{"id":"https://openalex.org/W2012860339","doi":"https://doi.org/10.1111/jth.12482","title":"Flow\u2010dependent thrombin and fibrin generation in vitro: opportunities for standardization: communication from SSC of the ISTH","display_name":"Flow\u2010dependent thrombin and fibrin generation in vitro: opportunities for standardization: communication from SSC of the ISTH","publication_year":2013,"publication_date":"2013-12-11","ids":{"openalex":"https://openalex.org/W2012860339","doi":"https://doi.org/10.1111/jth.12482","mag":"2012860339","pmid":"https://pubmed.ncbi.nlm.nih.gov/24330648"},"language":"en","primary_location":{"id":"doi:10.1111/jth.12482","doi":"https://doi.org/10.1111/jth.12482","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jth.12482","pdf_url":"http://www.jthjournal.org/article/S1538783622038697/pdf","source":{"id":"https://openalex.org/S164469042","display_name":"Journal of Thrombosis and Haemostasis","issn_l":"1538-7836","issn":["1538-7836","1538-7933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thrombosis and Haemostasis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jthjournal.org/article/S1538783622038697/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070205215","display_name":"Keith B. Neeves","orcid":"https://orcid.org/0000-0001-7546-4588","observed_orcids":["https://orcid.org/0000-0001-7546-4588"]},"institutions":[{"id":"https://openalex.org/I167576493","display_name":"Colorado School of Mines","ror":"https://ror.org/04raf6v53","country_code":"US","type":"education","lineage":["https://openalex.org/I167576493"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"K.B. Neeves","raw_affiliation_strings":["Department of Chemical and Biological Engineering, Colorado School of Mines, Golden, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering, Colorado School of Mines, Golden, CO, USA","institution_ids":["https://openalex.org/I167576493"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050978437","display_name":"Owen J. T. McCarty","orcid":"https://orcid.org/0000-0001-9481-0124","observed_orcids":["https://orcid.org/0000-0001-9481-0124"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"O.J.T. McCarty","raw_affiliation_strings":["Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA","Department of Biomedical Engineering, Oregon Health & Science University , Portland, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Oregon Health & Science University , Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066175035","display_name":"Armin J. Reininger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101150","display_name":"Baxter (Austria)","ror":"https://ror.org/013xmn143","country_code":"AT","type":"company","lineage":["https://openalex.org/I4210101150","https://openalex.org/I99484792"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"A.J. Reininger","raw_affiliation_strings":["Global Medical Affairs Hemophilia, Baxter Innovations GmbH, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Medical Affairs Hemophilia, Baxter Innovations GmbH, Vienna, Austria","institution_ids":["https://openalex.org/I4210101150"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018221265","display_name":"Mitsuhiko Sugimoto","orcid":"https://orcid.org/0000-0003-2935-5502","observed_orcids":["https://orcid.org/0000-0003-2935-5502"]},"institutions":[{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Sugimoto","raw_affiliation_strings":["Department of Regulatory Medicine for Thrombosis, Nara Medical University, Nara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Regulatory Medicine for Thrombosis, Nara Medical University, Nara, Japan","institution_ids":["https://openalex.org/I64926303"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081005464","display_name":"Michael R. King","orcid":"https://orcid.org/0000-0002-0223-7808","observed_orcids":["https://orcid.org/0000-0002-0223-7808","https://orcid.org/0009-0006-4643-3663"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.R. King","raw_affiliation_strings":["Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5070205215"],"corresponding_institution_ids":["https://openalex.org/I167576493"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":2.4384,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.88768617,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"12","issue":"3","first_page":"418","last_page":"420"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.7060999870300293,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.7060999870300293,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.2912999987602234,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/blood-flow","display_name":"blood flow","score":0.6449999809265137},{"id":"https://openalex.org/keywords/thrombin-generation","display_name":"thrombin generation","score":0.8960000276565552},{"id":"https://openalex.org/keywords/fibrin-formation","display_name":"fibrin formation","score":0.9810000061988831},{"id":"https://openalex.org/keywords/shear-rate","display_name":"shear rate","score":0.9419999718666077},{"id":"https://openalex.org/keywords/hemodynamics","display_name":"hemodynamics","score":0.6430000066757202},{"id":"https://openalex.org/keywords/deep-vein-thrombosis","display_name":"deep vein thrombosis","score":0.949999988079071},{"id":"https://openalex.org/keywords/thromboembolism","display_name":"thromboembolism","score":0.8460000157356262},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.7009999752044678},{"id":"https://openalex.org/keywords/platelet-adhesion","display_name":"platelet adhesion","score":0.75},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.847000002861023},{"id":"https://openalex.org/keywords/antithrombotic-agents","display_name":"antithrombotic agents","score":0.8370000123977661},{"id":"https://openalex.org/keywords/factor-deficiency","display_name":"factor deficiency","score":0.6899999976158142}],"concepts":[{"id":"https://openalex.org/C3018972837","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin generation","level":4,"score":0.839978039264679},{"id":"https://openalex.org/C188087704","wikidata":"https://www.wikidata.org/wiki/Q369577","display_name":"Standardization","level":2,"score":0.6566647291183472},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.6375536918640137},{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.5776519775390625},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5305754542350769},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43360763788223267},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30616527795791626},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3043941259384155},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2275075614452362},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.17295098304748535},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12653964757919312},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005337","descriptor_name":"Fibrin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007391","descriptor_name":"International Cooperation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012955","descriptor_name":"Societies, Medical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013925","descriptor_name":"Thromboplastin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/jth.12482","doi":"https://doi.org/10.1111/jth.12482","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jth.12482","pdf_url":"http://www.jthjournal.org/article/S1538783622038697/pdf","source":{"id":"https://openalex.org/S164469042","display_name":"Journal of Thrombosis and Haemostasis","issn_l":"1538-7836","issn":["1538-7836","1538-7933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thrombosis and Haemostasis","raw_type":"journal-article"},{"id":"pmid:24330648","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24330648","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of thrombosis and haemostasis : JTH","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/jth.12482","doi":"https://doi.org/10.1111/jth.12482","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jth.12482","pdf_url":"http://www.jthjournal.org/article/S1538783622038697/pdf","source":{"id":"https://openalex.org/S164469042","display_name":"Journal of Thrombosis and Haemostasis","issn_l":"1538-7836","issn":["1538-7836","1538-7933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thrombosis and Haemostasis","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2778287584","display_name":"A Systems Biology Approach to Predicting Bleeding in Hemophilia","funder_award_id":"R01HL120728","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2012860339.pdf","grobid_xml":"https://content.openalex.org/works/W2012860339.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W1585667212","https://openalex.org/W1995289649","https://openalex.org/W2004336126","https://openalex.org/W2008655148","https://openalex.org/W2045683734","https://openalex.org/W2051957959","https://openalex.org/W2062491146","https://openalex.org/W2072336447","https://openalex.org/W2087291640","https://openalex.org/W2107371049","https://openalex.org/W2115796512","https://openalex.org/W2132244872","https://openalex.org/W2132612915","https://openalex.org/W2163264213"],"related_works":["https://openalex.org/W2296444155","https://openalex.org/W2087069387","https://openalex.org/W2257416106","https://openalex.org/W2072344433","https://openalex.org/W1585667212","https://openalex.org/W2148958040","https://openalex.org/W1975286710","https://openalex.org/W2410335576","https://openalex.org/W2338084760","https://openalex.org/W3176230736"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}