{"id":"https://openalex.org/W2012897240","doi":"https://doi.org/10.1159/000205321","title":"Acute Promyelocytic Leukemia: A 5-Year Experience with New Antileukemic Agents and a New Approach to Preventing Fatal Hemorrhage","display_name":"Acute Promyelocytic Leukemia: A 5-Year Experience with New Antileukemic Agents and a New Approach to Preventing Fatal Hemorrhage","publication_year":2009,"publication_date":"2009-02-20","ids":{"openalex":"https://openalex.org/W2012897240","doi":"https://doi.org/10.1159/000205321","mag":"2012897240","pmid":"https://pubmed.ncbi.nlm.nih.gov/2510432"},"language":"en","primary_location":{"id":"doi:10.1159/000205321","doi":"https://doi.org/10.1159/000205321","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000205321","pdf_url":null,"source":{"id":"https://openalex.org/S182948766","display_name":"Acta Haematologica","issn_l":"0001-5792","issn":["0001-5792","1421-9662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Haematologica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040539933","display_name":"Eric Jay Feldman","orcid":"https://orcid.org/0009-0006-8191-7698","observed_orcids":["https://orcid.org/0009-0006-8191-7698"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric.J Feldman","raw_affiliation_strings":["New York Medical College, Valhalla","New York Medical College, Valhalla, N.Y., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York Medical College, Valhalla","institution_ids":["https://openalex.org/I181190671"]},{"raw_affiliation_string":"New York Medical College, Valhalla, N.Y., USA","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111695845","display_name":"Zalmen A. Arlin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zalmen.A Arlin","raw_affiliation_strings":["New York Medical College, Valhalla, N.Y., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York Medical College, Valhalla, N.Y., USA","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023200705","display_name":"Tauseef Ahmed","orcid":"https://orcid.org/0000-0003-1260-594X","observed_orcids":["https://orcid.org/0000-0003-1260-594X"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tauseef Ahmed","raw_affiliation_strings":["New York Medical College, Valhalla, N.Y., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York Medical College, Valhalla, N.Y., USA","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085244083","display_name":"Abraham Mittelman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abraham Mittelman","raw_affiliation_strings":["New York Medical College, Valhalla, N.Y., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York Medical College, Valhalla, N.Y., USA","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059061125","display_name":"Jo\u00e3o L. Ascens\u00e3o","orcid":"https://orcid.org/0000-0001-6317-1569","observed_orcids":["https://orcid.org/0000-0001-6317-1569"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joao.L Ascensao","raw_affiliation_strings":["New York Medical College, Valhalla, N.Y., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York Medical College, Valhalla, N.Y., USA","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110077069","display_name":"Carmelo A. Puccio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carmelo.A Puccio","raw_affiliation_strings":["New York Medical College, Valhalla, N.Y., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York Medical College, Valhalla, N.Y., USA","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077132810","display_name":"Nancy Coombe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy Coombe","raw_affiliation_strings":["New York Medical College, Valhalla, N.Y., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York Medical College, Valhalla, N.Y., USA","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014886100","display_name":"Paul Baskind","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Baskind","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2681,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.55739285,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"82","issue":"3","first_page":"117","last_page":"121"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-promyelocytic-leukemia","display_name":"acute promyelocytic leukemia","score":1.0},{"id":"https://openalex.org/keywords/induction-chemotherapy","display_name":"induction chemotherapy","score":0.8759999871253967},{"id":"https://openalex.org/keywords/amsacrine","display_name":"amsacrine","score":0.7910000085830688},{"id":"https://openalex.org/keywords/high-dose-cytarabine","display_name":"high-dose cytarabine","score":0.9819999933242798},{"id":"https://openalex.org/keywords/homoharringtonine","display_name":"homoharringtonine","score":0.9760000109672546},{"id":"https://openalex.org/keywords/daunorubicin","display_name":"daunorubicin","score":0.9190000295639038},{"id":"https://openalex.org/keywords/idarubicin","display_name":"idarubicin","score":0.984000027179718},{"id":"https://openalex.org/keywords/mitoxantrone","display_name":"mitoxantrone","score":0.9929999709129333},{"id":"https://openalex.org/keywords/bisantrene","display_name":"bisantrene","score":0.9729999899864197},{"id":"https://openalex.org/keywords/heparin-prophylaxis","display_name":"heparin