{"id":"https://openalex.org/W2012808576","doi":"https://doi.org/10.1159/000226024","title":"Serum Interferon as a Biological Marker in Malignant Tumors","display_name":"Serum Interferon as a Biological Marker in Malignant Tumors","publication_year":2009,"publication_date":"2009-06-17","ids":{"openalex":"https://openalex.org/W2012808576","doi":"https://doi.org/10.1159/000226024","mag":"2012808576","pmid":"https://pubmed.ncbi.nlm.nih.gov/2582327"},"language":"en","primary_location":{"id":"doi:10.1159/000226024","doi":"https://doi.org/10.1159/000226024","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000226024","pdf_url":null,"source":{"id":"https://openalex.org/S198727964","display_name":"Oncology","issn_l":"0030-2414","issn":["0030-2414","1423-0232"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111643215","display_name":"Yoav Horn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114157","display_name":"Assaf Harofeh Medical Center","ror":"https://ror.org/02722hp10","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I4210114157"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Yoav Horn","raw_affiliation_strings":["Department of Oncology, Assaf Harofch Medical Center, Zerifin, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Assaf Harofch Medical Center, Zerifin, and","institution_ids":["https://openalex.org/I4210114157"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018002981","display_name":"Jacob L. Zeidman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114157","display_name":"Assaf Harofeh Medical Center","ror":"https://ror.org/02722hp10","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I4210114157"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Jacob L. Zeidman","raw_affiliation_strings":["Department of Oncology, Assaf Harofch Medical Center, Zerifin, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Assaf Harofch Medical Center, Zerifin, and","institution_ids":["https://openalex.org/I4210114157"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026697112","display_name":"Adi Heller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114157","display_name":"Assaf Harofeh Medical Center","ror":"https://ror.org/02722hp10","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I4210114157"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Adi Heller","raw_affiliation_strings":["Department of Oncology, Assaf Harofch Medical Center, Zerifin, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Assaf Harofch Medical Center, Zerifin, and","institution_ids":["https://openalex.org/I4210114157"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113500404","display_name":"Dalia Hacohen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114157","display_name":"Assaf Harofeh Medical Center","ror":"https://ror.org/02722hp10","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I4210114157"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Dalia Hacohen","raw_affiliation_strings":["Department of Oncology, Assaf Harofch Medical Center, Zerifin, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Assaf Harofch Medical Center, Zerifin, and","institution_ids":["https://openalex.org/I4210114157"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111839696","display_name":"Samuel Salzberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Samuel Salzberg","raw_affiliation_strings":["Department of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel","institution_ids":["https://openalex.org/I13955877"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"3","first_page":"164","last_page":"168"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.8554999828338623,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.8554999828338623,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.07349999994039536,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12379","display_name":"Cancer Diagnosis and Treatment","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serum-interferon","display_name":"serum interferon","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.671999990940094},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.8550000190734863},{"id":"https://openalex.org/keywords/disease-activity-monitoring","display_name":"disease activity monitoring","score":0.8980000019073486},{"id":"https://openalex.org/keywords/chemotherapy-response","display_name":"chemotherapy response","score":0.7649999856948853},{"id":"https://openalex.org/keywords/radiotherapy-response","display_name":"radiotherapy response","score":0.9210000038146973},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8069999814033508},{"id":"https://openalex.org/keywords/rectal-cancer","display_name":"rectal cancer","score":0.9409999847412109},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/female-genital-tract-cancer","display_name":"female