{"id":"https://openalex.org/W2012841918","doi":"https://doi.org/10.4161/isl.19569","title":"Mathematical models for insulin secretion in pancreatic \u03b2-cells","display_name":"Mathematical models for insulin secretion in pancreatic \u03b2-cells","publication_year":2012,"publication_date":"2012-03-01","ids":{"openalex":"https://openalex.org/W2012841918","doi":"https://doi.org/10.4161/isl.19569","mag":"2012841918","pmid":"https://pubmed.ncbi.nlm.nih.gov/22627505"},"language":"en","primary_location":{"id":"doi:10.4161/isl.19569","doi":"https://doi.org/10.4161/isl.19569","is_oa":true,"landing_page_url":"https://doi.org/10.4161/isl.19569","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/isl.19569?needAccess=true&role=button","source":{"id":"https://openalex.org/S135054477","display_name":"Islets","issn_l":"1938-2014","issn":["1938-2014","1938-2022"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Islets","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/isl.19569?needAccess=true&role=button","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084984855","display_name":"Kyungreem Han","orcid":"https://orcid.org/0000-0002-2290-4858","observed_orcids":["https://orcid.org/0000-0002-2290-4858"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kyungreem Han","raw_affiliation_strings":["College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul, South Korea","College of Pharmacy and Research Institute of Pharmaceutical Sciences","Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul, South Korea","institution_ids":[]},{"raw_affiliation_string":"College of Pharmacy and Research Institute of Pharmaceutical Sciences","institution_ids":[]},{"raw_affiliation_string":"Seoul, South Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100849905","display_name":"Hyuk Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158432","display_name":"National Institute for Mathematical Sciences","ror":"https://ror.org/04n7py080","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210158432"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyuk Kang","raw_affiliation_strings":["National Institute for Mathematical Sciences; Daejeon, South Korea","2 National Institute for Mathematical Sciences","Daejeon, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Mathematical Sciences; Daejeon, South Korea","institution_ids":["https://openalex.org/I4210158432"]},{"raw_affiliation_string":"2 National Institute for Mathematical Sciences","institution_ids":["https://openalex.org/I4210158432"]},{"raw_affiliation_string":"Daejeon, South Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100765035","display_name":"Jinwoong Kim","orcid":"https://orcid.org/0000-0001-9579-738X","observed_orcids":["https://orcid.org/0000-0001-9579-738X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jinwoong Kim","raw_affiliation_strings":["College of Pharmacy and Research Institute of Pharmaceutical Sciences; Seoul, South Korea","College of Pharmacy and Research Institute of Pharmaceutical Sciences","Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and Research Institute of Pharmaceutical Sciences; Seoul, South Korea","institution_ids":[]},{"raw_affiliation_string":"College of Pharmacy and Research Institute of Pharmaceutical Sciences","institution_ids":[]},{"raw_affiliation_string":"Seoul, South Korea","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056662128","display_name":"M. Y. Choi","orcid":"https://orcid.org/0000-0001-8070-7716","observed_orcids":["https://orcid.org/0000-0001-8070-7716"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I3019243323","display_name":"Center for Theoretical Physics","ror":"https://ror.org/04kfyt897","country_code":"PL","type":"facility","lineage":["https://openalex.org/I3019243323","https://openalex.org/I99542240"]}],"countries":["KR","PL"],"is_corresponding":true,"raw_author_name":"MooYoung Choi","raw_affiliation_strings":["Department of Physics and Astronomy and Center for Theoretical Physics; Seoul National University; Seoul, South Korea","Department of Physics and Astronomy and Center for Theoretical Physics","Seoul National University","Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics and Astronomy and Center for Theoretical Physics; Seoul National University; Seoul, South Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Physics and Astronomy and Center for Theoretical Physics","institution_ids":["https://openalex.org/I3019243323"]},{"raw_affiliation_string":"Seoul National University","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Seoul, South Korea","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5056662128","https://openalex.org/A5100765035"],"corresponding_institution_ids":["https://openalex.org/I139264467","https://openalex.org/I3019243323"],"apc_list":{"value":2180,"currency":"EUR","value_usd":2390},"apc_paid":null,"fwci":0.3084,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.29256198,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"4","issue":"2","first_page":"94","last_page":"107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.9079999923706055},{"id":"https://openalex.org/keywords/mathematical-model","display_name":"mathematical model","score":0.9089999794960022},{"id":"https://openalex.org/keywords/electrical-coupling","display_name":"electrical coupling","score":0.9620000123977661},{"id":"https://openalex.org/keywords/paracrine-interactions","display_name":"paracrine interactions","score":0.8209999799728394},{"id":"https://openalex.org/keywords/islet-cells","display_name":"pancreatic endocrine