYLOID ANGIOPATHY, EARLY PLAQUES &AGING","funder_award_id":"R01AG008721","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5468171654","display_name":null,"funder_award_id":"P01 HD35897-11","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2025911651","https://openalex.org/W2397220074","https://openalex.org/W7132647464","https://openalex.org/W2232572728","https://openalex.org/W2043415277","https://openalex.org/W3021327035","https://openalex.org/W7206457912","https://openalex.org/W1965252410","https://openalex.org/W2055670958","https://openalex.org/W2000397440"],"abstract_inverted_index":{"The":[0,35,85,108,163,186],"presenilin-1":[1],"(PS1)":[2],"gene":[3],"mutation":[4,43,191],"(Pro117Leu),":[5],"recently":[6],"identified":[7],"in":[8,95,102,120,172,214],"a":[9,27,77,92,134,148,177,223],"Polish":[10,86,130],"family":[11],"is":[12],"characterized":[13],"by":[14],"the":[15,96,106,115,129,141,145,173,205,208],"earliest":[16],"reported":[17],"onset":[18],"(from":[19],"24-31":[20],"years)":[21,50,64],"of":[22,31,37,80,82,99,105,123,128,137,144,182,188,207],"Alzheimer":[23],"disease":[24,32,81],"(AD)":[25],"and":[26,48,65,150,158,200],"very":[28],"short":[29],"duration":[30,79],"(4-6":[33],"years).":[34,84],"neuropathology":[36],"2":[38,100],"subjects":[39],"with":[40,76,156],"this":[41,189],"PS1":[42,190],"(ages":[44],"at":[45,61,72],"death:":[46,62,73],"35":[47],"37":[49],"was":[51,111,118,153,168],"compared":[52,155],"to":[53],"four":[54],"Down":[55],"syndrome":[56],"(DS)":[57],"patients":[58,69,90,132,161],"(mean":[59,70],"age":[60,71],"62":[63],"4":[66],"sporadic":[67,159],"AD":[68,88,160],"79":[74],"years":[75],"mean":[78],"18":[83],"familial":[87],"(FAD)":[89],"showed":[91,133],"marked":[93],"increase":[94,136,152,181],"amyloid":[97,116,166,183,202,209,227],"burden":[98,117,167],"6-fold":[101],"most":[103],"areas":[104],"brain.":[107],"entorhinal":[109],"cortex":[110],"an":[112,193],"exception":[113],"where":[114,147],"similar":[119],"each":[121],"category":[122],"patient.":[124],"Some":[125],"brain":[126],"regions":[127],"FAD":[131,174],"massive":[135],"amyloid,":[138],"such":[139],"as":[140],"molecular":[142],"layer":[143],"cerebellum":[146],"7-":[149],"25-fold":[151],"noted,":[154],"DS":[157,215],"respectively.":[162],"cerebellar":[164],"vessel":[165],"also":[169],"greatly":[170],"increased":[171],"patients,":[175,216],"reflecting":[176],"vascular":[178,199],"compartment":[179],"specific":[180],"beta":[184,210],"deposition.":[185,228],"presence":[187],"has":[192],"even":[194],"greater":[195],"effect":[196],"on":[197],"both":[198],"parenchymal":[201],"deposition,":[203],"than":[204],"overexpression":[206],"precursor":[211],"protein":[212],"present":[213],"suggesting":[217],"that":[218],"PS":[219],"mutations":[220],"can":[221],"be":[222],"critical":[224],"factor":[225],"determining":[226]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}