prophylaxis","score":0.7990000247955322},{"id":"https://openalex.org/keywords/platelet-transfusion","display_name":"platelet transfusion","score":0.7369999885559082},{"id":"https://openalex.org/keywords/fresh-frozen-plasma","display_name":"fresh frozen plasma","score":0.8970000147819519},{"id":"https://openalex.org/keywords/bleeding-prevention","display_name":"bleeding prevention","score":0.9330000281333923},{"id":"https://openalex.org/keywords/complete-remission","display_name":"complete remission","score":0.9399999976158142},{"id":"https://openalex.org/keywords/relapsed-leukemia","display_name":"relapsed leukemia","score":0.828000009059906},{"id":"https://openalex.org/keywords/refractory-leukemia","display_name":"refractory leukemia","score":0.972000002861023}],"concepts":[{"id":"https://openalex.org/C2776601000","wikidata":"https://www.wikidata.org/wiki/Q612108","display_name":"Acute promyelocytic leukemia","level":4,"score":0.7704675197601318},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7016725540161133},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5987066030502319},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33853912353515625},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.12747398018836975},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08612915873527527},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004211","descriptor_name":"Disseminated Intravascular Coagulation","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015473","descriptor_name":"Leukemia, Promyelocytic, Acute","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D015473","descriptor_name":"Leukemia, Promyelocytic, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1159/000205321","doi":"https://doi.org/10.1159/000205321","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000205321","pdf_url":null,"source":{"id":"https://openalex.org/S182948766","display_name":"Acta Haematologica","issn_l":"0001-5792","issn":["0001-5792","1421-9662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Haematologica","raw_type":"journal-article"},{"id":"pmid:2510432","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2510432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta haematologica","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1581043688","https://openalex.org/W2037949275","https://openalex.org/W2474307831","https://openalex.org/W2002552414","https://openalex.org/W1982426748","https://openalex.org/W94282444","https://openalex.org/W2053306416","https://openalex.org/W2414768692","https://openalex.org/W2373467619","https://openalex.org/W2397931777"],"abstract_inverted_index":{"Forty-six":[0],"induction":[1,42,182],"courses":[2,113],"were":[3,13,29,33,38,64,119],"administered":[4],"to":[5,40,66],"32":[6,32],"patients":[7,28,71],"with":[8,19,80,91,99,168],"acute":[9],"promyelocytic":[10],"leukemia.":[11],"There":[12],"28":[14],"males":[15],"and":[16,36,54,85,102,140,152,170],"18":[17],"females":[18],"a":[20,136,144],"median":[21],"age":[22],"of":[23,52,57,111,155,166,179],"39.5":[24],"(range":[25],"19-68).":[26],"Twelve":[27],"previously":[30,122],"untreated,":[31],"in":[34,78,107,135],"relapse,":[35],"2":[37],"refractory":[39,86,130],"primary":[41,129,159],"chemotherapy.":[43],"Heparin":[44],"7.5-10":[45],"units/kg/h":[46],"by":[47],"continuous":[48],"infusion,":[49],"4-6":[50],"units":[51,56],"platelets":[53],"1-2":[55],"fresh-frozen":[58],"plasma":[59],"(FFP)":[60],"every":[61,173],"12":[62,174],"h":[63,175],"given":[65],"all":[67],"patients.":[68],"Previously":[69],"untreated":[70,123],"received":[72],"either":[73],"daunorubicin,":[74],"idarubicin":[75],"or":[76,98],"mitoxantrone":[77,101],"combination":[79],"cytarabine":[81,93],"(Ara-C).":[82],"For":[83],"relapsed":[84,126],"patients,":[87],"regimens":[88,142,149],"included":[89],"amsacrine":[90],"high-dose":[92],"(Amsa/HiDac),":[94],"homoharringtonine":[95],"(HHT)":[96],"alone,":[97],"Ara-C,":[100],"bisantrene.":[103],"Hemorrhagic":[104],"complications":[105],"occurred":[106],"only":[108],"1":[109],"out":[110],"46":[112],"(2%).":[114],"Complete":[115],"remission":[116],"rates":[117],"(CR)":[118],"as":[120],"follows:":[121],"83%":[124],"(10/12),":[125],"66%":[127],"(21/32),":[128],"50%":[131],"(1/2).":[132],"Amsa/HiDac":[133],"resulted":[134],"71%":[137],"(10/14)":[138],"CR":[139],"HHT-based":[141],"achieved":[143],"46%":[145],"(6/13)":[146],"CR.":[147],"These":[148],"are":[150],"effective":[151],"the":[153,177],"value":[154],"their":[156],"incorporation":[157],"into":[158],"therapy":[160],"should":[161],"be":[162],"studied.":[163],"The":[164],"use":[165],"heparin":[167],"platelet":[169],"FFP":[171],"transfusions":[172],"reduces":[176],"risk":[178],"hemorrhage":[180],"during":[181],"therapy.":[183]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}