{"id":"https://openalex.org/W2012792124","doi":"https://doi.org/10.1063/1.2217737","title":"Cation and anion transport through hydrophilic pores in lipid bilayers","display_name":"Cation and anion transport through hydrophilic pores in lipid bilayers","publication_year":2006,"publication_date":"2006-08-17","ids":{"openalex":"https://openalex.org/W2012792124","doi":"https://doi.org/10.1063/1.2217737","mag":"2012792124","pmid":"https://pubmed.ncbi.nlm.nih.gov/16942374"},"language":"en","primary_location":{"id":"doi:10.1063/1.2217737","doi":"https://doi.org/10.1063/1.2217737","is_oa":false,"landing_page_url":"https://doi.org/10.1063/1.2217737","pdf_url":null,"source":{"id":"https://openalex.org/S77047749","display_name":"The Journal of Chemical Physics","issn_l":"0021-9606","issn":["0021-9606","1089-7690","1520-9032"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320257","host_organization_name":"American Institute of Physics","host_organization_lineage":["https://openalex.org/P4310320257"],"host_organization_lineage_names":["American Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Chemical Physics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://deepblue.lib.umich.edu/bitstream/2027.42/87872/2/074901_1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086175359","display_name":"Senthil Kumar Kandasamy","orcid":"https://orcid.org/0000-0003-2133-2701","observed_orcids":["https://orcid.org/0000-0003-2133-2701"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Senthil K. Kandasamy","raw_affiliation_strings":["The University of Michigan Chemical Engineering Department, , Ann Arbor, Michigan 48109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Michigan Chemical Engineering Department, , Ann Arbor, Michigan 48109","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029067826","display_name":"Ronald G. Larson","orcid":"https://orcid.org/0000-0001-7465-1963","observed_orcids":["https://orcid.org/0000-0001-7465-1963"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald G. Larson","raw_affiliation_strings":["The University of Michigan Chemical Engineering Department, , Ann Arbor, Michigan 48109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Michigan Chemical Engineering Department, , Ann Arbor, Michigan 48109","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":1.5719,"has_fulltext":true,"cited_by_count":57,"citation_normalized_percentile":{"value":0.79955694,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"125","issue":"7","first_page":"074901","last_page":"074901"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11582","display_name":"Nanopore and Nanochannel Transport Studies","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ion-transport","display_name":"ion transport","score":0.5830000042915344},{"id":"https://openalex.org/keywords/lipid-bilayers","display_name":"lipid bilayers","score":0.824999988079071},{"id":"https://openalex.org/keywords/water-pores","display_name":"water pores","score":0.5460000038146973},{"id":"https://openalex.org/keywords/membrane-potential","display_name":"membrane potential","score":0.8690000176429749},{"id":"https://openalex.org/keywords/popc","display_name":"POPC","score":0.5690000057220459},{"id":"https://openalex.org/keywords/chloride","display_name":"chloride","score":0.5680000185966492},{"id":"https://openalex.org/keywords/sodium-ions","display_name":"sodium ions","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ion-residence-time","display_name":"ion residence time","score":0.5659999847412109},{"id":"https://openalex.org/keywords/lipid-flip-flop","display_name":"lipid flip-flop","score":0.890999972820282},{"id":"https://openalex.org/keywords/membrane-stability","display_name":"membrane stability","score":0.6000000238418579},{"id":"https://openalex.org/keywords/hydrophilic-pores","display_name":"hydrophilic pores","score":0.5529999732971191},{"id":"https://openalex.org/keywords/atomistic-molecular-dynamics","display_name":"atomistic molecular dynamics","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.7578192353248596},{"id":"https://openalex.org/C2780943371","wikidata":"https://www.wikidata.org/wiki/Q10860475","display_name":"POPC","level":4,"score":0.7427613139152527},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7310857772827148},{"id":"https://openalex.org/C192157962","wikidata":"https://www.wikidata.org/wiki/Q4087243","display_name":"Bilayer","level":3,"score":0.7212194204330444},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.6379746794700623},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.5832123756408691},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.5596017241477966},{"id":"https://openalex.org/C175634916","wikidata":"https://www.wikidata.org/wiki/Q17075777","display_name":"Potential of mean force","level":3,"score":0.5503860116004944},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5150992274284363},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.5082340240478516},{"id":"https://openalex.org/C76564549","wikidata":"https://www.wikidata.org/wiki/Q17154515","display_name":"Lipid bilayer phase behavior","level":4,"score":0.4461626410484314},{"id":"https://openalex.org/C2776330855","wikidata":"https://www.wikidata.org/wiki/Q650187","display_name":"Phosphatidylcholine","level":4,"score":0.4208720028400421},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.41268178820610046},{"id":"https://openalex.org/C99975950","wikidata":"https://www.wikidata.org/wiki/Q911011","display_name":"Ion