{"id":"https://openalex.org/W2012805484","doi":"https://doi.org/10.1021/jp066021i","title":"Diffusion in a Sol\u2212Gel-Derived Medium with a View toward Biosensor Applications","display_name":"Diffusion in a Sol\u2212Gel-Derived Medium with a View toward Biosensor Applications","publication_year":2007,"publication_date":"2007-03-13","ids":{"openalex":"https://openalex.org/W2012805484","doi":"https://doi.org/10.1021/jp066021i","mag":"2012805484","pmid":"https://pubmed.ncbi.nlm.nih.gov/17388494"},"language":"en","primary_location":{"id":"doi:10.1021/jp066021i","doi":"https://doi.org/10.1021/jp066021i","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jp066021i","pdf_url":null,"source":{"id":"https://openalex.org/S185621672","display_name":"The Journal of Physical Chemistry B","issn_l":"1520-5207","issn":["1520-5207","1520-6106"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry B","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090826437","display_name":"Graham Hungerford","orcid":"https://orcid.org/0000-0002-9944-5688","observed_orcids":["https://orcid.org/0000-0002-9944-5688"]},"institutions":[{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Graham Hungerford","raw_affiliation_strings":["Departamento de F\u00edsica, Universidade do Minho, 4710-057 Braga, Portugal. graham@fisica.uminho.pt","Departamento de F\u0131\u0301sica, Universidade do Minho, 4710-057 Braga, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de F\u00edsica, Universidade do Minho, 4710-057 Braga, Portugal. graham@fisica.uminho.pt","institution_ids":["https://openalex.org/I99682543"]},{"raw_affiliation_string":"Departamento de F\u0131\u0301sica, Universidade do Minho, 4710-057 Braga, Portugal","institution_ids":["https://openalex.org/I99682543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049736173","display_name":"Ana Rei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["GB","PT"],"is_corresponding":false,"raw_author_name":"Ana Rei","raw_affiliation_strings":["Departamento de F\u00edsica, Universidade do Minho, 4710-057 Braga, Portugal","Department of Physics, Kings College London, Strand, London WC2R 2LS, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de F\u00edsica, Universidade do Minho, 4710-057 Braga, Portugal","institution_ids":["https://openalex.org/I99682543"]},{"raw_affiliation_string":"Department of Physics, Kings College London, Strand, London WC2R 2LS, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101530925","display_name":"Marta Ferreira","orcid":"https://orcid.org/0000-0003-4808-2378","observed_orcids":["https://orcid.org/0000-0003-4808-2378"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["GB","PT"],"is_corresponding":false,"raw_author_name":"M. Isabel C. Ferreira","raw_affiliation_strings":["Departamento de F\u00edsica, Universidade do Minho, 4710-057 Braga, Portugal","Department of Physics, Kings College London, Strand, London WC2R 2LS, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de F\u00edsica, Universidade do Minho, 4710-057 Braga, Portugal","institution_ids":["https://openalex.org/I99682543"]},{"raw_affiliation_string":"Department of Physics, Kings College London, Strand, London WC2R 2LS, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042501275","display_name":"Klaus Suhling","orcid":"https://orcid.org/0000-0001-8797-5430","observed_orcids":["https://orcid.org/0000-0001-8797-5430"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["GB","PT"],"is_corresponding":false,"raw_author_name":"Klaus Suhling","raw_affiliation_strings":["Departamento de F\u00edsica, Universidade do Minho, 4710-057 Braga, Portugal","Department of Physics, Kings College London, Strand, London WC2R 2LS, United Kingdom","Physics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de F\u00edsica, Universidade do Minho, 4710-057 Braga, Portugal","institution_ids":["https://openalex.org/I99682543"]},{"raw_affiliation_string":"Department of Physics, Kings College London, Strand, London WC2R 2LS, United Kingdom","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"Physics","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006537715","display_name":"Carolyn L. Tregidgo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["GB","PT"],"is_corresponding":false,"raw_author_name":"Carolyn Tregidgo","raw_affiliation_strings":["Departamento de F\u00edsica, Universidade do Minho, 4710-057 Braga, Portugal","Department of Physics, Kings College London, Strand, London WC2R 2LS, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de F\u00edsica, Universidade do Minho, 4710-057 Braga, Portugal","institution_ids":["https://openalex.org/I99682543"]},{"raw_affiliation_string":"Department