{"id":"https://openalex.org/W2012899538","doi":"https://doi.org/10.1006/mben.2002.0231","title":"Mathematical Modeling of in vitro Enzymatic Production of 2-Keto-L-gulonic Acid Using NAD(H) or NADP(H) as Cofactors","display_name":"Mathematical Modeling of in vitro Enzymatic Production of 2-Keto-L-gulonic Acid Using NAD(H) or NADP(H) as Cofactors","publication_year":2002,"publication_date":"2002-10-01","ids":{"openalex":"https://openalex.org/W2012899538","doi":"https://doi.org/10.1006/mben.2002.0231","mag":"2012899538","pmid":"https://pubmed.ncbi.nlm.nih.gov/12646322"},"language":"en","primary_location":{"id":"doi:10.1006/mben.2002.0231","doi":"https://doi.org/10.1006/mben.2002.0231","is_oa":false,"landing_page_url":"https://doi.org/10.1006/mben.2002.0231","pdf_url":null,"source":{"id":"https://openalex.org/S173328182","display_name":"Metabolic Engineering","issn_l":"1096-7176","issn":["1096-7176","1096-7184"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolic Engineering","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063109716","display_name":"Scott A. Banta","orcid":"https://orcid.org/0000-0001-7885-0150","observed_orcids":["https://orcid.org/0000-0001-7885-0150"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Banta","raw_affiliation_strings":["Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway 08854, USA","Center for Advanced Biotechnology and Medicine, 679 Hoes Lane, Piscataway, New Jersey, 08854","Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway, New Jersey, 08854"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway 08854, USA","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Center for Advanced Biotechnology and Medicine, 679 Hoes Lane, Piscataway, New Jersey, 08854","institution_ids":[]},{"raw_affiliation_string":"Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway, New Jersey, 08854","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010127428","display_name":"Matt Boston","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matt Boston","raw_affiliation_strings":["Genencor International, 925 Page Mill Road, Palo Alto, California, 94304"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genencor International, 925 Page Mill Road, Palo Alto, California, 94304","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071097332","display_name":"Alisha Jarnagin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alisha Jarnagin","raw_affiliation_strings":["Genencor International, 925 Page Mill Road, Palo Alto, California, 94304"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genencor International, 925 Page Mill Road, Palo Alto, California, 94304","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"Stephen Anderson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen Anderson","raw_affiliation_strings":["Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway, New Jersey, 08854","Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, New Jersey, 08854"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway, New Jersey, 08854","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, New Jersey, 08854","institution_ids":["https://openalex.org/I102322142"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I102322142"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":0.2317,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.50391606,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"4","issue":"4","first_page":"273","last_page":"284"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.8446999788284302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.8446999788284302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.09480000287294388,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12688","display_name":"Microbial metabolism and enzyme function","score":0.020400000736117363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/2-keto-l-gulonic-acid","display_name":"2-keto-L-gulonic acid","score":0.9900000095367432},{"id":"https://openalex.org/keywords/vitamin-c-synthesis","display_name":"vitamin C biosynthesis","score":0.8460000157356262},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.6359999775886536},{"id":"https://openalex.org/keywords/rate-equation-model","display_name":"rate equation model","score":0.8289999961853027}],"concepts":[{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.9052264094352722},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.8877370357513428},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.6117949485778809},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5668900012969971},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5530923008918762},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5501693487167358},{"id":"https://openalex.org/C2780388412","wikidata":"https://www.wikidata.org/wiki/Q407569","display_name":"Gluconic acid","level":2,"score":0.4938097894191742},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4497159421443939},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.42545557022094727},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003067","descriptor_name":"Coenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013400","descriptor_name":"Sugar Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013401","descriptor_name":"Sugar Alcohol Dehydrogenases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013401","descriptor_name":"Sugar Alcohol Dehydrogenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019149","descriptor_name":"Bioreactors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020636","descriptor_name":"Pantoea","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020636","descriptor_name":"Pantoea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1006/mben.2002.0231","doi":"https://doi.org/10.1006/mben.2002.0231","is_oa":false,"landing_page_url":"https://doi.org/10.1006/mben.2002.0231","pdf_url":null,"source":{"id":"https://openalex.org/S173328182","display_name":"Metabolic Engineering","issn_l":"1096-7176","issn":["1096-7176","1096-7184"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolic Engineering","raw_type":"journal-article"},{"id":"pmid:12646322","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12646322","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolic engineering","raw_type":"Comparative Study"},{"id":"pmh:oai:alma.01RUT_INST:11663504410004646","doi":null,"is_oa":false,"landing_page_url":"https://scholarship.libraries.rutgers.edu/esploro/outputs/journalArticle/Mathematical-modeling-of-in-vitro-enzymatic/991031654476404646","pdf_url":null,"source":{"id":"https://openalex.org/S4306401388","display_name":"Rutgers University Community Repository (Rutgers University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102322142","host_organization_name":"Rutgers, The State University of New Jersey","host_organization_lineage":["https://openalex.org/I102322142"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5690000057220459,"id":"https://metadata.un.org/sdg/7","display_name":"Affordable and clean energy"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6549768257","display_name":"Rutgers University Biotechnology Training Program","funder_award_id":"T32GM008339","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332178","display_name":"National Institute of Standards and Technology","ror":"https://ror.org/05xpvk416"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W71123245","https://openalex.org/W419688385","https://openalex.org/W1496323484","https://openalex.org/W1543819219","https://openalex.org/W1567974798","https://openalex.org/W1606879577","https://openalex.org/W1755321768","https://openalex.org/W1787690277","https://openalex.org/W1994797166","https://openalex.org/W2000315362","https://openalex.org/W2046915036","https://openalex.org/W2051821755","https://openalex.org/W2061955884","https://openalex.org/W2065163714","https://openalex.org/W2093433336","https://openalex.org/W2149617706","https://openalex.org/W2151524849","https://openalex.org/W4246090862"],"related_works":["https://openalex.org/W2015510280","https://openalex.org/W2061955884","https://openalex.org/W2149617706","https://openalex.org/W2093433336","https://openalex.org/W7099731207","https://openalex.org/W7014855553","https://openalex.org/W2044922082","https://openalex.org/W2901101993","https://openalex.org/W4380372694","https://openalex.org/W2244673767"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}