transporter","level":3,"score":0.4103039503097534},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3910577595233917},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3761441111564636},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.16584625840187073},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.1646212339401245},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0909414291381836},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.059313297271728516},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000838","descriptor_name":"Anions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000838","descriptor_name":"Anions","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002412","descriptor_name":"Cations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002412","descriptor_name":"Cations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1063/1.2217737","doi":"https://doi.org/10.1063/1.2217737","is_oa":false,"landing_page_url":"https://doi.org/10.1063/1.2217737","pdf_url":null,"source":{"id":"https://openalex.org/S77047749","display_name":"The Journal of Chemical Physics","issn_l":"0021-9606","issn":["0021-9606","1089-7690","1520-9032"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320257","host_organization_name":"American Institute of Physics","host_organization_lineage":["https://openalex.org/P4310320257"],"host_organization_lineage_names":["American Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Chemical Physics","raw_type":"journal-article"},{"id":"pmid:16942374","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16942374","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of chemical physics","raw_type":"Journal Article"},{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/87872","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2027.42/87872","pdf_url":"http://deepblue.lib.umich.edu/bitstream/2027.42/87872/2/074901_1.pdf","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/87872","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2027.42/87872","pdf_url":"http://deepblue.lib.umich.edu/bitstream/2027.42/87872/2/074901_1.pdf","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2012792124.pdf","grobid_xml":"https://content.openalex.org/works/W2012792124.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1605166042","https://openalex.org/W1970413180","https://openalex.org/W1972800394","https://openalex.org/W1990862734","https://openalex.org/W2021125439","https://openalex.org/W2028479107","https://openalex.org/W2032284161","https://openalex.org/W2035687084","https://openalex.org/W2045715258","https://openalex.org/W2053882954","https://openalex.org/W2055701049","https://openalex.org/W2057973387","https://openalex.org/W2066476716","https://openalex.org/W2072496065","https://openalex.org/W2079416519","https://openalex.org/W2081260116","https://openalex.org/W2084137175","https://openalex.org/W2089791519","https://openalex.org/W2122042576","https://openalex.org/W2123768693","https://openalex.org/W2125099476","https://openalex.org/W2125807298","https://openalex.org/W2128572087","https://openalex.org/W2130016462","https://openalex.org/W2154986125","https://openalex.org/W2161065969","https://openalex.org/W2171268876"],"related_works":["https://openalex.org/W2079416519","https://openalex.org/W2118733096","https://openalex.org/W2027769882","https://openalex.org/W2093596096","https://openalex.org/W4311569790","https://openalex.org/W2072718785","https://openalex.org/W2950243449","https://openalex.org/W2092587448","https://openalex.org/W2598177410","https://openalex.org/W1984014838"],"abstract_inverted_index":{"To":[0],"understand":[1],"the":[2,12,47,55,86,91,95,106,125,136,139,160,164,170,173,187,190,215,220],"origin":[3],"of":[4,8,14,29,62,80,94,105,113,145,163,172,189],"transmembrane":[5,41,60,77],"potentials,":[6],"formation":[7,112],"transient":[9],"pores,":[10],"and":[11,16,39,50,121],"movement":[13],"anions":[15,128],"cations":[17,140],"across":[18],"lipid":[19,155,202,207],"membranes,":[20],"we":[21,166,179,184],"have":[22,130],"performed":[23],"systematic":[24],"atomistic":[25],"molecular":[26],"dynamics":[27],"simulations":[28,96],"palmitoyl-oleoyl-phosphatidylcholine":[30],"(POPC)":[31],"lipids.":[32],"A":[33,59],"double":[34],"bilayer":[35,70,212],"setup":[36],"was":[37,66],"employed":[38],"different":[40],"potentials":[42],"were":[43,88],"generated":[44,68],"by":[45,219],"varying":[46],"anion":[48,120],"(Cl-)":[49],"cation":[51,122],"(Na+)":[52],"concentrations":[53],"in":[54,204],"two":[56,107],"water":[57,115,221],"compartments.":[58],"potential":[61,78,102,175],"approximately":[63,83],"350":[64],"mV":[65],"thereby":[67],"per":[69],"for":[71],"a":[72,114,131,142,154,200,206],"unit":[73],"charge":[74],"imbalance.":[75],"For":[76],"differences":[79],"up":[81],"to":[82,118,153,214],"1.4":[84],"V,":[85],"bilayers":[87,108],"stable,":[89],"over":[90],"time":[92,134,161],"scale":[93,162],"(10-50":[97],"ns).":[98],"At":[99],"larger":[100],"imposed":[101],"differences,":[103],"one":[104,211],"breaks":[109],"down":[110],"through":[111,124],"pore,":[116,137],"leading":[117],"both":[119],"translocations":[123],"pore.":[126,222],"The":[127],"typically":[129],"short":[132],"residence":[133,146],"inside":[135],"while":[138],"show":[141],"wider":[143],"range":[144],"times":[147],"depending":[148],"on":[149],"whether":[150],"they":[151],"bind":[152],"molecule":[156,208],"or":[157],"not.":[158],"Over":[159],"simulations,":[165],"do":[167,178],"not":[168],"observe":[169,180,185],"discharge":[171],"entire":[174],"difference,":[176],"nor":[177],"pore":[181,191],"closing,":[182],"although":[183],"that":[186],"size":[188],"decreases":[192],"as":[193],"more":[194],"ions":[195],"translocate.":[196],"We":[197],"also":[198],"observed":[199],"rare":[201],"flip-flop,":[203],"which":[205],"translocated":[209],"from":[210],"leaflet":[213],"opposite":[216],"leaflet,":[217],"assisted":[218]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}