{"id":"https://openalex.org/W2012889194","doi":"https://doi.org/10.1002/ajh.20483","title":"Variability of ZAP 70 expression in a patient with CLL","display_name":"Variability of ZAP 70 expression in a patient with CLL","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2012889194","doi":"https://doi.org/10.1002/ajh.20483","mag":"2012889194","pmid":"https://pubmed.ncbi.nlm.nih.gov/16823829"},"language":"en","primary_location":{"id":"doi:10.1002/ajh.20483","doi":"https://doi.org/10.1002/ajh.20483","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ajh.20483","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajh.20483","source":{"id":"https://openalex.org/S199810014","display_name":"American Journal of Hematology","issn_l":"0361-8609","issn":["0361-8609","1096-8652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hematology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajh.20483","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089082003","display_name":"Bassem T. Chaar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bassem T. Chaar","raw_affiliation_strings":["Department of Hematology/Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology/Oncology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109846250","display_name":"Leonard Grosso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonard Grosso","raw_affiliation_strings":["Department of Pathology, St. Louis University, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, St. Louis University, St. Louis, Missouri","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088180532","display_name":"Paul J. Petruska","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul J. Petruska","raw_affiliation_strings":["Department of Hematology/Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology/Oncology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":0.467,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.68751432,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"81","issue":"8","first_page":"645","last_page":"645"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.7480000257492065,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.7480000257492065,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.23070000112056732,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zap-70","display_name":"ZAP-70","score":0.8370000123977661},{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.9789999723434448},{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":0.9139999747276306},{"id":"https://openalex.org/keywords/tonsillectomy","display_name":"tonsillectomy","score":0.9760000109672546},{"id":"https://openalex.org/keywords/immunoglobulin-gene-rearrangement","display_name":"immunoglobulin gene rearrangement","score":0.9259999990463257},{"id":"https://openalex.org/keywords/ki-67-proliferation-index","display_name":"Ki-67 proliferation index","score":0.7850000262260437},{"id":"https://openalex.org/keywords/non-hodgkin-lymphoma","display_name":"non-Hodgkin lymphoma","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.7977827787399292},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.6440240144729614},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5876219272613525},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5524267554283142},{"id":"https://openalex.org/C2778805511","wikidata":"https://www.wikidata.org/wiki/Q1713","display_name":"Citation","level":2,"score":0.5053532719612122},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.433709055185318},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.39097851514816284},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.3791370391845703},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.10664036870002747}],"mesh":[{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002880","descriptor_name":"Chromosomes, Human, Pair 11","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002882","descriptor_name":"Chromosomes, Human, Pair 13","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015973","descriptor_name":"Gene Expression Regulation, Leukemic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020732","descriptor_name":"Cytogenetic Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051746","descriptor_name":"ZAP-70 Protein-Tyrosine Kinase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051746","descriptor_name":"ZAP-70 