{"id":"https://openalex.org/W2012804478","doi":"https://doi.org/10.1111/sji.12070","title":"Humoral Pattern Recognition and the Complement System","display_name":"Humoral Pattern Recognition and the Complement System","publication_year":2013,"publication_date":"2013-05-14","ids":{"openalex":"https://openalex.org/W2012804478","doi":"https://doi.org/10.1111/sji.12070","mag":"2012804478","pmid":"https://pubmed.ncbi.nlm.nih.gov/23672641"},"language":"en","primary_location":{"id":"doi:10.1111/sji.12070","doi":"https://doi.org/10.1111/sji.12070","is_oa":false,"landing_page_url":"https://doi.org/10.1111/sji.12070","pdf_url":null,"source":{"id":"https://openalex.org/S79173686","display_name":"Scandinavian Journal of Immunology","issn_l":"0300-9475","issn":["0300-9475","1365-3083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081503278","display_name":"S\u00f8ren Egedal Degn","orcid":"https://orcid.org/0000-0001-5409-045X","observed_orcids":["https://orcid.org/0000-0001-5409-045X"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"S. E. Degn","raw_affiliation_strings":["Department of Biomedicine, Aarhus University, Aarhus, Denmark,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine, Aarhus University, Aarhus, Denmark,","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006404917","display_name":"Steffen Thiel","orcid":"https://orcid.org/0000-0002-4817-155X","observed_orcids":["https://orcid.org/0000-0002-4817-155X"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"S. Thiel","raw_affiliation_strings":["Department of Biomedicine, Aarhus University, Aarhus, Denmark,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine, Aarhus University, Aarhus, Denmark,","institution_ids":["https://openalex.org/I204337017"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5081503278"],"corresponding_institution_ids":["https://openalex.org/I204337017"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":1.517,"has_fulltext":false,"cited_by_count":145,"citation_normalized_percentile":{"value":0.84717608,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"78","issue":"2","first_page":"181","last_page":"193"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.9160000085830688},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"pattern recognition","score":0.8399999737739563},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.8840000033378601},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.753000020980835},{"id":"https://openalex.org/keywords/lectin-complement-pathway","display_name":"lectin pathway","score":0.9419999718666077},{"id":"https://openalex.org/keywords/pattern-recognition-molecules","display_name":"pattern recognition molecules","score":0.6579999923706055},{"id":"https://openalex.org/keywords/classical-pathway","display_name":"classical pathway","score":0.6039999723434448},{"id":"https://openalex.org/keywords/alternative-pathway","display_name":"alternative pathway","score":0.9929999709129333}],"concepts":[{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.7968177795410156},{"id":"https://openalex.org/C171279029","wikidata":"https://www.wikidata.org/wiki/Q5128320","display_name":"Classical complement pathway","level":4,"score":0.6828928589820862},{"id":"https://openalex.org/C111289621","wikidata":"https://www.wikidata.org/wiki/Q418772","display_name":"Pattern recognition receptor","level":4,"score":0.6575169563293457},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.6371829509735107},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6270260810852051},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5749441981315613},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.5730783939361572},{"id":"https://openalex.org/C136015124","wikidata":"https://www.wikidata.org/wiki/Q13566093","display_name":"Complement component 2","level":5,"score":0.5679337978363037},{"id":"https://openalex.org/C175773311","wikidata":"https://www.wikidata.org/wiki/Q5156412","display_name":"Complement receptor","level":4,"score":0.5648667812347412},{"id":"https://openalex.org/C189446657","wikidata":"https://www.wikidata.org/wiki/Q4736500","display_name":"Alternative complement pathway","level":4,"score":0.5644527673721313},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.49831318855285645},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4966636300086975},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.48585841059684753},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46288037300109863},{"id":"https://openalex.org/C203880312","wikidata":"https://www.wikidata.org/wiki/Q14864145","display_name":"Lectin