{"id":"https://openalex.org/W2012806347","doi":"https://doi.org/10.1016/0041-008x(90)90355-x","title":"Importance of protein thiols during N-methyl-N\u2032-nitro-N-nitrosoguanidine toxicity in primary rat hepatocytes","display_name":"Importance of protein thiols during N-methyl-N\u2032-nitro-N-nitrosoguanidine toxicity in primary rat hepatocytes","publication_year":1990,"publication_date":"1990-08-01","ids":{"openalex":"https://openalex.org/W2012806347","doi":"https://doi.org/10.1016/0041-008x(90)90355-x","mag":"2012806347","pmid":"https://pubmed.ncbi.nlm.nih.gov/2392804"},"language":"en","primary_location":{"id":"doi:10.1016/0041-008x(90)90355-x","doi":"https://doi.org/10.1016/0041-008x(90)90355-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0041-008x(90)90355-x","pdf_url":null,"source":{"id":"https://openalex.org/S42307217","display_name":"Toxicology and Applied Pharmacology","issn_l":"0041-008X","issn":["0041-008X","1096-0333"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and Applied Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025906356","display_name":"Howard G. Shertzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92156820","display_name":"University of Cincinnati Medical Center","ror":"https://ror.org/02p72h367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I92156820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H.G. Shertzer","raw_affiliation_strings":["Department of Environmental Health, University of Cincinnati Medical Center, Ohio 45267-0056","Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, Ohio 45267-0056 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health, University of Cincinnati Medical Center, Ohio 45267-0056","institution_ids":["https://openalex.org/I92156820"]},{"raw_affiliation_string":"Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, Ohio 45267-0056 USA","institution_ids":["https://openalex.org/I92156820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079532497","display_name":"M. Sainsbury","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51601045","display_name":"University of Bath","ror":"https://ror.org/002h8g185","country_code":"GB","type":"education","lineage":["https://openalex.org/I51601045"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. Sainsbury","raw_affiliation_strings":["School of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, England","institution_ids":["https://openalex.org/I51601045"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103527775","display_name":"Marc L. Berger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M.L. Berger","raw_affiliation_strings":["Jefferson Medical College, Philadelphia, Pennsylvania 19107 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jefferson Medical College, Philadelphia, Pennsylvania 19107 USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":1.6079,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.80918109,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"105","issue":"1","first_page":"19","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.45210000872612,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.45210000872612,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.1754000037908554,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.15139999985694885,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/n-methyl-n-nitro-n-nitrosoguanidine","display_name":"N-methyl-N'-nitro-N-nitrosoguanidine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.859000027179718},{"id":"https://openalex.org/keywords/protein-thiols","display_name":"protein thiols","score":0.8420000076293945},{"id":"https://openalex.org/keywords/non-protein-thiols","display_name":"non-protein thiols","score":0.9559999704360962},{"id":"https://openalex.org/keywords/thiol-depletion","display_name":"thiol depletion","score":0.7379999756813049},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6150000095367432},{"id":"https://openalex.org/keywords/oxygen-toxicity","display_name":"oxygen toxicity","score":0.9049999713897705},{"id":"https://openalex.org/keywords/alkylating-agents","display_name":"alkylating agents","score":0.6389999985694885},{"id":"https://openalex.org/keywords/covalent-attachment","display_name":"covalent binding","score":0.8420000076293945},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.6060000061988831},{"id":"https://openalex.org/keywords/indole-3-carbinol","display_name":"indole-3-carbinol","score":0.8299999833106995},{"id":"https://openalex.org/keywords/1-10-phenanthroline","display_name":"1,10-phenanthroline","score":0.9520000219345093},{"id":"https://openalex.org/keywords/antioxidant-depletion","display_name":"antioxidant depletion","score":0.5519999861717224},{"id":"https://openalex.org/keywords/rat-hepatocytes","display_name":"rat hepatocytes","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6024008393287659},{"id":"https://openalex.org/C2780625556","wikidata":"https://www.wikidata.org/wiki/Q12263499","display_name":"Methylnitronitrosoguanidine","level":4,"score":0.5914683938026428},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.526091456413269},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5220508575439453},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5128012299537659},{"id":"https://openalex.org/C2780473477","wikidata":"https://www.wikidata.org/wiki/Q3072135","display_name":"Toxicant","level":3,"score":0.49129289388656616},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4653053879737854},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.451200395822525},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.43899446725845337},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3986668288707733},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3296574354171753},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2716221213340759},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2311120629310608},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.17604172229766846},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004336","descriptor_name":"Drug Antagonism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008769","descriptor_name":"Methylnitronitrosoguanidine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013438","descriptor_name":"Sulfhydryl Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0041-008x(90)90355-x","doi":"https://doi.org/10.1016/0041-008x(90)90355-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0041-008x(90)90355-x","pdf_url":null,"source":{"id":"https://openalex.org/S42307217","display_name":"Toxicology and Applied Pharmacology","issn_l":"0041-008X","issn":["0041-008X","1096-0333"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and Applied Pharmacology","raw_type":"journal-article"},{"id":"pmid:2392804","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2392804","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and applied pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G465538194","display_name":null,"funder_award_id":"ES03373","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G6221672225","display_name":"PROTECTION FROM ENVIRONMENTAL TOXINS/MUTAGENS BY INDOLES","funder_award_id":"R01ES003373","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W518185","https://openalex.org/W1511717231","https://openalex.org/W1609961433","https://openalex.org/W1920518078","https://openalex.org/W1971081936","https://openalex.org/W1983616439","https://openalex.org/W1998065879","https://openalex.org/W2004102021","https://openalex.org/W2028586805","https://openalex.org/W2029335737","https://openalex.org/W2038894393","https://openalex.org/W2048267115","https://openalex.org/W2063208611","https://openalex.org/W2063252913","https://openalex.org/W2064587136","https://openalex.org/W2070194097","https://openalex.org/W2082046153","https://openalex.org/W2105262783","https://openalex.org/W2260383328","https://openalex.org/W2345840229"],"related_works":["https://openalex.org/W2081383557","https://openalex.org/W2064862450","https://openalex.org/W2018044701","https://openalex.org/W2072361067","https://openalex.org/W1968862146","https://openalex.org/W1983616439","https://openalex.org/W2063208611","https://openalex.org/W2466905361","https://openalex.org/W2070194097","https://openalex.org/W1510734480"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}