cells","score":0.8090000152587891},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/glucose-regulation","display_name":"glucose regulation","score":0.9620000123977661}],"concepts":[{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.7785694003105164},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6671741604804993},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.6481003761291504},{"id":"https://openalex.org/C195221683","wikidata":"https://www.wikidata.org/wiki/Q5000649","display_name":"Bursting","level":2,"score":0.5586254000663757},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5164111256599426},{"id":"https://openalex.org/C2779855799","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic islets","level":4,"score":0.49774840474128723},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.45844176411628723},{"id":"https://openalex.org/C158157758","wikidata":"https://www.wikidata.org/wiki/Q232438","display_name":"Gap junction","level":3,"score":0.45239582657814026},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.4367116689682007},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.43484681844711304},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4173317849636078},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3818546235561371},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.340686559677124},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2964977025985718},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.29160359501838684},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13719874620437622},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1173439621925354},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1047717034816742},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.10277208685874939},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.4161/isl.19569","doi":"https://doi.org/10.4161/isl.19569","is_oa":true,"landing_page_url":"https://doi.org/10.4161/isl.19569","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/isl.19569?needAccess=true&role=button","source":{"id":"https://openalex.org/S135054477","display_name":"Islets","issn_l":"1938-2014","issn":["1938-2014","1938-2022"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Islets","raw_type":"journal-article"},{"id":"pmid:22627505","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22627505","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Islets","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4161/isl.19569","doi":"https://doi.org/10.4161/isl.19569","is_oa":true,"landing_page_url":"https://doi.org/10.4161/isl.19569","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/isl.19569?needAccess=true&role=button","source":{"id":"https://openalex.org/S135054477","display_name":"Islets","issn_l":"1938-2014","issn":["1938-2014","1938-2022"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Islets","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4968447015","display_name":null,"funder_award_id":"370C-20110083","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G7686325270","display_name":null,"funder_award_id":"2009-0080791","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G8052825294","display_name":null,"funder_award_id":"2011-0012331","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322109","display_name":"Korea Research Council of Fundamental Science and Technology","ror":"https://ror.org/058rymf81"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2012841918.pdf","grobid_xml":"https://content.openalex.org/works/W2012841918.grobid-xml"},"referenced_works_count":168,"referenced_works":["https://openalex.org/W160260397","https://openalex.org/W198411775","https://openalex.org/W1493727686","https://openalex.org/W1522924058","https://openalex.org/W1728461111","https://openalex.org/W1743153984","https://openalex.org/W1779889804","https://openalex.org/W1844237527","https://openalex.org/W1944989204","https://openalex.org/W1963670622","https://openalex.org/W1964988818","https://openalex.org/W1965002111","https://openalex.org/W1967009002","https://openalex.org/W1967074601","https://openalex.org/W1971705620","https://openalex.org/W1972867003","https://openalex.org/W1973533455","https://openalex.org/W1975024023","https://openalex.org/W1975370433","https://openalex.org/W1976480628","https://openalex.org/W1978598042","https://openalex.org/W1979533263","https://openalex.org/W1981542036","https://openalex.org/W1984995573","https://openalex.org/W1985515689","https://openalex.org/W1985770721","https://openalex.org/W1985940938","https://openalex.org/W1986405863","https://openalex.org/W1988247834","https://openalex.org/W1989582790","https://openalex.org/W1991537946","https://openalex.org/W1992045485","https://openalex.org/W1992962897","https://openalex.org/W1993153103","https://openalex.org/W1993352089","https://openalex.org/W1994265886","https://openalex.org/W1994924615","https://openalex.org/W1995412062","https://openalex.org/W2000569688","https://openalex.org/W2000804473","https://openalex.org/W2002014786","https://openalex.org/W2002056541","https://openalex.org/W2002724792","https://openalex.org/W2006588864","https://openalex.org/W2006617024","https://openalex.org/W2009127988","https://openalex.org/W2009389608","https://openalex.org/W2009710495","https://openalex.org/W2010490492","https://openalex.org/W2011503711","https://openalex.org/W2013773716","https://openalex.org/W2014746245","https://openalex.org/W2015256748","https://openalex.org/W2015823678","https://openalex.org/W2016944998","https://openalex.org/W2017509811","https://openalex.org/W2019115250","https://openalex.org/W2019906703","https://openalex.org/W2019926410","https://openalex.org/W2020214116","https://openalex.org/W2020348172","https://openalex.org/W2021279362","https://openalex.org/W2022545708","https://openalex.org/W2022680688","https://openalex.org/W2022870633","https://openalex.org/W2023183151","https://openalex.org/W2024255334","https://openalex.org/W2025039101","https://openalex.org/W2027411301","https://openalex.org/W2028467165","https://openalex.org/W2029543367","https://openalex.org/W2029559333","https://openalex.org/W2031643955","https://openalex.org/W2035420051","https://openalex.org/W2036071665","https://openalex.org/W2038828643","https://openalex.org/W2040692229","https://openalex.org/W2044121793","https://openalex.org/W2045268980","https://openalex.org/W2045312491","https://openalex.org/W2046647799","https://openalex.org/W2047169725","https://openalex.org/W2048618700","https://openalex.org/W2048903649","https://openalex.org/W2051944535","https://openalex.org/W2056139517","https://openalex.org/W2058534940","https://openalex.org/W2059418034","https://openalex.org/W2059881362","https://openalex.org/W2062783006","https://openalex.org/W2065249636","https://openalex.org/W2065430703","https://openalex.org/W2067019552","https://openalex.org/W2068836222","https://openalex.org/W2071081949","https://openalex.org/W2072210701","https://openalex.org/W2073405263","https://openalex.org/W2075130034","https://openalex.org/W2075353339","https://openalex.org/W2075786190","https://openalex.org/W2077186412","https://openalex.org/W2077621497","https://openalex.org/W2078245629","https://openalex.org/W2078470986","https://openalex.org/W2080041388","https://openalex.org/W2081566180","https://openalex.org/W2082358964","https://openalex.org/W2084095098","https://openalex.org/W2088522673","https://openalex.org/W2091389339","https://openalex.org/W2091454529","https://openalex.org/W2091609447","https://openalex.org/W2092162739","https://openalex.org/W2095976960","https://openalex.org/W2096595413","https://openalex.org/W2097246969","https://openalex.org/W2098902968","https://openalex.org/W2101826414","https://openalex.org/W2105144092","https://openalex.org/W2105955034","https://openalex.org/W2108896758","https://openalex.org/W2109412929","https://openalex.org/W2109808763","https://openalex.org/W2112043438","https://openalex.org/W2112942028","https://openalex.org/W2113958896","https://openalex.org/W2119858526","https://openalex.org/W2121760611","https://openalex.org/W2124258312","https://openalex.org/W2125122514","https://openalex.org/W2126229699","https://openalex.org/W2127109293","https://openalex.org/W2128958676","https://openalex.org/W2129934366","https://openalex.org/W2130258021","https://openalex.org/W2139132103","https://openalex.org/W2139636911","https://openalex.org/W2139902621","https://openalex.org/W2140777158","https://openalex.org/W2144462653","https://openalex.org/W2146169475","https://openalex.org/W2146619796","https://openalex.org/W2147702014","https://openalex.org/W2147868795","https://openalex.org/W2147961809","https://openalex.org/W2148175667","https://openalex.org/W2154662304","https://openalex.org/W2154785285","https://openalex.org/W2157250957","https://openalex.org/W2161530127","https://openalex.org/W2162438875","https://openalex.org/W2164573981","https://openalex.org/W2164861152","https://openalex.org/W2165476856","https://openalex.org/W2166243077","https://openalex.org/W2169254921","https://openalex.org/W2181446446","https://openalex.org/W2211925726","https://openalex.org/W2335958328","https://openalex.org/W2336304679","https://openalex.org/W2338065281","https://openalex.org/W2340855943","https://openalex.org/W2396196877","https://openalex.org/W2405844394","https://openalex.org/W2419533792","https://openalex.org/W2430565266","https://openalex.org/W4244751289","https://openalex.org/W4323238561"],"related_works":["https://openalex.org/W2071081949","https://openalex.org/W1998853054","https://openalex.org/W1975024023","https://openalex.org/W2155126124","https://openalex.org/W2278123085","https://openalex.org/W8289832","https://openalex.org/W2041646707","https://openalex.org/W2139333781","https://openalex.org/W563041185","https://openalex.org/W2084957552"],"abstract_inverted_index":{"Insulin":[0],"secretion":[1],"is":[2],"one":[3],"of":[4,9,23,34,46,65,74,79,101,110],"the":[5,32,35,47,55,66,72,108],"most":[6],"characteristic":[7],"features":[8],"\u03b2-cell":[10],"physiology.":[11],"As":[12],"it":[13],"plays":[14],"a":[15,21],"central":[16],"role":[17],"in":[18,59],"glucose":[19,105],"regulation,":[20],"number":[22],"experimental":[24],"and":[25,89,103],"theoretical":[26],"studies":[27],"have":[28],"been":[29],"performed":[30],"since":[31],"discovery":[33],"pancreatic":[36,60],"\u03b2-cell.":[37],"This":[38],"review":[39],"article":[40],"aims":[41],"to":[42,50],"give":[43],"an":[44],"overview":[45],"mathematical":[48,96],"approaches":[49],"insulin":[51,75,111],"secretion.":[52,76,112],"Beginning":[53],"with":[54],"bursting":[56],"electrical":[57],"activity":[58],"\u03b2-cells,":[61],"we":[62,94],"describe":[63],"effects":[64,100],"gap-junction":[67],"coupling":[68],"between":[69],"\u03b2-cells":[70],"on":[71,107],"dynamics":[73],"Then,":[77],"implications":[78],"paracrine":[80],"interactions":[81],"among":[82],"such":[83],"islet":[84],"cells":[85],"as":[86],"\u03b1-,":[87],"\u03b2-,":[88],"\u03b4-cells":[90],"are":[91],"discussed.":[92],"Finally,":[93],"present":[95],"models":[97],"which":[98],"incorporate":[99],"glycolysis":[102],"mitochondrial":[104],"metabolism":[106],"control":[109]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}