pathway","level":5,"score":0.4263080954551697},{"id":"https://openalex.org/C79196540","wikidata":"https://www.wikidata.org/wiki/Q14905298","display_name":"Complement membrane attack complex","level":4,"score":0.4152714014053345},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3179968595504761},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18287238478660583},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000936","descriptor_name":"Antigen-Antibody Complex","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000936","descriptor_name":"Antigen-Antibody Complex","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003170","descriptor_name":"Complement Pathway, Alternative","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003171","descriptor_name":"Complement Pathway, Classical","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037582","descriptor_name":"Complement Pathway, Mannose-Binding Lectin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051192","descriptor_name":"Receptors, Pattern Recognition","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051192","descriptor_name":"Receptors, Pattern Recognition","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056724","descriptor_name":"Immunity, Humoral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/sji.12070","doi":"https://doi.org/10.1111/sji.12070","is_oa":false,"landing_page_url":"https://doi.org/10.1111/sji.12070","pdf_url":null,"source":{"id":"https://openalex.org/S79173686","display_name":"Scandinavian Journal of Immunology","issn_l":"0300-9475","issn":["0300-9475","1365-3083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:23672641","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23672641","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian journal of immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:publications/2f4a160b-c063-4f64-94f1-d37d611f13c1","doi":null,"is_oa":false,"landing_page_url":"https://pure.au.dk/portal/en/publications/2f4a160b-c063-4f64-94f1-d37d611f13c1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Degn, S E & Thiel, S 2013, 'Humoral pattern recognition and the complement system', Scandinavian Journal of Immunology, vol. 78, no. 2, pp. 181-93. https://doi.org/10.1111/sji.12070","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":103,"referenced_works":["https://openalex.org/W183757317","https://openalex.org/W225128635","https://openalex.org/W1042731763","https://openalex.org/W1535906610","https://openalex.org/W1571263856","https://openalex.org/W1574595419","https://openalex.org/W1588736007","https://openalex.org/W1618869301","https://openalex.org/W1660694569","https://openalex.org/W1665913188","https://openalex.org/W1672094780","https://openalex.org/W1890886311","https://openalex.org/W1892414117","https://openalex.org/W1912866866","https://openalex.org/W1923930491","https://openalex.org/W1966052933","https://openalex.org/W1967130686","https://openalex.org/W1970365484","https://openalex.org/W1972700981","https://openalex.org/W1978786706","https://openalex.org/W1980493655","https://openalex.org/W1980799612","https://openalex.org/W1984219496","https://openalex.org/W1986616655","https://openalex.org/W1986682502","https://openalex.org/W1990169059","https://openalex.org/W1991163875","https://openalex.org/W1991504286","https://openalex.org/W1995268249","https://openalex.org/W1996033641","https://openalex.org/W1996364990","https://openalex.org/W1997462314","https://openalex.org/W2001453076","https://openalex.org/W2002178602","https://openalex.org/W2002884360","https://openalex.org/W2021074141","https://openalex.org/W2021158077","https://openalex.org/W2021926340","https://openalex.org/W2023355522","https://openalex.org/W2024541829","https://openalex.org/W2026664617","https://openalex.org/W2027696704","https://openalex.org/W2027951805","https://openalex.org/W2030545744","https://openalex.org/W2032575731","https://openalex.org/W2035044909","https://openalex.org/W2037994603","https://openalex.org/W2038113812","https://openalex.org/W2040408805","https://openalex.org/W2040896508","https://openalex.org/W2046303658","https://openalex.org/W2048215714","https://openalex.org/W2050936113","https://openalex.org/W2057649456","https://openalex.org/W2058083644","https://openalex.org/W2059882274","https://openalex.org/W2061147238","https://openalex.org/W2064129201","https://openalex.org/W2065800530","