of Physics, Kings College London, Strand, London WC2R 2LS, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9843,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.89921671,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"111","issue":"13","first_page":"3558","last_page":"3562"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.36739999055862427,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.36739999055862427,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11472","display_name":"Analytical Chemistry and Sensors","score":0.0957999974489212,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10544","display_name":"Glass properties and applications","score":0.06509999930858612,"subfield":{"id":"https://openalex.org/subfields/2503","display_name":"Ceramics and Composites"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/silica","display_name":"silica","score":0.3799999952316284},{"id":"https://openalex.org/keywords/diffusion-coefficient","display_name":"diffusion coefficient","score":0.6050000190734863},{"id":"https://openalex.org/keywords/rotational-diffusion","display_name":"rotational diffusion","score":0.7960000038146973},{"id":"https://openalex.org/keywords/lateral-diffusion","display_name":"lateral diffusion","score":0.9779999852180481},{"id":"https://openalex.org/keywords/horseradish-peroxidase","display_name":"horseradish peroxidase","score":0.8600000143051147},{"id":"https://openalex.org/keywords/enzyme-immobilization","display_name":"enzyme immobilization","score":0.9120000004768372},{"id":"https://openalex.org/keywords/frap-assay","display_name":"FRAP","score":0.8600000143051147},{"id":"https://openalex.org/keywords/time-resolved-fluorescence-anisotropy","display_name":"time-resolved fluorescence anisotropy","score":0.9890000224113464},{"id":"https://openalex.org/keywords/catalytic-activity","display_name":"catalytic activity","score":0.6190000176429749},{"id":"https://openalex.org/keywords/biosensors","display_name":"biosensors","score":0.6520000100135803},{"id":"https://openalex.org/keywords/dye-diffusion","display_name":"dye diffusion","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C26659971","wikidata":"https://www.wikidata.org/wiki/Q729923","display_name":"Fluorescence recovery after photobleaching","level":3,"score":0.7039206624031067},{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.6197403073310852},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.6061690449714661},{"id":"https://openalex.org/C31332276","wikidata":"https://www.wikidata.org/wiki/Q899750","display_name":"Photobleaching","level":3,"score":0.5790889263153076},{"id":"https://openalex.org/C2777676563","wikidata":"https://www.wikidata.org/wiki/Q413665","display_name":"Horseradish peroxidase","level":3,"score":0.5518317818641663},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48490673303604126},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.46758484840393066},{"id":"https://openalex.org/C152815550","wikidata":"https://www.wikidata.org/wiki/Q653208","display_name":"Monolith","level":3,"score":0.4430030882358551},{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.43204444646835327},{"id":"https://openalex.org/C158711907","wikidata":"https://www.wikidata.org/wiki/Q1768467","display_name":"Fluorescence spectroscopy","level":3,"score":0.42304620146751404},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.40682700276374817},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3238917887210846},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2609119415283203},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.2058071792125702},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10617628693580627},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.09577450156211853},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07306504249572754},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005454","descriptor_name":"Fluorescence Polarization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006735","descriptor_name":"Horseradish Peroxidase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012822","descriptor_name":"Silicon Dioxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019793","descriptor_name":"Fluorescein","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D036681","descriptor_name":"Fluorescence Recovery After Photobleaching","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044367","descriptor_name":"Phase Transition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058428","descriptor_name":"Silica Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/jp066021i","doi":"https://doi.org/10.1021/jp066021i","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jp066021i","pdf_url":null,"source":{"id":"https://openalex.org/S185621672","display_name":"The