Protein-Tyrosine Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/ajh.20483","doi":"https://doi.org/10.1002/ajh.20483","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ajh.20483","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajh.20483","source":{"id":"https://openalex.org/S199810014","display_name":"American Journal of Hematology","issn_l":"0361-8609","issn":["0361-8609","1096-8652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hematology","raw_type":"journal-article"},{"id":"pmid:16823829","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16823829","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of hematology","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.1002/ajh.20483","doi":"https://doi.org/10.1002/ajh.20483","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ajh.20483","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajh.20483","source":{"id":"https://openalex.org/S199810014","display_name":"American Journal of Hematology","issn_l":"0361-8609","issn":["0361-8609","1096-8652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hematology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2012889194.pdf","grobid_xml":"https://content.openalex.org/works/W2012889194.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W2031192472","https://openalex.org/W2086637735","https://openalex.org/W4211220949"],"related_works":["https://openalex.org/W1979652220","https://openalex.org/W2037322632","https://openalex.org/W2011261861","https://openalex.org/W1971423378","https://openalex.org/W2219647013","https://openalex.org/W166612491","https://openalex.org/W7077081105","https://openalex.org/W2296608127","https://openalex.org/W4206663663","https://openalex.org/W2615948813"],"abstract_inverted_index":{"To":[0],"the":[1,21,32,108,139,168,183],"Editor:":[2],"Primary":[3],"tonsillary":[4,54],"lymphoma":[5],"accounts":[6],"for":[7,27,73,90,129,188,233],"less":[8],"than":[9],"1%":[10],"of":[11,66,110,117,186,208,223],"head":[12],"and":[13,23,56,76,102,138,196],"neck":[14],"malignancies.Tonsillectomy":[15],"is":[16,171,181],"used":[17],"to":[18,48],"mainly":[19],"establish":[20],"diagnosis":[22,116],"can":[24],"be":[25,238],"performed":[26,95],"localized":[28,189,234],"small":[29],"lesions.In":[30],"general,":[31,178],"patients":[33],"are":[34],"treated":[35],"by":[36,78],"chemotherapy":[37],"and/or":[38],"radiotherapy":[39],"[1,2].We":[40],"present":[41],"a":[42,63,104,111,205],"23-year-old":[43],"woman":[44],"who":[45,216],"was":[46,59,80,83,94,123,136,141,155,164,176],"referred":[47],"our":[49,229],"ENT":[50],"clinic":[51],"with":[52],"asymmetric":[53],"enlargement":[55],"acute":[57],"bleeding.Tonsillectomy":[58],"performed.In":[60],"paraffin":[61],"sections;":[62],"tumor":[64,130],"composed":[65],"large":[67],"lymphoid":[68],"cells":[69],"that":[70],"were":[71],"positive":[72],"CD20,":[74],"bcl-2,":[75],"p53":[77],"immunohistochemistry":[79],"identified.Ki-67":[81],"index":[82],"roughly":[84],"80%":[85,209],"(Figure":[86],"1).Polymerase":[87],"chain":[88],"reaction":[89],"immunoglobulin":[91],"gene":[92],"rearrangements":[93],"using":[96],"DNA":[97],"extracted":[98],"from":[99],"paraffin-embedded":[100],"tissue":[101],"showed":[103],"single":[105],"band":[106],"indicating":[107],"presence":[109],"clonal":[112],"B":[113,120],"cell":[114],"proliferation.A":[115],"''Diffuse":[118],"Large":[119],"Cell":[121],"Lymphoma''":[122],"rendered.No":[124],"clinical":[125],"or":[126,161],"radiological":[127],"evidence":[128],"involvement":[131,163],"in":[132,191],"any":[133,151,220],"other":[134],"site":[135],"identified":[137],"patient":[140,147,154],"accepted":[142],"as":[143,226,228],"Stage":[144],"I":[145,195,213],"clinically.The":[146],"did":[148],"not":[149,165],"accept":[150],"further":[152],"treatment.The":[153],"followed":[156,218],"periodically":[157],"every":[158],"6":[159],"months.Recurrence":[160],"systemic":[162],"observed":[166],"during":[167],"5-year-follow-up.This":[169],"case":[170],"unusual":[172],"since":[173],"only":[174],"tonsillectomy":[175],"curative.In":[177],"radiation":[179],"therapy":[180,187,231],"considered":[182],"primary":[184],"mode":[185],"disease":[190],"tonsil":[192],"lymphomas":[193],"(stages":[194],"II)":[197],"[3,4].In":[198],"one":[199],"study,":[200],"Jelic":[201],"et":[202],"al.":[203],"reported":[204],"cure":[206],"rate":[207],"among":[210],"their":[211,224],"stage":[212],"NHL":[214,235],"patients,":[215],"they":[217],"without":[219],"therapy.In":[221],"light":[222],"experience":[225],"well":[227],"observation,":[230],"options":[232],"cases":[236],"should":[237],"re-evaluated.":[239]},"counts_by_year":[{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