https://openalex.org/W2066582706","https://openalex.org/W2068795221","https://openalex.org/W2070418993","https://openalex.org/W2072426213","https://openalex.org/W2073676623","https://openalex.org/W2080504796","https://openalex.org/W2081536457","https://openalex.org/W2084271278","https://openalex.org/W2086382677","https://openalex.org/W2090162049","https://openalex.org/W2093329141","https://openalex.org/W2094661843","https://openalex.org/W2097771036","https://openalex.org/W2100000068","https://openalex.org/W2100596063","https://openalex.org/W2101994976","https://openalex.org/W2104868426","https://openalex.org/W2108563067","https://openalex.org/W2109529646","https://openalex.org/W2110673949","https://openalex.org/W2112741101","https://openalex.org/W2114563488","https://openalex.org/W2114737175","https://openalex.org/W2116742387","https://openalex.org/W2117644242","https://openalex.org/W2117677427","https://openalex.org/W2121540469","https://openalex.org/W2121783932","https://openalex.org/W2121841864","https://openalex.org/W2124536046","https://openalex.org/W2133449490","https://openalex.org/W2134221241","https://openalex.org/W2136220283","https://openalex.org/W2140851438","https://openalex.org/W2143701484","https://openalex.org/W2149039469","https://openalex.org/W2149383583","https://openalex.org/W2151508727","https://openalex.org/W2158500407","https://openalex.org/W2160795660","https://openalex.org/W2162915566","https://openalex.org/W2172296955","https://openalex.org/W2405090893","https://openalex.org/W2408466945"],"related_works":["https://openalex.org/W2266045247","https://openalex.org/W1879975360","https://openalex.org/W1567120968","https://openalex.org/W4230448311","https://openalex.org/W4411677865","https://openalex.org/W2896718743","https://openalex.org/W2598536317","https://openalex.org/W3035775664","https://openalex.org/W4280536206","https://openalex.org/W2608232849"],"abstract_inverted_index":{"In":[0],"the":[1,8,24,84,107,140,143,147,159,162,188,191,203],"context":[2],"of":[3,10,21,26,106,133,161,190,202,215],"immunity,":[4],"pattern":[5,163,192],"recognition":[6,55,164,193],"is":[7,23,88],"art":[9],"discriminating":[11],"friend":[12],"from":[13,17],"foe":[14],"and":[15,38,43,56,77,98,117,130,146,206],"innocuous":[16],"noxious.":[18],"The":[19,122],"basis":[20],"discrimination":[22],"existence":[25],"evolutionarily":[27],"conserved":[28],"patterns":[29,50],"on":[30,200],"microorganisms,":[31],"which":[32,150],"are":[33,51],"intrinsic":[34],"to":[35,186],"these":[36],"microorganisms":[37],"necessary":[39],"for":[40,54,181,212],"their":[41,173,213],"function":[42],"existence.":[44],"Such":[45],"immutable":[46],"or":[47,178],"slowly":[48],"evolving":[49],"ideal":[52],"handles":[53],"have":[57],"been":[58],"targeted":[59],"by":[60,78,218],"early":[61],"cellular":[62],"immune":[63,109,120],"defence":[64,80],"mechanisms":[65,81],"such":[66,82],"as":[67,83,170,172],"Toll-like":[68],"receptors,":[69,71,73],"NOD-like":[70],"RIG-I-like":[72],"C-type":[74],"lectin":[75,148,204],"receptors":[76],"humoral":[79],"complement":[85,123,168,197],"system.":[86],"Complement":[87],"a":[89,103,209],"proteolytic":[90],"cascade":[91,124],"system":[92],"comprising":[93],"around":[94],"35":[95],"different":[96],"soluble":[97],"membrane-bound":[99],"proteins.":[100],"It":[101],"constitutes":[102],"central":[104],"part":[105],"innate":[108,114],"system,":[110],"mediating":[111],"several":[112],"major":[113],"effector":[115,154],"functions":[116],"modulating":[118],"adaptive":[119],"responses.":[121],"proceeds":[125],"via":[126],"controlled,":[127],"limited":[128],"proteolysis":[129],"conformational":[131],"changes":[132],"constituent":[134],"proteins":[135],"through":[136],"three":[137],"activation":[138],"pathways:":[139],"classical":[141],"pathway,":[142,149,205],"alternative":[144],"pathway":[145],"converge":[151],"in":[152,167,196],"common":[153],"functions.":[155],"Here,":[156],"we":[157],"review":[158],"nature":[160],"molecules":[165],"involved":[166,195],"activation,":[169,198],"well":[171],"close":[174],"relatives":[175],"with":[176],"no":[177],"unknown":[179],"capacity":[180],"activating":[182],"complement.":[183],"We":[184],"proceed":[185],"examine":[187],"composition":[189],"complexes":[194],"focusing":[199],"those":[201],"arrive":[207],"at":[208],"new":[210],"model":[211],"mechanism":[214],"operation,":[216],"supported":[217],"recently":[219],"emerging":[220],"evidence.":[221]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