genital cancer","score":0.8240000009536743},{"id":"https://openalex.org/keywords/tumor-immunology","display_name":"tumor immunology","score":0.4099999964237213}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8032059073448181},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.760560154914856},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6205562353134155},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.6135784983634949},{"id":"https://openalex.org/C2781074409","wikidata":"https://www.wikidata.org/wiki/Q158716","display_name":"Rectum","level":2,"score":0.56195467710495},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5454905033111572},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5086437463760376},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.5049336552619934},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48783257603645325},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.4758293926715851},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.44267037510871887},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4152616858482361},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2860962152481079},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09971851110458374},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D012194","descriptor_name":"RNA-Directed DNA Polymerase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000226024","doi":"https://doi.org/10.1159/000226024","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000226024","pdf_url":null,"source":{"id":"https://openalex.org/S198727964","display_name":"Oncology","issn_l":"0030-2414","issn":["0030-2414","1423-0232"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology","raw_type":"journal-article"},{"id":"pmid:2582327","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2582327","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322248","display_name":"Israel Academy of Sciences and Humanities","ror":"https://ror.org/03c6c9520"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W165767762","https://openalex.org/W3150203768","https://openalex.org/W1998410138","https://openalex.org/W2094409668","https://openalex.org/W2376471713","https://openalex.org/W2415072694","https://openalex.org/W2404117136","https://openalex.org/W986581423","https://openalex.org/W2127145481","https://openalex.org/W2359651749"],"abstract_inverted_index":{"A":[0,57],"total":[1],"of":[2,14,21,39,55,62,67,73,122,133,142,158,189,210,229],"745":[3],"serum":[4,13,66,134,159,198],"interferon":[5],"(IFN)":[6],"determinations":[7],"were":[8,47,111],"carried":[9],"out":[10],"on":[11,34,216],"the":[12,37,65,83,120,143,186,197,227],"332":[15],"cancer":[16,165],"patients":[17,89,104,166],"with":[18],"a":[19,79,100,129,139,147,154,183],"variety":[20],"tumors.":[22],"Disease":[23],"activity":[24,52,204],"was":[25,76,86,136,161],"defined":[26],"as":[27,32,69,93,170],"either":[28],"'active'":[29],"or":[30],"'nonactive'":[31],"based":[33],"clinical":[35],"examination,":[36],"results":[38],"laboratory":[40],"tests":[41],"and":[42,53,125,199,218],"radiological":[43],"criteria.":[44],"IFN":[45,63,84,135,160,211],"levels":[46],"estimated":[48],"for":[49,222],"both":[50],"disease":[51,203],"mode":[54],"treatment.":[56,151],"statistically":[58,116],"significant":[59,130,155],"higher":[60],"level":[61,85,132,157],"in":[64,82,88,102,119,163,185,196,205,214],"active,":[68],"compared":[70,94,171],"to":[71,95,114,172,181,201],"that":[72,178],"nonactive":[74],"disease,":[75,144],"established.":[77],"Furthermore,":[78],"slight":[80],"increase":[81],"observed":[87,137],"before":[90,174],"initiating":[91],"chemotherapy":[92,150],"untreated":[96],"patients,":[97],"followed":[98,145],"by":[99,146],"decrease":[101,148],"those":[103,173],"undergoing":[105],"chemotherapy.":[106],"These":[107],"differences":[108],"between":[109],"groups":[110],"not":[112],"found":[113],"be":[115,194,220],"significant.":[117],"However,":[118],"cases":[121],"rectum,":[123],"prostate":[124],"female":[126],"genital":[127],"cancers,":[128],"elevated":[131],"at":[138],"late":[140],"stage":[141],"after":[149,168],"In":[152],"addition,":[153],"lower":[156],"detected":[162],"breast":[164],"shortly":[167],"radiotherapy":[169],"radiotherapy.":[175],"We":[176],"conclude":[177],"IFN,":[179],"known":[180],"play":[182],"role":[184],"control":[187],"mechanisms":[188],"developing":[190],"malignant":[191],"processes,":[192],"can":[193,219],"determined":[195],"used":[200,221],"monitor":[202],"individual":[206],"patients.":[207],"The":[208],"inhibition":[209],"release":[212],"depends":[213],"part":[215],"therapy":[217],"monitoring":[223],"treatment":[224],"schedules":[225],"along":[226],"course":[228],"disease.":[230]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