Journal of Physical Chemistry B","issn_l":"1520-5207","issn":["1520-5207","1520-6106"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry B","raw_type":"journal-article"},{"id":"pmid:17388494","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17388494","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of physical chemistry. B","raw_type":"Journal Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/a6967d86-da9d-4283-9ec2-4f8f0c7cbbe0","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/a6967d86-da9d-4283-9ec2-4f8f0c7cbbe0","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hungerford, G, Rei, A, Tregidgo, C, Suhling, K & Ferreira, M I C 2007, 'Diffusion in a sol-gel-derived medium with a view toward biosensor applications', JOURNAL OF PHYSICAL CHEMISTRY B, vol. 111, no. 13, pp. 3558 - 3562. https://doi.org/10.1021/jp066021i","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W124697062","https://openalex.org/W200349964","https://openalex.org/W287728300","https://openalex.org/W586102426","https://openalex.org/W1523593112","https://openalex.org/W1597994956","https://openalex.org/W1974292841","https://openalex.org/W1987442198","https://openalex.org/W1988463504","https://openalex.org/W1993645665","https://openalex.org/W1994033949","https://openalex.org/W2006822851","https://openalex.org/W2017934591","https://openalex.org/W2042149919","https://openalex.org/W2043017906","https://openalex.org/W2053915652","https://openalex.org/W2062435551","https://openalex.org/W2066227033","https://openalex.org/W2084317732","https://openalex.org/W2086834660","https://openalex.org/W2093397115","https://openalex.org/W2100056576","https://openalex.org/W2164540743","https://openalex.org/W2166168429","https://openalex.org/W4300177093"],"related_works":["https://openalex.org/W2040641781","https://openalex.org/W51120788","https://openalex.org/W1996977664","https://openalex.org/W2083288163","https://openalex.org/W2086610836","https://openalex.org/W4236672641","https://openalex.org/W2090712802","https://openalex.org/W2082159825","https://openalex.org/W1989806342","https://openalex.org/W141907434"],"abstract_inverted_index":{"Time-resolved":[0],"fluorescence":[1,4,114],"anisotropy":[2],"and":[3,16,43,66,78,112,120,142,149,166,180],"recovery":[5],"after":[6],"photobleaching":[7],"were":[8,172],"applied":[9],"to":[10,75,95,116,145,182],"study":[11,117],"the":[12,102,147,150,154,185,192],"diffusion":[13,122],"of":[14,26,84,160,178,188],"dyes":[15],"a":[17,21,57,96,127],"fluorescence-labeled":[18],"enzyme":[19,148],"in":[20,184,191],"sol-gel-derived":[22],"medium.":[23],"This":[24,54,82],"type":[25,83],"medium":[27],"exhibits":[28],"attractive":[29],"properties":[30],"such":[31],"as":[32,46],"robustness,":[33],"low":[34],"processing":[35],"temperature,":[36],"high":[37],"porosity,":[38],"large":[39],"internal":[40],"surface":[41],"area,":[42],"can":[44,88],"act":[45],"protective":[47],"immobilization":[48],"media":[49],"for":[50,60,71],"biologically":[51],"active":[52],"molecules.":[53],"makes":[55],"it":[56],"suitable":[58],"candidate":[59],"biosensor":[61],"applications.":[62],"The":[63],"glasslike":[64],"nature":[65],"good":[67],"optical":[68],"quality":[69],"allows":[70],"light":[72],"addressable":[73],"entities":[74],"be":[76,89],"incorporated":[77,190],"accessed":[79],"using":[80],"spectroscopy.":[81],"matrix,":[85],"once":[86],"formed,":[87],"anything":[90],"from":[91,174],"an":[92],"ordered":[93],"gel":[94],"robust":[97],"glassy":[98],"block":[99],"depending":[100],"on":[101],"aging":[103,124,156],"process.":[104,157],"In":[105],"this":[106],"work":[107],"we":[108],"apply":[109],"confocal":[110],"microscopy":[111],"time-resolved":[113],"techniques":[115],"both":[118,146],"rotational":[119],"lateral":[121],"with":[123,138],"time":[125],"within":[126],"silica":[128],"sol-gel":[129],"derived":[130],"monolith.":[131,193],"An":[132],"enzyme,":[133],"horseradish":[134],"peroxidase,":[135],"was":[136],"labeled":[137],"Alexa":[139],"Fluor":[140],"488":[141],"rotation":[143],"related":[144],"probe":[151],"monitored":[152],"during":[153],"matrix":[155],"Diffusion":[158],"coefficients":[159],"between":[161],"ca.":[162],"0.5":[163],"x":[164,168],"10(-7)":[165,169],"4":[167],"cm2":[170],"s(-1)":[171],"obtained":[173],"preliminary":[175],"FRAP":[176],"measurements":[177],"fluorescein":[179],"correlated":[181],"differences":[183],"catalytic":[186],"activity":[187],"HRP":[189]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}